{"id":"https://openalex.org/W2291245029","doi":null,"title":"Charakterisierung der Funktion des Transkriptionsfaktors Gfi1 w\u00e4hrend der T-Zell-vermittelten Immunantwort in Gfi1-defizienten M\u00e4usen","display_name":"Charakterisierung der Funktion des Transkriptionsfaktors Gfi1 w\u00e4hrend der T-Zell-vermittelten Immunantwort in Gfi1-defizienten M\u00e4usen","publication_year":2006,"publication_date":"2006-01-30","ids":{"openalex":"https://openalex.org/W2291245029","mag":"2291245029"},"language":"de","primary_location":{"id":"pmh:oai:duepublico.uni-duisburg-essen.de:12624","doi":null,"is_oa":true,"landing_page_url":"http://duepublico.uni-duisburg-essen.de/servlets/DocumentServlet?id=12624","pdf_url":"http://duepublico.uni-duisburg-essen.de/servlets/DocumentServlet?id=12624","source":{"id":"https://openalex.org/S4306400212","display_name":"DuEPublico (University of Duisburg-Essen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62318514","host_organization_name":"University of Duisburg-Essen","host_organization_lineage":["https://openalex.org/I62318514"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Wissenschaftliche Abschlussarbeiten \u00bb Dissertation"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://duepublico.uni-duisburg-essen.de/servlets/DocumentServlet?id=12624","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034160052","display_name":"Denise Pargmann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Denise Pargmann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5034160052"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.19960852,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gfi1","display_name":"GFI1","score":0.9819999933242798},{"id":"https://openalex.org/keywords/zinc-finger-transcription-factor","display_name":"zinc finger transcription factor","score":0.9340000152587891},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.7200000286102295},{"id":"https://openalex.org/keywords/t-cell-mediated-immunity","display_name":"T cell immunity","score":0.6940000057220459},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.800000011920929},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":1.0},{"id":"https://openalex.org/keywords/t-cell-differentiation","display_name":"T cell differentiation","score":0.5600000023841858},{"id":"https://openalex.org/keywords/memory-t-cells","display_name":"memory T cells","score":0.7080000042915344},{"id":"https://openalex.org/keywords/il-7-receptor","display_name":"IL-7 receptor","score":0.824999988079071},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.7260000109672546},{"id":"https://openalex.org/keywords/cell-cycle-progression","display_name":"cell cycle progression","score":0.8569999933242798},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.656000018119812},{"id":"https://openalex.org/keywords/t-cell-survival","display_name":"T cell survival","score":0.6200000047683716},{"id":"https://openalex.org/keywords/t-cell-receptor-activation","display_name":"T cell receptor stimulation","score":0.5740000009536743},{"id":"https://openalex.org/keywords/thymus","display_name":"thymus","score":0.5669999718666077},{"id":"https://openalex.org/keywords/spleen","display_name":"spleen","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.543445885181427},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5248905420303345},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21359750628471375}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:duepublico.uni-duisburg-essen.de:12624","doi":null,"is_oa":true,"landing_page_url":"http://duepublico.uni-duisburg-essen.de/servlets/DocumentServlet?id=12624","pdf_url":"http://duepublico.uni-duisburg-essen.de/servlets/DocumentServlet?id=12624","source":{"id":"https://openalex.org/S4306400212","display_name":"DuEPublico (University of