{"id":"https://openalex.org/W2291279429","doi":null,"title":"Charakterisierung der molekularen Mechanismen der Aktivierung des Ras-spezifischen Austauschfaktors RasGRP3 durch den EGF-Rezeptor","display_name":"Charakterisierung der molekularen Mechanismen der Aktivierung des Ras-spezifischen Austauschfaktors RasGRP3 durch den EGF-Rezeptor","publication_year":2007,"publication_date":"2007-01-05","ids":{"openalex":"https://openalex.org/W2291279429","mag":"2291279429"},"language":"de","primary_location":{"id":"pmh:oai:duepublico.uni-duisburg-essen.de:14715","doi":null,"is_oa":true,"landing_page_url":"http://duepublico.uni-duisburg-essen.de/servlets/DocumentServlet?id=14715","pdf_url":"http://duepublico.uni-duisburg-essen.de/servlets/DerivateServlet/Derivate-16029/Dissertation.pdf","source":{"id":"https://openalex.org/S4306400212","display_name":"DuEPublico (University of Duisburg-Essen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62318514","host_organization_name":"University of Duisburg-Essen","host_organization_lineage":["https://openalex.org/I62318514"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Wissenschaftliche Abschlussarbeiten \u00bb Dissertation"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://duepublico.uni-duisburg-essen.de/servlets/DerivateServlet/Derivate-16029/Dissertation.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054081371","display_name":"Daniel Szatkowski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Daniel Szatkowski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5054081371"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18308761,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rasgrp3","display_name":"RasGRP3","score":0.984000027179718},{"id":"https://openalex.org/keywords/rasgrp1","display_name":"RasGRP1","score":0.7490000128746033},{"id":"https://openalex.org/keywords/rasgrp2","display_name":"RASGRP2","score":0.9890000224113464},{"id":"https://openalex.org/keywords/egf-receptor","display_name":"EGF receptor","score":0.7979999780654907},{"id":"https://openalex.org/keywords/phospholipase-c-epsilon","display_name":"phospholipase C epsilon","score":0.8859999775886536},{"id":"https://openalex.org/keywords/rap2b","display_name":"Rap2B","score":0.8100000023841858},{"id":"https://openalex.org/keywords/guanine-nucleotide-exchange-factor","display_name":"guanine nucleotide exchange factor","score":0.7419999837875366},{"id":"https://openalex.org/keywords/ras-like-gtpases","display_name":"Ras-related GTPases","score":0.7649999856948853},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinase-signaling","display_name":"receptor tyrosine kinase signaling","score":0.8650000095367432},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.625},{"id":"https://openalex.org/keywords/diacylglycerol","display_name":"diacylglycerol","score":0.9399999976158142},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.8960000276565552},{"id":"https://openalex.org/keywords/plcgamma1","display_name":"PLC\u03b31","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.779059112071991},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.7227640151977539},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14576196670532227}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:duepublico.uni-duisburg-essen.de:14715","doi":null,"is_oa":true,"landing_page_url":"http://duepublico.uni-duisburg-essen.de/servlets/DocumentServlet?id=14715","pdf_url":"http://duepublico.uni-duisburg-essen.de/servlets/DerivateServlet/Derivate-16029/Dissertation.pdf","source":{"id":"https://openalex.org/S4306400212","display_name":"DuEPublico (University of Duisburg-Essen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62318514","host_organization_name":"University of Duisburg-Essen","host_organization_lineage":["https://openalex.org/I62318514"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Wissenschaftliche Abschlussarbeiten \u00bb Dissertation"},{"id":"pmh:oai:duepublico2.uni-due.de:duepublico_mods_00014715","doi":null,"is_oa":true,"landing_page_url":"https://nbn-resolving.org/urn:nbn:de:hbz:465-20070124-152113-6","pdf_url":"https://duepublico2.uni-due.de/servlets/MCRFileNodeServlet/duepublico_derivate_00016029/Dissertation.pdf","source":{"id":"https://openalex.org/S4306400212","display_name":"DuEPublico (University of Duisburg-Essen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62318514","host_organization_name":"University of