{"id":"https://openalex.org/W2292829504","doi":null,"title":"Progression of solitary and multifocal papillary thyroid carcinoma - a retrospective study of 368 patients.","display_name":"Progression of solitary and multifocal papillary thyroid carcinoma - a retrospective study of 368 patients.","publication_year":2012,"publication_date":"2012-12-01","ids":{"openalex":"https://openalex.org/W2292829504","mag":"2292829504","pmid":"https://pubmed.ncbi.nlm.nih.gov/23253715"},"language":"en","primary_location":{"id":"pmid:23253715","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23253715","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical journal","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078104635","display_name":"Xiang Zheng","orcid":"https://orcid.org/0000-0001-7675-7278","observed_orcids":["https://orcid.org/0000-0001-7675-7278"]},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiang-qian Zheng","raw_affiliation_strings":["Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, China","institution_ids":["https://openalex.org/I2802573037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100337663","display_name":"Chen Wang","orcid":"https://orcid.org/0000-0003-2271-5587","observed_orcids":["https://orcid.org/0000-0003-2271-5587"]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Wang","raw_affiliation_strings":["Tianjin Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin Medical University","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101657359","display_name":"Meng Xu","orcid":"https://orcid.org/0000-0001-7834-6755","observed_orcids":["https://orcid.org/0000-0001-7834-6755","https://orcid.org/0000-0002-9930-0403"]},"institutions":[{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meng Xu","raw_affiliation_strings":["General Hospital of People's Liberation Army"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General Hospital of People's Liberation Army","institution_ids":["https://openalex.org/I4210160531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028485839","display_name":"Yang Yu","orcid":"https://orcid.org/0000-0001-6513-6898","observed_orcids":["https://orcid.org/0000-0001-6513-6898"]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Yu","raw_affiliation_strings":["Tianjin Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin Medical University","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011475371","display_name":"Xin Wei Yun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin-wei Yun","raw_affiliation_strings":["Tianjin Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin Medical University","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110610864","display_name":"Yong Jia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong-sheng Jia","raw_affiliation_strings":["Tianjin Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin Medical University","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102231816","display_name":"Song Feng Wei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Song-feng Wei","raw_affiliation_strings":["Tianjin Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tianjin Medical University","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033827545","display_name":"Xiu Bao Ren","orcid":"https://orcid.org/0000-0002-2934-454X","observed_orcids":["https://orcid.org/0000-0002-2934-454X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiu-bao Ren","raw_affiliation_strings":["Biotherapy Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotherapy Center","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103152927","display_name":"Ming Gao","orcid":"https://orcid.org/0000-0003-4602-4393","observed_orcids":["https://orcid.org/0000-0003-4602-4393"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ming Gao","raw_affiliation_strings":["Thyroid Cancer"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thyroid Cancer","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0293,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.75732117,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"125","issue":"24","first_page":"4434","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12631","display_name":"Head and Neck Anomalies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/papillary-thyroid-carcinoma","display_name":"papillary thyroid carcinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/multifocal-thyroid-carcinoma","display_name":"multifocal thyroid carcinoma","score":0.8420000076293945},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.8190000057220459},{"id":"https://openalex.org/keywords/braf-v600e-mutation","display_name":"BRAF V600E mutation","score":0.9589999914169312},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/vascular-invasion","display_name":"vascular invasion","score":0.9950000047683716},{"id":"https://openalex.org/keywords/distant-metastasis","display_name":"distant