{"id":"https://openalex.org/W2292396403","doi":null,"title":"Gene Expression Profiles of Cytokines During Osteogenic Differentiation of Human Gingiva Derived Mesenchymal Stem Cells","display_name":"Gene Expression Profiles of Cytokines During Osteogenic Differentiation of Human Gingiva Derived Mesenchymal Stem Cells","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2292396403","mag":"2292396403"},"language":"en","primary_location":{"id":"pmh:oai:nsuworks.nova.edu:hpd_cdm_stuetd-1034","doi":null,"is_oa":true,"landing_page_url":"https://nsuworks.nova.edu/hpd_cdm_stuetd/42","pdf_url":"https://nsuworks.nova.edu/cgi/viewcontent.cgi?article=1034&context=hpd_cdm_stuetd","source":{"id":"https://openalex.org/S4377196410","display_name":"NSUWorks (Nova Southeastern University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I203088144","host_organization_name":"Nova Southeastern University","host_organization_lineage":["https://openalex.org/I203088144"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Student Theses, Dissertations and Capstones","raw_type":"thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://nsuworks.nova.edu/cgi/viewcontent.cgi?article=1034&context=hpd_cdm_stuetd","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069159366","display_name":"Reem Almashat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Reem Almashat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5069159366"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gingival-mesenchymal-stem-cells","display_name":"gingival mesenchymal stem cells","score":0.9269999861717224},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cytokine-gene-expression","display_name":"cytokine gene expression","score":0.9380000233650208},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.7699999809265137},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9869999885559082},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9020000100135803},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.902999997138977},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9990000128746033},{"id":"https://openalex.org/keywords/anti-inflammatory-cytokines","display_name":"anti-inflammatory cytokines","score":0.8960000276565552},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.722000002861023},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.7720000147819519},{"id":"https://openalex.org/keywords/alkaline-phosphatase-activity","display_name":"alkaline phosphatase activity","score":0.8169999718666077},{"id":"https://openalex.org/keywords/osteogenic-markers","display_name":"osteogenic markers","score":0.722000002861023},{"id":"https://openalex.org/keywords/allogeneic-transplantation","display_name":"allogeneic transplantation","score":0.4410000145435333}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.8701105117797852},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.557400643825531},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5212600827217102},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5161358118057251},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4822281301021576},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43657630681991577},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.357513427734375},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1934744119644165}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:nsuworks.nova.edu:hpd_cdm_stuetd-1034","doi":null,"is_oa":true,"landing_page_url":"https://nsuworks.nova.edu/hpd_cdm_stuetd/42","pdf_url":"https://nsuworks.nova.edu/cgi/viewcontent.cgi?article=1034&context=hpd_cdm_stuetd","source":{"id":"https://openalex.org/S4377196410","display_name":"NSUWorks (Nova Southeastern University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I203088144","host_organization_name":"Nova Southeastern University","host_organization_lineage":["https://openalex.org/I203088144"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Student Theses, Dissertations and Capstones","raw_type":"thesis"},{"id":"mag:2292396403","doi":null,"is_oa":false,"landing_page_url":"https://nsuworks.nova.edu/cgi/viewcontent.cgi?article=1034&context=hpd_cdm_stuetd","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:nsuworks.nova.edu:hpd_cdm_stuetd-1034","doi":null,"is_oa":true,"landing_page_url":"https://nsuworks.nova.edu/hpd_cdm_stuetd/42","pdf_url":"https://nsuworks.nova.edu/cgi/viewcontent.cgi?article=1034&context=hpd_cdm_stuetd","source":{"id":"https://openalex.org/S4377196410","display_name":"NSUWorks (Nova Southeastern University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I203088144","host_organization_name":"Nova Southeastern University","host_organization_lineage":["https://openalex.org/I203088144"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Student Theses, Dissertations and Capstones","raw_type":"thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2292396403.pdf","grobid_xml":"https://content.openalex.org/works/W2292396403.