{"id":"https://openalex.org/W2292804979","doi":null,"title":"RNA AND DNA INACTIVATION STRATEGIES TO PREVENT OR INHIBIT HIV-1 REPLICATION VIA GENE THERAPY","display_name":"RNA AND DNA INACTIVATION STRATEGIES TO PREVENT OR INHIBIT HIV-1 REPLICATION VIA GENE THERAPY","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2292804979","mag":"2292804979"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/16777","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/16777","pdf_url":"https://utoronto.scholaris.ca/bitstreams/ca5a2269-a88a-48d2-9f95-839d7673b63b/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/ca5a2269-a88a-48d2-9f95-839d7673b63b/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111717952","display_name":"Reza Nazari","orcid":"https://orcid.org/0000-0001-5146-8154","observed_orcids":["https://orcid.org/0000-0001-5146-8154"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Reza Nazari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5111717952"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.6205999851226807,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.6205999851226807,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.32350000739097595,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.026100000366568565,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.7870000004768372},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.8960000276565552},{"id":"https://openalex.org/keywords/hammerhead-ribozyme","display_name":"hammerhead ribozyme","score":0.9810000061988831},{"id":"https://openalex.org/keywords/group-ii-introns","display_name":"group II introns","score":0.7979999780654907},{"id":"https://openalex.org/keywords/hiv-1-replication-inhibition","display_name":"HIV-1 replication inhibition","score":0.8050000071525574},{"id":"https://openalex.org/keywords/hiv-1-proviral-dna","display_name":"HIV-1 proviral DNA","score":0.5950000286102295},{"id":"https://openalex.org/keywords/viral-escape-mutants","display_name":"viral escape mutants","score":0.4440000057220459},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.7580000162124634},{"id":"https://openalex.org/keywords/lentivirus","display_name":"lentivirus","score":0.47099998593330383},{"id":"https://openalex.org/keywords/hiv-1-pol-gene","display_name":"HIV-1 pol gene","score":0.5090000033378601}],"concepts":[{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.622842013835907},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5028273463249207},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.48144739866256714},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.47477006912231445},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4561518728733063},{"id":"https://openalex.org/C12590798","wikidata":"https://www.wikidata.org/wiki/Q3933199","display_name":"Replication (statistics)","level":2,"score":0.43421247601509094},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.42443016171455383},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3384099006652832},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33033597469329834}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/16777","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/16777","pdf_url":"https://utoronto.scholaris.ca/bitstreams/ca5a2269-a88a-48d2-9f95-839d7673b63b/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:collectionscanada.gc.ca:OTU.1807/16777","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1807/16777","pdf_url":null,"source":{"id":"https://openalex.org/S4306402307","display_name":"Library and Archives Canada (Government of Canada)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802286613","host_organization_name":"Government of Canada","host_organization_lineage":["https://openalex.org/I2802286613"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2292804979","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/bitstream/1807/16777/1/Nazari_Reza_200811_Phd_thesis.pdf.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/16777","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/16777","pdf_url":"https://utoronto.scholaris.ca/bitstreams/ca5a2269-a88a-48d2-9f95-839d7673b63b/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1412571906","display_name":null,"funder_award_id":"pNL4-3","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6511232711","display_name":null,"funder_award_id":"pNL4-3","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2292804979.pdf","grobid_xml":"https://content.openalex.org/works/W2292804979.grobid-xml"},"referenced_works_count":294,"referenced_works":["https://openalex.org/W14052271","https://openalex.org/W26333867","https://openalex.org/W78320112","https://openalex.org/W82820957","https://openalex.org/W118109569","https://openalex