{"id":"https://openalex.org/W2293682282","doi":null,"title":"99mTc-antimicrobial peptides: promising candidates for infection imaging.","display_name":"99mTc-antimicrobial peptides: promising candidates for infection imaging.","publication_year":2003,"publication_date":"2003-12-01","ids":{"openalex":"https://openalex.org/W2293682282","mag":"2293682282","pmid":"https://pubmed.ncbi.nlm.nih.gov/14973416"},"language":"en","primary_location":{"id":"pmid:14973416","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14973416","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR)","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009501506","display_name":"Antonella Lupetti","orcid":"https://orcid.org/0000-0002-6975-8114","observed_orcids":["https://orcid.org/0000-0002-6975-8114"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"A Lupetti","raw_affiliation_strings":["Department of Infectious Diseases, Leiden University Medical Center (LUMC), C4-Q, NL-2300 RC Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Leiden University Medical Center (LUMC), C4-Q, NL-2300 RC Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111607767","display_name":"E.K.J. Pauwels","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E K J Pauwels","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062066729","display_name":"Peter H. Nibbering","orcid":"https://orcid.org/0000-0002-0432-8340","observed_orcids":["https://orcid.org/0000-0002-0432-8340"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P H Nibbering","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5012033996","display_name":"Mick M. Welling","orcid":"https://orcid.org/0000-0002-2249-5601","observed_orcids":["https://orcid.org/0000-0002-2249-5601"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M M Welling","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4202,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.590307,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"47","issue":"4","first_page":"238","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.5054000020027161,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.5054000020027161,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.46799999475479126,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/technetium-99m","display_name":"technetium-99m","score":0.8989999890327454},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.9940000176429749},{"id":"https://openalex.org/keywords/infection-imaging","display_name":"infection imaging","score":0.9549999833106995},{"id":"https://openalex.org/keywords/bacterial-infection","display_name":"bacterial infection","score":0.746999979019165},{"id":"https://openalex.org/keywords/fungal-infection","display_name":"fungal infection","score":1.0},{"id":"https://openalex.org/keywords/radiopharmaceuticals","display_name":"radiopharmaceuticals","score":0.8769999742507935},{"id":"https://openalex.org/keywords/sterile-inflammation","display_name":"sterile inflammation","score":0.7450000047683716},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"nuclear medicine","score":0.36899998784065247}],"concepts":[{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.8701145648956299},{"id":"https://openalex.org/C540938839","wikidata":"https://www.wikidata.org/wiki/Q1201508","display_name":"Antimicrobial peptides","level":3,"score":0.8334882259368896},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6437174081802368},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6093205213546753},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.595032811164856},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5743712186813354},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5319122672080994},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.42815518379211426},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41187161207199097},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3847759962081909},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28229761123657227},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0783284604549408},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007239","descriptor_name":"Infections","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D007239","descriptor_name":"Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007781","descriptor_name":"Lactoferrin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012269","descriptor_name":"Ribosomal Proteins","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016719","descriptor_name":"Radioimmunodetection","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017556","descriptor_name":"Technetium Compounds","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D023084","descriptor_name":"alpha-Defensins","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D023181","descriptor_name":"Antimicrobial Cationic Peptides","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:14973416","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14973416","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR)","raw_type":"Journal Article"},{"id":"pmh:oai:arpi.unipi.it:11568/79917","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11568/79917","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2293682282","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14973416","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1946298453","https://openalex.org/W1957747208","https://openalex.org/W1964758221","https://openalex.org/W1983052875","https://openalex.org/W1984123399","https://openalex.org/W1993500415","https://openalex.org/W2000327035","https://openalex.org/W2024122170","https://openalex.org/W2049695588","https://openalex.org/W2054602599","https://openalex.org/W2104159258","https://openalex.org/W2145435383","https://openalex.org/W2147979924","https://openalex.org/W2167925233","https://openalex.org/W2321004554"],"related_works":["https://openalex.org/W2107525095","https://openalex.org/W2047795757","https://openalex.org/W2033989718","https://openalex.org/W1913783447","https://openalex.org/W2058035814","https://openalex.org/W3188590004","https://openalex.org/W2188973368","https://openalex.org/W2004237891","https://openalex.org/W1983052875","https://openalex.org/W2159178811"],"abstract_inverted_index":{"This":[0],"review":[1],"presents":[2],"the":[3,6,90,111,118,121,156,159,165,178,181],"state":[4],"of":[5,8,10,28,38,47,64,67,83,92,141,167,180,183,199],"art":[7],"imaging":[9,198],"bacterial":[11,200],"and":[12,53,74,97,107,114,201],"fungal":[13,202],"infections":[14,203],"in":[15,42,95,98,149,204],"laboratory":[16,71,151],"animals":[17,152],"using":[18],"antimicrobial":[19,85,184],"peptides":[20,34,68,78,86,126,148,175,189],"labelled":[21],"with":[22,146,164],"technetium-99m":[23],"((99m)Tc).":[24],"The":[25],"mechanistic":[26],"basis":[27,91],"this":[29],"approach":[30],"is":[31],"that":[32,155,172],"these":[33,134,173],"accumulate":[35],"at":[36,158],"sites":[37,140],"infection,":[39],"but":[40],"not":[41],"sterile":[43,142],"inflammatory":[44],"lesions,":[45],"because":[46],"their":[48,93],"preferential":[49,94],"binding":[50,81,100],"to":[51,101],"bacteria":[52,169],"fungi":[54],"over":[55,103],"mammalian":[56],"cells.":[57],"For":[58],"practical":[59],"reasons,":[60],"such":[61,80],"as":[62],"production":[63],"large":[65],"amounts":[66],"under":[69],"good":[70],"practice":[72],"conditions":[73],"favourable":[75],"pharmacokinetics,":[76],"synthetic":[77,188],"representing":[79],"domains":[82],"natural":[84],"are":[87,194],"preferred.":[88],"On":[89],"vitro":[96],"vivo":[99],"microorganisms":[102],"human":[104,192],"cells,":[105],"fast":[106],"easy":[108],"penetration":[109],"into":[110],"target":[112],"area,":[113],"rapid":[115],"clearance":[116],"from":[117,139,191],"circulation":[119],"via":[120],"urinary":[122],"tract,":[123],"various":[124],"(99m)Tc-antimicrobial":[125],"were":[127],"identified.":[128],"Next,":[129],"it":[130],"was":[131],"determined":[132],"whether":[133],"radiopharmaceuticals":[135],"distinguish":[136],"infectious":[137,160],"foci":[138],"inflammation.":[143],"Further":[144],"experiments":[145],"(99m)Tc-ubiquicidin-derived":[147],"infected":[150],"have":[153],"revealed":[154],"radioactivity":[157],"site":[161],"correlated":[162],"well":[163],"number":[166],"viable":[168],"present,":[170],"indicating":[171],"(99m)Tc-labelled":[174,187],"may":[176],"enable":[177],"monitoring":[179],"efficacy":[182],"therapy.":[185],"Together,":[186],"derived":[190],"ubiquicidin":[193],"promising":[195],"candidates":[196],"for":[197],"nuclear":[205],"medicine.":[206]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}