{"id":"https://openalex.org/W2293366814","doi":"https://doi.org/10.1182/blood.v122.21.855.855","title":"Therapeutic Efficacy and Cure Of Sensitive and T315I Pan-Resistant Human Ph+ Leukemia In Mice Using a TCR-Like Antibody To WT1/HLA-A0201 Alone, Or In Combination With Tyrosine Kinase Inhibitors","display_name":"Therapeutic Efficacy and Cure Of Sensitive and T315I Pan-Resistant Human Ph+ Leukemia In Mice Using a TCR-Like Antibody To WT1/HLA-A0201 Alone, Or In Combination With Tyrosine Kinase Inhibitors","publication_year":2013,"publication_date":"2013-11-15","ids":{"openalex":"https://openalex.org/W2293366814","doi":"https://doi.org/10.1182/blood.v122.21.855.855","mag":"2293366814"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v122.21.855.855","doi":"https://doi.org/10.1182/blood.v122.21.855.855","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v122.21.855.855","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083621673","display_name":"Leonid Dubrovsky","orcid":"https://orcid.org/0000-0003-2799-4765","observed_orcids":["https://orcid.org/0000-0003-2799-4765"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Leonid Dubrovsky","raw_affiliation_strings":["Sloan Kettering Institute, New York, NY, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sloan Kettering Institute, New York, NY, USA,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035010583","display_name":"Elliott Joseph Brea","orcid":"https://orcid.org/0000-0002-6283-0267","observed_orcids":["https://orcid.org/0000-0002-6283-0267"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Elliott Brea","raw_affiliation_strings":["Memorial Sloan Kettering Institute, New York, NY, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Institute, New York, NY, USA,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103182824","display_name":"Dmitry Pankov","orcid":"https://orcid.org/0000-0002-2262-9294","observed_orcids":["https://orcid.org/0000-0002-2262-9294","https://orcid.org/0009-0000-5562-7925"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dmitry Pankov","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY, USA,","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029624769","display_name":"Nicholas J. Veomett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nicholas Veomett","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY, USA,","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062508226","display_name":"Tao Dao","orcid":"https://orcid.org/0000-0001-9937-6283","observed_orcids":["https://orcid.org/0000-0001-9937-6283"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tao Dao","raw_affiliation_strings":["Sloan Kettering Institute, New York, NY, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sloan Kettering Institute, New York, NY, USA,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100723687","display_name":"Su Yan","orcid":"https://orcid.org/0000-0001-5621-1438","observed_orcids":["https://orcid.org/0000-0001-5621-1438"]},"institutions":[{"id":"https://openalex.org/I4210087205","display_name":"Eureka Therapeutics (United States)","ror":"https://ror.org/0056pgw95","country_code":"US","type":"company","lineage":["https://openalex.org/I4210087205"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Su Yan","raw_affiliation_strings":["Eureka Therapeutics, Emeryville, CA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eureka Therapeutics, Emeryville, CA, USA,","institution_ids":["https://openalex.org/I4210087205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100681942","display_name":"Liu C","orcid":"https://orcid.org/0000-0002-2219-1018","observed_orcids":["https://orcid.org/0000-0002-2219-1018"]},"institutions":[{"id":"https://openalex.org/I4210087205","display_name":"Eureka Therapeutics (United States)","ror":"https://ror.org/0056pgw95","country_code":"US","type":"company","lineage":["https://openalex.org/I4210087205"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Cheng Liu","raw_affiliation_strings":["Eureka Therapeutics, Emeryville, CA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eureka Therapeutics, Emeryville, CA, USA,","institution_ids":["https://openalex.org/I4210087205"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006680533","display_name":"David