{"id":"https://openalex.org/W2293438552","doi":"https://doi.org/10.3177/jnsv.61.s103","title":"Probiotics as an Immune Modulator","display_name":"Probiotics as an Immune Modulator","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2293438552","doi":"https://doi.org/10.3177/jnsv.61.s103","mag":"2293438552","pmid":"https://pubmed.ncbi.nlm.nih.gov/26598815"},"language":"en","primary_location":{"id":"doi:10.3177/jnsv.61.s103","doi":"https://doi.org/10.3177/jnsv.61.s103","is_oa":true,"landing_page_url":"https://doi.org/10.3177/jnsv.61.s103","pdf_url":"https://www.jstage.jst.go.jp/article/jnsv/61/Supplement/61_S103/_pdf","source":{"id":"https://openalex.org/S150433807","display_name":"Journal of Nutritional Science and Vitaminology","issn_l":"0301-4800","issn":["0301-4800","1881-7742"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4323283980","host_organization_name":"Center for Academic Publications Japan","host_organization_lineage":["https://openalex.org/P4323283980"],"host_organization_lineage_names":["Center for Academic Publications Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nutritional Science and Vitaminology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jstage.jst.go.jp/article/jnsv/61/Supplement/61_S103/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064359049","display_name":"Hye-Ji Kang","orcid":"https://orcid.org/0000-0002-7006-2915","observed_orcids":["https://orcid.org/0000-0002-7006-2915"]},"institutions":[{"id":"https://openalex.org/I4210104335","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210104335"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hye-Ji KANG","raw_affiliation_strings":["Academy of Immunology and Microbiology (AIM), Institute for Basic Science (IBS)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Immunology and Microbiology (AIM), Institute for Basic Science (IBS)","institution_ids":["https://openalex.org/I4210104335"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018682015","display_name":"Sin\u2010Hyeog Im","orcid":"https://orcid.org/0000-0002-3173-1856","observed_orcids":["https://orcid.org/0000-0002-3173-1856"]},"institutions":[{"id":"https://openalex.org/I123900574","display_name":"Pohang University of Science and Technology","ror":"https://ror.org/04xysgw12","country_code":"KR","type":"education","lineage":["https://openalex.org/I123900574"]},{"id":"https://openalex.org/I4210104335","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210104335"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sin-Hyeog IM","raw_affiliation_strings":["Academy of Immunology and Microbiology (AIM), Institute for Basic Science (IBS)","Division of Integrative Biosciences and Biotechnology (IBB), Pohang University of Science and Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Immunology and Microbiology (AIM), Institute for Basic Science (IBS)","institution_ids":["https://openalex.org/I4210104335"]},{"raw_affiliation_string":"Division of Integrative Biosciences and Biotechnology (IBB), Pohang University of Science and Technology","institution_ids":["https://openalex.org/I123900574"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":10.0517,"has_fulltext":true,"cited_by_count":156,"citation_normalized_percentile":{"value":0.98668648,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"61","issue":"Supplement","first_page":"S103","last_page":"S105"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12489","display_name":"Microbial Metabolites in Food Biotechnology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10506","display_name":"Aquaculture disease management and microbiota","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":1.0},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.9490000009536743},{"id":"https://openalex.org/keywords/immune-homeostasis","display_name":"immune homeostasis","score":0.8109999895095825},{"id":"https://openalex.org/keywords/probiotic-selection","display_name":"probiotic strain selection","score":0.7590000033378601},{"id":"https://openalex.org/keywords/antigen-presenting-cells","display_name":"antigen-presenting cells","score":0.718999981880188},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/allergic-asthma","display_name":"allergic asthma","score":0.8980000019073486},{"id":"https://openalex.org/keywords/atopic-dermatitis","display_name":"atopic dermatitis","score":1.0},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":1.0},{"id":"https://openalex.org/keywords/probiotic-metabolites","display_name":"probiotic metabolites","score":0.765999972820282},{"id":"https://openalex.org/keywords/functional-foods","display_name":"functional foods","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.8626194000244141},{"id":"https://openalex.org/C2780255968","wikidata":"https://www.wikidata.org/wiki/Q1816730","display_name":"Probiotic","level":3,"score":0.8619487285614014},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5912750363349915},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5207600593566895},{"id":"https://openalex.org/C2991678113","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immune modulation","level":3,"score":0.5124204754829407},{"id":"https://openalex.org/C2780132029","wikidata":"https://www.wikidata.org/wiki/Q752276","display_name":"Functional food","level":2,"score":0.4736817181110382},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.41714999079704285},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3342065215110779},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.1739637553691864},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.07139506936073303},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07135841250419617}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007154","descriptor_name":"Immune System Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019936","descriptor_name":"Probiotics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3177/jnsv.61.s103","doi":"https://doi.org/10.3177/jnsv.61.s103","is_oa":true,"landing_page_url":"https://doi.org/10.3177/jnsv.61.s103","pdf_url":"https://www.jstage.jst.go.jp/article/jnsv/61/Supplement/61_S103/_pdf","source":{"id":"https://openalex.org/S150433807","display_name":"Journal of Nutritional Science and Vitaminology","issn_l":"0301-4800","issn":["0301-4800","1881-7742"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4323283980","host_organization_name":"Center for Academic Publications Japan","host_organization_lineage":["https://openalex.org/P4323283980"],"host_organization_lineage_names":["Center for Academic Publications Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nutritional Science and Vitaminology","raw_type":"journal-article"},{"id":"pmid:26598815","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26598815","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nutritional science and vitaminology","raw_type":"Journal Article"},{"id":"pmh:oai:oasis.postech.ac.kr:2014.oak/35488","doi":null,"is_oa":false,"landing_page_url":"https://oasis.postech.ac.kr/handle/2014.oak/35488","pdf_url":null,"source":{"id":"https://openalex.org/S4306401965","display_name":"Open Access System for Information Sharing (Pohang University of Science and Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123900574","host_organization_name":"Pohang University of Science and Technology","host_organization_lineage":["https://openalex.org/I123900574"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article; Proceedings Paper"}],"best_oa_location":{"id":"doi:10.3177/jnsv.61.s103","doi":"https://doi.org/10.3177/jnsv.61.s103","is_oa":true,"landing_page_url":"https://doi.org/10.3177/jnsv.61.s103","pdf_url":"https://www.jstage.jst.go.jp/article/jnsv/61/Supplement/61_S103/_pdf","source":{"id":"https://openalex.org/S150433807","display_name":"Journal of Nutritional Science and Vitaminology","issn_l":"0301-4800","issn":["0301-4800","1881-7742"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4323283980","host_organization_name":"Center for Academic Publications Japan","host_organization_lineage":["https://openalex.org/P4323283980"],"host_organization_lineage_names":["Center for Academic Publications Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nutritional Science and Vitaminology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2293438552.pdf","grobid_xml":"https://content.openalex.org/works/W2293438552.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W1829239725","https://openalex.org/W1974738011","https://openalex.org/W1981859401","https://openalex.org/W1992019228","https://openalex.org/W1997895988","https://openalex.org/W2008981449","https://openalex.org/W2014011574","https://openalex.org/W2016375372","https://openalex.org/W2017443683","https://openalex.org/W2018426052","https://openalex.org/W2026987139","https://openalex.org/W2043009704","https://openalex.org/W2049511586","https://openalex.org/W2072505334","https://openalex.org/W2078792455","https://openalex.org/W2102200314","https://openalex.org/W2110916716","https://openalex.org/W2114164427","https://openalex.org/W2168514301"],"related_works":["https://openalex.org/W2309246673","https://openalex.org/W1770836628","https://openalex.org/W4389579145","https://openalex.org/W2483847873","https://openalex.org/W7161628489","https://openalex.org/W119579859","https://openalex.org/W2078135673","https://openalex.org/W2909724744","https://openalex.org/W1571610752","https://openalex.org/W1486514399"],"abstract_inverted_index":{"Probiotics":[0,20],"are":[1,21],"nonpathogenic":[2],"live":[3,98],"microorganism":[4],"that":[5,42,97],"can":[6],"provide":[7],"a":[8,156,170],"diverse":[9,24,55,106,153],"health":[10,36],"benefits":[11],"on":[12,82],"the":[13,83,88,140,185],"host":[14],"when":[15],"consumed":[16,22],"in":[17,23,54,144,191],"adequate":[18],"amounts.":[19],"ways":[25],"including":[26,57],"dairy":[27],"product,":[28],"food":[29],"supplements":[30],"and":[31,62,73,87,93,112,115,135,184],"functional":[32,162],"foods":[33],"with":[34,105,164],"specific":[35,165],"claims.":[37],"Recently,":[38],"many":[39],"reports":[40],"suggest":[41],"certain":[43],"probiotic":[44,76,182],"strains":[45,86,183],"or":[46,100,146],"multi":[47],"strain":[48],"mixture":[49],"have":[50,95,119],"potent":[51],"immunomodulatory":[52,181],"activity":[53],"disorders":[56],"allergic":[58],"asthma,":[59],"atopic":[60],"dermatitis":[61],"rheumatoid":[63],"arthritis.":[64],"However,":[65,139],"underlying":[66],"mechanism":[67,186],"of":[68,75,85,90,142,148,161,187,189],"action":[69,188],"is":[70,78,151,169],"still":[71],"unclear":[72],"efficacy":[74],"administration":[77],"quite":[79,152],"different":[80],"depending":[81],"type":[84],"amounts":[89],"doses.":[91],"We":[92],"others":[94],"suggested":[96],"probiotics":[99,125,143,163,190],"their":[101],"metabolites":[102],"could":[103,126],"interact":[104],"immune":[107,130,137,166,192],"cells":[108,111],"(antigen":[109],"presenting":[110],"T":[113],"cells)":[114],"confer":[116],"them":[117],"to":[118,128],"immunoregulatory":[120],"functions.":[121],"Through":[122],"this":[123],"interaction,":[124],"contribute":[127],"maintaining":[129],"homeostasis":[131],"by":[132],"balancing":[133],"pro-inflammatory":[134],"anti-inflammatory":[136],"responses.":[138],"effect":[141],"prevention":[145],"modulation":[147],"ongoing":[149],"disease":[150],"even":[154],"within":[155],"same":[157],"species.":[158],"Therefore,":[159],"identification":[160],"regulatory":[167],"property":[168],"certainly":[171],"important":[172],"issue.":[173],"Herein,":[174],"we":[175],"briefly":[176],"review":[177],"selection":[178],"methods":[179],"for":[180],"modulation.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":29},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":24},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
