{"id":"https://openalex.org/W2292856586","doi":"https://doi.org/10.1136/heartjnl-2015-308852","title":"Microvascular endothelial dysfunction in heart failure with preserved ejection fraction","display_name":"Microvascular endothelial dysfunction in heart failure with preserved ejection fraction","publication_year":2016,"publication_date":"2016-01-27","ids":{"openalex":"https://openalex.org/W2292856586","doi":"https://doi.org/10.1136/heartjnl-2015-308852","mag":"2292856586","pmid":"https://pubmed.ncbi.nlm.nih.gov/27655221"},"language":"en","primary_location":{"id":"doi:10.1136/heartjnl-2015-308852","doi":"https://doi.org/10.1136/heartjnl-2015-308852","is_oa":false,"landing_page_url":"https://doi.org/10.1136/heartjnl-2015-308852","pdf_url":null,"source":{"id":"https://openalex.org/S191565391","display_name":"Heart","issn_l":"1355-6037","issn":["1355-6037","1468-201X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart","raw_type":"journal-article"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067422552","display_name":"Carolyn S.P. Lam","orcid":"https://orcid.org/0000-0003-1903-0018","observed_orcids":["https://orcid.org/0000-0003-1903-0018"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210147238","display_name":"National Heart Centre Singapore","ror":"https://ror.org/04f8k9513","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I4210147238"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Carolyn S P Lam","raw_affiliation_strings":["National Heart Centre Singapore and Duke-National University of Singapore, Singapore, Singapore","National Heart Center Singapore, 5 Hospital Drive, Singapore 169609, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Heart Centre Singapore and Duke-National University of Singapore, Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210147238"]},{"raw_affiliation_string":"National Heart Center Singapore, 5 Hospital Drive, Singapore 169609, Singapore","institution_ids":["https://openalex.org/I4210147238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067972379","display_name":"Lars H. Lund","orcid":"https://orcid.org/0000-0003-1411-4482","observed_orcids":["https://orcid.org/0000-0003-1411-4482"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Lars H Lund","raw_affiliation_strings":["Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden","Department of Medicine, Karolinska Institute, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]},{"raw_affiliation_string":"Department of Medicine, Karolinska Institute, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5067422552"],"corresponding_institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4210147238"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":82,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"102","issue":"4","first_page":"257","last_page":"259"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.5634999871253967,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.5634999871253967,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.1454000025987625,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.05790000036358833,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-failure-with-preserved-ejection-fraction","display_name":"heart failure with preserved ejection fraction","score":0.9950000047683716},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.9020000100135803},{"id":"https://openalex.org/keywords/microvascular-dysfunction","display_name":"microvascular dysfunction","score":0.9279999732971191},{"id":"https://openalex.org/keywords/diastolic-dysfunction","display_name":"diastolic dysfunction","score":0.7129999995231628},{"id":"https://openalex.org/keywords/left-ventricular-remodeling","display_name":"left ventricular remodeling","score":0.8899999856948853},{"id":"https://openalex.org/keywords/endothelial-mesenchymal-transition","display_name":"endothelial-to-mesenchymal transition","score":0.847000002861023},{"id":"https://openalex.org/keywords/nitric-oxide-bioavailability","display_name":"nitric oxide bioavailability","score":0.9409999847412109},{"id":"https://openalex.org/keywords/microvascular-inflammation","display_name":"microvascular inflammation","score":0.6230000257492065},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.8019999861717224},{"id":"https://openalex.org/keywords/cardiomyocyte-dysfunction","display_name":"cardiomyocyte dysfunction","score":0.6830000281333923},{"id":"https://openalex.org/keywords/neuroendocrine-activation","display_name":"neuroendocrine activation","score":0.7630000114440918},{"id":"https://openalex.org/keywords/heart-failure-with-reduced-ejection-fraction","display_name":"heart failure with reduced ejection fraction","score":0.7639999985694885}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8847229480743408},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.8186967372894287},{"id":"https://openalex.org/C2777099384","wikidata":"https://www.wikidata.org/wiki/Q3799239","display_name":"Heart failure with preserved ejection