{"id":"https://openalex.org/W2291810330","doi":null,"title":"Investigating the effects of curcumin and resveratrol on pancreatic cancer stem cells","display_name":"Investigating the effects of curcumin and resveratrol on pancreatic cancer stem cells","publication_year":2015,"publication_date":"2015-08-21","ids":{"openalex":"https://openalex.org/W2291810330","mag":"2291810330"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/10176458","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/thesis/Investigating_the_effects_of_curcumin_and_resveratrol_on_pancreatic_cancer_stem_cells/10176458","pdf_url":"https://figshare.com/articles/thesis/Investigating_the_effects_of_curcumin_and_resveratrol_on_pancreatic_cancer_stem_cells/10176458","source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/thesis/Investigating_the_effects_of_curcumin_and_resveratrol_on_pancreatic_cancer_stem_cells/10176458","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024241644","display_name":"Karzan Khowaraham Karim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Karzan Khowaraham Karim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5024241644"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.7660999894142151,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.7660999894142151,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.08290000259876251,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.07249999791383743,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/resveratrol","display_name":"resveratrol","score":1.0},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.871999979019165},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.843999981880188},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.8029999732971191},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":1.0},{"id":"https://openalex.org/keywords/aldh1","display_name":"ALDH1","score":0.8659999966621399},{"id":"https://openalex.org/keywords/nanog","display_name":"Nanog","score":0.9190000295639038},{"id":"https://openalex.org/keywords/cd44","display_name":"CD44","score":0.7350000143051147},{"id":"https://openalex.org/keywords/cd24","display_name":"CD24","score":0.9890000224113464},{"id":"https://openalex.org/keywords/stellate-cells","display_name":"stellate cells","score":0.8519999980926514},{"id":"https://openalex.org/keywords/curcumin-metabolites","display_name":"curcumin metabolites","score":0.800000011920929},{"id":"https://openalex.org/keywords/capan-1-cells","display_name":"Capan-1 cells","score":0.8980000019073486},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C2778250585","wikidata":"https://www.wikidata.org/wiki/Q312266","display_name":"Curcumin","level":2,"score":0.9310891628265381},{"id":"https://openalex.org/C2776816829","wikidata":"https://www.wikidata.org/wiki/Q407329","display_name":"Resveratrol","level":2,"score":0.8065507411956787},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.7300593256950378},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.605202853679657},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.5227230191230774},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43328726291656494},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3974657654762268},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.36441856622695923},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3520236015319824},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.324973464012146},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3164181709289551},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.21186679601669312}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/10176458","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/thesis/Investigating_the_effects_of_curcumin_and_resveratrol_on_pancreatic_cancer_stem_cells/10176458","pdf_url":"https://figshare.com/articles/thesis/Investigating_the_effects_of_curcumin_and_resveratrol_on_pancreatic_cancer_stem_cells/10176458","source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:oai:lra.le.ac.uk:2381/33155","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2381/33155","pdf_url":"http://hdl.handle.net/2381/33155","source":{"id":"https://openalex.org/S4306402365","display_name":"Leicester Research Archive (University of Leicester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I153648349","host_organization_name":"University of Leicester","host_organization_lineage":["https://openalex.org/I153648349"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2291810330","doi":null,"is_oa":false,"landing_page_url":"https://lra.le.ac.uk/bitstream/2381/33155/1/Final%20submission%20of%20my%20theses.