{"id":"https://openalex.org/W2291908392","doi":"https://doi.org/10.1186/s12885-016-2218-0","title":"More expression of BDNF associates with lung squamous cell carcinoma and is critical to the proliferation and invasion of lung cancer cells","display_name":"More expression of BDNF associates with lung squamous cell carcinoma and is critical to the proliferation and invasion of lung cancer cells","publication_year":2016,"publication_date":"2016-02-29","ids":{"openalex":"https://openalex.org/W2291908392","doi":"https://doi.org/10.1186/s12885-016-2218-0","mag":"2291908392","pmid":"https://pubmed.ncbi.nlm.nih.gov/26926340","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4772289"},"language":"en","primary_location":{"id":"doi:10.1186/s12885-016-2218-0","doi":"https://doi.org/10.1186/s12885-016-2218-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-016-2218-0","pdf_url":"https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-016-2218-0","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-016-2218-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115592949","display_name":"Siyang Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Si-yang Zhang","raw_affiliation_strings":["Center of Laboratory Technology and Experimental Medicine, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, People's Republic of China. neko200321063@126.com","Center of Laboratory Technology and Experimental Medicine, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Laboratory Technology and Experimental Medicine, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, People's Republic of China. neko200321063@126.com","institution_ids":["https://openalex.org/I91656880"]},{"raw_affiliation_string":"Center of Laboratory Technology and Experimental Medicine, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, People's Republic of China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lin-ping Hui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099028","display_name":"Fourth Affiliated Hospital of China Medical University","ror":"https://ror.org/012sz4c50","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099028"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin-ping Hui","raw_affiliation_strings":["Laboratory Center, the Fourth Affiliated Hospital of China Medical University, No.4 Chongshan East Road, Huanggu District, Shenyang, Liaoning, People's Republic of China. 46236572@qq.com","Laboratory Center, the Fourth Affiliated Hospital of China Medical University, No.4 Chongshan East Road, Huanggu District, Shenyang, Liaoning, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory Center, the Fourth Affiliated Hospital of China Medical University, No.4 Chongshan East Road, Huanggu District, Shenyang, Liaoning, People's Republic of China. 46236572@qq.com","institution_ids":["https://openalex.org/I4210099028"]},{"raw_affiliation_string":"Laboratory Center, the Fourth Affiliated Hospital of China Medical University, No.4 Chongshan East Road, Huanggu District, Shenyang, Liaoning, People's Republic of China","institution_ids":["https://openalex.org/I4210099028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100409210","display_name":"Chunyan Li","orcid":"https://orcid.org/0000-0001-5169-3976","observed_orcids":["https://orcid.org/0000-0001-5169-3976"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chun-yan Li","raw_affiliation_strings":["Center of Laboratory Technology and Experimental Medicine, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, People's Republic of China. 1753027976@qq.com","Center of Laboratory Technology and Experimental Medicine, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Laboratory Technology and Experimental Medicine, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, People's Republic of China. 1753027976@qq.com","institution_ids":["https://openalex.org/I91656880"]},{"raw_affiliation_string":"Center of Laboratory Technology and Experimental Medicine, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, People's Republic of China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042028161","display_name":"Jian Gao","orcid":"https://orcid.org/0000-0002-5928-412X","observed_orcids":["https://orcid.org/0000-0002-5928-412X"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Gao","raw_affiliation_strings":["Center of Laboratory Technology and Experimental Medicine, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, People's Republic of China. cmulab@qq.com","Center of Laboratory Technology and Experimental Medicine, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Laboratory Technology and Experimental Medicine, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, People's Republic of China. cmulab@qq.com","institution_ids":["https://openalex.org/I91656880"]},{"raw_affiliation_string":"Center of Laboratory Technology and Experimental Medicine, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, People's Republic of China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021968671","display_name":"Zeshi Cui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ze-shi Cui","raw_affiliation_strings":["Center of Laboratory Technology and Experimental Medicine, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, People's Republic of China. labczs@mail.cmu.edu.cn","Center of Laboratory Technology and Experimental Medicine, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Laboratory Technology and