{"id":"https://openalex.org/W2292531950","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.801.20","title":"Mitochondria co\u2010opt exercise adaptations in defense against oxidative stress in vivo","display_name":"Mitochondria co\u2010opt exercise adaptations in defense against oxidative stress in vivo","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W2292531950","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.801.20","mag":"2292531950"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.24.1_supplement.801.20","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.801.20","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.24.1_supplement.801.20","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088162643","display_name":"Kevin E. Conley","orcid":"https://orcid.org/0000-0002-2843-5204","observed_orcids":["https://orcid.org/0000-0002-2843-5204"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Conley","raw_affiliation_strings":["Radiology, University of Washington, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiology, University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085722494","display_name":"Sharon A. Jubrias","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharon Jubrias","raw_affiliation_strings":["Radiology, University of Washington, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiology, University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032021300","display_name":"Michael P. Siegel","orcid":"https://orcid.org/0000-0003-4263-3220","observed_orcids":["https://orcid.org/0000-0003-4263-3220"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Siegel","raw_affiliation_strings":["Radiology, University of Washington, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiology, University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083861938","display_name":"Karen Leslie Syrjala","orcid":"https://orcid.org/0000-0001-8378-2797","observed_orcids":["https://orcid.org/0000-0001-8378-2797"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen Syrjala","raw_affiliation_strings":["Fred Hutchinson Caner Research Center, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Caner Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000765673","display_name":"Holly Van Remmen","orcid":"https://orcid.org/0000-0003-0883-0642","observed_orcids":["https://orcid.org/0000-0003-0883-0642"]},"institutions":[{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Holly van Remmen","raw_affiliation_strings":["University of Texas, San Antonio, San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas, San Antonio, San Antonio, TX","institution_ids":["https://openalex.org/I45438204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010644944","display_name":"Elizabeth Aylward","orcid":"https://orcid.org/0000-0003-0406-6202","observed_orcids":["https://orcid.org/0000-0003-0406-6202"]},"institutions":[{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Aylward","raw_affiliation_strings":["Seattle Children's Research Institute, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seattle Children's Research Institute, Seattle, WA","institution_ids":["https://openalex.org/I4405262941"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046458049","display_name":"David Joseph Marcinek","orcid":"https://orcid.org/0000-0001-5187-2149","observed_orcids":["https://orcid.org/0000-0001-5187-2149"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Marcinek","raw_affiliation_strings":["Radiology, University of Washington, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiology, University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.19004621,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.7476000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.7476000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.21629999577999115,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondria","display_name":"mitochondria","score":0.6729999780654907},{"id":"https://openalex.org/keywords/exercise-adaptation","display_name":"exercise adaptation","score":0.6200000047683716},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9810000061988831},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cu-zn-superoxide-dismutase","display_name":"Cu/Zn superoxide dismutase","score":0.8360000252723694},{"id":"https://openalex.org/keywords/mitochondrial-uncoupling","display_name":"mitochondrial uncoupling","score":0.9340000152587891},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.8140000104904175},{"id":"https://openalex.org/keywords/mitochondrial-respiration","display_name":"mitochondrial respiration","score":0.6959999799728394},{"id":"https://openalex.org/keywords/mitochondrial-biogenesis","display_name":"mitochondrial