{"id":"https://openalex.org/W2291458005","doi":"https://doi.org/10.1097/shk.0000000000000564","title":"Cardiac Output Monitoring Managing Intravenous Therapy (COMMIT) to Treat Emergency Department Patients with Sepsis","display_name":"Cardiac Output Monitoring Managing Intravenous Therapy (COMMIT) to Treat Emergency Department Patients with Sepsis","publication_year":2016,"publication_date":"2016-02-24","ids":{"openalex":"https://openalex.org/W2291458005","doi":"https://doi.org/10.1097/shk.0000000000000564","mag":"2291458005","pmid":"https://pubmed.ncbi.nlm.nih.gov/26925867","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4957967"},"language":"en","primary_location":{"id":"doi:10.1097/shk.0000000000000564","doi":"https://doi.org/10.1097/shk.0000000000000564","is_oa":true,"landing_page_url":"https://doi.org/10.1097/shk.0000000000000564","pdf_url":null,"source":{"id":"https://openalex.org/S174819509","display_name":"Shock","issn_l":"1073-2322","issn":["1073-2322","1540-0514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1097/shk.0000000000000564","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083632547","display_name":"Peter Chuanyi Hou","orcid":"https://orcid.org/0000-0002-7726-2901","observed_orcids":["https://orcid.org/0000-0002-7726-2901","https://orcid.org/0000-0002-3177-2754"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I1324520350","display_name":"Hackensack University Medical Center","ror":"https://ror.org/008zj0x80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324520350"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I156802259","display_name":"Eastern Virginia Medical School","ror":"https://ror.org/056hr4255","country_code":"US","type":"education","lineage":["https://openalex.org/I156802259"]},{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2801983979","display_name":"Denver Health Medical Center","ror":"https://ror.org/01fbz6h17","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801983979"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter C. Hou","raw_affiliation_strings":["*Department of Emergency Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts \u2020Department of Emergency Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts \u2021Department of Emergency Medicine, Brown University School of Medicine, Providence, Rhode Island \u00a7Department of Emergency Medicine, Hackensack University Medical Center, Hackensack, New Jersey ||Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, Indiana \u00b6Department of Emergency Medicine, Denver General Hospital, Denver, Colorado #Department of Emergency Medicine, Eastern Virginia Medical School/Sentara Norfolk General, Norfolk, Virginia **Department of Emergency Medicine, HMHP/Mercy Health, Northeast Ohio Medical University (NEOMED), Rootstown, Ohio \u2020\u2020Department of Emergency Medicine, New York Methodist Hospital, Brooklyn, New York \u2021\u2021Department of Emergency Medicine, Beth Israel Deaconess Medical Center and Harvard Medical S","Authors contributions: All investigators participated in the original study conception and approval of the protocol. All authors recruited patients into the study at their study sites. NIS led the initiative and conducted the primary data analysis and interpretation. PCH and NIS drafted the primary manuscript and all authors reviewed the manuscript and gave critical input","The author reports no conflicts of interest. Since this was an industry sponsored trial, all authors received research funding from Cheetah medical (as described above)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Department of Emergency Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts \u2020Department of Emergency Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts \u2021Department of Emergency Medicine, Brown University School of Medicine, Providence, Rhode Island \u00a7Department of Emergency Medicine, Hackensack University Medical Center, Hackensack, New Jersey ||Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, Indiana \u00b6Department of Emergency Medicine, Denver General Hospital, Denver, Colorado #Department of Emergency Medicine, Eastern Virginia Medical School/Sentara Norfolk General, Norfolk, Virginia **Department of Emergency Medicine, HMHP/Mercy Health, Northeast Ohio Medical University (NEOMED), Rootstown, Ohio \u2020\u2020Department of Emergency Medicine, New York Methodist Hospital, Brooklyn, New York \u2021\u2021Department of Emergency Medicine, Beth Israel Deaconess Medical Center and Harvard Medical S","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I1316535847","https://openalex.org/I1324520350","https://openalex.org/I136199984","https://openalex.org/I156802259","https://openalex.org/I27804330","https://openalex.org/I2801983979","https://openalex.org/I4210087915","https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Authors contributions: All investigators