{"id":"https://openalex.org/W2292294286","doi":null,"title":"Relationships among Prenatal Risk Factors, Early Life Events, and Asthma in At-Risk Children","display_name":"Relationships among Prenatal Risk Factors, Early Life Events, and Asthma in At-Risk Children","publication_year":2015,"publication_date":"2015-07-21","ids":{"openalex":"https://openalex.org/W2292294286","mag":"2292294286"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/10917371","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/thesis/Relationships_among_Prenatal_Risk_Factors_Early_Life_Events_and_Asthma_in_At-Risk_Children/10917371","pdf_url":"https://figshare.com/articles/thesis/Relationships_among_Prenatal_Risk_Factors_Early_Life_Events_and_Asthma_in_At-Risk_Children/10917371","source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/thesis/Relationships_among_Prenatal_Risk_Factors_Early_Life_Events_and_Asthma_in_At-Risk_Children/10917371","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045918267","display_name":"Brittany R. Lapin","orcid":"https://orcid.org/0000-0002-4314-2282","observed_orcids":["https://orcid.org/0000-0002-4314-2282"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Brittany Lapin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4314-2282","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5045918267"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12208","display_name":"Occupational exposure and asthma","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/childhood-asthma","display_name":"childhood asthma","score":0.8840000033378601},{"id":"https://openalex.org/keywords/wheezing","display_name":"wheezing","score":0.9829999804496765},{"id":"https://openalex.org/keywords/prenatal-antibiotic-exposure","display_name":"prenatal antibiotic exposure","score":0.9309999942779541},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.8619999885559082},{"id":"https://openalex.org/keywords/hygiene-hypothesis","display_name":"hygiene hypothesis","score":0.8930000066757202},{"id":"https://openalex.org/keywords/early-life-microbial-exposure","display_name":"early life microbial exposure","score":0.6129999756813049},{"id":"https://openalex.org/keywords/at-risk-children","display_name":"vulnerable children","score":0.7369999885559082},{"id":"https://openalex.org/keywords/latina-mothers","display_name":"Hispanic mothers","score":0.7599999904632568},{"id":"https://openalex.org/keywords/urban-children","display_name":"urban children","score":0.6520000100135803},{"id":"https://openalex.org/keywords/respiratory-tract-infections","display_name":"respiratory infections","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.8160043954849243},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7725765705108643},{"id":"https://openalex.org/C2778338976","wikidata":"https://www.wikidata.org/wiki/Q517104","display_name":"Wheeze","level":3,"score":0.7650880813598633},{"id":"https://openalex.org/C78635009","wikidata":"https://www.wikidata.org/wiki/Q2109172","display_name":"Hygiene hypothesis","level":3,"score":0.705838680267334},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.607882559299469},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.515637993812561},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.5066574215888977},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.49593910574913025},{"id":"https://openalex.org/C2775887326","wikidata":"https://www.wikidata.org/wiki/Q3308829","display_name":"Prenatal care","level":3,"score":0.4569036066532135},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.45631277561187744},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.45479798316955566},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.44954532384872437},{"id":"https://openalex.org/C201614185","wikidata":"https://www.wikidata.org/wiki/Q396833","display_name":"In utero","level":4,"score":0.4224848747253418},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.42038509249687195},{"id":"https://openalex.org/C2777402568","wikidata":"https://www.wikidata.org/wiki/Q779038","display_name":"Respiratory sounds","level":3,"score":0.4178483188152313},{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.41174018383026123},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4101662039756775},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3011741638183594},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25825124979019165},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.2230633795261383},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.22145801782608032},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.11872163414955139},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.09957987070083618},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08514070510864258},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:figshare.com:article/10917371","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/thesis/Relationships_among_Prenatal_Risk_Factors_Early_Life_Events_and_Asthma_in_At-Risk_Children/10917371","pdf_url":"https://figshare.com/articles/thesis/Relationships_among_Prenatal_Risk_Factors_Early_Life