{"id":"https://openalex.org/W2292294839","doi":"https://doi.org/10.11606/t.42.2015.tde-10062015-160611","title":"Caracteriza\u00e7\u00e3o da prote\u00edna Pic (protein involved in colonization) em Escherichia coli enteropatog\u00eanica at\u00edpica.","display_name":"Caracteriza\u00e7\u00e3o da prote\u00edna Pic (protein involved in colonization) em Escherichia coli enteropatog\u00eanica at\u00edpica.","publication_year":2015,"publication_date":"2015-03-13","ids":{"openalex":"https://openalex.org/W2292294839","doi":"https://doi.org/10.11606/t.42.2015.tde-10062015-160611","mag":"2292294839"},"language":"pt","primary_location":{"id":"doi:10.11606/t.42.2015.tde-10062015-160611","doi":"https://doi.org/10.11606/t.42.2015.tde-10062015-160611","is_oa":true,"landing_page_url":"https://doi.org/10.11606/t.42.2015.tde-10062015-160611","pdf_url":"http://www.teses.usp.br/teses/disponiveis/42/42132/tde-10062015-160611/publico/Versao_integral_Tese_AfonsoGomesAbreuJunior.pdf","source":{"id":"https://openalex.org/S4377196381","display_name":"Digital Library of Theses and Dissertations  (Universidade de S\u00e3o Paulo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I17974374","host_organization_name":"Universidade de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/I17974374"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Universidade de S\u00e3o Paulo","raw_type":"dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://www.teses.usp.br/teses/disponiveis/42/42132/tde-10062015-160611/publico/Versao_integral_Tese_AfonsoGomesAbreuJunior.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010764903","display_name":"Afonso Gomes Abreu","orcid":"https://orcid.org/0000-0003-1665-0879","observed_orcids":["https://orcid.org/0000-0003-1665-0879"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Afonso Gomes Abreu Junior","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5010764903"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13849","display_name":"Enterobacteriaceae and Cronobacter Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atypical-enteropathogenic-e-coli","display_name":"atypical enteropathogenic E. coli","score":0.8830000162124634},{"id":"https://openalex.org/keywords/autotransporters","display_name":"autotransporters","score":0.8949999809265137},{"id":"https://openalex.org/keywords/serine-protease","display_name":"serine protease","score":0.781000018119812},{"id":"https://openalex.org/keywords/mucin-degradation","display_name":"mucin degradation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/gastrointestinal-colonization","display_name":"intestinal colonization","score":0.6240000128746033},{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.5460000038146973},{"id":"https://openalex.org/keywords/hemagglutination","display_name":"hemagglutination","score":0.8109999895095825},{"id":"https://openalex.org/keywords/plasmids","display_name":"plasmids","score":0.49000000953674316},{"id":"https://openalex.org/keywords/virulence-factors","display_name":"virulence factors","score":0.7459999918937683}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6386891603469849},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.627690315246582},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4427978992462158},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4151155650615692},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3404160141944885},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2737639546394348},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19198060035705566}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.11606/t.42.2015.tde-10062015-160611","doi":"https://doi.org/10.11606/t.42.2015.tde-10062015-160611","is_oa":true,"landing_page_url":"https://doi.org/10.11606/t.42.2015.tde-10062015-160611","pdf_url":"http://www.teses.usp.br/teses/disponiveis/42/42132/tde-10062015-160611/publico/Versao_integral_Tese_AfonsoGomesAbreuJunior.pdf","source":{"id":"https://openalex.org/S4377196381","display_name":"Digital