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/10176458","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/thesis/Investigating_the_effects_of_curcumin_and_resveratrol_on_pancreatic_cancer_stem_cells/10176458","pdf_url":"https://figshare.com/articles/thesis/Investigating_the_effects_of_curcumin_and_resveratrol_on_pancreatic_cancer_stem_cells/10176458","source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2291810330.pdf","grobid_xml":"https://content.openalex.org/works/W2291810330.grobid-xml"},"referenced_works_count":140,"referenced_works":["https://openalex.org/W17355599","https://openalex.org/W74993898","https://openalex.org/W114316834","https://openalex.org/W135187779","https://openalex.org/W296450459","https://openalex.org/W1233353675","https://openalex.org/W1511966243","https://openalex.org/W1520325432","https://openalex.org/W1548210045","https://openalex.org/W1548257928","https://openalex.org/W1548389972","https://openalex.org/W1569631204","https://openalex.org/W1595577626","https://openalex.org/W1835750525","https://openalex.org/W1877439680","https://openalex.org/W1931508686","https://openalex.org/W1963764467","https://openalex.org/W1963822535","https://openalex.org/W1967182685","https://openalex.org/W1967304777","https://openalex.org/W1969721611","https://openalex.org/W1973147485","https://openalex.org/W1973823907","https://openalex.org/W1975770667","https://openalex.org/W1977945213","https://openalex.org/W1979590056","https://openalex.org/W1981561877","https://openalex.org/W1982184962","https://openalex.org/W1982605706","https://openalex.org/W1984328540","https://openalex.org/W1986034385","https://openalex.org/W1987855320","https://openalex.org/W1988161053","https://openalex.org/W1988783376","https://openalex.org/W1997520180","https://openalex.org/W1998196049","https://openalex.org/W1998201418","https://openalex.org/W2001333573","https://openalex.org/W2002013266","https://openalex.org/W2004211520","https://openalex.org/W2010073511","https://openalex.org/W2014442719","https://openalex.org/W2016236483","https://openalex.org/W2017990196","https://openalex.org/W2018667790","https://openalex.org/W2019199359","https://openalex.org/W2020131167","https://openalex.org/W2021310315","https://openalex.org/W2023427658","https://openalex.org/W2023695651","https://openalex.org/W2024480685","https://openalex.org/W2029231546","https://openalex.org/W2033203721","https://openalex.org/W2033320521","https://openalex.org/W2033459915","https://openalex.org/W2033567537","https://openalex.org/W2034269086","https://openalex.org/W2037345578","https://openalex.org/W2037619415","https://openalex.org/W2037911497","https://openalex.org/W2040149979","https://openalex.org/W2041629401","https://openalex.org/W2041764058","https://openalex.org/W2041820616","https://openalex.org/W2043398720","https://openalex.org/W2045246542","https://openalex.org/W2045617306","https://openalex.org/W2051248877","https://openalex.org/W2051615139","https://openalex.org/W2053989508","https://openalex.org/W2054786727","https://openalex.org/W2056041663","https://openalex.org/W2057436861","https://openalex.org/W2060344107","https://openalex.org/W2061153713","https://openalex.org/W2063468735","https://openalex.org/W2064703543","https://openalex.org/W2066646758","https://openalex.org/W2067693899","https://openalex.org/W2068004114","https://openalex.org/W2071569202","https://openalex.org/W2073302269","https://openalex.org/W2075827370","https://openalex.org/W2079356804","https://openalex.org/W2084280570","https://openalex.org/W2085057626","https://openalex.org/W2085626804","https://openalex.org/W2086263057","https://openalex.org/W2088181957","https://openalex.org/W2090982381","https://openalex.org/W2091362934","https://openalex.org/W2091799578","https://openalex.org/W2095637939","https://openalex.org/W2099023480","https://openalex.org/W2102085111","https://openalex.org/W2107461722","https://openalex.org/W2107859602","https://openalex.org/W2111175587","https://openalex.org/W2112545979","https://openalex.org/W2116394959","https://openalex.org/W2117569814","https://openalex.org/W2117692326","https://openalex.org/W2119417619","https://openalex.org/W2121411068","https://openalex.org/W2122598808","https://openalex.org/W2125121177","https://openalex.org/W2125923072","https://openalex.org/W2129883523","https://openalex.org/W2131070390","https://openalex.org/W2131170195","https://openalex.org/W2134461109","https://openalex.org/W2137520