Experimental Medicine, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, People's Republic of China. labczs@mail.cmu.edu.cn","institution_ids":["https://openalex.org/I91656880"]},{"raw_affiliation_string":"Center of Laboratory Technology and Experimental Medicine, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, People's Republic of China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"last","author":{"id":null,"display_name":"Xue-shan Qiu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140515","display_name":"First Hospital of China Medical University","ror":"https://ror.org/04wjghj95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140515"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xue-shan Qiu","raw_affiliation_strings":["Department of Pathology, the First Affiliated Hospital of China Medical University, No.155 Nanjing North Street, Heping District, Shenyang, Liaoning, People's Republic of China. qiuxues@hotmail.com","Department of Pathology, the First Affiliated Hospital of China Medical University, No.155 Nanjing North Street, Heping District, Shenyang, Liaoning, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, the First Affiliated Hospital of China Medical University, No.155 Nanjing North Street, Heping District, Shenyang, Liaoning, People's Republic of China. qiuxues@hotmail.com","institution_ids":["https://openalex.org/I4210140515"]},{"raw_affiliation_string":"Department of Pathology, the First Affiliated Hospital of China Medical University, No.155 Nanjing North Street, Heping District, Shenyang, Liaoning, People's Republic of China","institution_ids":["https://openalex.org/I4210140515"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5021968671"],"corresponding_institution_ids":["https://openalex.org/I91656880"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":3390,"currency":"USD","value_usd":3390},"fwci":2.1575,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.88633543,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"16","issue":"1","first_page":"171","last_page":"171"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.020400000736117363,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-squamous-cell-carcinoma","display_name":"lung squamous cell carcinoma","score":0.9430000185966492},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":1.0},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.6980000138282776},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.8019999861717224},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/shrna","display_name":"shRNA","score":0.609000027179718},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.3499999940395355},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7170000076293945}],"concepts":[{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6129143834114075},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5834731459617615},{"id":"https://openalex.org/C2778790584","wikidata":"https://www.wikidata.org/wiki/Q123045","display_name":"Brain-derived neurotrophic factor","level":4,"score":0.5668401718139648},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.548040509223938},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5017116069793701},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.49953746795654297},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4903002083301544},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.44656142592430115},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.44365715980529785},{"id":"https://openalex.org/C81729549","wikidata":"https://www.wikidata.org/wiki/Q4649475","display_name":"A549 cell","level":3,"score":0.4356536865234375},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.42115235328674316},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41060858964920044},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3927723169326782},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39015811681747437},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.35822436213493347},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2645917534828186},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07067415118217468},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047368","descriptor_name":"Tumor Burden","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047368","descriptor_name":"Tumor Burden","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047368","descriptor_name":"Tumor Burden","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060787","descriptor_name":"Neoplasm Grading","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060787","descriptor_name":"Neoplasm Grading","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060787","descriptor_name":"Neoplasm Grading","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/s12885-016-2218-0","doi":"https://doi.org/10.1186/s12885-016-2218-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-016-2218-0","pdf_url":"https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-016-2218-0","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4772289","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4772289","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"Text"},{"id":"pmid:26926340","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26926340","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1186/s12885-016-2218-0","doi":"https://doi.org/10.1186/s12885-016-2218-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-016-2218-0","pdf_url":"https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-016-2218-0","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7699999809265137}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1798597496","display_name":"BDNF\u81ea\u5206\u6ccc\u9014\u5f84\u5728\u80ba\u764c\u7ec6\u80de\u4fb5\u88ad\u8f6c\u79fb\u4e2d\u7684\u4f5c\u7528\u53ca\u5176\u8bf1\u5bfcPyk2\u78f7\u9178\u5316\u7684\u673a\u5236\u7814\u7a76","funder_award_id":"81101599","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2291908392.pdf","grobid_xml":"https://content.openalex.org/works/W2291908392.