.org/W177323295","https://openalex.org/W179460930","https://openalex.org/W184792323","https://openalex.org/W280992628","https://openalex.org/W1473837638","https://openalex.org/W1481273911","https://openalex.org/W1488192195","https://openalex.org/W1500789577","https://openalex.org/W1502972645","https://openalex.org/W1517417834","https://openalex.org/W1535745579","https://openalex.org/W1537629327","https://openalex.org/W1538958153","https://openalex.org/W1539122984","https://openalex.org/W1542320852","https://openalex.org/W1544116011","https://openalex.org/W1544280182","https://openalex.org/W1590468645","https://openalex.org/W1592445034","https://openalex.org/W1596576376","https://openalex.org/W1622439358","https://openalex.org/W1623426438","https://openalex.org/W1628484047","https://openalex.org/W1635348995","https://openalex.org/W1642524132","https://openalex.org/W1644579564","https://openalex.org/W1644708200","https://openalex.org/W1659719610","https://openalex.org/W1723922714","https://openalex.org/W1731073298","https://openalex.org/W1770932653","https://openalex.org/W1831019962","https://openalex.org/W1840552006","https://openalex.org/W1842798465","https://openalex.org/W1847328459","https://openalex.org/W1900729316","https://openalex.org/W1946734657","https://openalex.org/W1949630295","https://openalex.org/W1955657492","https://openalex.org/W1958554861","https://openalex.org/W1963984954","https://openalex.org/W1965019797","https://openalex.org/W1965423166","https://openalex.org/W1966515400","https://openalex.org/W1966700067","https://openalex.org/W1966815718","https://openalex.org/W1968478258","https://openalex.org/W1968594568","https://openalex.org/W1972389078","https://openalex.org/W1973398091","https://openalex.org/W1974224443","https://openalex.org/W1974835556","https://openalex.org/W1975260126","https://openalex.org/W1977074400","https://openalex.org/W1977282539","https://openalex.org/W1977632850","https://openalex.org/W1979989142","https://openalex.org/W1981012370","https://openalex.org/W1981292246","https://openalex.org/W1981449360","https://openalex.org/W1981644527","https://openalex.org/W1983325963","https://openalex.org/W1983466424","https://openalex.org/W1984811742","https://openalex.org/W1985087864","https://openalex.org/W1986574361","https://openalex.org/W1986665636","https://openalex.org/W1989701896","https://openalex.org/W1990398742","https://openalex.org/W1990679519","https://openalex.org/W1991210664","https://openalex.org/W1992951628","https://openalex.org/W1993591984","https://openalex.org/W1993634191","https://openalex.org/W1994075300","https://openalex.org/W1994122530","https://openalex.org/W1996183144","https://openalex.org/W1996428487","https://openalex.org/W1998513236","https://openalex.org/W1999295945","https://openalex.org/W1999940504","https://openalex.org/W2000564337","https://openalex.org/W2001243226","https://openalex.org/W2001981734","https://openalex.org/W2002120651","https://openalex.org/W2003425131","https://openalex.org/W2003858277","https://openalex.org/W2004258189","https://openalex.org/W2005288455","https://openalex.org/W2005535987","https://openalex.org/W2006074662","https://openalex.org/W2007021820","https://openalex.org/W2007099197","https://openalex.org/W2009412962","https://openalex.org/W2009908550","https://openalex.org/W2010750399","https://openalex.org/W2011630381","https://openalex.org/W2012090718","https://openalex.org/W2013948998","https://openalex.org/W2017286564","https://openalex.org/W2017331352","https://openalex.org/W2017630194","https://openalex.org/W2017705439","https://openalex.org/W2018359511","https://openalex.org/W2019316496","https://openalex.org/W2019508559","https://openalex.org/W2022442231","https://openalex.org/W2022792630","https://openalex.org/W2023241219","https://openalex.org/W2024004004","https://openalex.org/W2024568805","https://openalex.org/W2025101131","https://openalex.org/W2026250515","https://openalex.org/W2026444780","https://openalex.org/W2026595768","https://openalex.org/W2027535761","https://openalex.org/W2029788603","https://openalex.org/W2030017358","https://openalex.org/W2030844138","https://openalex.org/W2031089158","https://openalex.org/W2032023518","https://openalex.org/W2032918869","https://openalex.org/W2032928842","https://openalex.org/W2033928634","https://openalex.org/W2034053987","https://openalex.org/W2034430377","https://openalex.org/W2035248803","https://openalex.org/W2035444138","https://openalex.org/W2035868736","https://openalex.org/W2036193618","https://openalex.org/W2037793240","https://openalex.org/W2038036667","https://openalex.org/W2039977144","https://openalex.org/W2040059091","https://openalex.org/W2040681869","https://openalex.org/W2041375942","https://openalex