{"id":"https://openalex.org/W2293653030","doi":"https://doi.org/10.1186/s12864-016-2477-9","title":"Photoreceptor proliferation and dysregulation of cell cycle genes in early onset inherited retinal degenerations","display_name":"Photoreceptor proliferation and dysregulation of cell cycle genes in early onset inherited retinal degenerations","publication_year":2016,"publication_date":"2016-03-11","ids":{"openalex":"https://openalex.org/W2293653030","doi":"https://doi.org/10.1186/s12864-016-2477-9","mag":"2293653030","pmid":"https://pubmed.ncbi.nlm.nih.gov/26969498","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4788844"},"language":"en","primary_location":{"id":"doi:10.1186/s12864-016-2477-9","doi":"https://doi.org/10.1186/s12864-016-2477-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12864-016-2477-9","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12864-016-2477-9.pdf","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s12864-016-2477-9.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064852430","display_name":"Kristin L. Gardiner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristin L. Gardiner","raw_affiliation_strings":["Section of Ophthalmology, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey Street, Philadelphia, PA, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Ophthalmology, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey Street, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111997090","display_name":"Louise M Downs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Louise Downs","raw_affiliation_strings":["Section of Ophthalmology, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey Street, Philadelphia, PA, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Ophthalmology, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey Street, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017388851","display_name":"A. Berta","orcid":"https://orcid.org/0000-0001-9000-8177","observed_orcids":["https://orcid.org/0000-0001-9000-8177"]},"institutions":[{"id":"https://openalex.org/I4210088053","display_name":"Universit\u00e4tsklinikum Erlangen","ror":"https://ror.org/0030f2a11","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210088053"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Agnes I. Berta-Antalics","raw_affiliation_strings":["Augenklinik Uniklinik Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany","Section of Ophthalmology, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey Street, Philadelphia, PA, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Augenklinik Uniklinik Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany","institution_ids":["https://openalex.org/I4210088053"]},{"raw_affiliation_string":"Section of Ophthalmology, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey Street, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064721594","display_name":"Evelyn Santana","orcid":"https://orcid.org/0009-0008-7904-0932","observed_orcids":["https://orcid.org/0009-0008-7904-0932"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evelyn Santana","raw_affiliation_strings":["Section of Ophthalmology, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey Street, Philadelphia, PA, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Ophthalmology, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey Street, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034839971","display_name":"Gustavo David Aguirre","orcid":"https://orcid.org/0000-0002-5228-256X","observed_orcids":["https://orcid.org/0000-0002-5228-256X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gustavo D. Aguirre","raw_affiliation_strings":["Section of Ophthalmology, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey Street, Philadelphia, PA, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Ophthalmology, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey Street, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012977912","display_name":"Sem Genini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sem Genini","raw_affiliation_strings":["Section of Ophthalmology, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey Street, Philadelphia, PA, 19104, USA. geninis@vet.upenn.edu","Section of Ophthalmology, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey Street, Philadelphia, PA, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Ophthalmology, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey Street, Philadelphia, PA, 19104, USA. geninis@vet.upenn.edu","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Section of Ophthalmology, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey Street, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5012977912","https://openalex.org/A5034839971"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":1.1389,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.76185312,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"17","issue":"1","first_page":"221","last_page":"221"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inherited-retinal-degeneration","display_name":"inherited retinal degeneration","score":0.8289999961853027},{"id":"https://openalex.org/keywords/cell-cycle-gene-expression","display_name":"cell cycle gene expression","score":0.8080000281333923},{"id":"https://openalex.org/keywords/rb1","display_name":"RB1","score":0.8420000076293945},{"id":"https://openalex.org/keywords/e2f1","display_name":"E2F1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cyclins","display_name":"cyclins","score":0.800000011920929},{"id":"https://openalex.org/keywords/ndr-kinase","display_name":"NDR kinase","score":0.6019999980926514},{"id":"https://openalex.org/keywords/hippo-signaling-pathway","display_name":"Hippo