{"id":"https://openalex.org/W2292851930","doi":null,"title":"Cholestase und Gallens\u00e4uren st\u00f6ren die Nebennierenrindenfunktion","display_name":"Cholestase und Gallens\u00e4uren st\u00f6ren die Nebennierenrindenfunktion","publication_year":2016,"publication_date":"2016-01-14","ids":{"openalex":"https://openalex.org/W2292851930","mag":"2292851930"},"language":"de","primary_location":{"id":"pmh:oai:kup.at:13277","doi":null,"is_oa":true,"landing_page_url":"http://www.kup.at/kup/pdf/13277.pdf","pdf_url":"http://www.kup.at/kup/pdf/13277.pdf","source":{"id":"https://openalex.org/S4306402201","display_name":"Journal f\u00fcr Kardiologie (Krause & Pachernegg GmbH)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"application/pdf"},"volume":null,"type":"other","is_traditional":false,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://www.kup.at/kup/pdf/13277.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009472267","display_name":"Alex Zaufel","orcid":"https://orcid.org/0009-0001-3924-4366","observed_orcids":["https://orcid.org/0009-0001-3924-4366"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alex Zaufel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068631395","display_name":"Peter Fickert","orcid":"https://orcid.org/0000-0003-0906-4636","observed_orcids":["https://orcid.org/0000-0003-0906-4636"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Fickert","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0906-4636","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5030496461","display_name":"Gernot Zollner","orcid":"https://orcid.org/0000-0002-8117-6061","observed_orcids":["https://orcid.org/0000-0002-8117-6061"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gernot Zollner","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8117-6061","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"1","first_page":"6","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholestasis","display_name":"cholestasis","score":0.902999997138977},{"id":"https://openalex.org/keywords/bile-acids","display_name":"bile acids","score":0.9980000257492065},{"id":"https://openalex.org/keywords/adrenal-insufficiency","display_name":"adrenal insufficiency","score":0.8610000014305115},{"id":"https://openalex.org/keywords/adrenal-cortex-dysfunction","display_name":"adrenal cortex dysfunction","score":0.7179999947547913},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.5820000171661377},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.7110000252723694},{"id":"https://openalex.org/keywords/cholesterol-metabolism","display_name":"cholesterol metabolism","score":0.7250000238418579},{"id":"https://openalex.org/keywords/cholesterol-export","display_name":"cholesterol export","score":0.6589999794960022},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.8489999771118164},{"id":"https://openalex.org/keywords/critically-ill-patients","display_name":"critically ill patients","score":0.824999988079071},{"id":"https://openalex.org/keywords/animal-models","display_name":"animal models","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.2587898373603821}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:kup.at:13277","doi":null,"is_oa":true,"landing_page_url":"http://www.kup.at/kup/pdf/13277.pdf","pdf_url":"http://www.kup.at/kup/pdf/13277.pdf","source":{"id":"https://openalex.org/S4306402201","display_name":"Journal f\u00fcr Kardiologie (Krause & Pachernegg GmbH)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"application/pdf"},{"id":"mag:2292851930","doi":null,"is_oa":false,"landing_page_url":"https://www.kup.at/kup/pdf/13277.