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1956322421","https://openalex.org/W1976454147","https://openalex.org/W1977950302","https://openalex.org/W1984424368","https://openalex.org/W1994250684","https://openalex.org/W2005528887","https://openalex.org/W2008737522","https://openalex.org/W2013970253","https://openalex.org/W2016931709","https://openalex.org/W2018072279","https://openalex.org/W2018602999","https://openalex.org/W2023849906","https://openalex.org/W2039751388","https://openalex.org/W2050277110","https://openalex.org/W2055845286","https://openalex.org/W2058522802","https://openalex.org/W2066385294","https://openalex.org/W2072939681","https://openalex.org/W2074084795","https://openalex.org/W2079278901","https://openalex.org/W2083116970","https://openalex.org/W2085832445","https://openalex.org/W2093424509","https://openalex.org/W2095666785","https://openalex.org/W2098734814","https://openalex.org/W2112174625","https://openalex.org/W2115444861","https://openalex.org/W2131598671","https://openalex.org/W2131978756","https://openalex.org/W2138889138","https://openalex.org/W2139719464","https://openalex.org/W2159999899","https://openalex.org/W2172503413","https://openalex.org/W2177231732"],"related_works":["https://openalex.org/W2115444861","https://openalex.org/W2767520362","https://openalex.org/W1995368810","https://openalex.org/W3177184544","https://openalex.org/W3162889591","https://openalex.org/W3017027613","https://openalex.org/W2942143115","https://openalex.org/W1584457534","https://openalex.org/W2172503413","https://openalex.org/W2027745827"],"abstract_inverted_index":{"A":[0,427],"thesis":[1],"submitted":[2],"to":[3,50,75,160,191,349,390,405,415,439],"the":[4,14,29,62,116,124,146,150,156,162,167,196,302,340,355,369,378,407,431,450],"College":[5],"of":[6,9,13,16,18,25,35,66,72,83,89,130,155,166,170,206,213,230,237,260,275,290,304,312,323,327,343,357,371,381,388,396,418,424,430,452],"Dental":[7],"Medicine":[8],"Nova":[10],"Southeastern":[11],"University":[12],"degree":[15],"Master":[17],"Science":[19],"in":[20,28,115,133,172,301,339,368],"Dentistry.":[21],"Background:":[22],"Therapeutic":[23],"management":[24],"bone":[26,68,138],"loss":[27],"craniofacial":[30,67,425],"region":[31],"as":[32],"a":[33,42,298,336,385],"consequence":[34],"trauma,":[36],"surgery":[37],"or":[38,148,316],"congenital":[39],"malformations":[40],"presents":[41],"clinical":[43],"challenge.":[44],"Mesenchymal":[45],"stem":[46,73],"cells":[47,74,108,194,417],"(MSCs),":[48],"due":[49],"their":[51,350],"inherent":[52],"plasticity,":[53],"are":[54],"potential":[55,386],"candidates":[56],"for":[57,61,136,420],"cell":[58,121],"based":[59],"therapies":[60],"repair":[63,421],"and":[64,97,106,118,174,195,208,222,233,249,271,345,354,375,398,410,422,443],"reconstruction":[65],"tissue.":[69],"Guided":[70],"differentiation":[71,197,215,259,380,438],"osteogenic":[76,175,192,214,254,258,276,379,437],"precursors":[77],"is":[78,159,364,401],"marked":[79],"by":[80,103,184,201,218,264,434],"spatio-temporally":[81],"regulation":[82],"gene":[84,163,270,310],"expression":[85,126,164,205,228,273,303,311,342,356,370,400],"profiles":[86,127,165,229,236],"including":[87],"that":[88,295,326,383],"transcription":[90],"factors,":[91],"cytokines,":[92],"extracellular":[93],"matrix":[94],"proteins,":[95],"enzymes":[96],"several":[98],"signaling":[99],"pathways.":[100],"Cytokines,":[101],"produced":[102],"both":[104,111],"immune":[105,392,446],"non-immune":[107],"can":[109],"influence":[110],"immuno-":[112],"modulatory":[113],"responses":[114,447],"host":[117],"also":[119],"affect":[120],"physiology.":[122],"Understanding":[123],"cytokine":[125,235,291],"will":[128,448],"be":[129,416],"great":[131],"advantage":[132,404],"developing":[134],"methods":[135],"effective":[137],"regeneration":[139,423],"with":[140,253,319,347],"minimal":[141],"immunological":[142],"insults":[143],"either":[144],"on":[145,149],"graft":[147],"host.":[151],"Objective:":[152],"The":[153,257,288,309,394],"objective":[154],"present":[157],"study":[158],"investigate":[161],"various":[168,231],"cytokines":[169,373,389,432],"HGMSCs":[171,178,188,238,261,382,414,435],"normal":[173],"conditions.":[176],"Methodology:":[177],"were":[179,189,239],"isolated":[180],"from":[181],"gingival":[182],"tissues":[183],"standard":[185],"enzymatic":[186],"methods.":[187,226],"guided":[190],"precursor":[193],"process":[198],"was":[199,216,262,281,297,314,359],"monitored":[200],"measuring":[202],"stage":[203],"specific":[204],"genes":[207],"proteins.":[209],"Mineral":[210,278],"nodule":[211,279],"formation":[212,280],"analyzed":[217],"using":[219,241],"Alizarin":[220],"red":[221],"Von":[223],"Kossa":[224],"Staining":[225],"Gene":[227],"pro-":[232],"anti-inflammatory":[234,372],"investigated":[240],"quantitative":[242],"real":[243],"time":[244,331],"PCR":[245],"at":[246,306,329],"1,":[247],"2":[248],"3":[250],"weeks":[251,285],"post-induction":[252],"medium.":[255],"Results:":[256],"confirmed":[263],"alkaline":[265],"phosphate":[266],"enzyme":[267],"activity":[268],"assay,":[269],"protein":[272],"studies":[274],"markers.":[277],"observed":[282,335],"after":[283],"4":[284],"ofosteogenic":[286],"induction.":[287],"results":[289],"profile":[292],"expressions":[293],"revealed":[294],"there":[296],"significant":[299,337],"upregulation":[300],"TGF-\u03b2":[305,376],"all-time":[307],"points.":[308],"IL-10":[313,374],"more":[315],"less":[317],"consistent":[318],"an":[320,365,402],"overall":[321,366],"increase":[322],"40%":[324],"over":[325],"controls":[328],"all":[330],"points":[332],"studied.":[333],"We":[334],"decrease":[338],"mRNA":[341],"IL-6":[344,397],"IL-1?":[346],"respect":[348],"control":[351],"group":[352],"(P<0.05)":[353],"IL-8":[358],"upregulated":[360],"significantly.":[361],"Conclusion:":[362],"There":[363],"enhancement":[367],"during":[377,436],"indicates":[384],"shift":[387],"dampen":[391],"responses.":[393],"reduction":[395],"IL-1\u03b2":[399],"added":[403],"reduce":[406,440],"acute":[408,441],"phase":[409,442],"inflammatory":[411],"responses,":[412],"favoring":[413],"choice":[419],"bones.":[426],"beneficial":[428],"combination":[429],"expressed":[433],"long":[444,454],"term":[445,455],"facilitate":[449],"achievement":[451],"our":[453],"goal.":[456]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