Library of Theses and Dissertations  (Universidade de S\u00e3o Paulo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I17974374","host_organization_name":"Universidade de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/I17974374"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Universidade de S\u00e3o Paulo","raw_type":"dissertation"},{"id":"pmh:oai:americanae.aecid.es:2205158","doi":null,"is_oa":true,"landing_page_url":"http://www.teses.usp.br/teses/disponiveis/42/42132/tde-10062015-160611/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da USP","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:teses.usp.br:tde-10062015-160611","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.11606/T.42.2015.tde-10062015-160611","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:USP","raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"doi:10.11606/t.42.2015.tde-10062015-160611","doi":"https://doi.org/10.11606/t.42.2015.tde-10062015-160611","is_oa":true,"landing_page_url":"https://doi.org/10.11606/t.42.2015.tde-10062015-160611","pdf_url":"http://www.teses.usp.br/teses/disponiveis/42/42132/tde-10062015-160611/publico/Versao_integral_Tese_AfonsoGomesAbreuJunior.pdf","source":{"id":"https://openalex.org/S4377196381","display_name":"Digital Library of Theses and Dissertations  (Universidade de S\u00e3o Paulo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I17974374","host_organization_name":"Universidade de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/I17974374"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Universidade de S\u00e3o Paulo","raw_type":"dissertation"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2292294839.pdf","grobid_xml":"https://content.openalex.org/works/W2292294839.grobid-xml"},"referenced_works_count":345,"referenced_works":["https://openalex.org/W3324225","https://openalex.org/W6527825","https://openalex.org/W17407505","https://openalex.org/W111835664","https://openalex.org/W124932162","https://openalex.org/W315197452","https://openalex.org/W569561726","https://openalex.org/W1482119916","https://openalex.org/W1487748486","https://openalex.org/W1492071541","https://openalex.org/W1495502437","https://openalex.org/W1505713822","https://openalex.org/W1507947745","https://openalex.org/W1512810258","https://openalex.org/W1514824482","https://openalex.org/W1518827890","https://openalex.org/W1552858500","https://openalex.org/W1566092905","https://openalex.org/W1567730256","https://openalex.org/W1582139709","https://openalex.org/W1592427016","https://openalex.org/W1662846517","https://openalex.org/W1849301104","https://openalex.org/W1865233364","https://openalex.org/W1877721062","https://openalex.org/W1891196086","https://openalex.org/W1892023593","https://openalex.org/W1894861662","https://openalex.org/W1903574298","https://openalex.org/W1904593082","https://openalex.org/W1904815041","https://openalex.org/W1921981683","https://openalex.org/W1932645010","https://openalex.org/W1936591551","https://openalex.org/W1938235722","https://openalex.org/W1944838415","https://openalex.org/W1946861124","https://openalex.org/W1947172933","https://openalex.org/W1964441761","https://openalex.org/W1965309958","https://openalex.org/W1965960475","https://openalex.org/W1966180767","https://openalex.org/W1966597734","https://openalex.org/W1966626818","https://openalex.org/W1968236380","https://openalex.org/W1968294861","https://openalex.org/W1969423416","https://openalex.org/W1971654435","https://openalex.org/W1971769790","https://openalex.org/W1971804098","https