{"id":"https://openalex.org/W2292116558","doi":"https://doi.org/10.3978/j.issn.2304-3865.2016.02.06","title":"Surgical management of intrahepatic cholangiocarcinoma in the modern era: advances and challenges.","display_name":"Surgical management of intrahepatic cholangiocarcinoma in the modern era: advances and challenges.","publication_year":2016,"publication_date":"2016-02-01","ids":{"openalex":"https://openalex.org/W2292116558","doi":"https://doi.org/10.3978/j.issn.2304-3865.2016.02.06","mag":"2292116558","pmid":"https://pubmed.ncbi.nlm.nih.gov/26932433"},"language":"en","primary_location":{"id":"pmid:26932433","doi":"https://doi.org/10.3978/j.issn.2304-3865.2016.02.06","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26932433","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese clinical oncology","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025473519","display_name":"Ioannis T. Konstantinidis","orcid":"https://orcid.org/0000-0002-2849-356X","observed_orcids":["https://orcid.org/0000-0002-2849-356X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210140282","display_name":"University General Hospital Attikon","ror":"https://ror.org/03gb7n667","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210140282"]}],"countries":["GR","US"],"is_corresponding":false,"raw_author_name":"Ioannis T Konstantinidis","raw_affiliation_strings":["Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Department of Surgery, University of Arizona, Tucson, AZ 85721, USA; 4th Department of Surgery, University of Athens Medical School, Attikon Hospital, Athens, Greece","University of Arizona, Tucson, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Department of Surgery, University of Arizona, Tucson, AZ 85721, USA; 4th Department of Surgery, University of Athens Medical School, Attikon Hospital, Athens, Greece","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I138006243","https://openalex.org/I200777214","https://openalex.org/I4210087915","https://openalex.org/I4210140282"]},{"raw_affiliation_string":"University of Arizona, Tucson, United States","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084151011","display_name":"Nikolaos F. Arkadopoulos","orcid":"https://orcid.org/0000-0002-0355-0417","observed_orcids":["https://orcid.org/0000-0002-0355-0417"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210140282","display_name":"University General Hospital Attikon","ror":"https://ror.org/03gb7n667","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210140282"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Nikolaos Arkadopoulos","raw_affiliation_strings":["4th Department of Surgery, University of Athens Medical School, Attikon Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4th Department of Surgery, University of Athens Medical School, Attikon Hospital, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210140282"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061627885","display_name":"Cristina Rosa Ferrone","orcid":"https://orcid.org/0000-0002-6295-1085","observed_orcids":["https://orcid.org/0000-0002-6295-1085"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cristina R Ferrone","raw_affiliation_strings":["Department of Surgery, Massachusetts General Hospital, Wang 460, 15 Parkman Street, Boston, MA 02114, USA. cferrone@partners.org","Department of Surgery, Massachusetts General Hospital, Wang 460, 15 Parkman Street, Boston, MA 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Massachusetts General Hospital, Wang 460, 15 Parkman Street, Boston, MA 02114, USA. cferrone@partners.org","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Surgery, Massachusetts General Hospital, Wang 460, 15 Parkman Street, Boston, MA 02114, USA","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.9516,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.89975358,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"5","issue":"1","first_page":"9","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intrahepatic-cholangiocarcinoma","display_name":"intrahepatic cholangiocarcinoma","score":1.0},{"id":"https://openalex.org/keywords/surgical-resection","display_name":"surgical resection","score":0.9169999957084656},{"id":"https://openalex.org/keywords/minimally-invasive-surgery","display_name":"minimally invasive surgery","score":0.871999979019165},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":0.8600000143051147},{"id":"https://openalex.org/keywords/unresectable-disease","display_name":"unresectable disease","score":0.8360000252723694},{"id":"https://openalex.org/keywords/hepatic-arterial-infusion","display_name":"hepatic artery infusion","score":0.7960000038146973},{"id":"https://openalex.org/keywords/proton-therapy","display_name":"proton therapy","score":0.996999979019165},{"id":"https://openalex.org/keywords/systemic-chemotherapy","display_name":"systemic chemotherapy","score":0.9259999990463257},{"id":"https://openalex.org/keywords/recurrence","display_name":"recurrence","score":0.8840000033378601}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.944243311882019},{"id":"https://openalex.org/C2909135397","wikidata":"https://www.wikidata.org/wiki/Q124292","display_name":"Intrahepatic Cholangiocarcinoma","level":2,"score":0.7002182006835938},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6343588829040527},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.588939905166626},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5394708514213562},{"id":"https://openalex.org/C3020562746","wikidata":"https://www.wikidata.org/wiki/Q7446275","display_name":"Surgical resection","level":2,"score":0.44931405782699585},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42973923683166504},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.349337637424469},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3380209803581238},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001650","descriptor_name":"Bile