{"id":"https://openalex.org/W2294044832","doi":"https://doi.org/10.1073/pnas.1519609113","title":"Allosteric switch regulates protein\u2013protein binding through collective motion","display_name":"Allosteric switch regulates protein\u2013protein binding through collective motion","publication_year":2016,"publication_date":"2016-03-09","ids":{"openalex":"https://openalex.org/W2294044832","doi":"https://doi.org/10.1073/pnas.1519609113","mag":"2294044832","pmid":"https://pubmed.ncbi.nlm.nih.gov/26961002","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4812760"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1519609113","doi":"https://doi.org/10.1073/pnas.1519609113","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.1519609113","pdf_url":"https://www.pnas.org/content/pnas/113/12/3269.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.pnas.org/content/pnas/113/12/3269.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087051940","display_name":"Colin A. Smith","orcid":"https://orcid.org/0000-0002-4651-167X","observed_orcids":["https://orcid.org/0000-0002-4651-167X"]},"institutions":[{"id":"https://openalex.org/I4210131661","display_name":"Max Planck Institute for Biophysical Chemistry","ror":"https://ror.org/03e76ya46","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210131661","https://openalex.org/I4387154714"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Colin A. Smith","raw_affiliation_strings":["Department for NMR-Based Structural Biology, Max Planck Institute for Biophysical Chemistry, 37077 Goettingen, Germany;","Department for Theoretical and Computational Biophysics, Max Planck Institute for Biophysical Chemistry, 37077 Goettingen, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for NMR-Based Structural Biology, Max Planck Institute for Biophysical Chemistry, 37077 Goettingen, Germany;","institution_ids":["https://openalex.org/I4210131661"]},{"raw_affiliation_string":"Department for Theoretical and Computational Biophysics, Max Planck Institute for Biophysical Chemistry, 37077 Goettingen, Germany;","institution_ids":["https://openalex.org/I4210131661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103219643","display_name":"David Ban","orcid":"https://orcid.org/0000-0002-4993-7983","observed_orcids":["https://orcid.org/0000-0002-4993-7983"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]},{"id":"https://openalex.org/I4210131661","display_name":"Max Planck Institute for Biophysical Chemistry","ror":"https://ror.org/03e76ya46","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210131661","https://openalex.org/I4387154714"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"David Ban","raw_affiliation_strings":["Department for NMR-Based Structural Biology, Max Planck Institute for Biophysical Chemistry, 37077 Goettingen, Germany;","Department of Medicine, James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202"],"raw_orcid":"https://orcid.org/0000-0002-4993-7983","affiliations":[{"raw_affiliation_string":"Department for NMR-Based Structural Biology, Max Planck Institute for Biophysical Chemistry, 37077 Goettingen, Germany;","institution_ids":["https://openalex.org/I4210131661"]},{"raw_affiliation_string":"Department of Medicine, James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072275874","display_name":"Supriya Pratihar","orcid":"https://orcid.org/0000-0001-6779-1490","observed_orcids":["https://orcid.org/0000-0001-6779-1490"]},"institutions":[{"id":"https://openalex.org/I4210131661","display_name":"Max Planck Institute for Biophysical Chemistry","ror":"https://ror.org/03e76ya46","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210131661","https://openalex.org/I4387154714"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Supriya Pratihar","raw_affiliation_strings":["Department for NMR-Based Structural Biology, Max Planck Institute for Biophysical Chemistry, 37077 Goettingen, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for NMR-Based Structural Biology, Max Planck Institute for Biophysical Chemistry, 37077 Goettingen, Germany;","institution_ids":["https://openalex.org/I4210131661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000234326","display_name":"Karin Giller","orcid":"https://orcid.org/0000-0002-4149-7899","observed_orcids":["https://orcid.org/0000-0002-4149-7899"]},"institutions":[{"id":"https://openalex.org/I4210131661","display_name":"Max Planck Institute for Biophysical