{"id":"https://openalex.org/W2291652247","doi":null,"title":"Therapeutic implication of molecular profiling in patients with non \u2013 small cell lung cancer","display_name":"Therapeutic implication of molecular profiling in patients with non \u2013 small cell lung cancer","publication_year":2012,"publication_date":"2012-09-30","ids":{"openalex":"https://openalex.org/W2291652247","mag":"2291652247"},"language":"en","primary_location":{"id":"pmh:oai:hrcak.srce.hr:101266","doi":null,"is_oa":true,"landing_page_url":"http://hrcak.srce.hr/101266","pdf_url":"http://hrcak.srce.hr/file/149273","source":{"id":"https://openalex.org/S4306400677","display_name":"Hr\u010dak Portal of scientific journals of Croatia (University Computing Centre)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210104502","host_organization_name":"United Nations University","host_organization_lineage":["https://openalex.org/I4210104502"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Periodicum biologorum","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hrcak.srce.hr/file/149273","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045353016","display_name":"Marko Jakopovi\u0107","orcid":"https://orcid.org/0000-0002-4815-7512","observed_orcids":["https://orcid.org/0000-0002-4815-7512"]},"institutions":[{"id":"https://openalex.org/I138937732","display_name":"University Hospital Centre Zagreb","ror":"https://ror.org/00r9vb833","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I138937732"]},{"id":"https://openalex.org/I181343428","display_name":"University of Zagreb","ror":"https://ror.org/00mv6sv71","country_code":"HR","type":"education","lineage":["https://openalex.org/I181343428"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Marko Jakopovi\u0107","raw_affiliation_strings":["University of Zagreb, School of Medicine, University Hospital Center Zagreb, Department for Respiratory Diseases Jordanovac, Jordanovac 104, Zagreb, Croatia"],"raw_orcid":"https://orcid.org/0000-0002-4815-7512","affiliations":[{"raw_affiliation_string":"University of Zagreb, School of Medicine, University Hospital Center Zagreb, Department for Respiratory Diseases Jordanovac, Jordanovac 104, Zagreb, Croatia","institution_ids":["https://openalex.org/I138937732","https://openalex.org/I181343428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078099265","display_name":"Silvana Smojver Je\u017eek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138937732","display_name":"University Hospital Centre Zagreb","ror":"https://ror.org/00r9vb833","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I138937732"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Silvana Smojver Je\u017eek","raw_affiliation_strings":["2University Hospital Center Zagreb, Department for Pathology and Cytology, Division for Pulmonary Cytology Jordanovac, Jordanovac 104, Zagreb, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University Hospital Center Zagreb, Department for Pathology and Cytology, Division for Pulmonary Cytology Jordanovac, Jordanovac 104, Zagreb, Croatia","institution_ids":["https://openalex.org/I138937732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004213896","display_name":"Nabil Chalfe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138937732","display_name":"University Hospital Centre Zagreb","ror":"https://ror.org/00r9vb833","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I138937732"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Nabil Chalfe","raw_affiliation_strings":["University Hospital Center Zagreb, Department for Respiratory Diseases Jordanovac, Jordanovac 104, Zagreb, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Center Zagreb, Department for Respiratory Diseases Jordanovac, Jordanovac 104, Zagreb, Croatia","institution_ids":["https://openalex.org/I138937732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051646751","display_name":"Gzim Red\u017eepi","orcid":"https://orcid.org/0000-0002-2288-8771","observed_orcids":["https://orcid.org/0000-0002-2288-8771"]},"institutions":[{"id":"https://openalex.org/I138937732","display_name":"University Hospital Centre Zagreb","ror":"https://ror.org/00r9vb833","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I138937732"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Gzim Red\u017eepi","raw_affiliation_strings":["University Hospital Center Zagreb, Department for Respiratory Diseases Jordanovac, Jordanovac 104, Zagreb, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Center Zagreb, Department for Respiratory Diseases Jordanovac, Jordanovac 104, Zagreb, Croatia","institution_ids":["https://openalex.org/I138937732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016182737","display_name":"Mateja Jankovi\u0107 Makek","orcid":"https://orcid.org/0000-0002-0171-764X","observed_orcids":["https://orcid.org/0000-0002-0171-764X"]},"institutions":[{"id":"https://openalex.org/I138937732","display_name":"University Hospital Centre Zagreb","ror":"https://ror.org/00r9vb833","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I138937732"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Mateja Jankovi\u0107","raw_affiliation_strings":["University Hospital Center Zagreb, Department for Respiratory Diseases Jordanovac, Jordanovac 104, Zagreb, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Center Zagreb, Department for Respiratory Diseases Jordanovac, Jordanovac 104, Zagreb, Croatia","institution_ids":["https://openalex.org/I138937732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090318611","display_name":"Branka \u010cu\u010devi\u0107","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138937732","display_name":"University Hospital Centre Zagreb","ror":"https://ror.org/00r9vb833","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I138937732"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Branka \u010cu\u010devi\u0107","raw_affiliation_strings":["University Hospital Center Zagreb, Department for Respiratory Diseases Jordanovac, Jordanovac 104, Zagreb, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Center Zagreb, Department for Respiratory Diseases Jordanovac, Jordanovac 104, Zagreb, Croatia","institution_ids":["https://openalex.org/I138937732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114095953","display_name":"Dina Mihel\u010di\u0107 Korte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138937732","display_name":"University Hospital Centre Zagreb","ror":"https://ror.org/00r9vb833","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I138937732"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Dina Mihel\u010di\u0107","raw_affiliation_strings":["University Hospital Center Zagreb, Department for Respiratory Diseases Jordanovac, Jordanovac 104, Zagreb, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Center Zagreb, Department for Respiratory Diseases Jordanovac, Jordanovac 104, Zagreb, Croatia","institution_ids":["https://openalex.org/I138937732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064775097","display_name":"Dinko Stan\u010di\u0107 Rokotov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138937732","display_name":"University Hospital Centre Zagreb","ror":"https://ror.org/00r9vb833","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I138937732"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Dinko Stan\u010di\u0107 Rokotov","raw_affiliation_strings":["4University Hospital Center Zagreb, Department for Thoracic Surgery Jordanovac, Jordanovac 104, Zagreb, Croatia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4University Hospital Center Zagreb, Department for Thoracic Surgery Jordanovac, Jordanovac 104, Zagreb, Croatia","institution_ids":["https://openalex.org/I138937732"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010674757","display_name":"Miroslav Samar\u017eija","orcid":"https://orcid.org/0000-0001-5303-9353","observed_orcids":["https://orcid.org/0000-0001-5303-9353"]},"institutions":[{"id":"https://openalex.org/I138937732","display_name":"University Hospital Centre Zagreb","ror":"https://ror.org/00r9vb833","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I138937732"]},{"id":"https://openalex.org/I181343428","display_name":"University of Zagreb","ror":"https://ror.org/00mv6sv71","country_code":"HR","type":"education","lineage":["https://openalex.org/I181343428"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Miroslav Samar\u017eija","raw_affiliation_strings":["University of Zagreb, School of Medicine, University Hospital Center Zagreb, Department for Respiratory Diseases Jordanovac, Jordanovac 104, Zagreb, Croatia"],"raw_orcid":"https://orcid.org/0000-0001-5303-9353","affiliations":[{"raw_affiliation_string":"University of Zagreb, School of Medicine, University Hospital Center Zagreb, Department for Respiratory Diseases Jordanovac, Jordanovac 104, Zagreb, Croatia","institution_ids":["https://openalex.org/I138937732","https://openalex.org/I181343428"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"114","issue":"4","first_page":"539","last_page":"548"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":1.0},{"id":"https://openalex.org/keywords/molecular-profiling","display_name":"molecular profiling","score":0.9390000104904175},{"id":"https://openalex.org/keywords/molecular-biomarkers","display_name":"molecular biomarkers","score":0.9810000061988831},{"id":"https://openalex.org/keywords/egfr-mutation","display_name":"EGFR mutation","score":0.8379999995231628},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.9340000152587891},{"id":"https://openalex.org/keywords/personalized-treatment","display_name":"personalized treatment","score":0.7310000061988831},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9430000185966492},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.9559999704360962}],"concepts":[{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6515727043151855},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.58750981092453},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.581813633441925},{"id":"https://openalex.org/C3019646584","wikidata":"https://www.wikidata.org/wiki/Q2311855","display_name":"Molecular biomarkers","level":2,"score":0.5764064788818359},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.573737382888794},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5048976540565491},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.48253270983695984},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4453933835029602},{"id":"https://openalex.org/C3019719930","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value","level":2,"score":0.4251462519168854},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.4175998866558075},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4003378748893738},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3293563425540924},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.25559961795806885},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19727963209152222},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.060148388147354126},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.058287620544433594},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:hrcak.srce.hr:101266","doi":null,"is_oa":true,"landing_page_url":"http://hrcak.srce.hr/101266","pdf_url":"http://hrcak.srce.hr/file/149273","source":{"id":"https://openalex.org/S4306400677","display_name":"Hr\u010dak