participated in the original study conception and approval of the protocol. All authors recruited patients into the study at their study sites. NIS led the initiative and conducted the primary data analysis and interpretation. PCH and NIS drafted the primary manuscript and all authors reviewed the manuscript and gave critical input","institution_ids":[]},{"raw_affiliation_string":"The author reports no conflicts of interest. Since this was an industry sponsored trial, all authors received research funding from Cheetah medical (as described above)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064289221","display_name":"Michael R. Filbin","orcid":"https://orcid.org/0000-0002-2588-7504","observed_orcids":["https://orcid.org/0000-0002-2588-7504"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael R. Filbin","raw_affiliation_strings":["Authors contributions: All investigators participated in the original study conception and approval of the protocol. All authors recruited patients into the study at their study sites. NIS led the initiative and conducted the primary data analysis and interpretation. PCH and NIS drafted the primary manuscript and all authors reviewed the manuscript and gave critical input","The author reports no conflicts of interest. Since this was an industry sponsored trial, all authors received research funding from Cheetah medical (as described above)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors contributions: All investigators participated in the original study conception and approval of the protocol. All authors recruited patients into the study at their study sites. NIS led the initiative and conducted the primary data analysis and interpretation. PCH and NIS drafted the primary manuscript and all authors reviewed the manuscript and gave critical input","institution_ids":[]},{"raw_affiliation_string":"The author reports no conflicts of interest. Since this was an industry sponsored trial, all authors received research funding from Cheetah medical (as described above)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037727928","display_name":"Anthony M. Napoli","orcid":"https://orcid.org/0000-0001-7622-7306","observed_orcids":["https://orcid.org/0000-0001-7622-7306"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anthony Napoli","raw_affiliation_strings":["Authors contributions: All investigators participated in the original study conception and approval of the protocol. All authors recruited patients into the study at their study sites. NIS led the initiative and conducted the primary data analysis and interpretation. PCH and NIS drafted the primary manuscript and all authors reviewed the manuscript and gave critical input","The author reports no conflicts of interest. Since this was an industry sponsored trial, all authors received research funding from Cheetah medical (as described above)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors contributions: All investigators participated in the original study conception and approval of the protocol. All authors recruited patients into the study at their study sites. NIS led the initiative and conducted the primary data analysis and interpretation. PCH and NIS drafted the primary manuscript and all authors reviewed the manuscript and gave critical input","institution_ids":[]},{"raw_affiliation_string":"The author reports no conflicts of interest. Since this was an industry sponsored trial, all authors received research funding from Cheetah medical (as described above)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110680390","display_name":"Joseph Feldman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph Feldman","raw_affiliation_strings":["Authors contributions: All investigators participated in the original study conception and approval of the protocol. All authors recruited patients into the study at their study sites. NIS led the initiative and conducted the primary data analysis and interpretation. PCH and NIS drafted the primary manuscript and all authors reviewed the manuscript and gave critical input","The author reports no conflicts of interest. Since this was an industry sponsored trial, all authors received research funding from Cheetah medical (as described above)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors contributions: All investigators participated in the original study conception and approval of the protocol. All authors recruited patients into the study at their study sites. NIS led the initiative and conducted the primary data analysis and interpretation. PCH and NIS drafted the primary manuscript and all authors reviewed the manuscript and gave critical input","institution_ids":[]},{"raw_affiliation_string":"The author reports no conflicts of interest. Since this was an industry sponsored trial, all authors received research funding from Cheetah medical (as described