{"id":"https://openalex.org/W2292178472","doi":"https://doi.org/10.1115/1.4031975","title":"Tissue Strain Reorganizes Collagen With a Switchlike Response That Regulates Neuronal Extracellular Signal-Regulated Kinase Phosphorylation In Vitro: Implications for Ligamentous Injury and Mechanotransduction","display_name":"Tissue Strain Reorganizes Collagen With a Switchlike Response That Regulates Neuronal Extracellular Signal-Regulated Kinase Phosphorylation In Vitro: Implications for Ligamentous Injury and Mechanotransduction","publication_year":2015,"publication_date":"2015-11-09","ids":{"openalex":"https://openalex.org/W2292178472","doi":"https://doi.org/10.1115/1.4031975","mag":"2292178472","pmid":"https://pubmed.ncbi.nlm.nih.gov/26549105","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4844078"},"language":"en","primary_location":{"id":"doi:10.1115/1.4031975","doi":"https://doi.org/10.1115/1.4031975","is_oa":true,"landing_page_url":"https://doi.org/10.1115/1.4031975","pdf_url":"https://asmedigitalcollection.asme.org/biomechanical/article-pdf/138/2/021013/6094132/bio_138_02_021013.pdf","source":{"id":"https://openalex.org/S4210187999","display_name":"Journal of Biomechanical Engineering","issn_l":"0148-0731","issn":["0148-0731","1528-8951"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310316053","host_organization_name":"ASM International","host_organization_lineage":["https://openalex.org/P4310316053"],"host_organization_lineage_names":["ASM International"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomechanical Engineering","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://asmedigitalcollection.asme.org/biomechanical/article-pdf/138/2/021013/6094132/bio_138_02_021013.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100733720","display_name":"Sijia Zhang","orcid":"https://orcid.org/0000-0002-7549-782X","observed_orcids":["https://orcid.org/0000-0002-7549-782X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sijia Zhang","raw_affiliation_strings":["Department of Bioengineering, University of Pennsylvania, 240 Skirkanich Hall, 210 South 33rd Street, Philadelphia, PA 19104 e-mail:"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Pennsylvania, 240 Skirkanich Hall, 210 South 33rd Street, Philadelphia, PA 19104 e-mail:","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003198921","display_name":"Xuan Cao","orcid":"https://orcid.org/0000-0001-9713-4192","observed_orcids":["https://orcid.org/0000-0001-9713-4192","https://orcid.org/0009-0005-4628-8788"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xuan Cao","raw_affiliation_strings":["Department of Materials Science and Engineering, University of Pennsylvania, 3231 Walnut Street, Philadelphia, PA 19104 e-mail:"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials Science and Engineering, University of Pennsylvania, 3231 Walnut Street, Philadelphia, PA 19104 e-mail:","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000727785","display_name":"Alec M. Stablow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alec M. Stablow","raw_affiliation_strings":["Department of Bioengineering, University of Pennsylvania, 240 Skirkanich Hall, 210 South 33rd Street, Philadelphia, PA 19104 e-mail:"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Pennsylvania, 240 Skirkanich Hall, 210 South 33rd Street, Philadelphia, PA 19104 e-mail:","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011906405","display_name":"Vivek B. Shenoy","orcid":"https://orcid.org/0000-0002-2645-1016","observed_orcids":["https://orcid.org/0000-0002-2645-1016"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vivek B. Shenoy","raw_affiliation_strings":["Department of Bioengineering, University of Pennsylvania, 3231 Walnut Street, Philadelphia, PA 19104;","Department of Materials Science and Engineering, University of Pennsylvania, 3231 Walnut Street, Philadelphia, PA 19104;","Department of Mechanical Engineering and Applied Mechanics, University of Pennsylvania, 3231 Walnut Street, Philadelphia, PA 19104 e-mail:"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Pennsylvania, 3231 Walnut Street, Philadelphia, PA 19104;","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Materials Science and Engineering, University of Pennsylvania, 3231 Walnut Street, Philadelphia, PA 19104;","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Mechanical Engineering and Applied Mechanics, University of Pennsylvania, 3231 Walnut Street, Philadelphia, PA 19104 e-mail:","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040997688","display_name":"Beth