{"id":"https://openalex.org/W2292843089","doi":"https://doi.org/10.1016/j.vetimm.2016.03.006","title":"Low-dose oral interferon modulates expression of inflammatory and autoimmune genes in cattle","display_name":"Low-dose oral interferon modulates expression of inflammatory and autoimmune genes in cattle","publication_year":2016,"publication_date":"2016-03-05","ids":{"openalex":"https://openalex.org/W2292843089","doi":"https://doi.org/10.1016/j.vetimm.2016.03.006","mag":"2292843089","pmid":"https://pubmed.ncbi.nlm.nih.gov/27032505","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7173013"},"language":"en","primary_location":{"id":"doi:10.1016/j.vetimm.2016.03.006","doi":"https://doi.org/10.1016/j.vetimm.2016.03.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.vetimm.2016.03.006","pdf_url":null,"source":{"id":"https://openalex.org/S194416120","display_name":"Veterinary Immunology and Immunopathology","issn_l":"0165-2427","issn":["0165-2427","1873-2534"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-2","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary Immunology and Immunopathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7173013/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042307886","display_name":"Stephen W. Mamber","orcid":"https://orcid.org/0000-0002-4003-7102","observed_orcids":["https://orcid.org/0000-0002-4003-7102"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen W. Mamber","raw_affiliation_strings":["Beech Tree Labs, 117 Chapman Street, Providence, RI 02905, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beech Tree Labs, 117 Chapman Street, Providence, RI 02905, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004577211","display_name":"Jeremy Lins","orcid":"https://orcid.org/0009-0007-0528-5307","observed_orcids":["https://orcid.org/0009-0007-0528-5307"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeremy Lins","raw_affiliation_strings":["Beech Tree Labs, 117 Chapman Street, Providence, RI 02905, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beech Tree Labs, 117 Chapman Street, Providence, RI 02905, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067513073","display_name":"Volkan Gurel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Volkan Gurel","raw_affiliation_strings":["Beech Tree Labs, 117 Chapman Street, Providence, RI 02905, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beech Tree Labs, 117 Chapman Street, Providence, RI 02905, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109126380","display_name":"D. P. Hutcheson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David P. Hutcheson","raw_affiliation_strings":["Animal Agricultural Consulting International, 63 Neches Court, Scroggins, TX 75480, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Animal Agricultural Consulting International, 63 Neches Court, Scroggins, TX 75480, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008691236","display_name":"Pablo J. Pinedo","orcid":"https://orcid.org/0000-0001-7491-2043","observed_orcids":["https://orcid.org/0000-0001-7491-2043"]},"institutions":[{"id":"https://openalex.org/I173268674","display_name":"Texas A&M University System","ror":"https://ror.org/0034eay46","country_code":"US","type":"education","lineage":["https://openalex.org/I173268674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pablo Pinedo","raw_affiliation_strings":["Texas A&M AgriLife Research Extension Center, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University System, Amarillo, TX 79106, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas A&M AgriLife Research Extension Center, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University System, Amarillo, TX 79106, United States","institution_ids":["https://openalex.org/I173268674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056747380","display_name":"David T. Bechtol","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Bechtol","raw_affiliation_strings":["Agri Research Center, 16851 Hope Road, Canyon, TX 79015, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Agri Research Center, 16851 Hope Road, Canyon, TX 79015, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017737032","display_name":"Steven G. Krakowka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Krakowka","raw_affiliation_strings":["Department of Veterinary Sciences, Ohio State University, Columbus, OH 43210, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Sciences, Ohio State University, Columbus, OH 43210, United States","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014347593","display_name":"Rachel Fields-Henderson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rachel Fields-Henderson","raw_affiliation_strings":["Colorado Serum Company, 4950 York Street, Denver, CO 80216, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Colorado Serum Company, 4950 York Street, Denver, CO 80216, United States","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052227994","display_name":"Joseph \u039c. Cummins","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Joseph M. Cummins","raw_affiliation_strings":["Bomunity Ltd., Co., 400 W. Walnut Street, Hereford, TX 79045, United States. Electronic address: shadynookfarms@hotmail.com","Bomunity Ltd., Co., 400 W. Walnut Street, Hereford, TX 79045, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bomunity Ltd., Co., 400 W. Walnut Street, Hereford, TX 79045, United States. Electronic address: shadynookfarms@hotmail.com","institution_ids":[]},{"raw_affiliation_string":"Bomunity Ltd., Co., 400 W. Walnut Street, Hereford, TX 79045, United States","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5052227994"],"corresponding_institution_ids":[],"apc_list":{"value":3250,"currency":"USD","value_usd":3250},"apc_paid":null,"fwci":0.6437,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.66521997,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"172","issue":null,"first_page":"64","last_page":"71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11560","display_name":"Animal Disease Management and Epidemiology","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12322","display_name":"Animal health and immunology","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.8500000238418579},{"id":"https://openalex.org/keywords/cattle","display_name":"cattle","score":0.8119999766349792},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.847000002861023},{"id":"https://openalex.org/keywords/inflammation-related-genes","display_name":"inflammatory