above)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054668121","display_name":"Peter S. Pang","orcid":"https://orcid.org/0000-0003-3444-2811","observed_orcids":["https://orcid.org/0000-0003-3444-2811"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter S. Pang","raw_affiliation_strings":["Authors contributions: All investigators participated in the original study conception and approval of the protocol. All authors recruited patients into the study at their study sites. NIS led the initiative and conducted the primary data analysis and interpretation. PCH and NIS drafted the primary manuscript and all authors reviewed the manuscript and gave critical input","The author reports no conflicts of interest. Since this was an industry sponsored trial, all authors received research funding from Cheetah medical (as described above)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors contributions: All investigators participated in the original study conception and approval of the protocol. All authors recruited patients into the study at their study sites. NIS led the initiative and conducted the primary data analysis and interpretation. PCH and NIS drafted the primary manuscript and all authors reviewed the manuscript and gave critical input","institution_ids":[]},{"raw_affiliation_string":"The author reports no conflicts of interest. Since this was an industry sponsored trial, all authors received research funding from Cheetah medical (as described above)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075234555","display_name":"Jeffrey D. Sankoff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey Sankoff","raw_affiliation_strings":["Authors contributions: All investigators participated in the original study conception and approval of the protocol. All authors recruited patients into the study at their study sites. NIS led the initiative and conducted the primary data analysis and interpretation. PCH and NIS drafted the primary manuscript and all authors reviewed the manuscript and gave critical input","The author reports no conflicts of interest. Since this was an industry sponsored trial, all authors received research funding from Cheetah medical (as described above)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors contributions: All investigators participated in the original study conception and approval of the protocol. All authors recruited patients into the study at their study sites. NIS led the initiative and conducted the primary data analysis and interpretation. PCH and NIS drafted the primary manuscript and all authors reviewed the manuscript and gave critical input","institution_ids":[]},{"raw_affiliation_string":"The author reports no conflicts of interest. Since this was an industry sponsored trial, all authors received research funding from Cheetah medical (as described above)","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bruce M. Lo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruce M. Lo","raw_affiliation_strings":["Authors contributions: All investigators participated in the original study conception and approval of the protocol. All authors recruited patients into the study at their study sites. NIS led the initiative and conducted the primary data analysis and interpretation. PCH and NIS drafted the primary manuscript and all authors reviewed the manuscript and gave critical input","The author reports no conflicts of interest. Since this was an industry sponsored trial, all authors received research funding from Cheetah medical (as described above)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors contributions: All investigators participated in the original study conception and approval of the protocol. All authors recruited patients into the study at their study sites. NIS led the initiative and conducted the primary data analysis and interpretation. PCH and NIS drafted the primary manuscript and all authors reviewed the manuscript and gave critical input","institution_ids":[]},{"raw_affiliation_string":"The author reports no conflicts of interest. Since this was an industry sponsored trial, all authors received research funding from Cheetah medical (as described above)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025142355","display_name":"Howard I Dickey-White","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Howard Dickey-White","raw_affiliation_strings":["Authors contributions: All investigators participated in the original study conception and approval of the protocol. All authors recruited patients into the study at their study sites. NIS led the initiative and conducted the primary data analysis and interpretation. PCH and NIS drafted the primary manuscript and all authors reviewed the manuscript and gave critical input","The author reports no conflicts of interest. Since this was an industry sponsored trial, all authors received research funding from