A. Winkelstein","orcid":"https://orcid.org/0000-0003-0414-0484","observed_orcids":["https://orcid.org/0000-0003-0414-0484"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Beth A. Winkelstein","raw_affiliation_strings":["Department of Neurosurgery, University of Pennsylvania, 240 Skirkanich Hall, 210 South 33rd Street, Philadelphia, PA 19104 e-mail:","Mem. ASME Department of Bioengineering, University of Pennsylvania, 240 Skirkanich Hall, 210 South 33rd Street, Philadelphia, PA 19104;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of Pennsylvania, 240 Skirkanich Hall, 210 South 33rd Street, Philadelphia, PA 19104 e-mail:","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Mem. ASME Department of Bioengineering, University of Pennsylvania, 240 Skirkanich Hall, 210 South 33rd Street, Philadelphia, PA 19104;","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5000727785","https://openalex.org/A5003198921","https://openalex.org/A5011906405","https://openalex.org/A5040997688","https://openalex.org/A5100733720"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":1.8664,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.84364024,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"138","issue":"2","first_page":"021013","last_page":"021013"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.6195999979972839,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.6195999979972839,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11068","display_name":"Tendon Structure and Treatment","score":0.2531999945640564,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.10080000013113022,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ligament-injury","display_name":"ligament injury","score":0.6460000276565552},{"id":"https://openalex.org/keywords/mechanotransduction","display_name":"mechanotransduction","score":0.9580000042915344},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.8820000290870667},{"id":"https://openalex.org/keywords/threshold-strain","display_name":"threshold strain","score":0.6340000033378601},{"id":"https://openalex.org/keywords/ligament-loading","display_name":"ligament loading","score":0.6790000200271606},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"neuroplasticity","score":0.7599999904632568}],"concepts":[{"id":"https://openalex.org/C181104049","wikidata":"https://www.wikidata.org/wiki/Q11936292","display_name":"Mechanotransduction","level":2,"score":0.7048949003219604},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5856934785842896},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5572484731674194},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.5212270021438599},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5204672813415527},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.49739840626716614},{"id":"https://openalex.org/C151166631","wikidata":"https://www.wikidata.org/wiki/Q904514","display_name":"Focal adhesion","level":3,"score":0.4817209839820862},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.4755361080169678},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.43501460552215576},{"id":"https://openalex.org/C519885992","wikidata":"https://www.wikidata.org/wiki/Q161","display_name":"Fiber","level":2,"score":0.4345601797103882},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4176103174686432},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.4093879759311676},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.37627169489860535},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3547991216182709},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20474347472190857},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16079914569854736},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.10607311129570007}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008022","descriptor_name":"Ligaments","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":true},{"descriptor_ui":"D008022","descriptor_name":"Ligaments","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016474","descriptor_name":"Weight-Bearing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1115/1.4031975","doi":"https://doi.org/10.1115/1.4031975","is_oa":true,"landing_page_url":"https://doi.org/10.1115/1.4031975","pdf_url":"https://asmedigitalcollection.asme.org/biomechanical/article-pdf/138/2/021013/6094132/bio_138_02_021013.pdf","source":{"id":"https://openalex.org/S4210187999","display_name":"Journal of Biomechanical Engineering","issn_l":"0148-0731","issn":["0148-0731","1528-8951"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310316053","host_organization_name":"ASM