{"id":"https://openalex.org/W2292243775","doi":"https://doi.org/10.1152/ajpregu.1990.258.1.r169","title":"Chronic cervical spinal cord injury and autonomic hyperreflexia in rats","display_name":"Chronic cervical spinal cord injury and autonomic hyperreflexia in rats","publication_year":1990,"publication_date":"1990-01-01","ids":{"openalex":"https://openalex.org/W2292243775","doi":"https://doi.org/10.1152/ajpregu.1990.258.1.r169","mag":"2292243775","pmid":"https://pubmed.ncbi.nlm.nih.gov/2301629"},"language":"en","primary_location":{"id":"doi:10.1152/ajpregu.1990.258.1.r169","doi":"https://doi.org/10.1152/ajpregu.1990.258.1.r169","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.1990.258.1.r169","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091827299","display_name":"John W. Osborn","orcid":"https://orcid.org/0000-0002-8109-1578","observed_orcids":["https://orcid.org/0000-0002-8109-1578"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. W. Osborn","raw_affiliation_strings":["Department of Biomedical Engineering, Johns Hopkins School ofMedicine, Baltimore, Maryland 21205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins School ofMedicine, Baltimore, Maryland 21205","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111835734","display_name":"Robert F. Taylor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. F. Taylor","raw_affiliation_strings":["Department of Biomedical Engineering, Johns Hopkins School ofMedicine, Baltimore, Maryland 21205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins School ofMedicine, Baltimore, Maryland 21205","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017290039","display_name":"Lawrence P. Schramm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. P. Schramm","raw_affiliation_strings":["Department of Biomedical Engineering, Johns Hopkins School ofMedicine, Baltimore, Maryland 21205"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins School ofMedicine, Baltimore, Maryland 21205","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":null,"apc_paid":null,"fwci":1.5122,"has_fulltext":false,"cited_by_count":75,"citation_normalized_percentile":{"value":0.83849803,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"258","issue":"1","first_page":"R169","last_page":"R174"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.011300000362098217,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.011300000362098217,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autonomic-dysreflexia","display_name":"autonomic dysreflexia","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cervical-spinal-cord-injury","display_name":"cervical spinal cord injury","score":0.8709999918937683},{"id":"https://openalex.org/keywords/bladder-distension","display_name":"bladder distension","score":0.7990000247955322},{"id":"https://openalex.org/keywords/bladder-pressure","display_name":"bladder pressure","score":0.7239999771118164},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.4950000047683716},{"id":"https://openalex.org/keywords/pressor-response","display_name":"pressor response","score":0.7020000219345093},{"id":"https://openalex.org/keywords/lidocaine","display_name":"lidocaine","score":0.7889999747276306},{"id":"https://openalex.org/keywords/chloralose-anesthesia","display_name":"chloralose anesthesia","score":0.9190000295639038},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.8579999804496765}],"concepts":[{"id":"https://openalex.org/C2777364249","wikidata":"https://www.wikidata.org/wiki/Q1429154","display_name":"Hyperreflexia","level":2,"score":0.8561106324195862},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8547080755233765},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.7557874917984009},{"id":"https://openalex.org/C2778334475","wikidata":"https://www.wikidata.org/wiki/Q1415275","display_name":"Spinal cord injury","level":3,"score":0.6120361685752869},{"id":"https://openalex.org/C2776625112","wikidata":"https://www.wikidata.org/wiki/Q5282934","display_name":"Distension","level":2,"score":0.5655921101570129},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.5519683361053467},{"id":"https://openalex.org/C2777312010","wikidata":"https://www.wikidata.org/wiki/Q4826775","display_name":"Autonomic dysreflexia","level":4,"score":0.5374278426170349},{"id":"https://openalex.org/C83974742","wikidata":"https://www.wikidata.org/wiki/Q179405","display_name":"Reflex","level":2,"score":0.5333715677261353},{"id":"https://openalex.org/C2776725644","wikidata":"https://www.wikidata.org/wiki/Q594365","display_name":"Chloralose","level":3,"score":0.4909978210926056},{"id":"https://openalex.org/C2777372248","wikidata":"https://www.wikidata.org/wiki/Q171064","display_name":"Autonomic nervous system","level":4,"score":0.43145692348480225},{"id":"https://openalex.org/C2779762690","wikidata":"https://www.wikidata.org/wiki/Q9382","display_name":"Urinary bladder","level":2,"score":0.42447933554649353},{"id":"https://openalex.org/C2775859210","wikidata":"https://www.wikidata.org/wiki/Q26272","display_name":"Atropine","level":2,"score":0.4149937927722931},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.38066136837005615},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25491178035736084},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.1403077244758606},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001341","descriptor_name":"Autonomic