_Events_and_Asthma_in_At-Risk_Children/10917371","source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2292294286","doi":null,"is_oa":false,"landing_page_url":"https://indigo.uic.edu/articles/Relationships_among_Prenatal_Risk_Factors_Early_Life_Events_and_Asthma_in_At-Risk_Children/10917371/1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/10917371","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/thesis/Relationships_among_Prenatal_Risk_Factors_Early_Life_Events_and_Asthma_in_At-Risk_Children/10917371","pdf_url":"https://figshare.com/articles/thesis/Relationships_among_Prenatal_Risk_Factors_Early_Life_Events_and_Asthma_in_At-Risk_Children/10917371","source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2292294286.pdf","grobid_xml":"https://content.openalex.org/works/W2292294286.grobid-xml"},"referenced_works_count":156,"referenced_works":["https://openalex.org/W5290505","https://openalex.org/W586828566","https://openalex.org/W1525839992","https://openalex.org/W1526519431","https://openalex.org/W1532263517","https://openalex.org/W1556471384","https://openalex.org/W1567445239","https://openalex.org/W1581606143","https://openalex.org/W1582582363","https://openalex.org/W1879339110","https://openalex.org/W1893824462","https://openalex.org/W1969898121","https://openalex.org/W1970031113","https://openalex.org/W1971252664","https://openalex.org/W1971440513","https://openalex.org/W1972993920","https://openalex.org/W1973403310","https://openalex.org/W1973788838","https://openalex.org/W1974724087","https://openalex.org/W1976077702","https://openalex.org/W1976145906","https://openalex.org/W1977480579","https://openalex.org/W1977489758","https://openalex.org/W1978589928","https://openalex.org/W1979423658","https://openalex.org/W1981863450","https://openalex.org/W1982487925","https://openalex.org/W1985478099","https://openalex.org/W1986117556","https://openalex.org/W1986796316","https://openalex.org/W1988831604","https://openalex.org/W1990420757","https://openalex.org/W1992153121","https://openalex.org/W1997393346","https://openalex.org/W1997671766","https://openalex.org/W1997774819","https://openalex.org/W1999422044","https://openalex.org/W2001881960","https://openalex.org/W2001935946","https://openalex.org/W2004383557","https://openalex.org/W2007110604","https://openalex.org/W2007889491","https://openalex.org/W2010699409","https://openalex.org/W2010928366","https://openalex.org/W2011096194","https://openalex.org/W2011809650","https://openalex.org/W2015699002","https://openalex.org/W2017789872","https://openalex.org/W2019018422","https://openalex.org/W2019756559","https://openalex.org/W2020742351","https://openalex.org/W2021075107","https://openalex.org/W2021333110","https://openalex.org/W2022930742","https://openalex.org/W2024116038","https://openalex.org/W2024886564","https://openalex.org/W2025192174","https://openalex.org/W2027275893","https://openalex.org/W2030686137","https://openalex.org/W2032096424","https://openalex.org/W2034630933","https://openalex.org/W2035250951","https://openalex.org/W2041605896","https://openalex.org/W2043241645","https://openalex.org/W2044617401","https://openalex.org/W2046586508","https://openalex.org/W2047075436","https://openalex.org/W2047943080","https://openalex.org/W2049571911","https://openalex.org/W2050814362","https://openalex.org/W2051480384","https://openalex.org/W2052969143","https://openalex.org/W2058189062","https://openalex.org/W2059378560","https://openalex.org/W2061419767","https://openalex.org/W2061603090","https://openalex.org/W2062977536","https://openalex.org/W2063012533","https://openalex.org/W2064718369","https://openalex.org/W2064772422","https://openalex.org/W2064849554","https://openalex.org/W2067311627","https://openalex.org/W2070308140","https://openalex.org/W2070873039","https://openalex.org/W2072454064","https://openalex.org/W2072474455","https://openalex.org/W2072743593","https://openalex.org/W2073070051","https://openalex.org/W2073947397","https://openalex.org/W2074629950","https://openalex.org/W2075905289","https://openalex.org/W2076239759","https://openalex.org/W2078809082","https://openalex.org/W2078891061","https://openalex.org/W2081375496","https://openalex.org/W2083850580","https://openalex.org/W2088705083","https://openalex.org/W2090709295","https://openalex.org/W2094422818","https://openalex.org/W2094986384","https://openalex.org/W2096153597","https://openalex.org/W2096891797","https://openalex.org/W2097361638","https://openalex.org/W2097740790","https://openalex.org/W2098286297","https://openalex.org/W2101356502","https://openalex.org/W2105559411","https://openalex.org/W2106366409","https://openalex.org/W2107016565","https://openalex.org/W2107209401","https://openalex.org/W2110031468","https://openalex.org/W2111947288","https://openalex.org/W2113051109","https://openalex.org/W2113734757","https://openalex.org/W2115061188","https://openalex.org/W2116728425","https://openalex.org/W2118006745","https://openalex.org/W2119353150","https://openalex.org/W2119539507","https://openalex.org/W2122030637","https://openalex.org/W2122290852","https://openalex.org/W2122539126