Duisburg-Essen","host_organization_lineage":["https://openalex.org/I62318514"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"dissertation"},{"id":"pmh:oai:bibliographie.ub.uni-due.de:ubo_mods_00002339","doi":null,"is_oa":false,"landing_page_url":"https://primo.uni-due.de/discovery/search?tab=Everything&search_scope=MyInst_and_CI_custom&vid=49HBZ_UDE:UDE&lang=de&offset=0&query=holding_call_number,exact,%22ZZX655091%22","pdf_url":null,"source":{"id":"https://openalex.org/S7407055102","display_name":"Universit\u00e4tsbibliographie, Universit\u00e4t Duisburg-Essen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"dissertation"},{"id":"mag:2291279429","doi":null,"is_oa":false,"landing_page_url":"https://duepublico.uni-duisburg-essen.de/servlets/DerivateServlet/Derivate-16029/Dissertation.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:duepublico.uni-duisburg-essen.de:14715","doi":null,"is_oa":true,"landing_page_url":"http://duepublico.uni-duisburg-essen.de/servlets/DocumentServlet?id=14715","pdf_url":"http://duepublico.uni-duisburg-essen.de/servlets/DerivateServlet/Derivate-16029/Dissertation.pdf","source":{"id":"https://openalex.org/S4306400212","display_name":"DuEPublico (University of Duisburg-Essen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62318514","host_organization_name":"University of Duisburg-Essen","host_organization_lineage":["https://openalex.org/I62318514"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Wissenschaftliche Abschlussarbeiten \u00bb Dissertation"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2291279429.pdf","grobid_xml":"https://content.openalex.org/works/W2291279429.grobid-xml"},"referenced_works_count":96,"referenced_works":["https://openalex.org/W20371925","https://openalex.org/W1481594784","https://openalex.org/W1486102976","https://openalex.org/W1492821183","https://openalex.org/W1511208409","https://openalex.org/W1519384361","https://openalex.org/W1547589333","https://openalex.org/W1599277155","https://openalex.org/W1627976720","https://openalex.org/W1630258713","https://openalex.org/W1654777050","https://openalex.org/W1767727568","https://openalex.org/W1832453319","https://openalex.org/W1884928912","https://openalex.org/W1953109900","https://openalex.org/W1958742527","https://openalex.org/W1965608446","https://openalex.org/W1966018982","https://openalex.org/W1971275530","https://openalex.org/W1971290197","https://openalex.org/W1971731547","https://openalex.org/W1972974751","https://openalex.org/W1973189139","https://openalex.org/W1975362204","https://openalex.org/W1975777705","https://openalex.org/W1979027806","https://openalex.org/W1979197786","https://openalex.org/W1980848219","https://openalex.org/W1983657784","https://openalex.org/W1984670510","https://openalex.org/W1986807291","https://openalex.org/W1986861517","https://openalex.org/W1993230013","https://openalex.org/W1994935528","https://openalex.org/W1996294295","https://openalex.org/W2001916228","https://openalex.org/W2002494433","https://openalex.org/W2003130852","https://openalex.org/W2004686233","https://openalex.org/W2004872546","https://openalex.org/W2006455216","https://openalex.org/W2017619080","https://openalex.org/W2017996683","https://openalex.org/W2018324622","https://openalex.org/W2019410656","https://openalex.org/W2020674613","https://openalex.org/W2023608012","https://openalex.org/W2028415754","https://openalex.org/W2029149519","https://openalex.org/W2033334272","https://openalex.org/W2039629780","https://openalex.org/W2045294455","https://openalex.org/W2050717506","https://openalex.org/W2051152907","https://openalex.org/W2054746739","https://openalex.org/W2063968553","https://openalex.org/W2066859825","https://openalex.org/W2073816668","https://openalex.org/W2074480647","https://openalex.org/W2077109125","https://openalex.org/W2077166985","https://openalex.org/W2079853404","https://openalex.org/W2086776394","https://openalex.org/W2087519729","https://openalex.org/W2093755587","https://openalex.org/W2095687368","https://openalex.org/W2096549360","https://openalex.org/W2097939257","https://openalex.org/W2100399825","https://openalex.org/W2100837269","https://openalex.org/W2101108802","https://openalex.org/W2104812730","https://openalex.org/W2111204400","https://openalex.org/W2111778006","https://openalex.org/W2113786709","https://openalex.org/W2117029515","https://openalex.org/W2118399632","https://openalex.org/W2118995428