Nervous System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001743","descriptor_name":"Urinary Bladder","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003655","descriptor_name":"Decerebrate State","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007267","descriptor_name":"Injections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008012","descriptor_name":"Lidocaine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009333","descriptor_name":"Neck","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010812","descriptor_name":"Physical Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012021","descriptor_name":"Reflex, Abnormal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013119","descriptor_name":"Spinal Cord Injuries","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpregu.1990.258.1.r169","doi":"https://doi.org/10.1152/ajpregu.1990.258.1.r169","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.1990.258.1.r169","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},{"id":"pmid:2301629","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2301629","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1001978115","display_name":"ARTERIAL PRESSURE IN PARAPLEGIA:  ROLE OF SPINAL SYSTEMS","funder_award_id":"7r29hl039619-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1276259663","display_name":null,"funder_award_id":"HL-16315","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1335529049","display_name":null,"funder_award_id":"HL-39619","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4258607723","display_name":null,"funder_award_id":"HL07581","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W176827724","https://openalex.org/W1482976240","https://openalex.org/W1972220994","https://openalex.org/W1977112561","https://openalex.org/W1979031904","https://openalex.org/W2001229044","https://openalex.org/W2006576395","https://openalex.org/W2076813892","https://openalex.org/W2087881584","https://openalex.org/W2171903444","https://openalex.org/W2197841046","https://openalex.org/W2220673278","https://openalex.org/W2280900885","https://openalex.org/W2417662543"],"related_works":["https://openalex.org/W2146132965","https://openalex.org/W2283106581","https://openalex.org/W1986233151","https://openalex.org/W6908813631","https://openalex.org/W2409049525","https://openalex.org/W2030606861","https://openalex.org/W2086524344","https://openalex.org/W1533494462","https://openalex.org/W1494081372","https://openalex.org/W122246487"],"abstract_inverted_index":{"Although":[0],"it":[1],"is":[2,191],"well":[3],"established":[4,193],"that":[5,169,181],"patients":[6],"with":[7,62,185],"cervical":[8,48,75,171],"spinal":[9,49,76,172,186,204],"cord":[10,50],"injury":[11,51],"are":[12,29,207],"prone":[13],"to":[14,87,138,155,180],"acute,":[15],"marked,":[16],"hypertensive":[17,85],"episodes,":[18],"i.e.,":[19],"autonomic":[20,53,148,177,189,205],"hyperreflexia,":[21],"the":[22,38,69,110,162,174,200,213],"specific":[23],"mechanisms":[24],"mediating":[25],"this":[26,34],"sometimes-fatal":[27],"phenomenon":[28],"not":[30,118,159],"completely":[31,142,192],"understood.":[32],"In":[33],"report,":[35],"we":[36],"describe":[37],"preparation":[39],"and":[40,52,65,79,123,147],"characterization":[41],"of":[42,46,91,164],"a":[43,73,88],"rat":[44,175],"model":[45],"chronic":[47],"hyperreflexia.":[54],"Adult":[55],"male":[56],"Sprague-Dawley":[57],"rats":[58],"were":[59,97,158],"chronically":[60],"instrumented":[61],"arterial,":[63],"venous,":[64],"gastric":[66],"catheters.":[67],"Beginning":[68],"first":[70,111],"day":[71,112],"after":[72,113,126,161,170,197],"complete":[74],"transection":[77,173],"(CST)":[78],"continuing":[80],"for":[81],"1":[82],"wk,":[83],"acute":[84],"responses":[86],"modest":[89],"increase":[90],"urinary":[92],"bladder":[93,108,139,156],"pressure":[94,101],"(0-20":[95],"mmHg)":[96],"studied.":[98],"Mean":[99],"arterial":[100],"increased":[102],"25.9":[103],"+/-":[104,132],"4.8":[105],"mmHg":[106],"during":[107],"distension":[109,140,157],"CST.":[114],"This":[115],"response":[116,137],"was":[117,141],"significantly":[119],"different":[120],"3,":[121],"5,":[122],"7":[124],"days":[125],"CST":[127,198],"(overall":[128],"average":[129],"=":[130],"18.0":[131],"2.3":[133],"mmHg).":[134],"The":[135],"pressor":[136],"abolished":[143],"by":[144,209],"intravesical":[145],"lidocaine":[146],"ganglionic":[149],"blockade":[150],"(atropine":[151],"+":[152],"hexamethonium).":[153],"Responses":[154],"observed":[160],"administration":[163],"chloralose":[165,210],"anesthesia.":[166],"We":[167],"conclude":[168],"exhibits":[176],"hyperreflexia":[178,190],"similar":[179],"seen":[182],"in":[183,199,212],"humans":[184],"injury.":[187],"Furthermore,":[188],"within":[194],"24":[195],"h":[196],"rat.":[201,214],"Finally,":[202],"some":[203],"reflexes":[206],"suppressed":[208],"anesthesia":[211]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