metastasis","score":0.9100000262260437},{"id":"https://openalex.org/keywords/10-year-survival","display_name":"10-year survival","score":0.8629999756813049},{"id":"https://openalex.org/keywords/tumor-size","display_name":"tumor size","score":0.7170000076293945},{"id":"https://openalex.org/keywords/histological-subtypes","display_name":"histological subtypes","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8258787393569946},{"id":"https://openalex.org/C2993294228","wikidata":"https://www.wikidata.org/wiki/Q13632630","display_name":"Thyroid carcinoma","level":3,"score":0.7815777063369751},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.5538691282272339},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5466585159301758},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5222909450531006},{"id":"https://openalex.org/C2776470698","wikidata":"https://www.wikidata.org/wiki/Q21851559","display_name":"V600E","level":4,"score":0.49003779888153076},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.47123584151268005},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.4640547037124634},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.45530030131340027},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43331557512283325},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4299634099006653},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3437514901161194},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.27405017614364624},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0927530825138092},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.053977906703948975},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077273","descriptor_name":"Thyroid Cancer, Papillary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002291","descriptor_name":"Carcinoma, Papillary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002291","descriptor_name":"Carcinoma, Papillary","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D048493","descriptor_name":"Proto-Oncogene Proteins B-raf","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:23253715","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23253715","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical journal","raw_type":"Journal Article"},{"id":"mag:2292829504","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23253715","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2136129617","https://openalex.org/W2567875275","https://openalex.org/W2009672378","https://openalex.org/W3108863708","https://openalex.org/W2145160118","https://openalex.org/W2159718023","https://openalex.org/W7026819695","https://openalex.org/W2011699883","https://openalex.org/W2397576868","https://openalex.org/W2466226295"],"abstract_inverted_index":{"BACKGROUND:":[0],"Papillary":[1],"thyroid":[2],"carcinoma":[3],"(PTC)":[4],"represents":[5],"one":[6],"of":[7,25,52,111,161,168,196],"the":[8,23,48,144],"most":[9,49],"frequent":[10,201],"endocrine":[11],"malignancies.":[12],"Several":[13],"factors":[14],"have":[15],"been":[16,59],"found":[17,60],"to":[18,61,72,88,133],"be":[19,62],"involved":[20],"in":[21,67,75,114,170,177,202],"determining":[22],"outcome":[24],"treatment":[26],"for":[27],"patients":[28,76,91,99,105,180,205],"with":[29,77,92,100,106,183,206],"PTC.":[30,68,81,108,142],"Large":[31],"tumor":[32,116,162],"size,":[33],"diagnosis":[34,186,211],"at":[35,187,212],"an":[36],"early":[37,188],"age,":[38],"extra-thyroidal":[39,191],"invasion,":[40],"aggressive":[41],"histological":[42],"variants,":[43],"and":[44,79,103,137,148,190,210],"distant":[45,145],"metastases":[46],"are":[47],"important":[50],"determinants":[51],"a":[53,63,85],"poor":[54],"outcome.":[55],"BRAF(V600E)":[56,112,197],"mutation":[57,113,198],"has":[58],"major":[64],"genetic":[65],"alteration":[66],"This":[69],"study":[70,87,125],"aimed":[71],"evaluate":[73],"progression":[74,167],"multifocal":[78,107,119,128,171,178,203],"solitary":[80,101,141],"METHODS:":[82],"We":[83],"performed":[84],"retrospective":[86],"analyze":[89],"368":[90],"PTC":[93,102,120,129,172,179,204],"who":[94],"underwent":[95],"surgery,":[96],"including":[97],"282":[98],"86":[104],"The":[109,159,194],"status":[110,195],"all":[115],"foci":[117,163],"from":[118],"was":[121,130,181,199],"detected.":[122],"RESULTS:":[123],"Our":[124],"suggested":[126],"that":[127],"more":[131,200],"related":[132],"lymph":[134,207],"node":[135,175,208],"metastasis":[136,146,176,209],"vascular":[138],"invasion":[139],"than":[140],"However,":[143],"rate":[147,151],"10-year":[149],"survival":[150],"showed":[152],"no":[153],"difference":[154],"between":[155],"these":[156],"two":[157],"groups.":[158],"number":[160],"did":[164],"not":[165],"affect":[166],"disease":[169],"patients.":[173],"Lymph":[174],"associated":[182],"larger":[184],"tumors,":[185],"stage,":[189],"invasion.":[192],"CONCLUSION:":[193],"later":[213],"age.":[214]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}