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1510306649","https://openalex.org/W1980243795","https://openalex.org/W1982889157","https://openalex.org/W1990702536","https://openalex.org/W1996036695","https://openalex.org/W2000722328","https://openalex.org/W2002457274","https://openalex.org/W2007612721","https://openalex.org/W2011637659","https://openalex.org/W2033180168","https://openalex.org/W2042736191","https://openalex.org/W2044261750","https://openalex.org/W2049170220","https://openalex.org/W2095184120","https://openalex.org/W2104320396","https://openalex.org/W2105530010","https://openalex.org/W2105536667","https://openalex.org/W2107930615","https://openalex.org/W2110574342","https://openalex.org/W2112978410","https://openalex.org/W2126026763","https://openalex.org/W2134399913","https://openalex.org/W2139565721","https://openalex.org/W2142535641","https://openalex.org/W2146453992","https://openalex.org/W2148089871","https://openalex.org/W2154690450","https://openalex.org/W2344614086"],"related_works":["https://openalex.org/W4380590552","https://openalex.org/W2623953495","https://openalex.org/W6906224833","https://openalex.org/W2796278978","https://openalex.org/W4225429181","https://openalex.org/W2751339508","https://openalex.org/W2362176048","https://openalex.org/W2388847845","https://openalex.org/W2333192581","https://openalex.org/W2007612721"],"abstract_inverted_index":{"BACKGROUND:":[0],"Brain-derived":[1],"neurotrophic":[2],"factor":[3],"(BDNF)":[4],"has":[5],"been":[6],"reported":[7],"to":[8,23,151,330,348],"promote":[9],"tumorigenesis":[10,313],"and":[11,35,51,69,86,103,113,124,136,161,170,183,190,201,214,223,245,265,273,277,302,317,337],"progression":[12],"in":[13,29,45,62,80,107,131,212,229,249,263,335],"several":[14],"human":[15,81],"malignancies.":[16],"The":[17,39,55,122,268,319],"purpose":[18],"of":[19,27,41,48,58,126,178,180,193,225,240,256,285,314,321,333,341],"this":[20],"study":[21],"was":[22,43,60,77,144,195,209,261,287],"explore":[24],"the":[25,139,154,220,238,274,283,312,331,339],"function":[26],"BDNF":[28,42,59,75,96,127,143,155,194,208,226,241,257,286,293,309,322,334,342],"lung":[30,49,64,88,181,230,315,349],"squamous":[31],"cell":[32,90,118,158,218,275],"carcinoma":[33],"(SCC)":[34],"adenocarcinoma":[36],"(ADC).":[37],"METHODS:":[38],"expression":[40,76,123,192,222,255,284,320],"examined":[44,61],"110":[46],"samples":[47,68,185],"SCC":[50,65,110,182,213,316],"ADC":[52,67,115,184,215],"by":[53,72,120,166,291],"immunohistochemistry.":[54],"protein":[56],"level":[57],"25":[63],"or":[66,148,299],"paired":[70],"non-tumors":[71],"western":[73,93,134],"blot.":[74,94],"also":[78,129],"evaluated":[79,106],"bronchial":[82],"epithelial":[83],"cells":[84,132,150,232,251,270,295],"(HBE)":[85],"4":[87],"cancer":[89,231,350],"lines":[91,119],"using":[92,133],"Three":[95],"mRNA":[97,242,258,323],"variants":[98],"containing":[99],"exons":[100],"IV,":[101],"VI":[102,246],"IX":[104,260,325],"were":[105,128,164,186,227,247,271,279],"HBE,":[108],"two":[109,114],"(SK,":[111],"LK2)":[112],"(A549,":[116],"LTE)":[117],"RT-PCR.":[121],"secretion":[125,224],"determined":[130],"blot":[135],"ELISA.":[137],"Then":[138],"shRNA":[140],"specific":[141],"for":[142],"transfected":[145],"into":[146],"LK2":[147,266],"A549":[149],"further":[152],"elucidate":[153],"knockdown":[156,294],"on":[157],"proliferation,":[159],"apoptosis":[160],"invasion,":[162],"which":[163],"confirmed":[165],"MTT,":[167],"flow":[168],"cytometry":[169],"transwell":[171],"examinations.":[172],"RESULTS:":[173],"71.8":[174],"%":[175],"(79":[176],"out":[177],"110)":[179],"detected":[187],"positive":[188],"BDNF,":[189],"high":[191],"significantly":[196],"correlated":[197],"with":[198,205,234],"histological":[199],"type":[200],"T":[202],"stage.":[203],"Compared":[204],"non-tumorous":[206],"counterparts,":[207],"apparently":[210],"overexpressed":[211],"tissues.":[216],"In":[217],"studies,":[219],"extensive":[221],"demonstrated":[228],"compared":[233],"HBE":[235],"cells.":[236,267],"Interestingly,":[237],"expressions":[239],"variant":[243,259,324],"IV":[244],"identical":[248],"all":[250],"examined.":[252],"However,":[253],"more":[254,300,328],"found":[262],"SK":[264],"apoptotic":[269,298],"increased,":[272],"proliferation":[276],"invasion":[278],"both":[280],"attenuated":[281],"once":[282],"inhibited.":[288],"When":[289],"retreated":[290],"rhBDNF,":[292],"showed":[296],"less":[297],"proliferative":[301],"invasive.":[303],"CONCLUSIONS:":[304],"Our":[305],"data":[306],"show":[307],"that":[308],"probably":[310,327],"facilitates":[311],"ADC.":[318],"is":[326],"helpful":[329],"upregulation":[332],"SCC,":[336],"intervening":[338],"production":[340],"could":[343],"be":[344],"a":[345],"possible":[346],"strategy":[347],"therapy.":[351]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}