fraction","level":4,"score":0.7898167371749878},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7894594669342041},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7874102592468262},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.7295111417770386},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.6884305477142334},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.4164290428161621},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.18683186173439026}],"mesh":[{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013318","descriptor_name":"Stroke Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014652","descriptor_name":"Vascular Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1136/heartjnl-2015-308852","doi":"https://doi.org/10.1136/heartjnl-2015-308852","is_oa":false,"landing_page_url":"https://doi.org/10.1136/heartjnl-2015-308852","pdf_url":null,"source":{"id":"https://openalex.org/S191565391","display_name":"Heart","issn_l":"1355-6037","issn":["1355-6037","1468-201X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart","raw_type":"journal-article"},{"id":"pmid:27655221","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27655221","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart (British Cardiac Society)","raw_type":"Editorial"},{"id":"pmh:oai:open-archive.highwire.org:heartjnl:102/4/257","doi":null,"is_oa":false,"landing_page_url":"http://heart.bmj.com/cgi/content/short/102/4/257","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W164205712","https://openalex.org/W1880552130","https://openalex.org/W1973304156","https://openalex.org/W1991875014","https://openalex.org/W2000117038","https://openalex.org/W2026488016","https://openalex.org/W2032093326","https://openalex.org/W2069060200","https://openalex.org/W2104375154","https://openalex.org/W2110064589","https://openalex.org/W2113439549","https://openalex.org/W2131184290","https://openalex.org/W2133123327","https://openalex.org/W2133427496","https://openalex.org/W2140244782","https://openalex.org/W2143676228","https://openalex.org/W2161918376","https://openalex.org/W2166977140","https://openalex.org/W2179146111","https://openalex.org/W2218389985"],"related_works":["https://openalex.org/W4284892950","https://openalex.org/W2982034151","https://openalex.org/W2904573211","https://openalex.org/W4390176436","https://openalex.org/W4211021836","https://openalex.org/W7111648026","https://openalex.org/W2999373397","https://openalex.org/W2644819006","https://openalex.org/W2012748167","https://openalex.org/W2914437367"],"abstract_inverted_index":{"A":[0],"new":[1,132],"paradigm":[2],"has":[3],"emerged":[4],"in":[5,35,53,86,91,98,114,117,125,142,162,174,268],"our":[6],"understanding":[7],"of":[8,11,82,105,147,169,245],"the":[9,59,83,106,131,143,170,180,227],"pathophysiology":[10,144],"heart":[12],"failure":[13,191],"(HF)":[14],"with":[15,22,192],"preserved":[16,193],"ejection":[17,24,194],"fraction":[18,25,195],"(HFpEF)":[19,196],"versus":[20],"HF":[21,84,181],"reduced":[23,236],"(HFrEF).":[26],"Comorbidity-driven":[27],"cardiac":[28],"endothelial":[29,122,155,222],"dysfunction":[30,123,156],"plays":[31,94],"a":[32,78,95,139,159],"primary":[33],"role":[34,97,141],"HFpEF,":[36,90,199],"leading":[37],"to":[38,137,187,218,262],"cardiomyocyte":[39,56,229],"dysfunction,":[40],"left":[41,250],"ventricular":[42,251],"(LV)":[43,252],"concentric":[44,249],"remodelling":[45,68,100,253],"and":[46,69,89,101,108,128,145,183,214,221,242,254],"predominantly":[47,70],"diastolic":[48,264],"dysfunction1":[49],"(figure":[50],"1).":[51],"Conversely":[52],"HFrEF,":[54,129],"direct":[55],"injury":[57],"is":[58,135,151],"key":[60],"trigger":[61],"for":[62,178],"systemic":[63],"neuroendocrine":[64,74],"activation,":[65],"LV":[66,263],"eccentric":[67],"systolic":[71],"dysfunction.1":[72],"Whereas":[73],"activation":[75],"exists":[76,124],"as":[77,167,202],"common":[79],"defining":[80],"domain":[81],"syndrome":[85],"both":[87,126],"HFrEF":[88,92],"it":[93,134],"dominant":[96,140],"adverse":[99],"outcomes;":[102],"thus":[103],"antagonists":[104],"renin-angiotensin-aldosterone":[107],"adrenergic":[109],"systems":[110],"have":[111],"been":[112],"effective":[113],"improving":[115],"survival":[116],"HFrEF.":[118],"Similarly,":[119],"whereas":[120],"cardiovascular":[121,175],"HFpEF":[127],"by":[130],"paradigm,":[133],"postulated":[136],"play":[138],"outcomes":[146],"HFpEF.":[148],"This":[149,224],"distinction":[150],"critical":[152],"since":[153],"targeting":[154],"may":[157],"be":[158],"winning":[160],"strategy":[161],"HFpEF\u2014a":[163],"condition":[164],"now":[165],"recognised":[166],"one":[168],"largest":[171],"unmet":[172],"needs":[173],"medicine,":[176],"responsible":[177],"half":[179],"epidemic":[182],"without":[184],"proven":[185],"therapies":[186],"improve":[188],"survival.2\n\n\n\nFigure\u00a01":[189],"\nHeart":[190],"paradigm.":[197],"In":[198,266],"comorbidities":[200],"(such":[201],"hypertension,":[203],"overweight,":[204],"diabetes,":[205],"chronic":[206,209],"kidney":[207],"disease,":[208,212],"obstructive":[210],"pulmonary":[211],"anaemia":[213],"iron":[215],"deficiency)":[216],"lead":[217],"microvascular":[219,247],"inflammation":[220],"activation.":[223],"adversely":[225],"affects":[226],"adjacent":[228],"through":[230],"decreased":[231],"nitric":[232],"oxide":[233],"(NO)":[234],"bioavailability,":[235],"cyclic":[237],"guanosine":[238],"monophosphate":[239],"(cGMP)":[240],"availability,":[241],"altered":[243],"phosphorylation":[244],"titin;":[246],"ischaemia,":[248],"fibrosis":[255],"from":[256],"endothelial-mesenchymal":[257],"transition":[258],"(EndMT)":[259],"contributes":[260],"further":[261],"dysfunction.":[265],"contrast,":[267],"\u2026":[269]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}