Chemistry","ror":"https://ror.org/03e76ya46","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210131661","https://openalex.org/I4387154714"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karin Giller","raw_affiliation_strings":["Department for NMR-Based Structural Biology, Max Planck Institute for Biophysical Chemistry, 37077 Goettingen, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for NMR-Based Structural Biology, Max Planck Institute for Biophysical Chemistry, 37077 Goettingen, Germany;","institution_ids":["https://openalex.org/I4210131661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035037006","display_name":"Maria Paulat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131661","display_name":"Max Planck Institute for Biophysical Chemistry","ror":"https://ror.org/03e76ya46","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210131661","https://openalex.org/I4387154714"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maria Paulat","raw_affiliation_strings":["Department for NMR-Based Structural Biology, Max Planck Institute for Biophysical Chemistry, 37077 Goettingen, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for NMR-Based Structural Biology, Max Planck Institute for Biophysical Chemistry, 37077 Goettingen, Germany;","institution_ids":["https://openalex.org/I4210131661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050687402","display_name":"Stefan Becker","orcid":"https://orcid.org/0000-0003-2041-5740","observed_orcids":["https://orcid.org/0000-0003-2041-5740"]},"institutions":[{"id":"https://openalex.org/I4210131661","display_name":"Max Planck Institute for Biophysical Chemistry","ror":"https://ror.org/03e76ya46","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210131661","https://openalex.org/I4387154714"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Becker","raw_affiliation_strings":["Department for NMR-Based Structural Biology, Max Planck Institute for Biophysical Chemistry, 37077 Goettingen, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for NMR-Based Structural Biology, Max Planck Institute for Biophysical Chemistry, 37077 Goettingen, Germany;","institution_ids":["https://openalex.org/I4210131661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037375841","display_name":"Christian Griesinger","orcid":"https://orcid.org/0000-0002-1266-4344","observed_orcids":["https://orcid.org/0000-0002-1266-4344"]},"institutions":[{"id":"https://openalex.org/I4210131661","display_name":"Max Planck Institute for Biophysical Chemistry","ror":"https://ror.org/03e76ya46","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210131661","https://openalex.org/I4387154714"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Griesinger","raw_affiliation_strings":["Department for NMR-Based Structural Biology, Max Planck Institute for Biophysical Chemistry, 37077 Goettingen, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for NMR-Based Structural Biology, Max Planck Institute for Biophysical Chemistry, 37077 Goettingen, Germany;","institution_ids":["https://openalex.org/I4210131661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007020226","display_name":"Donghan Lee","orcid":"https://orcid.org/0000-0002-3971-986X","observed_orcids":["https://orcid.org/0000-0002-3971-986X","https://orcid.org/0000-0002-6530-8060"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]},{"id":"https://openalex.org/I4210131661","display_name":"Max Planck Institute for Biophysical Chemistry","ror":"https://ror.org/03e76ya46","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210131661","https://openalex.org/I4387154714"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Donghan Lee","raw_affiliation_strings":["Department for NMR-Based Structural Biology, Max Planck Institute for Biophysical Chemistry, 37077 Goettingen, Germany;","Department of Medicine, James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for NMR-Based Structural Biology, Max Planck Institute for Biophysical Chemistry, 37077 Goettingen, Germany;","institution_ids":["https://openalex.org/I4210131661"]},{"raw_affiliation_string":"Department of Medicine, James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044839728","display_name":"Bert L. de Groot","orcid":"https://orcid.org/0000-0003-3570-3534","observed_orcids":["https://orcid.org/0000-0003-3570-3534"]},"institutions":[{"id":"https://openalex.org/I4210131661","display_name":"Max Planck Institute for Biophysical Chemistry","ror":"https://ror.org/03e76ya46","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210131661","https://openalex.org/I4387154714"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bert