://openalex.org/W1972078523","https://openalex.org/W1972515246","https://openalex.org/W1972527322","https://openalex.org/W1974319248","https://openalex.org/W1974971813","https://openalex.org/W1975057095","https://openalex.org/W1975758800","https://openalex.org/W1979649414","https://openalex.org/W1980537409","https://openalex.org/W1983147020","https://openalex.org/W1983311630","https://openalex.org/W1983960596","https://openalex.org/W1985021877","https://openalex.org/W1985396638","https://openalex.org/W1985469117","https://openalex.org/W1986541454","https://openalex.org/W1986588137","https://openalex.org/W1989814427","https://openalex.org/W1989992559","https://openalex.org/W1990619678","https://openalex.org/W1990845730","https://openalex.org/W1994634407","https://openalex.org/W1995278899","https://openalex.org/W1995507202","https://openalex.org/W1995513720","https://openalex.org/W1995590346","https://openalex.org/W1996061958","https://openalex.org/W1997407055","https://openalex.org/W1997438069","https://openalex.org/W1998271375","https://openalex.org/W1999016882","https://openalex.org/W2000282637","https://openalex.org/W2000939882","https://openalex.org/W2001556525","https://openalex.org/W2003046928","https://openalex.org/W2003429229","https://openalex.org/W2004065145","https://openalex.org/W2005108404","https://openalex.org/W2006721213","https://openalex.org/W2007960706","https://openalex.org/W2008080212","https://openalex.org/W2008931521","https://openalex.org/W2010717419","https://openalex.org/W2012507271","https://openalex.org/W2013542515","https://openalex.org/W2014017011","https://openalex.org/W2016041798","https://openalex.org/W2016510254","https://openalex.org/W2017007088","https://openalex.org/W2017760005","https://openalex.org/W2017871159","https://openalex.org/W2018271515","https://openalex.org/W2018568586","https://openalex.org/W2020306031","https://openalex.org/W2020986381","https://openalex.org/W2021519227","https://openalex.org/W2027831845","https://openalex.org/W2028081076","https://openalex.org/W2028819914","https://openalex.org/W2029836902","https://openalex.org/W2032744623","https://openalex.org/W2033464290","https://openalex.org/W2033517112","https://openalex.org/W2034035871","https://openalex.org/W2034048814","https://openalex.org/W2037744835","https://openalex.org/W2039308194","https://openalex.org/W2039457979","https://openalex.org/W2039887581","https://openalex.org/W2040643012","https://openalex.org/W2040779438","https://openalex.org/W2041721199","https://openalex.org/W2043317687","https://openalex.org/W2043545998","https://openalex.org/W2043890907","https://openalex.org/W2044841261","https://openalex.org/W2045136590","https://openalex.org/W2045769299","https://openalex.org/W2048199055","https://openalex.org/W2048328585","https://openalex.org/W2049243733","https://openalex.org/W2050119515","https://openalex.org/W2050217807","https://openalex.org/W2050499271","https://openalex.org/W2051347791","https://openalex.org/W2052148269","https://openalex.org/W2052308516","https://openalex.org/W2053043355","https://openalex.org/W2053574509","https://openalex.org/W2053754839","https://openalex.org/W2053769493","https://openalex.org/W2055798634","https://openalex.org/W2056348323","https://openalex.org/W2056399792","https://openalex.org/W2061034641","https://openalex.org/W2061385538","https://openalex.org/W2061650330","https://openalex.org/W2062734560","https://openalex.org/W2066019882","https://openalex.org/W2066663106","https://openalex.org/W2069508712","https://openalex.org/W2069513962","https://openalex.org/W2069741608","https://openalex.org/W2071657131","https://openalex.org/W2071759761","https://openalex.org/W2072557356","https://openalex.org/W2073360625","https://openalex.org/W2074898010","https://openalex.org/W2075983828","https://openalex.org/W2076446987","https://openalex.org/W2076812433","https://openalex.org/W2076959396","https://openalex.org/W2078787530","https://openalex.org/W2078846038","https://openalex.org/W2079104693","https://openalex.org/W2079528125","https://openalex.org/W2079610507","https://openalex.org/W2079622277","https://openalex.org/W2079667258","https://openalex.org/W2079731893","https://openalex.org/W2080560063","https://openalex.org/W2080931089","https://openalex.org/W2082292081","https://openalex.org/W2082661031","https://openalex.org/W2083203482","https://openalex.org/W2083917706","https://openalex.org/W2085386763","https://openalex.org/W2087928405","https://openalex.org/W2088812171","https://openalex.org/W2089085698","https://openalex.org/W2090985686","https://openalex.org/W2091521301","https://openalex.org/W2091591930","https://openalex.org/W2091846368","https://openalex.org/W2092438171","https://openalex.org/W2093107554","https://openalex.org/W2094079380","https://openalex.org/W2094288404","https://openalex.org/W2096520287","https://openalex.org/W2096624392","https://openalex.org/W2096974471","https://openalex.org/W2097739005","https://openalex.org/W2098093769","https://openalex.org/W2099476014","https://openalex.org/W2099949684","https://openalex.org/W2100325336","https://openalex.org/W2100837269","https://openalex.org/W2102627208","https://openalex.org/W2102628698","https://openalex.org/W2103891603","https://openalex.org/W2105422426","https://openalex.org/W2105544315","https://openalex.org/W2106072980","https://openalex.org/W2106383495","https://openalex.org/W2107414352","https://openalex.org/W2108575112","https://openalex.org/W2109764507","https://openalex.org/W2109951903","https://openalex.org/W2110105673","https://openalex.org/W2110553890","https://openalex.org/W2111069670","https://openalex.org/W2112111992","https://openalex.org/W2112549939","https://openalex.org/W2114674713","https://openalex.org/W2116137883","https://openalex.org/W2116203390","https://openalex.org/W2116754285","https://openalex.org/W2119479912","https://openalex.org/W2121695290","https://openalex.org/W2121956307","https://openalex.org/W2122581173","https://openalex.org/W2122730022","https://openalex.org/W2122976061","https://openalex.org/W2123942680","https://openalex.org/W2124372802","https://openalex.org/W2124701809","https://openalex.org/W2124763241","https://openalex.org/W2124827139","https://openalex.org/W2125014381","https://openalex.org/W2125314126","https://openalex.org/W2125339057","https://openalex.org/W2127402814","https://openalex.org/W2127683898","https://openalex.org/W2127985466","https://openalex.org/W2128592628","https://openalex.org/W2128875254","https://openalex.org/W2129566418","https://openalex.org/W2129585842","https://openalex.org/W2129668858","https://openalex.org/W2129766717","https://openalex.org/W2129785704","https://openalex.org/W2130920390","https://openalex.org/W2131165092","https://openalex.org/W2132523725","https://openalex.org/W2133152400","https://openalex.org/W2135316483","https://openalex.org/W2135421886","https://openalex.org/W2135838357","https://openalex.org/W2135894069","https://openalex.org/W2136125842","https://openalex.org/W2136648677","https://openalex.org/W2136912630","https://openalex.org/W2137087452","https://openalex.org/W2138115889","https://openalex.org/W2138738692","https://openalex.org/W2138952930","https://openalex.org/W2139089172","https://openalex.org/W2139488399","https://openalex.org/W2139592344","https://openalex.org/W2139761661","https://openalex.org/W2139813645","https://openalex.org/W2140145998","https://openalex.org/W2140808900","https://openalex.org/W2141066076","https://openalex.org/W2141747047","https://openalex.org/W2142276846","https://openalex.org