.org/W2041525705","https://openalex.org/W2043810954","https://openalex.org/W2043855995","https://openalex.org/W2044874413","https://openalex.org/W2045663070","https://openalex.org/W2045772303","https://openalex.org/W2046126827","https://openalex.org/W2046164345","https://openalex.org/W2050396617","https://openalex.org/W2050992506","https://openalex.org/W2052392655","https://openalex.org/W2052584610","https://openalex.org/W2052615997","https://openalex.org/W2053297567","https://openalex.org/W2055396596","https://openalex.org/W2055697700","https://openalex.org/W2060576378","https://openalex.org/W2060952336","https://openalex.org/W2061244260","https://openalex.org/W2062006468","https://openalex.org/W2062148688","https://openalex.org/W2064059889","https://openalex.org/W2064069756","https://openalex.org/W2064085023","https://openalex.org/W2064268136","https://openalex.org/W2064621970","https://openalex.org/W2065672846","https://openalex.org/W2066121768","https://openalex.org/W2067217123","https://openalex.org/W2067520621","https://openalex.org/W2067964854","https://openalex.org/W2068576110","https://openalex.org/W2070558900","https://openalex.org/W2070949673","https://openalex.org/W2078308455","https://openalex.org/W2078699438","https://openalex.org/W2080589169","https://openalex.org/W2081805554","https://openalex.org/W2082485360","https://openalex.org/W2083612980","https://openalex.org/W2084208256","https://openalex.org/W2084833442","https://openalex.org/W2084851425","https://openalex.org/W2085464725","https://openalex.org/W2085724830","https://openalex.org/W2086044183","https://openalex.org/W2087809591","https://openalex.org/W2088851522","https://openalex.org/W2089471930","https://openalex.org/W2090630729","https://openalex.org/W2090669079","https://openalex.org/W2092084907","https://openalex.org/W2093046469","https://openalex.org/W2095822026","https://openalex.org/W2095919862","https://openalex.org/W2097357414","https://openalex.org/W2098781795","https://openalex.org/W2098899288","https://openalex.org/W2100182517","https://openalex.org/W2100292137","https://openalex.org/W2100581167","https://openalex.org/W2102299427","https://openalex.org/W2102548388","https://openalex.org/W2108612435","https://openalex.org/W2109122063","https://openalex.org/W2110182256","https://openalex.org/W2110936823","https://openalex.org/W2112044573","https://openalex.org/W2112349562","https://openalex.org/W2112940264","https://openalex.org/W2115906128","https://openalex.org/W2116296362","https://openalex.org/W2116375659","https://openalex.org/W2116973451","https://openalex.org/W2117025121","https://openalex.org/W2117149353","https://openalex.org/W2119293746","https://openalex.org/W2120996101","https://openalex.org/W2122003863","https://openalex.org/W2122833547","https://openalex.org/W2124846613","https://openalex.org/W2125524484","https://openalex.org/W2127815795","https://openalex.org/W2129875326","https://openalex.org/W2131376910","https://openalex.org/W2131490666","https://openalex.org/W2131748930","https://openalex.org/W2134176652","https://openalex.org/W2135135539","https://openalex.org/W2135559013","https://openalex.org/W2139551787","https://openalex.org/W2140306302","https://openalex.org/W2140406760","https://openalex.org/W2142918729","https://openalex.org/W2143663670","https://openalex.org/W2144266543","https://openalex.org/W2145237484","https://openalex.org/W2145893781","https://openalex.org/W2147169218","https://openalex.org/W2147413871","https://openalex.org/W2147803810","https://openalex.org/W2147949158","https://openalex.org/W2148463169","https://openalex.org/W2149182242","https://openalex.org/W2149758729","https://openalex.org/W2150758953","https://openalex.org/W2152003330","https://openalex.org/W2154428643","https://openalex.org/W2154676797","https://openalex.org/W2154852791","https://openalex.org/W2155691564","https://openalex.org/W2155989561","https://openalex.org/W2156117117","https://openalex.org/W2157646080","https://openalex.org/W2160272188","https://openalex.org/W2160318665","https://openalex.org/W2161545291","https://openalex.org/W2161717286","https://openalex.org/W2161961972","https://openalex.org/W2162417096","https://openalex.org/W2162703129","https://openalex.org/W2162994634","https://openalex.org/W2163611230","https://openalex.org/W2164167813","https://openalex.org/W2164371532","https://openalex.org/W2164835084","https://openalex.org/W2165918134","https://openalex.org/W2168325635","https://openalex.org/W2169601134","https://openalex.org/W2171790482","https://openalex.org/W2171871646","https://openalex.org/W2171881861","https://openalex.org/W2172208936","https://openalex.org/W2173401606","https://openalex.org/W2222462351","https://openalex.org/W2241071176","https://openalex.org/W2256756668","https://openalex.org/W2282756759","https://openalex.org/W2297007843","https://openalex.org/W2307505398","https://openalex.org/W2327332106","https://openalex.org/W2329979483","https://openalex.org/W2394971593","https://openalex.org/W2403785546","https://openalex.org/W2404135320","https://openalex.org/W2410981273","https://openalex.org/W2416010263","https://openalex.org/W2460186931","https://openalex.org/W2897034676","https://openalex.org/W3024389904","https://openalex.org/W4237573105","https://openalex.org/W4313347724","https://openalex.org/W7098400432"],"related_works":["https://openalex.org/W2045772303","https://openalex.org/W2117210846","https://openalex.org/W2010065764","https://openalex.org/W2051585221","https://openalex.org/W2026102468","https://openalex.org/W2026018374","https://openalex.org/W2009066388","https://openalex.org/W2161076191","https://openalex.org/W1974167211","https://openalex.org/W2046164345"],"abstract_inverted_index":{"AIDS":[0],"is":[1,53,88,186],"caused":[2],"by":[3,55,80,121],"a":[4,20,67,81,89,94,116,162,169,214,228,237,302],"lentivirus,":[5],"HIV-1.":[6],"In":[7],"addition":[8],"to":[9,42,99,152,167,207,221,310,345],"antiretroviral":[10],"drugs":[11],"that":[12,92,190,320],"are":[13,40,205,341],"currently":[14],"in":[15,48,58,109,133,177,298,353],"use":[16],"for":[17,128],"HIV/AIDS":[18],"therapy,":[19],"number":[21],"of":[22,33,45,61,115,119,130,140,174,236,252,280,301,329,335,338],"gene":[23,68,179,255],"therapy":[24,69],"strategies":[25,189],"have":[26,232],"been":[27],"designed":[28],"as":[29,66,292],"alternative":[30],"therapies.":[31],"Most":[32],"these":[34],"therapies":[35],"target":[36,95,191],"HIV":[37],"RNA/proteins,":[38],"which":[39,204],"subject":[41],"high":[43],"rate":[44],"mutation,":[46],"resulting":[47],"escape":[49],"mutants.":[50],"Viral":[51],"entry":[52],"mediated":[54],"CCR5":[56,65,78],"co-receptor":[57],"most":[59],"routes":[60],"transmission.":[62],"To":[63],"downregulate":[64],"approach,":[70,230],"we":[71,231],"targeted":[72],"seven":[73],"unique":[74],"sites":[75,247],"within":[76,248],"the":[77,102,134,158,178,192,249,263,290,299,305,333],"mRNA":[79],"multimeric":[82],"hammerhead":[83],"ribozyme,":[84],"Rz1-7.":[85],"Hammerhead":[86],"ribozyme":[87],"small":[90],"RNA":[91,96],"cleaves":[93],"upon":[97],"binding":[98],"it.":[100],"Expressing":[101],"Rz1-7":[103,124],"from":[104,289,293],"HIV-1-":[105],"and":[106,137,171,182,210,268,284,312],"MSCV-based":[107],"vectors":[108,344],"otherwise":[110],"susceptible":[111],"cells":[112,181,270],"inhibited":[113],"replication":[114,132,176,314,331],"CCR5-tropic":[117],"strain":[118],"HIV-1":[120,131,154,193,243,253,264,275,281,295,306],"99-100%.":[122],"The":[123],"will":[125],"be":[126,150,219],"tested":[127],"inhibition":[129,173,328],"CD4+":[135],"T-lymphoid":[136],"myeloid":[138],"progeny":[139,285],"transduced":[141],"human":[142],"CD34+":[143],"hematopoietic":[144],"progenitor":[145],"stem":[146],"cells.":[147,355],"It":[148],"may":[149],"preferable":[151],"interfere":[153],"life":[155],"cycle":[156],"at":[157,245,332],"DNA":[159,216,224,308],"level":[160,334],"since":[161],"one-time":[163],"inactivation":[164],"might":[165],"suffice":[166],"confer":[168,326],"complete":[170,327],"permanent":[172],"virus":[175,258,286,313,330],"modified":[180,238,321],"their":[183],"progeny.":[184],"This":[185],"what":[187],"other":[188],"RNA/protein":[194],"can":[195,218,325,350],"hardly":[196],"offer.":[197],"For":[198],"this":[199],"purpose,":[200],"group":[201,322],"II":[202,323],"introns,":[203],"able":[206],"splice":[208],"out":[209],"get":[211],"incorporated":[212],"into":[213,240,262],"specific":[215],"sequence,":[217],"designed/modified":[220],"gain":[222],"novel":[223,229],"targeting":[225],"specificities.":[226],"As":[227],"examined":[233],"whether":[234,347],"insertion":[235,261,349],"intron":[239,348],"an":[241],"infectious":[242],"clone":[244,265],"two":[246],"integrase":[250],"domain":[251],"pol":[254],"could":[256],"inhibit":[257],"replication.":[259],"Intron":[260],"was":[266,315],"induced":[267],"mammalian":[269,354],"were":[271,287],"transfected":[272],"with":[273],"intron-inserted":[274],"clones.":[276],"Although":[277],"similar":[278],"amounts":[279],"RNA,":[282],"protein,":[283],"produced":[288],"clones":[291],"wild-type":[294],"provirus":[296],"DNA,":[297],"absence":[300],"functional":[303],"integrase,":[304],"reverse-transcribed":[307],"failed":[309],"integrate":[311],"aborted.":[316],"These":[317],"results":[318],"demonstrate":[319],"introns":[324],"second":[336],"round":[337],"infection.":[339],"We":[340],"now":[342],"developing":[343],"assess":[346],"take":[351],"place":[352]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