Cheetah medical (as described above)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors contributions: All investigators participated in the original study conception and approval of the protocol. All authors recruited patients into the study at their study sites. NIS led the initiative and conducted the primary data analysis and interpretation. PCH and NIS drafted the primary manuscript and all authors reviewed the manuscript and gave critical input","institution_ids":[]},{"raw_affiliation_string":"The author reports no conflicts of interest. Since this was an industry sponsored trial, all authors received research funding from Cheetah medical (as described above)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055290002","display_name":"Robert Birkhahn","orcid":"https://orcid.org/0000-0001-8486-7741","observed_orcids":["https://orcid.org/0000-0001-8486-7741"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert H. Birkhahn","raw_affiliation_strings":["Authors contributions: All investigators participated in the original study conception and approval of the protocol. All authors recruited patients into the study at their study sites. NIS led the initiative and conducted the primary data analysis and interpretation. PCH and NIS drafted the primary manuscript and all authors reviewed the manuscript and gave critical input","The author reports no conflicts of interest. Since this was an industry sponsored trial, all authors received research funding from Cheetah medical (as described above)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors contributions: All investigators participated in the original study conception and approval of the protocol. All authors recruited patients into the study at their study sites. NIS led the initiative and conducted the primary data analysis and interpretation. PCH and NIS drafted the primary manuscript and all authors reviewed the manuscript and gave critical input","institution_ids":[]},{"raw_affiliation_string":"The author reports no conflicts of interest. Since this was an industry sponsored trial, all authors received research funding from Cheetah medical (as described above)","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039748898","display_name":"Nathan Ivan Shapiro","orcid":"https://orcid.org/0000-0003-3508-4390","observed_orcids":["https://orcid.org/0000-0003-3508-4390"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan I. Shapiro","raw_affiliation_strings":["Address reprint requests to Nathan I. Shapiro, MD, MPH, Beth Israel Deaconess Medical Center, 1 Deaconess Road, CC2-W, Boston, MA 02215. E-mail: [email\u00a0protected]","Authors contributions: All investigators participated in the original study conception and approval of the protocol. All authors recruited patients into the study at their study sites. NIS led the initiative and conducted the primary data analysis and interpretation. PCH and NIS drafted the primary manuscript and all authors reviewed the manuscript and gave critical input","The author reports no conflicts of interest. Since this was an industry sponsored trial, all authors received research funding from Cheetah medical (as described above)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Address reprint requests to Nathan I. Shapiro, MD, MPH, Beth Israel Deaconess Medical Center, 1 Deaconess Road, CC2-W, Boston, MA 02215. E-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I1316535847"]},{"raw_affiliation_string":"Authors contributions: All investigators participated in the original study conception and approval of the protocol. All authors recruited patients into the study at their study sites. NIS led the initiative and conducted the primary data analysis and interpretation. PCH and NIS drafted the primary manuscript and all authors reviewed the manuscript and gave critical input","institution_ids":[]},{"raw_affiliation_string":"The author reports no conflicts of interest. Since this was an industry sponsored trial, all authors received research funding from Cheetah medical (as described above)","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1858,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.86500875,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"46","issue":"2","first_page":"132","last_page":"138"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.5917999744415283,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.5917999744415283,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.4059999883174896,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12333","display_name":"Abdominal Surgery and Complications","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.859000027179718},{"id":"https://openalex.org/keywords/fluid-responsiveness","display_name":"fluid responsiveness","score":0.9909999966621399},{"id":"https://openalex.org/keywords/noninvasive-cardiac-output-monitoring","display_name":"noninvasive