","https://openalex.org/W2124815474","https://openalex.org/W2126871888","https://openalex.org/W2131578461","https://openalex.org/W2132405776","https://openalex.org/W2132501718","https://openalex.org/W2133124288","https://openalex.org/W2134064952","https://openalex.org/W2134713324","https://openalex.org/W2136129328","https://openalex.org/W2136529912","https://openalex.org/W2139845378","https://openalex.org/W2140170096","https://openalex.org/W2141272031","https://openalex.org/W2142758173","https://openalex.org/W2142854930","https://openalex.org/W2143460192","https://openalex.org/W2143997012","https://openalex.org/W2144964836","https://openalex.org/W2147848849","https://openalex.org/W2150826151","https://openalex.org/W2151287143","https://openalex.org/W2152107216","https://openalex.org/W2153448146","https://openalex.org/W2155057743","https://openalex.org/W2157110918","https://openalex.org/W2158072557","https://openalex.org/W2162092049","https://openalex.org/W2167836944","https://openalex.org/W2168332876","https://openalex.org/W2168954954","https://openalex.org/W2402078016","https://openalex.org/W2466039345","https://openalex.org/W2564361316","https://openalex.org/W4255188360"],"related_works":["https://openalex.org/W2074629950","https://openalex.org/W2172036956","https://openalex.org/W2754660651","https://openalex.org/W2915841456","https://openalex.org/W2501563263","https://openalex.org/W2800371426","https://openalex.org/W2795017701","https://openalex.org/W1972370464","https://openalex.org/W1950073326","https://openalex.org/W2122290852"],"abstract_inverted_index":{"Introduction:":[0],"Asthma":[1],"and":[2,20,24,48,61,66,119,138,169,201,238,266,286,291,311,341],"wheezing":[3,139,206,239,267,292,342],"in":[4,59,110,140,155,221,283,316,325,343],"children":[5,285],"are":[6,12],"still":[7],"not":[8],"well":[9],"understood":[10],"but":[11],"the":[13,41,62,88,94,111,127,133,141,156,178,262,277,312],"result":[14],"of":[15,91,98,114,130,136,144,159,230,261,264,289,314],"interactions":[16],"between":[17,280,307],"genetic,":[18],"environmental,":[19],"microbiome":[21,68],"factors":[22],"prenatally":[23],"postnatally.":[25],"The":[26],"hygiene":[27],"hypothesis":[28],"suggests":[29,304],"that":[30,333],"birth":[31],"into":[32],"an":[33,269,305],"environment":[34,332],"with":[35,126,205],"fewer":[36],"microbial":[37],"exposures":[38,105],"may":[39,57,293,328],"lead":[40],"developing":[42],"immune":[43,54],"system":[44,55],"toward":[45],"allergic":[46],"responses":[47],"asthma.":[49],"Emerging":[50],"research":[51,255],"has":[52,256],"shown":[53],"development":[56,129,263,288,313],"begin":[58],"utero":[60],"maternal":[63,120],"placental,":[64],"vaginal,":[65],"gut":[67],"could":[69,334],"influence":[70],"this":[71],"development.":[72],"\\nMethods:":[73],"Using":[74],"data":[75],"from":[76,87],"a":[77,162,191,330],"longitudinal":[78],"prospective":[79],"cohort":[80],"study,":[81],"300":[82],"mother-child":[83],"pairs":[84],"were":[85,106,146,216,228],"followed":[86],"first":[89,112,157],"trimester":[90],"pregnancy":[92,324],"through":[93],"child\u2019s":[95],"third":[96,134,142],"year":[97,113,135,143,158],"life.":[99,345],"Controlling":[100],"for":[101,166,175,181,194],"temporal":[102],"confounders,":[103],"three":[104,250],"investigated:":[107],"antibiotic":[108,117,176,188,281,309],"use":[109,154,183,189,282,310],"life,":[115],"prenatal":[116,187,213,225,308,331],"use,":[118,177],"C-reactive":[121],"protein":[122],"levels.":[123],"Their":[124],"associations":[125,278],"subsequent":[128,287],"asthma":[131,168,195,231,265,290,315,340],"by":[132,173,298],"life":[137,145,160],"assessed":[147],"using":[148],"multivariable":[149],"logistic":[150],"regression":[151],"models.\\nResults:":[152],"Antibiotic":[153],"was":[161,190,202],"significant":[163],"risk":[164,192,252],"factor":[165,193],"both":[167],"wheezing.":[170],"After":[171,185],"stratifying":[172],"reason":[174],"association":[179,306],"held":[180],"respiratory":[182,299],"only.":[184],"adjustment,":[186],"(OR:":[196,207,232,240],"3.1,":[197],"95%":[198,209,234,242],"CI:":[199,210,235,243],"1.4\u20136.8)":[200],"weakly":[203],"associated":[204],"1.8;":[208],"0.9\u20133.3).":[211],"Median":[212],"CRP":[214,226],"levels":[215,227],"4.9":[217],"mg/L":[218],"(IQR:":[219],"3.2\u20137.7)":[220],"244":[222],"mothers.":[223],"Continuous":[224],"predictive":[229],"3.2,":[233],"1.4,":[236],"7.6)":[237],"2.2,":[241],"1.1,":[244],"4.3).":[245],"\\nConclusions:":[246],"We":[247,275,319],"focused":[248],"on":[249],"main":[251],"factors;":[253],"our":[254,302],"helped":[257],"elucidate":[258],"some":[259],"aspects":[260],"within":[268],"at-risk":[270,317,326],"urban,":[271],"mostly":[272],"Hispanic,":[273],"cohort.":[274],"conclude":[276,320],"found":[279],"young":[284],"be":[294],"due":[295],"to":[296,338],"confounding":[297],"infections.":[300],"However,":[301],"study":[303],"children.":[318],"systemic":[321],"inflammation":[322],"during":[323],"mothers":[327],"reflect":[329],"increase":[335],"offspring":[336],"susceptibility":[337],"develop":[339],"early":[344]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}