International","host_organization_lineage":["https://openalex.org/P4310316053"],"host_organization_lineage_names":["ASM International"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomechanical Engineering","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4844078","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4844078","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biomech Eng","raw_type":"Text"},{"id":"pmid:26549105","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26549105","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomechanical engineering","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1115/1.4031975","doi":"https://doi.org/10.1115/1.4031975","is_oa":true,"landing_page_url":"https://doi.org/10.1115/1.4031975","pdf_url":"https://asmedigitalcollection.asme.org/biomechanical/article-pdf/138/2/021013/6094132/bio_138_02_021013.pdf","source":{"id":"https://openalex.org/S4210187999","display_name":"Journal of Biomechanical Engineering","issn_l":"0148-0731","issn":["0148-0731","1528-8951"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310316053","host_organization_name":"ASM International","host_organization_lineage":["https://openalex.org/P4310316053"],"host_organization_lineage_names":["ASM International"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomechanical Engineering","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4795121339","display_name":"From Reconstituted Actin Networks to 3D Multi-cellular Microtissues: Multi-scale Models and Experiments on Contractility in Active Cytoskeletal Networks","funder_award_id":"1312392","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6247246315","display_name":"Multiscale Modeling of Facet Capsule Mechanobiology","funder_award_id":"U01EB016638","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G9000884048","display_name":"Pathological consequences of altered tissue mechanics in fibrosis","funder_award_id":"R01EB017753","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"},{"id":"https://openalex.org/F4320337391","display_name":"Division of Civil, Mechanical and Manufacturing Innovation","ror":"https://ror.org/028yd4c30"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2292178472.pdf","grobid_xml":"https://content.openalex.org/works/W2292178472.grobid-xml"},"referenced_works_count":93,"referenced_works":["https://openalex.org/W2141023","https://openalex.org/W4994875","https://openalex.org/W80804055","https://openalex.org/W1172221980","https://openalex.org/W1530030261","https://openalex.org/W1892547786","https://openalex.org/W1893208632","https://openalex.org/W1966197218","https://openalex.org/W1966733788","https://openalex.org/W1969249976","https://openalex.org/W1969912732","https://openalex.org/W1971066754","https://openalex.org/W1974844073","https://openalex.org/W1974880258","https://openalex.org/W1977769825","https://openalex.org/W1978620393","https://openalex.org/W1979091044","https://openalex.org/W1981026504","https://openalex.org/W1983359194","https://openalex.org/W1983800020","https://openalex.org/W1986172289","https://openalex.org/W1988023823","https://openalex.org/W1996545459","https://openalex.org/W1999813904","https://openalex.org/W2001885978","https://openalex.org/W2003434610","https://openalex.org/W2004092055","https://openalex.org/W2004395999","https://openalex.org/W2005163420","https://openalex.org/W2008134058","https://openalex.org/W2014036182","https://openalex.org/W2014297650","https://openalex.org/W2015223213","https://openalex.org/W2017174170","https://openalex.org/W2024791310","https://openalex.org/W2032878969","https://openalex.org/W2035790611","https://openalex.org/W2039067866","https://openalex.org/W2042399623","https://openalex.org/W2043159644","https://openalex.org/W2044145172","https://openalex.org/W2048410146","https://openalex.org/W2051860857","https://openalex.org/W2052345670","https://openalex.org/W2052798961","https://openalex.org/W2053716273","https://openalex.org/W2057185402","https://openalex.org/W2057275253","https://openalex.org/W2061888490","https://openalex.org/W2063167928","https://openalex.org/W2066908475","https://openalex.org/W2071868735","https://openalex.org/W2072427355","https://openalex.org/W2074203377","https://openalex.org/W2074298791","https://openalex.org/W2074434372","https://openalex.org/W2075014244","https://openalex.org/W2076107364","https://openalex.org/W2083649543","https://openalex.org/W2085266659","https://openalex.org/W2085988912","https://openalex.org/W2088179197","https://openalex.org/W2089880580","https://openalex.org/W2090208171","https://openalex.org/W2098829275","https://openalex.org/W2100563107","https://openalex.org/W2103411737","https://openalex.org/W2106343205","https://openalex.org/W2107598333","https://openalex.org/W2108328978","https://openalex.org/W2113414816","https://openalex.org/W2116295181","https://openalex.org/W2116517871","https://openalex.org/W2127454617","https://openalex.org/W2132497639","https://openalex.org/W2133809313","https://openalex.org/W2134288497","https://openalex.org/W2137029158","https://openalex.org/W2139294439","https://openalex.org/W2144007430","https://openalex.org/W2145399035","https://openalex.org/W2146667034","https://openalex.org/W2147516066","https://openalex.org/W2148303398","https://openalex.org/W2152342826","https://openalex.org/W2154577866","https://openalex.org/W2160500827","https://openalex.org/W2284433791","https://openalex.org/W2312892246","https://openalex.org/W2333527690","https://openalex.org/W2963318102","https://openalex.org/W4406443911","https://openalex.org/W7096974372"],"related_works":["https://openalex.org/W2737915169","https://openalex.org/W4220798873","https://openalex.org/W2254632009","https://openalex.org/W2883410258","https://openalex.org/W3199387366","https://openalex.org/W2763552376","https://openalex.org/W2600974413","https://openalex.org/W2952607027","https://openalex.org/W4385307758","https://openalex.org/W2035790611"],"abstract_inverted_index":{"Excessive":[0],"loading":[1,45,58,82,128,183,234],"of":[2,18,34,69,87,146,213,229,248],"ligaments":[3],"can":[4],"activate":[5],"the":[6,11,32,37,42,163,182,186,203,226,233,239,268],"neural":[7],"afferents":[8],"that":[9,158,255,263],"innervate":[10],"collagenous":[12,70],"tissue,":[13],"leading":[14],"to":[15,30,41,47,49,56,66,74,95,243],"a":[16,125,130,143,209],"host":[17],"pathologies":[19],"including":[20],"pain.":[21],"An":[22],"integrated":[23],"experimental":[24],"and":[25,36,46,59,103,172,174],"modeling":[26],"approach":[27],"was":[28,135,200,236],"used":[29],"define":[31],"responses":[33],"neurons":[35],"surrounding":[38],"collagen":[39,138,197,223,258,274],"fibers":[40,180],"ligamentous":[43],"matrix":[44],"begin":[48],"understand":[50],"how":[51],"macroscopic":[52],"deformation":[53],"is":[54,93],"translated":[55],"neuronal":[57,85,104,230,249],"signaling.":[60],"A":[61,149],"neuron-collagen":[62],"construct":[63],"(NCC)":[64],"developed":[65],"mimic":[67],"innervation":[68],"tissue":[71,264],"underwent":[72],"tension":[73],"strains":[75,122,161,168,177,254],"simulating":[76],"nonpainful":[77],"(8%)":[78],"or":[79],"painful":[80,244],"ligament":[81],"(16%).":[83],"Both":[84],"phosphorylation":[86,218],"extracellular":[88],"signal-regulated":[89],"kinase":[90],"(ERK),":[91],"which":[92],"related":[94],"neuroplasticity":[96],"(R2":[97,108],"\u2265":[98,109],"0.041;":[99],"p":[100,111],"\u2264":[101],"0.0171)":[102],"aspect":[105],"ratio":[106],"(AR)":[107],"0.250;":[110],"<":[112],"0.0001),":[113],"were":[114,169],"significantly":[115],"correlated":[116],"with":[117,137,176,202,208,222,280],"tissue-level":[118],"strains.":[119],"As":[120,221],"NCC":[121,240],"increased":[123],"during":[124],"slowly":[126],"applied":[127,187],"(1%/s),":[129],"\"switchlike\"":[131],"fiber":[132,153,167,198,224,259,275],"realignment":[133,199],"response":[134],"detected":[136],"reorganization":[139],"occurring":[140],"only":[141,252],"above":[142,162],"transition":[144,164,191],"point":[145,192],"11.3%":[147],"strain.":[148,189],"finite-element":[150],"based":[151],"discrete":[152],"network":[154],"(DFN)":[155],"model":[156],"predicted":[157],"at":[159,238,253],"bulk":[160,188],"point,":[165],"heterogeneous":[166],"both":[170],"tensile":[171],"compressive":[173],"increased,":[175],"in":[178,196,267,283],"some":[179],"along":[181],"direction":[184,235],"exceeding":[185],"The":[190],"identified":[193],"for":[194,215],"changes":[195,266],"consistent":[201],"measured":[204],"strain":[205],"threshold":[206],"(11.7%":[207],"95%":[210],"confidence":[211],"interval":[212],"10.2-13.4%)":[214],"elevating":[216],"ERK":[217,250],"after":[219],"loading.":[220,245],"realignment,":[225,260],"greatest":[227],"degree":[228],"reorientation":[231],"toward":[232],"observed":[237],"distraction":[241],"corresponding":[242],"Because":[246],"activation":[247],"occurred":[251],"produced":[256],"evident":[257],"findings":[261],"suggest":[262],"strain-induced":[265],"micromechanical":[269],"environment,":[270],"especially":[271],"altered":[272],"local":[273],"kinematics,":[276],"may":[277],"be":[278],"associated":[279],"mechanotransduction":[281],"signaling":[282],"neurons.":[284]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}