{"id":"https://openalex.org/W2292087673","doi":"https://doi.org/10.1007/0-306-46817-4_30","title":"Modulation of the Immune Response Through 4-1BB","display_name":"Modulation of the Immune Response Through 4-1BB","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W2292087673","doi":"https://doi.org/10.1007/0-306-46817-4_30","mag":"2292087673","pmid":"https://pubmed.ncbi.nlm.nih.gov/10810639"},"language":"en","primary_location":{"id":"doi:10.1007/0-306-46817-4_30","doi":"https://doi.org/10.1007/0-306-46817-4_30","is_oa":false,"landing_page_url":"https://doi.org/10.1007/0-306-46817-4_30","pdf_url":null,"source":{"id":"https://openalex.org/S43790123","display_name":"Advances in experimental medicine and biology","issn_l":"0065-2598","issn":["0065-2598","2214-8019"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Experimental Medicine and Biology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2492767249","display_name":"Cancer Gene Therapy"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023971012","display_name":"Gabriel Sica","orcid":"https://orcid.org/0000-0002-1080-2432","observed_orcids":["https://orcid.org/0000-0002-1080-2432"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriel Sica","raw_affiliation_strings":["Department of Immunology, Mayo Clinic, Rochester, Minnesota 55905, USA","Department of Immunology, Mayo Clinic, 200 First Street, Southwest, Rochester, Minnesota, 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Mayo Clinic, Rochester, Minnesota 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Immunology, Mayo Clinic, 200 First Street, Southwest, Rochester, Minnesota, 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035295243","display_name":"Lieping Chen","orcid":"https://orcid.org/0000-0002-6825-3069","observed_orcids":["https://orcid.org/0000-0002-6825-3069"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lieping Chen","raw_affiliation_strings":["Department of Immunology, Mayo Clinic, 200 First Street, Southwest, Rochester, Minnesota, 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Mayo Clinic, 200 First Street, Southwest, Rochester, Minnesota, 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":null,"apc_paid":null,"fwci":6.395,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.96634615,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"465","issue":null,"first_page":"355","last_page":"362"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.4894999861717224,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.4894999861717224,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.290800005197525,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.15489999949932098,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/4-1bb","display_name":"4-1BB","score":0.996999979019165},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.7940000295639038},{"id":"https://openalex.org/keywords/costimulatory-molecules","display_name":"costimulatory molecules","score":0.6460000276565552},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/immune-checkpoint","display_name":"immune checkpoint","score":0.39500001072883606}],"concepts":[{"id":"https://openalex.org/C2991678113","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immune modulation","level":3,"score":0.7176057696342468},{"id":"https://openalex.org/C123079801","wikidata":"https://www.wikidata.org/wiki/Q750240","display_name":"Modulation (music)","level":2,"score":0.5600531697273254},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5562074780464172},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1878816783428192},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.156795471906662},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15214067697525024},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.06218603253364563}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014180","descriptor_name":"Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017475","descriptor_name":"Receptors, Nerve Growth Factor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018124","descriptor_name":"Receptors, Tumor Necrosis Factor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D053261","descriptor_name":"Tumor Necrosis Factor Receptor Superfamily, Member 9","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/0-306-46817-4_30","doi":"https://doi.org/10.1007/0-306-46817-4_30","is_oa":false,"landing_page_url":"https://doi.org/10.1007/0-306-46817-4_30","pdf_url":null,"source":{"id":"https://openalex.org/S43790123","display_name":"Advances in experimental medicine and biology","issn_l":"0065-2598","issn":["0065-2598","2214-8019"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Experimental Medicine and Biology","raw_type":"book-chapter"},{"id":"pmid:10810639","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10810639","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in experimental medicine and biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1524274652","https://openalex.org/W1596693997","https://openalex.org/W1598604401","https://openalex.org/W1605840687","https://openalex.org/W1635113215","https://openalex.org/W1656949393","https://openalex.org/W1971274849","https://openalex.org/W1978416272","https://openalex.org/W1980954153","https://openalex.org/W1987891097","https://openalex.org/W1994942266","https://openalex.org/W1998006783","https://openalex.org/W2004159506","https://openalex.org/W2013165543","https://openalex.org/W2024084278","https://openalex.org/W2024281858","https://openalex.org/W2024321915","https://openalex.org/W2051870875","https://openalex.org/W2065533784","https://openalex.org/W2067080052","https://openalex.org/W2067575839","https://openalex.org/W2068683838","https://openalex.org/W2080942668","https://openalex.org/W2097765486","https://openalex.org/W2099241614","https://openalex.org/W2130011409","https://openalex.org/W2131931464","https://openalex.org/W2147051992","https://openalex.org/W2164770890","https://openalex.org/W2413768866","https://openalex.org/W4239413745"],"related_works":["https://openalex.org/W2996796873","https://openalex.org/W2583728429","https://openalex.org/W3026432546","https://openalex.org/W4299124781","https://openalex.org/W7030565978","https://openalex.org/W2005722817","https://openalex.org/W4242816950","https://openalex.org/W2460335346","https://openalex.org/W2265177702","https://openalex.org/W2410682083"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}