Duct Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D001653","descriptor_name":"Bile Ducts, Intrahepatic","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D019468","descriptor_name":"Disease Management","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:26932433","doi":"https://doi.org/10.3978/j.issn.2304-3865.2016.02.06","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26932433","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese clinical oncology","raw_type":"Journal Article"},{"id":"mag:2292116558","doi":"https://doi.org/10.3978/j.issn.2304-3865.2016.02.06","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26932433","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":87,"referenced_works":["https://openalex.org/W1504363060","https://openalex.org/W1576268148","https://openalex.org/W1604905924","https://openalex.org/W1797756137","https://openalex.org/W1840728003","https://openalex.org/W1942118595","https://openalex.org/W1965889446","https://openalex.org/W1966510389","https://openalex.org/W1966709946","https://openalex.org/W1975836447","https://openalex.org/W1976576973","https://openalex.org/W1977751340","https://openalex.org/W1981051246","https://openalex.org/W1986546158","https://openalex.org/W1986963948","https://openalex.org/W1987782132","https://openalex.org/W2000027599","https://openalex.org/W2000042204","https://openalex.org/W2002956764","https://openalex.org/W2007176622","https://openalex.org/W2008777301","https://openalex.org/W2017019986","https://openalex.org/W2020215421","https://openalex.org/W2023197994","https://openalex.org/W2023341702","https://openalex.org/W2025130792","https://openalex.org/W2025958291","https://openalex.org/W2026604057","https://openalex.org/W2028804415","https://openalex.org/W2031834285","https://openalex.org/W2035964911","https://openalex.org/W2036558320","https://openalex.org/W2037207145","https://openalex.org/W2037927710","https://openalex.org/W2040145532","https://openalex.org/W2041101650","https://openalex.org/W2041941116","https://openalex.org/W2047314052","https://openalex.org/W2049811920","https://openalex.org/W2050864654","https://openalex.org/W2052205828","https://openalex.org/W2053483691","https://openalex.org/W2061914529","https://openalex.org/W2062463207","https://openalex.org/W2068222332","https://openalex.org/W2069014220","https://openalex.org/W2071155328","https://openalex.org/W2073724631","https://openalex.org/W2075238843","https://openalex.org/W2076548039","https://openalex.org/W2078797029","https://openalex.org/W2079586464","https://openalex.org/W2082421121","https://openalex.org/W2085417547","https://openalex.org/W2090483604","https://openalex.org/W2094122269","https://openalex.org/W2095101789","https://openalex.org/W2096888043","https://openalex.org/W2097924418","https://openalex.org/W2101637122","https://openalex.org/W2113988779","https://openalex.org/W2115261608","https://openalex.org/W2118520585","https://openalex.org/W2119442895","https://openalex.org/W2122047548","https://openalex.org/W2122754781","https://openalex.org/W2127664669","https://openalex.org/W2128125049","https://openalex.org/W2128560156","https://openalex.org/W2129322549","https://openalex.org/W2136264959","https://openalex.org/W2141750100","https://openalex.org/W2147188187","https://openalex.org/W2148193307","https://openalex.org/W2149686378","https://openalex.org/W2163486683","https://openalex.org/W2164470576","https://openalex.org/W2164507773","https://openalex.org/W2165010366","https://openalex.org/W2167011778","https://openalex.org/W2167762927","https://openalex.org/W2168106806","https://openalex.org/W2171559250","https://openalex.org/W2344073120","https://openalex.org/W2395053451","https://openalex.org/W2590483598","https://openalex.org/W2590618851"],"related_works":["https://openalex.org/W3115665358","https://openalex.org/W7141737324","https://openalex.org/W2890999440","https://openalex.org/W3032716655","https://openalex.org/W4391256731","https://openalex.org/W3210595105","https://openalex.org/W4238989635","https://openalex.org/W3046096071","https://openalex.org/W2589201226","https://openalex.org/W3028932532"],"abstract_inverted_index":{"Intrahepatic":[0],"cholangiocarcinoma":[1],"(ICC)":[2],"is":[3,103],"one":[4],"of":[5,33,42],"the":[6,31,40],"few":[7],"gastrointestinal":[8],"cancers":[9],"with":[10,45],"increasing":[11],"incidence":[12],"and":[13,62,106],"mortality":[14],"worldwide.":[15],"Unlike":[16],"hepatocellular":[17],"carcinoma":[18],"(HCC)":[19],"which":[20],"arises":[21,29],"usually":[22],"in":[23,30],"a":[24],"cirrhotic":[25],"environment":[26],"ICC":[27],"frequently":[28],"context":[32],"normal":[34],"hepatic":[35,77],"parenchyma.":[36],"Surgical":[37],"resection":[38],"represents":[39],"mainstay":[41],"curative":[43],"treatment,":[44],"minimally":[46],"invasive":[47],"approaches":[48],"being":[49,111],"increasingly":[50],"utilized.":[51],"Despite":[52],"good":[53],"surgical":[54],"outcomes,":[55],"most":[56],"patients":[57],"suffer":[58],"from":[59],"disease":[60,76,91],"recurrence":[61],"eventually":[63],"succumb":[64],"to":[65,113],"their":[66],"disease.":[67],"Effective":[68],"adjuvant":[69],"treatments":[70,87],"are":[71,81,98,110],"therefore":[72],"needed.":[73],"For":[74],"unresectable":[75],"artery":[78],"utilization":[79],"techniques":[80],"becoming":[82],"more":[83],"widely":[84],"used.":[85],"New":[86],"for":[88],"non":[89],"metastatic":[90],"such":[92],"as":[93],"proton":[94],"beam":[95],"therapy":[96],"(PBT)":[97],"also":[99,104],"emerging.":[100],"Systemic":[101],"chemotherapy":[102],"changing":[105],"targeted":[107],"biologic":[108],"agents":[109],"added":[112],"conventional":[114],"chemotherapeutic":[115],"agents.":[116]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