signaling pathway","score":0.968999981880188},{"id":"https://openalex.org/keywords/mob1","display_name":"MOB1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/lats1","display_name":"LATS1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/rod-photoreceptors","display_name":"rod photoreceptors","score":0.7710000276565552},{"id":"https://openalex.org/keywords/s-cones","display_name":"S-cones","score":0.7329999804496765}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8460733890533447},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.573527455329895},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.5578299760818481},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4987802505493164},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.49224773049354553},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4824131727218628},{"id":"https://openalex.org/C2781040256","wikidata":"https://www.wikidata.org/wiki/Q7316761","display_name":"Retinal degeneration","level":3,"score":0.4686443507671356},{"id":"https://openalex.org/C124320809","wikidata":"https://www.wikidata.org/wiki/Q46292","display_name":"Cyclin-dependent kinase","level":4,"score":0.4491075873374939},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4385860562324524},{"id":"https://openalex.org/C2776062698","wikidata":"https://www.wikidata.org/wiki/Q21111463","display_name":"Retinoblastoma protein","level":4,"score":0.43773382902145386},{"id":"https://openalex.org/C120089663","wikidata":"https://www.wikidata.org/wiki/Q59250999","display_name":"Cyclin","level":4,"score":0.4318813383579254},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4232403635978699},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3731396198272705},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004283","descriptor_name":"Dog Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010786","descriptor_name":"Photoreceptor Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012162","descriptor_name":"Retinal Degeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012162","descriptor_name":"Retinal Degeneration","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D016160","descriptor_name":"Retinoblastoma Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016213","descriptor_name":"Cyclins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018816","descriptor_name":"Genes, cdc","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050687","descriptor_name":"E2F1 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/s12864-016-2477-9","doi":"https://doi.org/10.1186/s12864-016-2477-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12864-016-2477-9","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12864-016-2477-9.pdf","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4788844","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4788844","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"Text"},{"id":"pmid:26969498","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26969498","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC genomics","raw_type":"Journal Article"},{"id":"pmh:oai:repository.upenn.edu:20.500.14332/48915","doi":null,"is_oa":true,"landing_page_url":"https://repository.upenn.edu/handle/20.500.14332/48915","pdf_url":null,"source":{"id":"https://openalex.org/S4306402083","display_name":"ScholarlyCommons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"17","raw_type":"Article"},{"id":"pmh:oai:repository.upenn.edu:vet_papers-1158","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/cgi/viewcontent.cgi?article=1158&context=vet_papers","pdf_url":null,"source":{"id":"https://openalex.org/S4306402083","display_name":"ScholarlyCommons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Departmental Papers (Vet)","raw_type":"text"},{"id":"pmh:oai:aleph.bib-bvb.de:BVB01-029412562","doi":null,"is_oa":false,"landing_page_url":"https://nbn-resolving.org/urn:nbn:de:bvb:29-opus4-80171","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"software, multimedia"},{"id":"pmh:oai:ub.uni-erlangen.de-opus:8017","doi":null,"is_oa":true,"landing_page_url":"https://nbn-resolving.org/urn:nbn:de:bvb:29-opus4-80171","pdf_url":null,"source":{"id":"https://openalex.org/S4306402340","display_name":"OPUS FAU (Kooperativer Bibliotheksverbund Berlin-Brandenburg (KOBV), on behalf of the Universit\u00e4tsbibliothek Erlangen-N\u00fcrnberg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12864-016-2477-9","doi":"https://doi.org/10.1186/s12864-016-2477-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12864-016-2477-9","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12864-016-2477-9.pdf","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9074000120162964}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1390634746","display_name":null,"funder_award_id":"EY\u201006855","funder_id":"https://openalex.org/F4320306340","funder_display_name":"Foundation Fighting Blindness"},{"id":"https://openalex.org/G2606015775","display_name":null,"funder_award_id":"EY 06855","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G4468494340","display_name":null,"funder_award_id":"EY06855","funder_id":"https://openalex.org/F4320312393","funder_display_name":"Hope For Vision"},{"id":"https://openalex.org/G5640549663","display_name":null,"funder_award_id":"EY-017549","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G8120170862","display_name":"Translational Research for Retinal Degeneration Therapies","funder_award_id":"R01EY017549","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000024960","display_name":null,"funder_award_id":"EY-06855","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000256854","display_name":null,"funder_award_id":"EY001583","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000869146","display_name":"Models