{"id":"https://openalex.org/W22925353","doi":null,"title":"DNA damage and genomic instability","display_name":"DNA damage and genomic instability","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W22925353","mag":"22925353"},"language":"en","primary_location":{"id":"mag:22925353","doi":null,"is_oa":false,"landing_page_url":"http://www.osti.gov/scitech/biblio/530847-dna-damage-genomic-instability","pdf_url":null,"source":{"id":"https://openalex.org/S204663187","display_name":"Environmental and Molecular Mutagenesis","issn_l":"0893-6692","issn":["0893-6692","1098-2280"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Environmental and Molecular Mutagenesis","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084243671","display_name":"Charles L. Limoli","orcid":"https://orcid.org/0000-0002-1321-4142","observed_orcids":["https://orcid.org/0000-0002-1321-4142"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles L. Limoli","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1321-4142","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5106266163","display_name":"William F. Morgan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W.F. Morgan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00132135,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.8496000170707703,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.8496000170707703,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.13339999318122864,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-strand-breaks","display_name":"DNA strand breaks","score":0.7630000114440918},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.9539999961853027},{"id":"https://openalex.org/keywords/chromosomal-instability","display_name":"chromosomal instability","score":0.9610000252723694},{"id":"https://openalex.org/keywords/bleomycin","display_name":"bleomycin","score":0.8659999966621399},{"id":"https://openalex.org/keywords/neocarzinostatin","display_name":"neocarzinostatin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.9539999961853027},{"id":"https://openalex.org/keywords/restriction-enzymes","display_name":"restriction enzymes","score":0.9919999837875366},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":1.0},{"id":"https://openalex.org/keywords/human-chromosome-4","display_name":"human chromosome 4","score":0.7509999871253967},{"id":"https://openalex.org/keywords/chromosomal-rearrangements","display_name":"chromosomal rearrangements","score":0.8679999709129333},{"id":"https://openalex.org/keywords/clonal-populations","display_name":"clonal populations","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.8432726860046387},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6894240379333496},{"id":"https://openalex.org/C140752955","wikidata":"https://www.wikidata.org/wiki/Q1087752","display_name":"Chromosome instability","level":4,"score":0.629706084728241},{"id":"https://openalex.org/C2777392692","wikidata":"https://www.wikidata.org/wiki/Q205145","display_name":"Neocarzinostatin","level":3,"score":0.5559136867523193},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5214787721633911},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5085257291793823},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5080564022064209},{"id":"https://openalex.org/C128319531","wikidata":"https://www.wikidata.org/wiki/Q219715","display_name":"Restriction enzyme","level":3,"score":0.5053732991218567},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5013134479522705},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5010290145874023},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.48314565420150757},{"id":"https://openalex.org/C2776232574","wikidata":"https://www.wikidata.org/wiki/Q415571","display_name":"Bleomycin","level":3,"score":0.4760796129703522},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15015071630477905},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:22925353","doi":null,"is_oa":false,"landing_page_url":"http://www.osti.gov/scitech/biblio/530847-dna-damage-genomic-instability","pdf_url":null,"source":{"id":"https://openalex.org/S204663187","display_name":"Environmental and Molecular Mutagenesis","issn_l":"0893-6692","issn":["0893-6692","1098-2280"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Environmental and Molecular Mutagenesis","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1615511139","display_name":null,"funder_award_id":"R01MH078151","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G3867041601","display_name":null,"funder_award_id":"MH081804","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G6046933279","display_name":"Collaborative Genomic Study of Bipolar Disorder","funder_award_id":"R01MH059567","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G6996694602","display_name":null,"funder_award_id":"MH078151","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G7335939829","display_name":"Analysis of Whole Genome Association Data for Bipolar Disorder","funder_award_id":"R01MH081804","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G8900721982","display_name":null,"funder_award_id":"MH059567","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":2,"referenced_works":["https://openalex.org/W201439045","https://openalex.org/W2188731812"],"related_works":["https://openalex.org/W1584183470","https://openalex.org/W177476023","https://openalex.org/W2118574139","https://openalex.org/W2131857695","https://openalex.org/W1971729092","https://openalex.org/W2595096904","https://openalex.org/W7100146757","https://openalex.org/W2046388443","https://openalex.org/W2414990292","https://openalex.org/W6998167517"],"abstract_inverted_index":{"To":[0],"investigate":[1],"the":[2,9,100,141],"role":[3],"of":[4,55,62,106,123,143,165,175],"DNA":[5,102],"strand":[6,19],"breakage":[7],"as":[8],"molecular":[10],"lesion":[11],"responsible":[12],"for":[13,33],"initiating":[14],"genomic":[15,137],"instability,":[16],"five":[17],"different":[18,154],"breaking":[20],"agents;":[21],"bleomycin,":[22],"neocarzinostatin,":[23],"hydrogen":[24,158],"peroxide,":[25],"restriction":[26,155],"endonucleases":[27,156],"and":[28,129,147],"ionizing":[29,126],"radiation":[30],"were":[31,43],"examined":[32],"their":[34],"capacity":[35],"to":[36,75,99],"induce":[37],"delayed":[38,136],"chromosomal":[39,77,166],"instability.":[40,138,167],"These":[41,168],"studies":[42],"carried":[44],"out":[45],"in":[46,59,72,89,173],"GM10115":[47],"human-hamster":[48],"hybrid":[49],"cells":[50,96],"which":[51],"contain":[52],"one":[53],"copy":[54],"human":[56,80],"chromosome":[57,81],"4":[58],"a":[60],"background":[61],"20-24":[63],"hamster":[64],"chromosomes.":[65],"Chromosomal":[66],"instability":[67],"was":[68],"investigated":[69],"using":[70],"fluorescence":[71],"situ":[73],"hybridization":[74],"visualize":[76],"rearrangements":[78],"involving":[79,150],"4.":[82],"Rearrangements":[83],"are":[84,131],"detected":[85],"multiple":[86],"generations":[87],"post-treatment,":[88],"clonal":[90],"populations":[91],"derived":[92],"from":[93],"single":[94],"progenitor":[95],"surviving":[97],"treatment":[98,151],"specified":[101],"damaging":[103],"agents.":[104],"Analysis":[105],"over":[107,112],"250":[108],"individual":[109],"clones":[110,146],"representing":[111],"50,000":[113],"metaphases":[114],"clearly":[115],"demonstrate":[116],"that":[117],"when":[118],"compared":[119],"at":[120,134],"comparable":[121],"levels":[122],"cell":[124],"kill,":[125],"radiation,":[127],"bleomycin":[128],"neocarzinostatin":[130],"equally":[132],"effective":[133],"eliciting":[135],"In":[139],"contrast,":[140],"analysis":[142],"nearly":[144],"300":[145],"60,000":[148],"metaphases,":[149],"with":[152],"four":[153],"and/or":[157],"peroxide":[159],"did":[160],"not":[161],"show":[162],"any":[163],"manifestation":[164],"data":[169],"will":[170],"be":[171],"discussed":[172],"terms":[174],"treatment/DNA":[176],"interactions.":[177]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