genes","score":0.7649999856948853},{"id":"https://openalex.org/keywords/foot-and-mouth-disease","display_name":"foot-and-mouth disease","score":0.8679999709129333},{"id":"https://openalex.org/keywords/foot-and-mouth-disease-virus","display_name":"foot-and-mouth disease virus","score":0.8659999966621399},{"id":"https://openalex.org/keywords/antiviral-immunity","display_name":"antiviral immunity","score":0.9369999766349792},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.9639999866485596},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.45100000500679016},{"id":"https://openalex.org/keywords/livestock-vaccination","display_name":"livestock vaccination","score":0.3889999985694885}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8047931790351868},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.5926228165626526},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.586169421672821},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5057849884033203},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.440888375043869},{"id":"https://openalex.org/C3020380090","wikidata":"https://www.wikidata.org/wiki/Q24741149","display_name":"Interferon \u03b3","level":4,"score":0.4379411041736603},{"id":"https://openalex.org/C2780841837","wikidata":"https://www.wikidata.org/wiki/Q24741149","display_name":"Interferon gamma","level":3,"score":0.33461302518844604},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30721285939216614},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.29264581203460693}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003402","descriptor_name":"Creatine Kinase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015551","descriptor_name":"Autoimmunity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015551","descriptor_name":"Autoimmunity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018121","descriptor_name":"Receptors, Cytokine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.vetimm.2016.03.006","doi":"https://doi.org/10.1016/j.vetimm.2016.03.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.vetimm.2016.03.006","pdf_url":null,"source":{"id":"https://openalex.org/S194416120","display_name":"Veterinary Immunology and Immunopathology","issn_l":"0165-2427","issn":["0165-2427","1873-2534"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-2","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary Immunology and Immunopathology","raw_type":"journal-article"},{"id":"pmid:27032505","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27032505","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary immunology and immunopathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7173013","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7173013/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vet Immunol Immunopathol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7173013","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7173013/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vet Immunol Immunopathol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831},{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.6735000014305115}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309070","display_name":"Brown University","ror":"https://ror.org/05gq02987"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W91783560","https://openalex.org/W116446150","https://openalex.org/W137526454","https://openalex.org/W160599993","https://openalex.org/W188403539","https://openalex.org/W208523023","https://openalex.org/W966850244","https://openalex.org/W1487135612","https://openalex.org/W1487597627","https://openalex.org/W1543326360","https://openalex.org/W1628822335","https://openalex.org/W1855419408","https://openalex.org/W1978283061","https://openalex.org/W1982831502","https://openalex.org/W1992948817","https://openalex.org/W1999316836","https://openalex.org/W2000748975","https://openalex.org/W2005048739","https://openalex.org/W2005769192","https://openalex.org/W2011479334","https://openalex.org/W2012226492","https://openalex.org/W2013219571","https://openalex.org/W2015204522","https://openalex.org/W2018061608","https://openalex.org/W2019550520","https://openalex.org/W2028428958","https://openalex.org/W2035677339","https://openalex.org/W2041492780","https://openalex.org/W2042376141","https://openalex.org/W2042421272","https://openalex.org/W2043966701","https://openalex.org/W2052133482","https://openalex.org/W2054669347","https://openalex.org/W2054945280","https://openalex.org/W2061339066","https://openalex.org/W2066031449","https://openalex.org/W2068612171","https://openalex.org/W2070284910","https://openalex.org/W2074719132","https://openalex.org/W2080841773","https://openalex.org/W2096976625","https://openalex.org/W2097722577","https://openalex.org/W2100969042","https://openalex.org/W2103738533","https://openalex.org/W2103906844","https://openalex.org/W2110764032","https://openalex.org/W2112670248","https://openalex.org/W2119428010","https://openalex.org/W2120955674","https://openalex.org/W2125252759","https://openalex.org/W2126022534","https://openalex.org/W2133129328","https://openalex.org/W2133465414","https://openalex.org/W2136245823","https://openalex.org/W2136830287","https://openalex.org/W2141077451","https://openalex.org/W2143205338","https://openalex.org/W2143242626","https://openalex.org/W2143819913","https://openalex.org/W2147818004","https://openalex.org/W2150672974","https://openalex.org/W2150782426","https://openalex.org/W2154217021","https://openalex.org/W2158217645","https://openalex.org/W2165015301","https://openalex.org/W2166880388","https://openalex.org/W2175593968","https://openalex.org/W2314825638","https://openalex.org/W2400569570","https://openalex.org/W2409822422","https://openalex.org/W2411127011","https://openalex.org/W3022242500","https://openalex.org/W4205458892","https://openalex.org/W4213222109","https://openalex.org/W4319054102","https://openalex.org/W6677010962"],"related_works":["https://openalex.org/W2018061608","https://openalex.org/W2082535819","https://openalex.org/W2126022534","https://openalex.org/W2061339066","https://openalex.org/W4390378287","https://openalex.org/W2902944883","https://openalex.org/W2074511009","https://openalex.org/W7171836724","https://openalex.org/W2074328128","https://openalex.org/W188403539"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