Portal of scientific journals of Croatia (University Computing Centre)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210104502","host_organization_name":"United Nations University","host_organization_lineage":["https://openalex.org/I4210104502"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Periodicum biologorum","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2291652247","doi":null,"is_oa":true,"landing_page_url":"https://hrcak.srce.hr/101266?lang=en","pdf_url":null,"source":{"id":"https://openalex.org/S152150123","display_name":"Periodicum Biologorum","issn_l":"0031-5362","issn":["0031-5362","1849-0964"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4363609400","host_organization_name":"Croatian Natural Society","host_organization_lineage":["https://openalex.org/P4363609400"],"host_organization_lineage_names":["Croatian Natural Society"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Periodicum Biologorum","raw_type":null}],"best_oa_location":{"id":"pmh:oai:hrcak.srce.hr:101266","doi":null,"is_oa":true,"landing_page_url":"http://hrcak.srce.hr/101266","pdf_url":"http://hrcak.srce.hr/file/149273","source":{"id":"https://openalex.org/S4306400677","display_name":"Hr\u010dak Portal of scientific journals of Croatia (University Computing Centre)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210104502","host_organization_name":"United Nations University","host_organization_lineage":["https://openalex.org/I4210104502"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Periodicum biologorum","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2291652247.pdf","grobid_xml":"https://content.openalex.org/works/W2291652247.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W1819148429","https://openalex.org/W1965606913","https://openalex.org/W1975088494","https://openalex.org/W1979133396","https://openalex.org/W1989116783","https://openalex.org/W1989123634","https://openalex.org/W1989548084","https://openalex.org/W1996283758","https://openalex.org/W1999213748","https://openalex.org/W2004718750","https://openalex.org/W2005599761","https://openalex.org/W2007661090","https://openalex.org/W2013733453","https://openalex.org/W2016489352","https://openalex.org/W2021027398","https://openalex.org/W2022490995","https://openalex.org/W2022689141","https://openalex.org/W2026707626","https://openalex.org/W2028415754","https://openalex.org/W2037139573","https://openalex.org/W2042278676","https://openalex.org/W2043696829","https://openalex.org/W2044293524","https://openalex.org/W2055402151","https://openalex.org/W2059835053","https://openalex.org/W2083292604","https://openalex.org/W2095618958","https://openalex.org/W2099725888","https://openalex.org/W2100406815","https://openalex.org/W2100912832","https://openalex.org/W2101221175","https://openalex.org/W2104339838","https://openalex.org/W2104830962","https://openalex.org/W2106245385","https://openalex.org/W2107183277","https://openalex.org/W2110835998","https://openalex.org/W2111662961","https://openalex.org/W2114784462","https://openalex.org/W2119340070","https://openalex.org/W2121110745","https://openalex.org/W2122553809","https://openalex.org/W2125514375","https://openalex.org/W2126387336","https://openalex.org/W2127101185","https://openalex.org/W2129168431","https://openalex.org/W2129360604","https://openalex.org/W2132157071","https://openalex.org/W2134787029","https://openalex.org/W2135192471","https://openalex.org/W2136137911","https://openalex.org/W2136549983","https://openalex.org/W2136950355","https://openalex.org/W2137583207","https://openalex.org/W2138297714","https://openalex.org/W2139110945","https://openalex.org/W2139799027","https://openalex.org/W2142148449","https://openalex.org/W2152755651","https://openalex.org/W2152905269","https://openalex.org/W2153447740","https://openalex.org/W2153477391","https://openalex.org/W2159060826","https://openalex.org/W2160336497","https://openalex.org/W2161167330","https://openalex.org/W2162429476","https://openalex.org/W2164529446","https://openalex.org/W2168106545","https://openalex.org/W2168168277","https://openalex.org/W2257265893","https://openalex.org/W2590932472"],"related_works":["https://openalex.org/W2004914343","https://openalex.org/W7170142874","https://openalex.org/W2914779878","https://openalex.org/W2141023753","https://openalex.org/W2108603842","https://openalex.org/W2999103725","https://openalex.org/W2000035904","https://openalex.org/W2136467807","https://openalex.org/W2335915311","https://openalex.org/W2053199152"],"abstract_inverted_index":{"Traditional,":[0],"'one":[1],"size":[2],"fits":[3],"all'":[4],"approach":[5],"to":[6,60],"chemotherapy":[7],"has":[8],"reached":[9],"efficacy":[10,20],"plateau.The":[11],"development":[12],"of":[13,21,32,42,51,62],"molecular":[14,33],"biomarkers":[15,34],"is":[16,45,48],"crucial":[17],"for":[18],"improving":[19],"therapy":[22,41],"in":[23],"patients":[24],"with":[25,35],"NSCLC.We":[26],"review":[27,47],"prognostic":[28],"and":[29,54],"predictive":[30],"value":[31],"special":[36],"overview":[37],"on":[38,49,58],"biomarker-driven":[39],"personalized":[40],"NSCLC.Main":[43],"focus":[44],"this":[46],"significance":[50],"EGFR":[52],"mutations":[53],"ALK":[55],"-EML4":[56],"alterations":[57],"due":[59],"availability":[61],"targeted":[63],"drugs":[64],"against":[65],"these":[66],"specific":[67],"aberrations.":[68]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}