biogenesis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/muscle-metabolism","display_name":"muscle metabolism","score":0.5759999752044678},{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":0.890999972820282},{"id":"https://openalex.org/keywords/cancer-survivors","display_name":"cancer survivors","score":0.8889999985694885},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.5}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.8189379572868347},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.7825889587402344},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.7183046340942383},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.6799885630607605},{"id":"https://openalex.org/C2778175917","wikidata":"https://www.wikidata.org/wiki/Q17125553","display_name":"Mitochondrial ROS","level":3,"score":0.6238033175468445},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5910696387290955},{"id":"https://openalex.org/C2777615887","wikidata":"https://www.wikidata.org/wiki/Q15328137","display_name":"SOD1","level":4,"score":0.5526396632194519},{"id":"https://openalex.org/C2777229759","wikidata":"https://www.wikidata.org/wiki/Q6881848","display_name":"Mitochondrial biogenesis","level":3,"score":0.5397869348526001},{"id":"https://openalex.org/C66517615","wikidata":"https://www.wikidata.org/wiki/Q912751","display_name":"Cellular respiration","level":3,"score":0.5372424721717834},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.4800173342227936},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4137399196624756},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4006710648536682},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34537798166275024}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.24.1_supplement.801.20","doi":"https://doi.org/10.1096/fasebj.24.1_supplement.801.20","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.24.1_supplement.801.20","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308687","display_name":"CHDI Foundation","ror":"https://ror.org/046eh8t80"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4224239609","https://openalex.org/W2978502263","https://openalex.org/W2365445660","https://openalex.org/W3216337028","https://openalex.org/W2323186100","https://openalex.org/W2548757381","https://openalex.org/W7011212087","https://openalex.org/W1596695660","https://openalex.org/W3103640741","https://openalex.org/W2019318363"],"abstract_inverted_index":{"Reactive":[0],"oxygen":[1],"species":[2],"(ROS)":[3],"are":[4,163],"implicated":[5,111],"in":[6,17,39,46,66,90,169,192],"oxidative":[7,71,78,157,186],"damage":[8,79],"but":[9,73,121,142],"at":[10,123],"low":[11],"levels":[12],"act":[13],"as":[14,112],"signals,":[15],"especially":[16],"exercise.":[18,32,200],"Here":[19],"we":[20],"show":[21],"that":[22,99,117,181],"the":[23,29,51,103,124,164,183,197,208],"mitochondrial":[24,91,104,153],"defense":[25,168],"against":[26],"ROS":[27,120,173],"emulates":[28],"impact":[30,184],"of":[31,50,53,77,126,135,159,167,177,185,199],"Innovative":[33],"spectroscopic":[34],"tools":[35],"applied":[36],"to":[37,75,155,171,196],"muscles":[38],"vivo":[40],"found":[41],"two":[42,67],"key":[43,55],"cell":[44],"changes":[45,63,180],"a":[47,54,113,133,175,193],"mouse":[48],"model":[49],"knockout":[52],"antioxidant":[56],"defense,":[57],"Cu,Zn\u2010superoxide":[58],"dismutase":[59],"(SOD1":[60],"\u2212/\u2212).":[61],"These":[62],"were":[64],"paralleled":[65],"human":[68],"conditions":[69],"with":[70,174],"stress":[72,187],"prior":[74],"development":[76],"(pre\u2010symptomatic":[80],"Huntington's":[81],"disease":[82],"and":[83,109,151,188,207],"cancer":[84],"survivors).":[85],"First":[86],"is":[87,110,132],"an":[88],"increase":[89],"uncoupling":[92,108],"(reduced":[93],"ATP":[94],"per":[95],"O":[96,128],"2":[97,129],")":[98],"raises":[100],"respiration.":[101],"Dissipating":[102],"membrane":[105],"potential":[106],"causes":[107],"negative":[114],"feedback":[115],"mechanism":[116],"counteracts":[118],"elevated":[119,172],"comes":[122],"cost":[125],"greater":[127],"uptake.":[130],"Second":[131],"mobilization":[134],"metabolism.":[136],"Uncoupling":[137],"not":[138],"only":[139],"elevates":[140],"respiration":[141],"also":[143],"cellular":[144,179,190],"AMP":[145],"level,":[146],"which":[147],"increases":[148],"substrate":[149],"supply":[150],"activates":[152],"biogenesis":[154],"raise":[156],"capacity":[158],"muscle.":[160],"Thus":[161],"mitochondria":[162],"first":[165],"line":[166],"response":[170],"series":[176],"compensatory":[178],"ameliorate":[182],"activate":[189],"metabolism":[191],"manner":[194],"similar":[195],"effect":[198],"Supported":[201],"by":[202],"AG028455,":[203],"AR041928,":[204],"AR036606,":[205],"CA103728":[206],"CHDI":[209],"Foundation.":[210]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}