A. Scheinberg","orcid":"https://orcid.org/0000-0002-4160-923X","observed_orcids":["https://orcid.org/0000-0002-4160-923X","https://orcid.org/0009-0009-0651-7389"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Scheinberg","raw_affiliation_strings":["Chairman, Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chairman, Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5029624769","https://openalex.org/A5035010583","https://openalex.org/A5083621673","https://openalex.org/A5100681942","https://openalex.org/A5100723687","https://openalex.org/A5103182824"],"corresponding_institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I4210087205"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.21713968,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"122","issue":"21","first_page":"855","last_page":"855"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.8925999999046326,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.8925999999046326,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.026000000536441803,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wt1","display_name":"WT1","score":0.5830000042915344},{"id":"https://openalex.org/keywords/hla-a-0201","display_name":"HLA-A*0201","score":0.8209999799728394},{"id":"https://openalex.org/keywords/bcr-abl","display_name":"BCR-ABL","score":0.722000002861023},{"id":"https://openalex.org/keywords/t315i-mutation","display_name":"T315I mutation","score":0.7630000114440918},{"id":"https://openalex.org/keywords/philadelphia-chromosome-positive-leukemia","display_name":"Philadelphia chromosome-positive leukemia","score":0.7170000076293945},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.8650000095367432},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.9139999747276306},{"id":"https://openalex.org/keywords/dasatinib","display_name":"dasatinib","score":0.9179999828338623},{"id":"https://openalex.org/keywords/imatinib","display_name":"imatinib","score":0.9919999837875366},{"id":"https://openalex.org/keywords/ponatinib","display_name":"ponatinib","score":0.9769999980926514},{"id":"https://openalex.org/keywords/antibody-dependent-cellular-cytotoxicity","display_name":"antibody-dependent cellular cytotoxicity","score":0.9649999737739563},{"id":"https://openalex.org/keywords/measurable-residual-disease","display_name":"minimal residual disease","score":0.824999988079071},{"id":"https://openalex.org/keywords/leukemia-xenograft","display_name":"leukemia xenograft","score":0.6480000019073486},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6890000104904175},{"id":"https://openalex.org/keywords/consolidation-therapy","display_name":"consolidation therapy","score":0.33899998664855957}],"concepts":[{"id":"https://openalex.org/C2779536868","wikidata":"https://www.wikidata.org/wiki/Q419940","display_name":"Dasatinib","level":4,"score":0.6460865139961243},{"id":"https://openalex.org/C40677261","wikidata":"https://www.wikidata.org/wiki/Q21418091","display_name":"Antibody-dependent cell-mediated cytotoxicity","level":4,"score":0.5213557481765747},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5056638717651367},{"id":"https://openalex.org/C3019892230","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib mesylate","level":4,"score":0.44079387187957764},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.41218051314353943},{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.4111140966415405},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3284606337547302},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.32775047421455383},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3151128590106964},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10412585735321045},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.08190217614173889},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v122.21.855.855","doi":"https://doi.org/10.1182/blood.v122.21.855.855","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v122.21.855.855","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2981735746","https://openalex.org/W1988837817","https://openalex.org/W2580601808","https://openalex.org/W1010922992","https://openalex.org/W2144242764","https://openalex.org/W2987083479","https://openalex.org/W2138821374","https://openalex.org/W3184041689","https://openalex.org/W2134799914","https://openalex.org/W2950073637"],"abstract_inverted_index":{"Abstract":[0],"