L. de Groot","raw_affiliation_strings":["Department for Theoretical and Computational Biophysics, Max Planck Institute for Biophysical Chemistry, 37077 Goettingen, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Theoretical and Computational Biophysics, Max Planck Institute for Biophysical Chemistry, 37077 Goettingen, Germany;","institution_ids":["https://openalex.org/I4210131661"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.4134,"has_fulltext":true,"cited_by_count":76,"citation_normalized_percentile":{"value":0.95576986,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"113","issue":"12","first_page":"3269","last_page":"3274"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allosteric-communication","display_name":"allosteric communication","score":0.9509999752044678},{"id":"https://openalex.org/keywords/collective-protein-motions","display_name":"collective protein motions","score":0.8240000009536743},{"id":"https://openalex.org/keywords/protein-protein-binding","display_name":"protein-protein binding","score":0.8289999961853027},{"id":"https://openalex.org/keywords/ubiquitin","display_name":"ubiquitin","score":0.9399999976158142},{"id":"https://openalex.org/keywords/conformational-switch","display_name":"conformational switching","score":0.8960000276565552},{"id":"https://openalex.org/keywords/ground-state-dynamics","display_name":"ground state dynamics","score":0.7580000162124634},{"id":"https://openalex.org/keywords/ubiquitin-specific-protease","display_name":"ubiquitin-specific protease","score":0.8740000128746033},{"id":"https://openalex.org/keywords/deubiquitinase","display_name":"deubiquitinase","score":0.9879999756813049},{"id":"https://openalex.org/keywords/allosteric-networks","display_name":"allosteric networks","score":0.8149999976158142}],"concepts":[{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.9843172430992126},{"id":"https://openalex.org/C109964505","wikidata":"https://www.wikidata.org/wiki/Q3321436","display_name":"Allosteric enzyme","level":4,"score":0.6567371487617493},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.6006473302841187},{"id":"https://openalex.org/C2775981520","wikidata":"https://www.wikidata.org/wiki/Q17156992","display_name":"Protein dynamics","level":3,"score":0.4491649270057678},{"id":"https://openalex.org/C2780499737","wikidata":"https://www.wikidata.org/wiki/Q24755076","display_name":"Collective motion","level":2,"score":0.4432589113712311},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.43000921607017517},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.41317445039749146},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3917604088783264},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3636557459831238},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3367202877998352},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2942522168159485},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.18377280235290527},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14879754185676575},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1073/pnas.1519609113","doi":"https://doi.org/10.1073/pnas.1519609113","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.1519609113","pdf_url":"https://www.pnas.org/content/pnas/113/12/3269.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3987584","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4812760","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4812760","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4812760","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:26961002","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26961002","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pure.mpg.de:item_2262648","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11858/00-001M-0000-002A-226C-0","pdf_url":"https://hdl.handle.net/11858/00-001M-0000-002A-226E-C","source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:publications.goettingen-research-online.de:2/180","doi":null,"is_oa":false,"landing_page_url":"https://resolver.sub.uni-goettingen.de/purl?gro-2/180","pdf_url":null,"source":{"id":"https://openalex.org/S7407055187","display_name":"GRO","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1073/pnas.1519609113","doi":"https://doi.org/10.1073/pnas.1519609113","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.1519609113","pdf_url":"https://www.pnas.org/content/pnas/113/12/3269.