for Therapy of Hereditary Retinal Degeneration","funder_award_id":"R01EY006855","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000875335","display_name":"Short-term Training: students in health professional schools","funder_award_id":"T35OD010919","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000900625","display_name":"P30 Core Grant For Vision Research","funder_award_id":"P30EY001583","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320306340","display_name":"Foundation Fighting Blindness","ror":"https://ror.org/011728q79"},{"id":"https://openalex.org/F4320312393","display_name":"Hope For Vision","ror":"https://ror.org/02yqjk243"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337578","display_name":"Alcon Research Institute","ror":"https://ror.org/028fhxy95"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2293653030.pdf","grobid_xml":"https://content.openalex.org/works/W2293653030.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W15527184","https://openalex.org/W172529645","https://openalex.org/W305774659","https://openalex.org/W1144453134","https://openalex.org/W1868174959","https://openalex.org/W1964341586","https://openalex.org/W1964381173","https://openalex.org/W1964645175","https://openalex.org/W1964836954","https://openalex.org/W1974113099","https://openalex.org/W1985585018","https://openalex.org/W1985654675","https://openalex.org/W1990153096","https://openalex.org/W1993058424","https://openalex.org/W1994869619","https://openalex.org/W1998691008","https://openalex.org/W2003422015","https://openalex.org/W2003875312","https://openalex.org/W2012698880","https://openalex.org/W2015203780","https://openalex.org/W2032195804","https://openalex.org/W2034980302","https://openalex.org/W2037205230","https://openalex.org/W2048131815","https://openalex.org/W2050748970","https://openalex.org/W2058737332","https://openalex.org/W2064304960","https://openalex.org/W2066854002","https://openalex.org/W2067470032","https://openalex.org/W2070864125","https://openalex.org/W2072555081","https://openalex.org/W2074668040","https://openalex.org/W2075177078","https://openalex.org/W2077293536","https://openalex.org/W2085103039","https://openalex.org/W2090494985","https://openalex.org/W2091158051","https://openalex.org/W2092598865","https://openalex.org/W2093125349","https://openalex.org/W2107277218","https://openalex.org/W2111274886","https://openalex.org/W2114360920","https://openalex.org/W2116231448","https://openalex.org/W2116869556","https://openalex.org/W2122524079","https://openalex.org/W2122545341","https://openalex.org/W2136625993","https://openalex.org/W2137084511","https://openalex.org/W2148410227","https://openalex.org/W2160276745","https://openalex.org/W2168420558","https://openalex.org/W2169879898","https://openalex.org/W2330379514"],"related_works":["https://openalex.org/W6902553633","https://openalex.org/W6958474031","https://openalex.org/W7096608748","https://openalex.org/W6921224990","https://openalex.org/W2003875312","https://openalex.org/W6977562358","https://openalex.org/W2066854002","https://openalex.org/W2071488506","https://openalex.org/W4223459560","https://openalex.org/W2091158051"],"abstract_inverted_index":{"BACKGROUND:":[0],"Mitotic":[1],"terminally":[2,168],"differentiated":[3,169],"photoreceptors":[4],"(PRs)":[5],"are":[6,61,134,172],"observed":[7],"in":[8,21,40,91,111,126,137,154],"early":[9,43],"retinal":[10,16,49],"degeneration":[11],"(erd),":[12],"an":[13],"inherited":[14],"canine":[15],"disease":[17,45],"driven":[18],"by":[19,176],"mutations":[20],"the":[22,72,112,138,155,164,182,185],"NDR":[23,141],"kinase":[24],"STK38L":[25],"(NDR2).":[26],"RESULTS:":[27],"We":[28],"demonstrate":[29],"that":[30,116,167],"a":[31,119],"similar":[32],"proliferative":[33],"response,":[34],"but":[35,86],"of":[36,71,121,140,150,187,196],"lower":[37],"magnitude,":[38],"occurs":[39],"two":[41],"other":[42],"onset":[44],"models,":[46],"X-linked":[47],"progressive":[48],"atrophy":[50],"2":[51],"(xlpra2)":[52],"and":[53,64,78,99,105,143,152],"rod":[54,62],"cone":[55],"dysplasia":[56],"1":[57],"(rcd1).":[58],"Proliferating":[59],"cells":[60],"PRs,":[63],"not":[65],"microglia":[66],"or":[67],"M\u00fcller":[68],"cells.":[69],"Expression":[70],"cell":[73,122],"cycle":[74,123],"related":[75],"genes":[76,189],"RB1":[77],"E2F1":[79],"as":[80,82,193],"well":[81],"CDK2,4,6":[83],"was":[84],"up-regulated,":[85],"changes":[87,136],"were":[88],"mutation-specific.":[89],"Changes":[90],"cyclin":[92],"expression":[93,107,125,139,149],"differed":[94],"across":[95],"all":[96,127],"genes,":[97],"diseases":[98],"time":[100],"points":[101],"analyzed,":[102],"although":[103],"CCNA1":[104],"CCNE1":[106],"increased":[108,148],"with":[109,147],"age":[110],"three":[113,128],"models":[114],"suggesting":[115],"there":[117],"is":[118],"dysregulation":[120],"gene":[124],"diseases.":[129],"Unique":[130],"to":[131],"erd,":[132],"however,":[133],"mutation-specific":[135],"kinases":[142],"Hippo":[144],"signaling":[145],"members":[146],"MOB1":[151],"LATS1":[153],"newly":[156],"generated":[157],"hybrid":[158],"rod/S-cones.":[159],"CONCLUSIONS:":[160],"Our":[161],"data":[162],"raise":[163],"intriguing":[165],"possibility":[166],"normal":[170],"PRs":[171],"kept":[173],"from":[174],"dividing":[175],"NDR2-MOB1":[177],"interaction.":[178],"Furthermore,":[179],"they":[180],"provide":[181],"framework":[183],"for":[184,190],"selection":[186],"candidate":[188],"further":[191],"investigation":[192],"potential":[194],"targets":[195],"therapy.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