cardiac output monitoring","score":0.8220000267028809},{"id":"https://openalex.org/keywords/fluid-resuscitation","display_name":"fluid resuscitation","score":0.8579999804496765},{"id":"https://openalex.org/keywords/organ-dysfunction","display_name":"organ dysfunction","score":0.7860000133514404},{"id":"https://openalex.org/keywords/sofa-score","display_name":"SOFA score","score":0.9319999814033508},{"id":"https://openalex.org/keywords/emergency-department","display_name":"emergency department","score":0.5199999809265137},{"id":"https://openalex.org/keywords/lactate","display_name":"lactate","score":0.7630000114440918},{"id":"https://openalex.org/keywords/preload","display_name":"preload","score":0.4269999861717224},{"id":"https://openalex.org/keywords/fluid-bolus","display_name":"fluid bolus","score":0.6700000166893005},{"id":"https://openalex.org/keywords/early-goal-directed-therapy","display_name":"early goal-directed therapy","score":0.5609999895095825},{"id":"https://openalex.org/keywords/underpowered-trials","display_name":"underpowered trials","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.891879141330719},{"id":"https://openalex.org/C2776494729","wikidata":"https://www.wikidata.org/wiki/Q1848900","display_name":"Contraindication","level":3,"score":0.6611265540122986},{"id":"https://openalex.org/C48277249","wikidata":"https://www.wikidata.org/wiki/Q1406926","display_name":"Preload","level":3,"score":0.6464393138885498},{"id":"https://openalex.org/C2778165595","wikidata":"https://www.wikidata.org/wiki/Q5491454","display_name":"Resuscitation","level":2,"score":0.643704891204834},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.5814778804779053},{"id":"https://openalex.org/C2777465075","wikidata":"https://www.wikidata.org/wiki/Q7392039","display_name":"SOFA score","level":3,"score":0.5432445406913757},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5342038869857788},{"id":"https://openalex.org/C195646399","wikidata":"https://www.wikidata.org/wiki/Q6058580","display_name":"Intravascular volume status","level":3,"score":0.4665603041648865},{"id":"https://openalex.org/C80461066","wikidata":"https://www.wikidata.org/wiki/Q1698533","display_name":"Stroke volume","level":4,"score":0.4632047414779663},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.42721447348594666},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.4256740212440491},{"id":"https://openalex.org/C2778426790","wikidata":"https://www.wikidata.org/wiki/Q1649580","display_name":"Organ dysfunction","level":3,"score":0.41211652755737305},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39989861845970154},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3961753845214844},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.35981065034866333},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.3291815519332886},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.1211070716381073},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002302","descriptor_name":"Cardiac Output","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004636","descriptor_name":"Emergency Service, Hospital","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005440","descriptor_name":"Fluid Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008991","descriptor_name":"Monitoring, Physiologic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D013318","descriptor_name":"Stroke Volume","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015337","descriptor_name":"Multicenter Studies as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1097/shk.0000000000000564","doi":"https://doi.org/10.1097/shk.0000000000000564","is_oa":true,"landing_page_url":"https://doi.org/10.1097/shk.0000000000000564","pdf_url":null,"source":{"id":"https://openalex.org/S174819509","display_name":"Shock","issn_l":"1073-2322","issn":["1073-2322","1540-0514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3933808","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4957967","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4957967","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4957967","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock","raw_type":"Text"},{"id":"pmid:26925867","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26925867","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock (Augusta, Ga.)","raw_type":"Journal Article"},{"id":"pmh:oai:dash.harvard.edu:1/29002399","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:29002399","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:scholarworks.indianapolis.iu.edu:1805/12847","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1805/12847","pdf_url":null,"source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"},{"id":"pmh:oai:scholarworks.iupui.edu:1805/12847","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1805/12847","pdf_url":null,"source":{"id":"https://openalex.org/S4306402593","display_name":"Purdue