Acute":[1],"and":[2,71,150,179,211,292,310,340,355,374,376,389,396],"chronic":[3],"leukemias,":[4],"including":[5],"CD34+":[6],"CML":[7],"stem":[8],"cells,":[9],"overexpress":[10],"the":[11,40,44,93,144,295,387],"Wilms":[12],"tumor":[13,201,344],"gene":[14],"1":[15],"(WT1)":[16],"protein,":[17],"making":[18],"WT1":[19,42],"an":[20,52,61,349],"attractive":[21],"therapeutic":[22,351],"target.":[23],"ESKM":[24,164,173,193,212,246,286,309,329,339,347,369,380],"is":[25,60,348,364,381],"a":[26,33,80,186,216],"fully":[27],"human":[28,63,111,189],"IgG1":[29],"antibody":[30,352],"that":[31,68],"targets":[32],"9":[34],"amino":[35],"acid":[36],"sequence":[37],"(RMF)":[38],"of":[39,46,146,204,209,235,255,266,308,338],"protein":[41],"in":[43,104,116,120,137,183,215,219,242,251,253,299],"context":[45],"HLA-A0201,":[47],"allowing":[48],"it":[49],"to":[50,132,156,238,290,372,383],"target":[51],"undruggable,":[53],"widely":[54],"expressed,":[55],"intracellular":[56],"oncogene":[57],"product.":[58],"BV173":[59,91,178,187],"HLA-A0201+,":[62],"Ph+":[64,357,361],"ALL":[65],"cell":[66,87,181],"line":[67,88],"expresses":[69],"WT1,":[70],"tagged":[72],"by":[73,89,106,258,274,368,386],"our":[74],"lab":[75],"with":[76,92,125,139,199,245,248,271,277,305,336,379],"luciferase.":[77],"We":[78],"engineered":[79],"tyrosine":[81],"kinase":[82],"inhibitor":[83],"(TKI)":[84],"resistant":[85,94,318],"BV173-R":[86,180,297],"transducing":[90],"T315I":[95,296,319,356,360],"Bcr-Abl":[96],"plasmid.":[97],"Antibody-dependent":[98],"cellular":[99],"cytotoxicity":[100],"(ADCC)":[101],"was":[102,118,130,165,194,228,281,287],"evaluated":[103],"vitro":[105],"chromium":[107],"release":[108],"assay,":[109],"utilizing":[110],"PBMC":[112],"effectors.":[113],"Tumor":[114],"growth":[115,202,363],"vivo":[117],"assessed":[119],"NOD/SCID":[121],"gamma":[122],"(NSG)":[123],"mice":[124,138,269,334],"bioluminescence":[126],"imaging":[127],"(BLI).":[128],"RT-PCR":[129,261],"used":[131,153],"evaluate":[133],"minimal":[134],"residual":[135],"disease":[136],"negative":[140],"BLI":[141],"signal":[142],"at":[143,154,167,322],"end":[145],"therapy.":[147,267],"Imatinib,":[148],"dasatinib,":[149,375],"ponatinib":[151,341],"were":[152,302],"up":[155],"maximally":[157],"tolerated":[158],"doses,":[159],"given":[160],"IP":[161],"once":[162],"daily.":[163],"administered":[166],"100":[168],"\u00b5g":[169],"twice":[170],"weekly":[171],"IP.":[172],"mediated":[174],"ADCC":[175],"against":[176,294,317,331],"both":[177],"lines":[182],"vitro.":[184],"In":[185],"engrafted":[188],"leukemia":[190,298],"xenograft":[191],"model,":[192],"more":[195,229,366],"potent":[196,230],"than":[197,231,328],"imatinib,":[198],"median":[200],"reduction":[203,218],"78%":[205],"vs":[206],"52%.":[207],"Combination":[208,244],"imatinib":[210,291,373],"therapy":[213,236,247,276,307,370,378],"resulted":[214,241,250],"94%":[217],"leukemic":[220,362],"growth.":[221],"High":[222],"dose":[223],"dasatinib":[224,239,249,272,293],"(40":[225],"mg/kg":[226,324],"daily)":[227],"ESKM,":[232,278],"but":[233,283,333],"discontinuation":[234],"due":[237],"toxicity":[240],"relapse.":[243],"cure":[252],"75%":[254],"mice,":[256],"confirmed":[257],"bone":[259],"marrow":[260],"three":[262],"weeks":[263],"after":[264],"termination":[265],"For":[268],"cytoreduced":[270],"followed":[273],"consolidation":[275],"delayed":[279],"relapse":[280],"observed,":[282],"no":[284],"cures.":[285],"highly":[288],"superior":[289,343,382],"vivo.":[300],"Cures":[301],"not":[303],"achieved":[304],"combination":[306,337,377],"either":[311],"first":[312],"or":[313],"second":[314],"generation":[315],"TKIs":[316],"leukemia.":[320],"Ponatinib":[321],"10":[323],"had":[325,342],"higher":[326],"efficacy":[327],"alone":[330],"BV173-R,":[332],"treated":[335],"reduction.":[345],"CONCLUSION:":[346],"effective":[350],"for":[353],"sensitive":[354],"ALL.":[358],"Resistant":[359],"inhibited":[365],"effectively":[367],"compared":[371],"ponatinib.":[384],"Supported":[385],"Leukemia":[388],"Lymphoma":[390],"Society,":[391],"NIH":[392],"R01CA55349,":[393],"P01":[394],"23766":[395],"T32CA62948-18.":[397],"Disclosures:":[398],"Yan:":[399],"Eureka":[400],"Therapeutics:":[401,404],"Employment.":[402],"Liu:Eureka":[403],"Employment,":[405],"Equity":[406],"Ownership.":[407]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}