/W2142742638","https://openalex.org/W2143045574","https://openalex.org/W2143256722","https://openalex.org/W2144101130","https://openalex.org/W2144113822","https://openalex.org/W2144268256","https://openalex.org/W2144634347","https://openalex.org/W2144774281","https://openalex.org/W2144878722","https://openalex.org/W2145152481","https://openalex.org/W2146052711","https://openalex.org/W2146517647","https://openalex.org/W2148528976","https://openalex.org/W2148800629","https://openalex.org/W2148924156","https://openalex.org/W2150081979","https://openalex.org/W2150352917","https://openalex.org/W2150581974","https://openalex.org/W2151777569","https://openalex.org/W2151932607","https://openalex.org/W2152019335","https://openalex.org/W2154274040","https://openalex.org/W2154421450","https://openalex.org/W2155208387","https://openalex.org/W2155643564","https://openalex.org/W2156080241","https://openalex.org/W2156801648","https://openalex.org/W2157612734","https://openalex.org/W2157747648","https://openalex.org/W2157756539","https://openalex.org/W2159861471","https://openalex.org/W2160039223","https://openalex.org/W2160127049","https://openalex.org/W2161414686","https://openalex.org/W2161738079","https://openalex.org/W2162539208","https://openalex.org/W2162740809","https://openalex.org/W2163288375","https://openalex.org/W2163351388","https://openalex.org/W2163759087","https://openalex.org/W2164645369","https://openalex.org/W2164977322","https://openalex.org/W2165065438","https://openalex.org/W2165851074","https://openalex.org/W2166661472","https://openalex.org/W2166785990","https://openalex.org/W2167109916","https://openalex.org/W2168717473","https://openalex.org/W2169030610","https://openalex.org/W2169420537","https://openalex.org/W2169655541","https://openalex.org/W2169690786","https://openalex.org/W2171228833","https://openalex.org/W2171752829","https://openalex.org/W2182544290","https://openalex.org/W2189110355","https://openalex.org/W2208528622","https://openalex.org/W2295187335","https://openalex.org/W2300968527","https://openalex.org/W2314225431","https://openalex.org/W2317729965","https://openalex.org/W2332367976","https://openalex.org/W2342507485","https://openalex.org/W2395525054","https://openalex.org/W2424735475","https://openalex.org/W2477377300","https://openalex.org/W2504083878","https://openalex.org/W2547329187","https://openalex.org/W2750896950","https://openalex.org/W2950674647","https://openalex.org/W4210590595","https://openalex.org/W4235847963","https://openalex.org/W4236524882","https://openalex.org/W4238247077","https://openalex.org/W4245129452","https://openalex.org/W4247333866","https://openalex.org/W4247547003","https://openalex.org/W4254760276","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W7120584931","https://openalex.org/W2341787842","https://openalex.org/W2161414686","https://openalex.org/W2140808900","https://openalex.org/W2948479051","https://openalex.org/W2132055913","https://openalex.org/W7120429556","https://openalex.org/W7017691583","https://openalex.org/W3101975517","https://openalex.org/W7055246241"],"abstract_inverted_index":{"Prote\u00ednas":[0],"denominadas":[1],"autotransportadoras":[2],"(AT)":[3],"t\u00eam":[4],"sido":[5],"identificadas":[6],"em":[7,43,101,156,160],"Escherichia":[8],"coli":[9,45,53,99,105],"patog\u00eanicas,":[10],"sendo":[11],"frequentemente":[12],"associadas":[13],"a":[14,38,56,88,125,193,218,320,337,347,358],"atributos":[15],"de":[16,24,68,71,73,78,90,92,94,97,103,131,163,176,180,195,197,201,205,212,221,250,257,263,273,282,302,308,350,364,369,375],"virul\u00eancia,":[17],"tais":[18],"como":[19,85,122],"ades\u00e3o,":[20,376],"agrega\u00e7\u00e3o,":[21],"invas\u00e3o,":[22],"forma\u00e7\u00e3o":[23],"biofilme":[25],"e":[26,51,76,141,146,169,209,233,255,316,