University Indianapolis (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1097/shk.0000000000000564","doi":"https://doi.org/10.1097/shk.0000000000000564","is_oa":true,"landing_page_url":"https://doi.org/10.1097/shk.0000000000000564","pdf_url":null,"source":{"id":"https://openalex.org/S174819509","display_name":"Shock","issn_l":"1073-2322","issn":["1073-2322","1540-0514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1983589225","https://openalex.org/W1987265446","https://openalex.org/W2006693793","https://openalex.org/W2010753973","https://openalex.org/W2049927822","https://openalex.org/W2053326844","https://openalex.org/W2057516105","https://openalex.org/W2062308880","https://openalex.org/W2090684346","https://openalex.org/W2106542431","https://openalex.org/W2133742416","https://openalex.org/W2135014153","https://openalex.org/W2147561122","https://openalex.org/W2160691650","https://openalex.org/W2170704093"],"related_works":["https://openalex.org/W3154027681","https://openalex.org/W2181346571","https://openalex.org/W4395014903","https://openalex.org/W2930612297","https://openalex.org/W2535584340","https://openalex.org/W2581987711","https://openalex.org/W2890636223","https://openalex.org/W7220425633","https://openalex.org/W3001703450","https://openalex.org/W4406300316"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Fluid":[1],"responsiveness":[2,28,39,81,93,279,284],"is":[3],"proposed":[4],"as":[5],"a":[6,26,37,43,109,148,264,277],"physiology-based":[7],"method":[8],"to":[9,23,60,75,89,101,147],"titrate":[10],"fluid":[11,27,38,77,80,92,104,278,283],"therapy":[12],"based":[13],"on":[14],"preload":[15],"dependence.":[16],"The":[17],"objectives":[18],"of":[19,33,108,190,197,202,263,273,289,293],"this":[20,261],"study":[21,262],"were":[22,157,166],"determine":[24],"if":[25],"protocol":[29,40,82,244,285],"would":[30,41],"decrease":[31],"progression":[32,272],"organ":[34,274],"dysfunction,":[35],"and":[36,57,73,298],"facilitate":[42,287],"more":[44,69,240],"aggressive":[45,76],"resuscitation.":[46,78],"METHODS:":[47],"Prospective,":[48],"10-center,":[49],"randomized":[50],"interventional":[51],"trial.":[52],"INCLUSION":[53],"CRITERIA:":[54],"suspected":[55],"sepsis":[56],"lactate":[58],"2.0":[59],"4.0":[61],"mmol/L.":[62],"Exclusion":[63],"criteria":[64],"(abbreviated):":[65],"systolic":[66],"blood":[67],"pressure":[68],"than":[70],"90":[71],"mmHg,":[72],"contraindication":[74],"INTERVENTION:":[79],"using":[83],"Non-Invasive":[84],"Cardiac":[85],"Output":[86],"Monitor":[87],"(NICOM)":[88],"assess":[90],"for":[91,184],"(>10%":[94],"increase":[95,198],"in":[96,99,112,121,150,161,172,195,199,271],"stroke":[97],"volume":[98,292],"response":[100],"5":[102],"mL/kg":[103],"bolus)":[105],"with":[106,159,276],"balance":[107],"liter":[110],"given":[111],"responsive":[113],"patients.":[114],"CONTROL:":[115],"standard":[116],"clinical":[117],"care.":[118],"OUTCOMES:":[119],"primary-change":[120],"Sepsis-related":[122],"Organ":[123],"Failure":[124],"Assessment":[125],"(SOFA)":[126],"score":[127,201],"at":[128,140,203],"least":[129,204],"1":[130,205],"over":[131],"72":[132],"h;":[133],"secondary-fluids":[134],"administered.":[135],"Trial":[136],"was":[137,192,268],"initially":[138],"powered":[139,297],"600":[141],"patients,":[142],"but":[143],"stopped":[144],"early":[145],"due":[146],"change":[149,270],"sponsor's":[151],"funding":[152],"priorities.":[153],"RESULTS:":[154],"Sixty-four":[155],"patients":[156,238],"enrolled":[158,299],"32":[160],"the":[162,243],"treatment":[163,187,237],"arm.":[164],"There":[165],"no":[167,193,269],"significant":[168],"differences":[169],"between":[170],"arms":[171],"age,":[173],"comorbidities,":[174],"baseline":[175],"vital":[176],"signs,":[177],"or":[178,216],"SOFA":[179,200],"scores":[180],"(P":[181,233,256],">":[182],"0.05":[183],"all).":[185],"Comparing":[186],"versus":[188],"Standard":[189],"Care-there":[191],"difference":[194],"proportion":[196],"point":[206],"(30%":[207],"vs.":[208,227,250],"33%)":[209],"(note":[210],"bene":[211],"underpowered,":[212],"P":[213],"=":[214,234],"1.0)":[215],"mean":[217],"preprotocol":[218],"fluids":[219,241],"1,050":[220],"mL":[221,229,246,252],"(95%":[222,230],"confidence":[223],"interval":[224],"[CI]:":[225],"786-1,314)":[226],"1,031":[228],"CI:":[231,248,254],"741-1,325)":[232],"0.93);":[235],"however,":[236],"received":[239],"during":[242],"(2,633":[245],"[95%":[247,253],"2,264-3,001]":[249],"1,002":[251],"707-1,298])":[255],"<":[257],"0.001).":[258],"CONCLUSIONS:":[259],"In":[260],"\"preshock\"":[265],"population,":[266],"there":[267],"dysfunction":[275],"protocol.":[280],"A":[281],"noninvasive":[282],"did":[286],"delivery":[288],"an":[290],"increased":[291],"fluid.":[294],"Additional":[295],"properly":[296],"outcomes":[300],"studies":[301],"are":[302],"needed.":[303]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}