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6476451274","display_name":"NMR detected nanosecond to microsecond dynamics for biomolecular recognition dynamics","funder_award_id":"233227","funder_id":"https://openalex.org/F4320338352","funder_display_name":"FP7 Ideas: European Research Council"},{"id":"https://openalex.org/G796298264","display_name":null,"funder_award_id":"233227","funder_id":"https://openalex.org/F4320334678","funder_display_name":"European Research Council"}],"funders":[{"id":"https://openalex.org/F4320308269","display_name":"Alexander von Humboldt-Stiftung","ror":"https://ror.org/012kf4317"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320322434","display_name":"Max-Planck-Gesellschaft","ror":"https://ror.org/01hhn8329"},{"id":"https://openalex.org/F4320334678","display_name":"European Research Council","ror":"https://ror.org/0472cxd90"},{"id":"https://openalex.org/F4320338352","display_name":"FP7 Ideas: European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2294044832.pdf","grobid_xml":"https://content.openalex.org/works/W2294044832.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W240415867","https://openalex.org/W1152703269","https://openalex.org/W1199870172","https://openalex.org/W1971916332","https://openalex.org/W1974389826","https://openalex.org/W1978598430","https://openalex.org/W1982615479","https://openalex.org/W1984748711","https://openalex.org/W1993200549","https://openalex.org/W1997477098","https://openalex.org/W2004577830","https://openalex.org/W2017229301","https://openalex.org/W2025587541","https://openalex.org/W2026911129","https://openalex.org/W2029120587","https://openalex.org/W2030384127","https://openalex.org/W2038689972","https://openalex.org/W2041051514","https://openalex.org/W2045089261","https://openalex.org/W2052045126","https://openalex.org/W2053967598","https://openalex.org/W2055093391","https://openalex.org/W2060728024","https://openalex.org/W2066000489","https://openalex.org/W2078070626","https://openalex.org/W2084493621","https://openalex.org/W2093626513","https://openalex.org/W2094460693","https://openalex.org/W2108067304","https://openalex.org/W2119749713","https://openalex.org/W2127295527","https://openalex.org/W2131639373","https://openalex.org/W2135867920","https://openalex.org/W2139591268","https://openalex.org/W2140038854","https://openalex.org/W2141378819","https://openalex.org/W2146933476","https://openalex.org/W2151581834","https://openalex.org/W2156012420","https://openalex.org/W2157182791","https://openalex.org/W2159013987","https://openalex.org/W2166035246","https://openalex.org/W2167096693","https://openalex.org/W4236858312"],"related_works":["https://openalex.org/W2469102853","https://openalex.org/W1886700512","https://openalex.org/W1991852266","https://openalex.org/W7141051046","https://openalex.org/W2004577830","https://openalex.org/W1943533769","https://openalex.org/W4281753901","https://openalex.org/W2099777386","https://openalex.org/W2280014486","https://openalex.org/W2074129172"],"abstract_inverted_index":{"Many":[0],"biological":[1],"processes":[2],"depend":[3],"on":[4,104],"allosteric":[5,62,92,127],"communication":[6,93],"between":[7],"different":[8],"parts":[9],"of":[10,16,35,84,108,115],"a":[11,44,53,120],"protein,":[12],"but":[13],"the":[14,24,36,58,79,109],"role":[15],"internal":[17],"protein":[18,111],"motion":[19,47,88],"in":[20,40,67],"propagating":[21],"signals":[22],"through":[23,98],"structure":[25],"remains":[26],"largely":[27],"unknown.":[28],"Through":[29],"an":[30],"experimental":[31],"and":[32,70,106,125],"computational":[33],"analysis":[34],"ground":[37],"state":[38],"dynamics":[39],"ubiquitin,":[41],"we":[42],"identify":[43],"collective":[45,87,117],"global":[46],"that":[48,89],"is":[49,64,71],"specifically":[50],"linked":[51],"to":[52,73,78],"conformational":[54],"switch":[55],"distant":[56],"from":[57],"binding":[59,77,97],"interface.":[60],"This":[61],"coupling":[63],"also":[65],"present":[66],"crystal":[68],"structures":[69],"found":[72],"facilitate":[74],"multispecificity,":[75],"particularly":[76],"ubiquitin-specific":[80],"protease":[81],"(USP)":[82],"family":[83],"deubiquitinases.":[85],"The":[86,113],"enables":[90],"this":[91],"does":[94],"not":[95],"affect":[96],"localized":[99],"changes":[100],"but,":[101],"instead,":[102],"depends":[103],"expansion":[105],"contraction":[107],"entire":[110],"domain.":[112],"characterization":[114],"these":[116],"motions":[118],"represents":[119],"promising":[121],"avenue":[122],"for":[123],"finding":[124],"manipulating":[126],"networks.":[128]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}