334,345,378],"toxicidade.A":[27],"serinoprotease":[28,359],"Pic":[29,58,127,215,264,329,360],"(protein":[30],"involved":[31],"in":[32,144,147],"colonization)":[33],"\u00e9":[34],"uma":[35,110,305],"dessas":[36],"AT,":[37],"qual":[39],"foi":[40,199,237,269,280,289,319],"originalmente":[41],"identificada":[42],"E.":[44,52,98,104],"enteroagregativa":[46],"(EAEC),":[47],"Shigella":[48],"flexneri":[49],"2a":[50],"uropatog\u00eanica.Em":[54],"EAEC":[55,181],"prote\u00edna":[57,126],"apresenta":[59],"papel":[60,262],"importante":[61],"na":[62,266,353,367],"coloniza\u00e7\u00e3o":[63,267,297,348,377],"da":[64,135,137,183,252,296],"mucosa":[65],"intestinal":[66,75,268,298,349],"atrav\u00e9s":[67,134],"suas":[69],"atividades":[70,142,332],"degrada\u00e7\u00e3o":[72,251],"muco":[74,309],"indu\u00e7\u00e3o":[77],"sua":[79,138],"secre\u00e7\u00e3o.Um":[80],"estudo":[81,120],"pr\u00e9vio,":[82],"que":[83,154,223,287],"teve":[84,121],"objetivo":[86,123],"analisar":[87],"preval\u00eancia":[89],"fatores":[91],"virul\u00eancia":[93,365],"outros":[95],"pat\u00f3tipos":[96],"diarreiog\u00eanicas":[100],"amostras":[102],"enteropatog\u00eanica":[106],"at\u00edpicas":[107],"(aEPEC),":[108],"detectou":[109],"cepa":[111,130,184,235,278,314,368],"(BA589)":[112],"portando":[113],"o":[114,118,170,243,284,286,292,317],"gene":[115,173],"pic.Dessa":[116],"forma,":[117,357],"presente":[119,159],"caracterizar":[124],"produzida":[128],"pela":[129,313],"aEPEC":[132,370],"BA589,":[133,371],"determina\u00e7\u00e3o":[136],"estrutura":[139],"gen\u00e9tica":[140],"biol\u00f3gicas":[143],"vitro":[145],"vivo.A":[148],"an\u00e1lise":[149,295],"por":[150,190,299],"Southern":[151],"blot":[152],"mostrou":[153,174,304],"pic":[155,179],"BA589":[157,185,236],"est\u00e1":[158],"um":[161,362],"plasm\u00eddeo":[162],"alto":[164],"peso":[165],"molecular":[166],"(~98":[167],"kb)":[168],"sequenciamento":[171],"desse":[172],"identidade":[175],"99%":[177],"com":[178,276,291],"042.Pic":[182],"(Pic":[186],"589":[187,216,265,330],"),":[188],"purificada":[189],"gel":[191],"filtra\u00e7\u00e3o":[192],"partir":[194],"sobrenadantes":[196],"cultura,":[198],"capaz":[200,281],"clivar":[202],"mucina":[203],"isolada":[204],"gl\u00e2ndula":[206],"submaxilar":[207],"bovina":[208],"hemaglutinar":[210],"eritr\u00f3citos":[211],"coelho.Al\u00e9m":[213],"disso,":[214],"promoveu":[217],"clivagem":[219,256],"direta":[220],"mol\u00e9culas":[222],"participam":[224],"das":[225,339],"tr\u00eas":[226,340],"vias":[227,341],"sistema":[228,240,260,343,381],"complemento":[229,344],"(C1q,":[230],"C2,":[231],"C3":[232],"C4).A":[234],"mutagenizada":[238],"pelo":[239],"lambda-red,":[241],"originando":[242],"mutante":[244,246,293],"BA589\u0394pic.Esse":[245],"perdeu":[247],"as":[248],"capacidades":[249],"mucina,":[253],"hemaglutina\u00e7\u00e3o":[254],"prote\u00ednas":[258],"do":[259,322,342,355,380],"complemento.O":[261],"avaliado":[270],"no":[271],"modelo":[272],"camundongos":[274,311],"tratados":[275],"estreptomicina.A":[277],"selvagem":[279,315],"colonizar":[283],"intestino,":[285],"n\u00e3o":[288],"observado":[290],"BA589\u0394pic.A":[294],"microscopia":[300],"eletr\u00f4nica":[301],"varredura":[303],"elevada":[306],"produ\u00e7\u00e3o":[307],"nos":[310],"infectados":[312],"ceco":[318],"regi\u00e3o":[321,354],"intestino":[323],"onde":[324],"houve":[325],"maior":[326],"coloniza\u00e7\u00e3o.Em":[327],"resumo,":[328],"possui":[331],"hemaglutinante":[333],"mucinol\u00edtica,":[335],"promove":[336],"inativa\u00e7\u00e3o":[338],"medeia":[346],"camundongos,":[351],"preferencialmente":[352],"ceco.Desta":[356],"representa":[361],"fator":[363],"adicional":[366],"relacionada":[372],"\u00e0s":[373],"etapas":[374],"evas\u00e3o":[379],"imune":[382],"inato.":[383]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