566","https://openalex.org/W2142739240","https://openalex.org/W2144719083","https://openalex.org/W2147381220","https://openalex.org/W2150585579","https://openalex.org/W2151089147","https://openalex.org/W2151089236","https://openalex.org/W2152036317","https://openalex.org/W2153382986","https://openalex.org/W2153745983","https://openalex.org/W2155462152","https://openalex.org/W2156872475","https://openalex.org/W2157304020","https://openalex.org/W2158811570","https://openalex.org/W2160152459","https://openalex.org/W2160905744","https://openalex.org/W2162085688","https://openalex.org/W2164034599","https://openalex.org/W2164157942","https://openalex.org/W2165428601","https://openalex.org/W2168992025","https://openalex.org/W2170558420","https://openalex.org/W2171794152","https://openalex.org/W2312309812","https://openalex.org/W2389947446","https://openalex.org/W2411568505","https://openalex.org/W2481052457","https://openalex.org/W4294309179","https://openalex.org/W4295813347"],"related_works":["https://openalex.org/W7098617251","https://openalex.org/W2004211520","https://openalex.org/W2253839661","https://openalex.org/W2564588275","https://openalex.org/W2353427250","https://openalex.org/W7100267383","https://openalex.org/W2205226578","https://openalex.org/W2583867926","https://openalex.org/W76275649","https://openalex.org/W2606815781"],"abstract_inverted_index":{"Anti-proliferative":[0],"and":[1,8,28,37,45,48,60,86,97,112,122,169,180,239,257,272,285],"cancer":[2,33,65,159,186,236,282],"stem-cell":[3],"targeting":[4,158,281],"abilities":[5],"of":[6,24,56,95,114,135,154,196,215],"curcumin":[7,44,96,109,168,211,216,219,271],"resveratrol":[9,46,155,170,273],"individually":[10],"have":[11,232],"been":[12],"shown":[13],"in":[14,29,31,49,132,157,172,206,246,294],"different":[15],"cancers.":[16],"This":[17],"project":[18],"aimed":[19],"to":[20,108,145,150,212,254,265],"assess":[21],"the":[22,72,142,152,262,267,290],"activity":[23,57,81,179,226,233],"these":[25,115],"compounds,":[26],"alone":[27,47,230],"combination":[30,247,278],"pancreatic":[32,185,235,295],"cell":[34,61,67,73,123,137,259],"lines":[35],"(PCCLs)":[36],"stellate":[38,286],"cells.\\nAnti-proliferation":[39],"assays":[40],"were":[41,69,105,191],"performed":[42],"for":[43,280,289],"combination,":[50],"combined":[51],"with":[52,176,248],"end":[53],"point":[54],"markers":[55,75],"including":[58],"apoptosis":[59,121],"cycle":[62,124],"arrest.":[63],"Pancreatic":[64],"stem":[66,237],"populations":[68,190],"defined":[70],"using":[71],"surface":[74],"CD44,":[76],"CD24,":[77],"ESA,":[78],"CD133,":[79],"ALDH-1":[80],"or":[82,198],"sphere":[83],"forming":[84],"ability,":[85],"finally":[87],"Nanog":[88,181],"expression":[89,195],"was":[90,100,148,164],"assessed.":[91],"The":[92],"intracellular":[93],"uptake":[94],"its":[98],"metabolites":[99,220],"analysed":[101],"by":[102,167],"HPLC.\\nThe":[103],"PCCLs":[104],"more":[106],"sensitive":[107],"than":[110],"resveratrol,":[111],"combinations":[113,171],"compounds":[116],"showed":[117],"anti-proliferative":[118],"efficacy":[119,241],"through":[120],"arrest":[125],"at":[126,227,242],"low,":[127],"clinically":[128],"achievable":[129],"concentrations":[130,244],"(CACs)":[131],"2":[133],"out":[134],"4":[136],"lines.":[138],"Capan-1":[139,173,208,250],"cells":[140,209,251,284,287],"exhibited":[141,261],"highest":[143],"sensitivity":[144,264],"curcumin,":[146,256],"which":[147,200],"able":[149,253],"enhance":[151],"effectiveness":[153],"treatments":[156],"stem-like":[160,189,283],"populations.":[161],"Spheroid":[162],"growth":[163],"significantly":[165],"inhibited":[166],"cells,":[174,238],"correlating":[175],"decreased":[177],"ALDH1":[178,197],"expression.":[182],"In":[183],"human":[184],"tissue,":[187],"various":[188],"identified":[192],"based":[193],"on":[194],"CD24+/CD44+,":[199],"may":[201,231],"provide":[202],"a":[203],"suitable":[204],"target":[205],"vivo.":[207],"metabolised":[210],"detectable":[213],"amounts":[214],"glucuronide.":[217],"However,":[218],"did":[221],"not":[222],"show":[223],"any":[224],"significant":[225],"CACs.":[228],"Curcumin":[229],"against":[234],"enhances":[240],"low":[243],"when":[245],"resveratrol.":[249],"are":[252],"internalise":[255],"this":[258],"line":[260],"greatest":[263],"treatment.\\nOverall,":[266],"results":[268],"suggest":[269],"that":[270],"warrant":[274],"further":[275],"investigation":[276],"as":[277],"therapies":[279],"responsible":[288],"dense":[291],"stroma":[292],"observed":[293],"cancer.":[296]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}