","https://openalex.org/W2121401590","https://openalex.org/W2128635872","https://openalex.org/W2131566341","https://openalex.org/W2132021366","https://openalex.org/W2134537331","https://openalex.org/W2141260882","https://openalex.org/W2144634347","https://openalex.org/W2152450220","https://openalex.org/W2157497390","https://openalex.org/W2157621939","https://openalex.org/W2165001829","https://openalex.org/W2165478978","https://openalex.org/W2167629420","https://openalex.org/W2168476632","https://openalex.org/W2169960679","https://openalex.org/W2170355588","https://openalex.org/W2418071088","https://openalex.org/W2425190918"],"related_works":["https://openalex.org/W7132003176","https://openalex.org/W7095968745","https://openalex.org/W7132200970","https://openalex.org/W3143176811","https://openalex.org/W6983805231","https://openalex.org/W7095384155","https://openalex.org/W3139033453","https://openalex.org/W2920580513","https://openalex.org/W2029149519","https://openalex.org/W2935709826"],"abstract_inverted_index":{"In":[0],"der":[1,7,42,55,89,104,113,133,243,259,278],"vorliegenden":[2],"Arbeit":[3,253],"wurde":[4],"die":[5,11,28,44,48,78,83,86,92,96,118,128,138,157,162,181,189,212,218,250,261],"Rezeptor-Tyrosinkinase-Regulation":[6],"Phospholipase":[8],"C-\u03b5":[9],"(PLC-\u03b5),":[10],"von":[12,60,65,76,80,98,142,159,175,191,195,224,237,263,269],"Ras-":[13],"und":[14,37,62,73,85,107,161,178,246,267],"Rho-\u00e4hnlichen":[15],"GTPasen":[16,57],"kontrolliert":[17],"wird,":[18],"in":[19,120,199,203,231,239,251],"HEK-293-Zellen":[20],"n\u00e4her":[21],"untersucht.":[22],"Diese":[23],"Zellen":[24],"exprimieren":[25],"den":[26,40,165],"an":[27,82,91],"PLC-\u03b5-gekoppelten":[29],"Epidermal":[30],"Growth":[31],"Factor":[32],"(EGF)-Rezeptor":[33],"endogen.":[34],"Die":[35,140,167,221,235],"PLC-":[36],"Ca2+-Signal\u00fcbertragung":[38],"durch":[39,53,63,102,108,164,211,217,228,271],"EGF-Rezeptor,":[41],"sowohl":[43,198],"PLC-\u03b31":[45,114],"als":[46,201],"auch":[47,202],"PLC-\u03b5":[49,84,90,119,134,279],"aktiviert,":[50],"wird":[51,95,208],"spezifisch":[52],"Inaktivierung":[54],"Ras-verwandten":[56],"mit":[58,242],"Toxinen":[59],"Clostridium-Spezies":[61],"Expression":[64,109,129,141,168],"dominant-negativem":[66],"Rap2B":[67,81,99,124,160,264],"unterdr\u00fcckt.":[68],"EGF":[69,187],"bewirkt":[70],"eine":[71],"schnelle":[72],"anhaltende":[74],"GTP-Beladung":[75,97,158],"Rap2B,":[77],"Bindung":[79],"Rap2B-abh\u00e4ngige":[87],"Translokation":[88],"Plasmamembran.":[93],"Zwar":[94],"nach":[100,183],"EGF-Stimulation":[101],"Chelatbildung":[103],"intrazellul\u00e4ren":[105],"Ca2+-Ionen":[106],"einer":[110,130],"Lipase-inaktiven":[111,131],"Mutante":[112,132],"gehemmt,":[115],"aber":[116,193],"weil":[117],"dem":[121],"beschriebenen":[122],"Signalweg":[123],"nachgeschaltet":[125],"ist,":[126],"hatte":[127],"keinen":[135],"Einfluss":[136],"auf":[137],"Rap2B-Aktivierung.":[139],"RasGRP3":[143,209,226,270],"(Ras":[144],"Guanine":[145],"nucleotide":[146],"Releasing":[147],"Protein":[148],"3),":[149],"einem":[150],"Ca2+/Diacylglycerol-regulierten":[151],"Guaninnukleotid-Austauschfaktor":[152],"f\u00fcr":[153,171],"Ras-\u00e4hnliche":[154,172],"GTPasen,":[155,173],"verst\u00e4rkte":[156],"PLC-/Ca2+-Signal\u00fcbertragung":[163],"EGF-Rezeptor.":[166],"anderer":[169],"Austauschfaktoren":[170],"insbesondere":[174],"RasGRP":[176],"1":[177],"2,":[179],"konnte":[180,227],"Rap2B-Aktivierung":[182,245],"EGF-Rezeptor-Stimulation":[184],"nicht":[185,194,210],"beeinflussen.":[186],"induziert":[188],"Tyrosinphosphorylierung":[190,223,268],"RasGRP3,":[192],"RasGRP1.":[196],"Wie":[197],"vivo":[200,240],"vitro":[204,232],"gezeigt":[205],"werden":[206],"konnte,":[207],"EGF-Rezeptor-Tyrosinkinase":[213],"selbst":[214],"phosphoryliert,":[215],"sondern":[216],"Nicht-Rezeptor-Tyrosinkinase":[219],"c-Src.":[220],"direkte":[222],"rekombinantem":[225],"rekombinantes":[229],"Src":[230],"nachgewiesen":[233],"werden.":[234],"Hemmung":[236],"c-Src":[238,272],"interferiert":[241],"EGF-induzierten":[244],"PLC-Stimulation.":[247],"Zusammengefasst":[248],"weisen":[249],"dieser":[252],"gezeigten":[254],"Ergebnisse":[255],"darauf":[256],"hin,":[257],"dass":[258],"EGF-Rezeptor":[260],"Aktivierung":[262],"via":[265],"PLC-\u03b31-Aktivierung":[266],"triggert,":[273],"was":[274],"schlie\u00dflich":[275],"zur":[276],"Stimulation":[277],"f\u00fchrt.":[280]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