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4210231978","display_name":"Journal f\u00fcr Gastroenterologische und Hepatologische Erkrankungen","issn_l":"1728-6263","issn":["1728-6263","1728-6271"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal f\u00fcr Gastroenterologische und Hepatologische Erkrankungen","raw_type":null}],"best_oa_location":{"id":"pmh:oai:kup.at:13277","doi":null,"is_oa":true,"landing_page_url":"http://www.kup.at/kup/pdf/13277.pdf","pdf_url":"http://www.kup.at/kup/pdf/13277.pdf","source":{"id":"https://openalex.org/S4306402201","display_name":"Journal f\u00fcr Kardiologie (Krause & Pachernegg GmbH)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"application/pdf"},"sustainable_development_goals":[{"score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2292851930.pdf","grobid_xml":"https://content.openalex.org/works/W2292851930.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W1998879779","https://openalex.org/W2009042237","https://openalex.org/W2042147502","https://openalex.org/W2082235567","https://openalex.org/W2083648263","https://openalex.org/W2096458389","https://openalex.org/W2100018795","https://openalex.org/W2117067906","https://openalex.org/W2125340913","https://openalex.org/W2142868723","https://openalex.org/W2142991094","https://openalex.org/W2149450249"],"related_works":["https://openalex.org/W2489452815","https://openalex.org/W2138830037","https://openalex.org/W2605961869","https://openalex.org/W2481657472","https://openalex.org/W2617291088","https://openalex.org/W2467521163","https://openalex.org/W2404794487","https://openalex.org/W1561461830","https://openalex.org/W2619625609","https://openalex.org/W7208441096"],"abstract_inverted_index":{"Nebennierenrindenfunktionsst\u00f6rungen":[0],"finden":[1],"sich":[2],"geh\u00e4uft":[3],"bei":[4,9,85],"kritisch-kranken":[5],"Patienten":[6,10],"wie":[7],"auch":[8,33],"mit":[11,112],"einer":[12],"Leberzirrhose.":[13],"Diese":[14],"Dysfunktion":[15],"ist":[16],"gekennzeichnet":[17],"durch":[18],"eine":[19,54,120],"verminderte":[20,121],"Produktion":[21,98],"von":[22,67,99],"Kortisol,":[23],"bezogen":[24],"auf":[25,49,72],"die":[26,65,73,104,139],"Schwere":[27],"der":[28,50,57,59,93,110,141],"Grundkrankheit,":[29],"und":[30,70,84,97,137],"wird":[31],"deshalb":[32],"als":[34],"relative":[35],"adrenale":[36],"Insuffizienz":[37],"(RAI)":[38],"bezeichnet.":[39],"Die":[40],"zugrunde":[41],"liegenden":[42],"Mechanismen":[43],"sind":[44],"nur":[45],"unzureichend":[46],"bekannt.":[47],"Basierend":[48],"Hypothese,":[51],"dass":[52,135],"Gallens\u00e4uren":[53,138],"Rolle":[55],"in":[56,107,126],"Pathogenese":[58],"Nebennierenfunktionsst\u00f6rung":[60],"spielen,":[61],"untersuchten":[62],"wir":[63,119],"systematisch":[64],"Effekte":[66],"mechanischer":[68],"Cholestase":[69,136],"Gallens\u00e4urenf\u00fctterung":[71],"Nebennierenfunktion":[74],"im":[75,81,88],"Tiermodell.br":[76],"Wir":[77],"fanden":[78,118],"erh\u00f6hte":[79],"Glukokortikoidkonzentrationen":[80],"Serum":[82],"gallengangsligierter":[83],"Gallens\u00e4uren-gef\u00fctterten":[86],"Tieren":[87],"Vergleich":[89],"zu":[90],"Kontrolltieren.":[91],"mRNA-Konzentrationen":[92],"Enzyme":[94],"f\u00fcr":[95,103],"Aufnahme":[96],"Cholesterin,":[100],"dem":[101],"Substrat":[102],"Glukokortikoidsynthese,":[105],"waren":[106],"den":[108,127],"Nebennieren":[109],"Tiere":[111],"hohen":[113],"Serumgallens\u00e4uren":[114],"deutlich":[115,143],"erh\u00f6ht.":[116],"Zus\u00e4tzlich":[117],"Expression":[122],"des":[123],"Cholesterin-":[124],"Exportsystems":[125],"Nebennieren.":[128],"Aus":[129],"diesen":[130],"experimentellen":[131],"Ergebnissen":[132],"folgern":[133],"wir,":[134],"Funktion":[140],"Nebenniere":[142],"beeinflussen.":[144]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2016-06-24T00:00:00"}