{"id":"https://openalex.org/W2291265736","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.601.12","title":"Soleus muscle of Down syndrome (Ds) mice does not exhibit impaired contractile function or resistance to fatigue","display_name":"Soleus muscle of Down syndrome (Ds) mice does not exhibit impaired contractile function or resistance to fatigue","publication_year":2009,"publication_date":"2009-04-01","ids":{"openalex":"https://openalex.org/W2291265736","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.601.12","mag":"2291265736"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.23.1_supplement.601.12","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.601.12","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.23.1_supplement.601.12","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010814330","display_name":"Patrick M. Cowley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I70983195","display_name":"Syracuse University","ror":"https://ror.org/025r5qe02","country_code":"US","type":"education","lineage":["https://openalex.org/I70983195"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick M Cowley","raw_affiliation_strings":["Department of Exercise Science, Syracuse University, Syracuse, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Exercise Science, Syracuse University, Syracuse, NY","institution_ids":["https://openalex.org/I70983195"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076743567","display_name":"Keith C. DeRuisseau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I70983195","display_name":"Syracuse University","ror":"https://ror.org/025r5qe02","country_code":"US","type":"education","lineage":["https://openalex.org/I70983195"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith C DeRuisseau","raw_affiliation_strings":["Department of Exercise Science, Syracuse University, Syracuse, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Exercise Science, Syracuse University, Syracuse, NY","institution_ids":["https://openalex.org/I70983195"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I70983195"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.21581856,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.6166999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.6166999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11015","display_name":"Down syndrome and intellectual disability research","score":0.3698999881744385,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/down-syndrome","display_name":"Down syndrome","score":0.9950000047683716},{"id":"https://openalex.org/keywords/ts65dn-mice","display_name":"Ts65Dn mouse model","score":0.906000018119812},{"id":"https://openalex.org/keywords/soleus-muscle","display_name":"soleus muscle","score":0.8190000057220459},{"id":"https://openalex.org/keywords/skeletal-muscle-contractile-function","display_name":"skeletal muscle contractile function","score":0.9039999842643738},{"id":"https://openalex.org/keywords/muscle-fatigue","display_name":"muscle fatigue","score":0.6349999904632568},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7620000243186951},{"id":"https://openalex.org/keywords/cu-zn-superoxide-dismutase","display_name":"Cu/Zn superoxide dismutase","score":0.871999979019165},{"id":"https://openalex.org/keywords/muscular-endurance","display_name":"muscular endurance","score":0.652999997138977},{"id":"https://openalex.org/keywords/intellectual-disability","display_name":"intellectual disability","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C2776874296","wikidata":"https://www.wikidata.org/wiki/Q6940317","display_name":"Muscle fatigue","level":3,"score":0.6272087693214417},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6237612366676331},{"id":"https://openalex.org/C2776104385","wikidata":"https://www.wikidata.org/wiki/Q1954164","display_name":"Soleus muscle","level":3,"score":0.590094268321991},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5680320858955383},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.5440463423728943},{"id":"https://openalex.org/C2776050358","wikidata":"https://www.wikidata.org/wiki/Q127006","display_name":"Muscle contraction","level":2,"score":0.4448852837085724},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4340086579322815},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3948618173599243},{"id":"https://openalex.org/C2777515770","wikidata":"https://www.wikidata.org/wiki/Q507369","display_name":"Electromyography","level":2,"score":0.22509172558784485},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.1865256130695343}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.23.1_supplement.601.12","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.601.12","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.23.1_supplement.601.12","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2112661596","https://openalex.org/W156789766","https://openalex.org/W2734261161","https://openalex.org/W1978784549","https://openalex.org/W7034362771","https://openalex.org/W1588980714","https://openalex.org/W2119691405","https://openalex.org/W2804810729","https://openalex.org/W2514116634","https://openalex.org/W2087800763"],"abstract_inverted_index":{"Individuals":[0],"with":[1,16],"Ds":[2,22,62],"perform":[3],"poorly":[4],"on":[5,104],"tests":[6],"of":[7,19,34,38,52,61,189,198,204],"neuromuscular":[8],"strength":[9],"compared":[10],"to":[11,79,97,131,148,185],"other":[12],"individuals,":[13],"including":[14],"those":[15],"different":[17],"forms":[18],"intellectual":[20],"disability.":[21],"individuals":[23],"also":[24],"exhibit":[25,90,176],"oxidative":[26],"stress":[27],"(OS),":[28],"which":[29,69,181],"may":[30],"be":[31],"the":[32,50,64,133,154,186],"result":[33],"triplication":[35],"and":[36,95,113,138],"over\u2010expression":[37],"copper\u2010zinc":[39],"superoxide":[40],"dismutase":[41],"(CuZnSOD)":[42],"that":[43,86,171],"could":[44],"play":[45],"a":[46],"causative":[47],"role":[48],"in":[49,119,153,183],"etiology":[51],"their":[53],"muscle":[54,81,92,101,178,197],"dysfunction.":[55],"A":[56],"well":[57],"established":[58],"mouse":[59],"model":[60],"is":[63,70,182],"Ts(17":[65],"16":[66],")65Dn":[67],"(Ts65Dn)":[68],"segmental":[71],"trisomic":[72],"for":[73,145],"CuZnSOD.":[74],"Since":[75],"OS":[76],"can":[77],"lead":[78],"skeletal":[80,177],"contractile":[82,102,179],"dysfunction,":[83,180],"we":[84],"hypothesized":[85],"Ts65Dn":[87,110,172,199],"mice":[88,112,173,200],"would":[89],"impaired":[91],"force":[93,134],"production":[94],"resistance":[96],"fatigue.":[98],"We":[99,191],"performed":[100],"measurements":[103],"soleus":[105,196],"muscles":[106],"obtained":[107],"from":[108,164],"male":[109],"(n=5)":[111,116],"wild\u2010type":[114],"controls":[115],"using":[117],"an":[118],"vitro":[120],"preparation.":[121],"Muscles":[122],"were":[123],"stimulated":[124],"between":[125],"1\u2010300Hz":[126],"(500\u2010ms":[127,141],"trains;":[128,142],"0.5\u2010ms":[129,143],"pulse)":[130,144],"examine":[132],"frequency":[135],"response":[136],"(FFR)":[137],"at":[139],"40Hz":[140],"5":[146],"minutes":[147],"study":[149],"endurance.":[150],"No":[151],"difference":[152],"FFR,":[155],"maximal":[156],"or":[157,162],"submaximal":[158],"specific":[159],"tension,":[160],"endurance,":[161],"recovery":[163],"fatigue":[165],"was":[166],"detected.":[167],"These":[168],"findings":[169],"suggest":[170],"do":[174],"not":[175],"contrast":[184],"human":[187],"phenotype":[188],"DS.":[190],"are":[192],"currently":[193],"investigating":[194],"if":[195],"exhibits":[201],"elevated":[202],"markers":[203],"OS.":[205],"Support:":[206],"Syracuse":[207],"University":[208],"SOE":[209]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}