Duisburg-Essen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62318514","host_organization_name":"University of Duisburg-Essen","host_organization_lineage":["https://openalex.org/I62318514"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Wissenschaftliche Abschlussarbeiten \u00bb Dissertation"},{"id":"pmh:oai:duepublico2.uni-due.de:duepublico_mods_00012624","doi":null,"is_oa":true,"landing_page_url":"https://nbn-resolving.org/urn:nbn:de:hbz:465-20060725-133958-8","pdf_url":"https://nbn-resolving.org/urn:nbn:de:hbz:465-20060725-133958-8","source":{"id":"https://openalex.org/S4306400212","display_name":"DuEPublico (University of Duisburg-Essen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62318514","host_organization_name":"University of Duisburg-Essen","host_organization_lineage":["https://openalex.org/I62318514"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"dissertation"},{"id":"pmh:oai:bibliographie.ub.uni-due.de:ubo_mods_00001367","doi":null,"is_oa":false,"landing_page_url":"https://primo.uni-due.de/discovery/search?tab=Everything&search_scope=MyInst_and_CI_custom&vid=49HBZ_UDE:UDE&lang=de&offset=0&query=holding_call_number,exact,%22ZZX651259%22","pdf_url":null,"source":{"id":"https://openalex.org/S7407055102","display_name":"Universit\u00e4tsbibliographie, Universit\u00e4t Duisburg-Essen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"dissertation"},{"id":"mag:2291245029","doi":null,"is_oa":false,"landing_page_url":"https://duepublico2.uni-due.de/receive/duepublico_mods_00012624;lang=en","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:duepublico.uni-duisburg-essen.de:12624","doi":null,"is_oa":true,"landing_page_url":"http://duepublico.uni-duisburg-essen.de/servlets/DocumentServlet?id=12624","pdf_url":"http://duepublico.uni-duisburg-essen.de/servlets/DocumentServlet?id=12624","source":{"id":"https://openalex.org/S4306400212","display_name":"DuEPublico (University of Duisburg-Essen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62318514","host_organization_name":"University of Duisburg-Essen","host_organization_lineage":["https://openalex.org/I62318514"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Wissenschaftliche Abschlussarbeiten \u00bb Dissertation"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2291245029.pdf","grobid_xml":"https://content.openalex.org/works/W2291245029.grobid-xml"},"referenced_works_count":300,"referenced_works":["https://openalex.org/W15081168","https://openalex.org/W16741803","https://openalex.org/W25281948","https://openalex.org/W50615129","https://openalex.org/W169978917","https://openalex.org/W187263029","https://openalex.org/W258316223","https://openalex.org/W303516377","https://openalex.org/W339325769","https://openalex.org/W1482928030","https://openalex.org/W1485596855","https://openalex.org/W1486854793","https://openalex.org/W1487911472","https://openalex.org/W1488377901","https://openalex.org/W1488447572","https://openalex.org/W1490351768","https://openalex.org/W1499206957","https://openalex.org/W1500160410","https://openalex.org/W1504468085","https://openalex.org/W1506642042","https://openalex.org/W1507800008","https://openalex.org/W1509454872","https://openalex.org/W1509514214","https://openalex.org/W1516581843","https://openalex.org/W1518656192","https://openalex.org/W1521515468","https://openalex.org/W1524671781","https://openalex.org/W1525631450","https://openalex.org/W1527612372","https://openalex.org/W1529149321","https://openalex.org/W1529965866","https://openalex.org/W1532194993","https://openalex.org/W1535244363","https://openalex.org/W1535365756","https://openalex.org/W1535548497","https://openalex.org/W1537543309","https://openalex.org/W1537606049","https://openalex.org/W1542406910","https://openalex.org/W1545740310","https://openalex.org/W1558865081","https://openalex.org/W1559716831","https://openalex.org/W1567258255","https://openalex.org/W1577393853","https://openalex.org/W1583957430","https://openalex.org/W1586297024","https://openalex.org/W1587890084","https://openalex.org/W1589415602","https://openalex.org/W1601504908","https://openalex.org/W1603997732","https://openalex.org/W1654634869","https://openalex.org/W1661676597","https://openalex.org/W1665898234","https://openalex.org/W1667997885","https://openalex.org/W1668774261","https://openalex.org/W1775427038","https://openalex.org/W1829757075","https://openalex.org/W1838639522","https://openalex.org/W1843553820","https://openalex.org/W1844361913","https://openalex.org/W1856781683","https://openalex.org/W1872615920","https://openalex.org/W1876294625","https://openalex.org/W1891785401","https://openalex.org/W1892623806","https://openalex.org/W1894645290","https://openalex.org/W1900471667","https://openalex.org/W1919305622","https://openalex.org/W1929236031","https://openalex.org/W1942668068","https://openalex.org/W1945834141","https://openalex.org/W1961068111","https://openalex.org/W1962631004","https://openalex.org/W1963838197","https://openalex.org/W1964699440","https://openalex.org/W1967456581","https://openalex.org/W1968328677","https://openalex.org/W1968546256","https://openalex.org/W1969778579","https://openalex.org/W1970735079","https://openalex.org/W1972511495","https://openalex.org/W1972940025","https://openalex.org/W1973109581","https://openalex.org/W1974842026","https://openalex.org/W1975291295","https://openalex.org/W1975358757","https://openalex.org/W1975584136","https://openalex.org/W1975771635","https://openalex.org/W1976692354","https://openalex.org/W1977895957","https://openalex.org/W1978326037","https://openalex.org/W1978373343","https://openalex.org/W1978957279","https://openalex.org/W1979535288","https://openalex.org/W1980000158","https://openalex.org/W1980682636","https://openalex.org/W1981106016","https://openalex.org/W1981166298","https://openalex.org/W1981480494","https://openalex.org/W1984903682","https://openalex.org/W1985620900","https://openalex.org/W1986308149","https://openalex.org/W1986979962","https://openalex.org/W1987791445","https://openalex.org/W1987894065","https://openalex.org/W1988409513","https://openalex.org/W1989041292","https://openalex.org/W1992031335","https://openalex.org/W1993520606","https://openalex.org/W1994710883","https://openalex.org/W1994911637","https://openalex.org/W1995179449","https://openalex.org/W1996642422","https://openalex.org/W1996822762","https://openalex.org/W1996837236","https://openalex.org/W1997196319","https://openalex.org/W1997491419","https://openalex.org/W1997582408","https://openalex.org/W1998724551","https://openalex.org/W1999201841","https://openalex.org/W1999430932","https://openalex.org/W2000355031","https://openalex.org/W2001031230","https://openalex.org/W2003182795","https://openalex.org/W2005634497","https://openalex.org/W2006027051","https://openalex.org/W2008750159","https://openalex.org/W2008890570","https://openalex.org/W2008895143","https://openalex.org/W2010234200","https://openalex.org/W2012173926","https://openalex.org/W2012972418","https://openalex.org/W2013255473","https://openalex.org/W2013592169","https://openalex.org/W2015450090","https://openalex.org/W2017208415","https://openalex.org/W2019112133","https://openalex.org/W2019670746","https://openalex.org/W2019719164","https://openalex.org/W2020100658","https://openalex.org/W2021074216","https://openalex.org/W2021144703","https://openalex.org/W2022272502","https://openalex.org/W2023076106","https://openalex.org/W2025082986","https://openalex.org/W2025948380","https://openalex.org/W2027421255","https://openalex.org/W2027645391","https://openalex.org/W2028091596","https://openalex.org/W2029836713","https://openalex.org/W2032032849","https://openalex.org/W2032592355","https://openalex.org/W2033144954","https://openalex.org/W2035638933","https://openalex.org/W2037670359","https://openalex.org/W2038114873","https://openalex.org/W2038377343","https://openalex.org/W2039492531","https://openalex.org/W2039970092","https://openalex.org/W2040053821","https://openalex.org/W2041696529","https://openalex.org/W2044163622","https://openalex.org/W2044512941","https://openalex.org/W2045108569","https://openalex.org/W2045202836","https://openalex.org/W2046279172","https://openalex.org/W2049998759","https://openalex.org/W2052437869","https://openalex.org/W2052853635","https://openalex.org/W2055933848","https://openalex.org/W2057618822","https://openalex.org/W2058767394","https://openalex.org/W2061434857","https://openalex.org/W2062443745","https://openalex.org/W2062567403","https://openalex.org/W2063053561","https://openalex.org/W2063648470","https://openalex.org/W2065655094","https://openalex.org/W2065663262","https://openalex.org/W2066112342","https://openalex.org/W2066781745","https://openalex.org/W2068728784","https://openalex.org/W2068903461","https://openalex.org/W2068960254","https://openalex.org/W2070467745","https://openalex.org/W2070673941","https://openalex.org/W2070862399","https://openalex.org/W2071329887","https://openalex.org/W2071632799","https://openalex.org/W2072984471","https://openalex.org/W2073848442","https://openalex.org/W2074249987","https://openalex.org/W2074820885","https://openalex.org/W2075477970","https://openalex.org/W2075928272","https://openalex.org/W2076261865","https://openalex.org/W2076338812","https://openalex.org/W2079749432","https://openalex.org/W2080809922","https://openalex.org/W2085033687","https://openalex.org/W2085229861","https://openalex.org/W2087025778","https://openalex.org/W2087128996","https://openalex.org/W2087526889","https://openalex.org/W2091429277","https://openalex.org/W2093602024","https://openalex.org/W2093628776","https://openalex.org/W2093958228","https://openalex.org/W2094278677","https://openalex.org/W2094290237","https://openalex.org/W2094366129","https://openalex.org/W2095433065","https://openalex.org/W2096413786","https://openalex.org/W2097106158","https://openalex.org/W2100837670","https://openalex.org/W2101462909","https://openalex.org/W2102551327","https://openalex.org/W2103390588","https://openalex.org/W2104036678","https://openalex.org/W2105420885","https://openalex.org/W2105556276","https://openalex.org/W2106157678","https://openalex.org/W2106238650","https://openalex.org/W2106539308","https://openalex.org/W2107219546","https://openalex.org/W2107860814","https://openalex.org/W2108131089","https://openalex.org/W2108617074","https://openalex.org/W2110244627","https://openalex.org/W2110338639","https://openalex.org/W2111220263","https://openalex.org/W2112446267","https://openalex.org/W2112552541","https://openalex.org/W2113086962","https://openalex.org/W2114951959","https://openalex.org/W2116350642","https://openalex.org/W2117342688","https://openalex.org/W2118803581","https://openalex.org/W2122043456","https://openalex.org/W2124116262","https://openalex.org/W2125957455","https://openalex.org/W2126397395","https://openalex.org/W2127868030","https://openalex.org/W2128810183","https://openalex.org/W2131785128","https://openalex.org/W2132411546","https://openalex.org/W2133567701","https://openalex.org/W2134269380","https://openalex.org/W2135209591","https://openalex.org/W2135530710","https://openalex.org/W2135662322","https://openalex.org/W2136317405","https://openalex.org/W2136358628","https://openalex.org/W2137636787","https://openalex.org/W2137926188","https://openalex.org/W2141666411","https://openalex.org/W2141743444","https://openalex.org/W2142285575","https://openalex.org/W2144473036","https://openalex.org/W2144701362","https://openalex.org/W2146603844","https://openalex.org/W2148047471","https://openalex.org/W2148562724","https://openalex.org/W2149122929","https://openalex.org/W2149291946","https://openalex.org/W2149967205","https://openalex.org/W2150798096","https://openalex.org/W2153899814","https://openalex.org/W2154241904","https://openalex.org/W2156339112","https://openalex.org/W2157740207","https://openalex.org/W2157822148","https://openalex.org/W2159244081","https://openalex.org/W2160129587","https://openalex.org/W2161020639","https://openalex.org/W2161339719","https://openalex.org/W2161503027","https://openalex.org/W2162466652","https://openalex.org/W2163391867","https://openalex.org/W2163426129","https://openalex.org/W2163579392","https://openalex.org/W2164903177","https://openalex.org/W2165083476","https://openalex.org/W2165453201","https://openalex.org/W2166291746","https://openalex.org/W2167721200","https://openalex.org/W2168335646","https://openalex.org/W2168945225","https://openalex.org/W2171026458","https://openalex.org/W2172255447","https://openalex.org/W2172466148","https://openalex.org/W2175325459","https://openalex.org/W2264869981","https://openalex.org/W2316977957","https://openalex.org/W2318059699","https://openalex.org/W2331010016","https://openalex.org/W2411165773","https://openalex.org/W2411895667","https://openalex.org/W2418087198","https://openalex.org/W2424287322","https://openalex.org/W4313331406"],"related_works":["https://openalex.org/W2289527228","https://openalex.org/W2739633798","https://openalex.org/W2030979842","https://openalex.org/W1989668607","https://openalex.org/W2991461097","https://openalex.org/W2339457650","https://openalex.org/W2199046319","https://openalex.org/W3032209035","https://openalex.org/W2275604624","https://openalex.org/W2230147515"],"abstract_inverted_index":{"In":[0],"der":[1,23,39,48,69,89,111,136,155,159,179,193,235,244,263,276,303,315,339,353,365,369,383],"vorliegenden":[2,384],"Arbeit":[3,385],"wurde":[4,147,381],"die":[5,27,37,107,134,143,157,183,191,231,254,288,305,313,318,327,331,399,414,416],"Funktion":[6,85],"des":[7,66,94,165,200,401],"Zinkfinger":[8],"Transkriptionsfaktors":[9],"Gfi1":[10,28,36,87,149,151,204,214,264,278,297,356,361],"in":[11,26,42,127,138,178,182,215,225,243,302,319,366,382],"peripheren":[12,44],"T-Zellen":[13,19,73,126,137,160,195,208,220,242,352],"untersucht.":[14,431],"Die":[15,337,405],"Analyse":[16,262],"von":[17,148,290,346],"Gfi1-defizienten":[18,129,194,236],"erm\u00f6glichte":[20],"eine":[21,221,261,280,386],"Charakterisierung":[22],"unterschiedlichen":[24,40],"Prozesse,":[25],"involviert":[29,375],"ist.":[30,162,376],"Es":[31,186],"konnte":[32,187,398],"gezeigt":[33,188],"werden,":[34,189],"dass":[35,190,239,275,360],"Zusammensetzung":[38],"T-Zellpopulationen":[41],"den":[43,51,128,206,216,248,320],"lymphatischen":[45],"Organen,":[46],"wie":[47],"Milz":[49],"und":[50,71,91,102,218,230,343,348,355,373,408,426],"zervikalen":[52],"Lymphknoten,":[53],"beeinflusst.":[54,150],"Insgesamt":[55],"besa\u00dfen":[56,77,99],"Gfi1-defiziente":[57],"M\u00e4use":[58,76,98,237],"weniger":[59],"T-Zellen,":[60,106,317],"wobei":[61,174],"es":[62],"zu":[63,168,196,251,307],"einer":[64,119,169,197,268],"Verschiebung":[65],"prozentualen":[67],"Verh\u00e4ltnisses":[68],"CD4+":[70,217],"CD8+":[72,81,219,241,316],"kam.":[74],"Gfi1-/-":[75,97,175,240,321],"prozentual":[78],"deutlich":[79],"mehr":[80,100,103,124,301],"T-Zellen.":[82],"Eine":[83],"weitere":[84],"\u00fcbernimmt":[86],"bei":[88],"Ausbildung":[90],"beim":[92],"Erhalt":[93],"immunologischen":[95],"Ged\u00e4chtnisses.":[96],"zentrale":[101],"Effektor":[104],"Ged\u00e4chtnis":[105,125],"sich":[108,117],"zus\u00e4tzlich":[109],"hinsichtlich":[110],"IL-7R":[112],"Expression":[113],"unterschieden.":[114],"Ebenso":[115],"bildeten":[116],"nach":[118,145,172],"Friend":[120,232,258],"Virus":[121,233,259,333],"Infektion":[122,234,270],"erheblich":[123],"M\u00e4usen.":[130],"Aber":[131],"nicht":[132,177,286,300,312,429],"nur":[133],"Differenzierung":[135],"bestimmte":[139],"Richtungen,":[140],"sondern":[141,325],"auch":[142,395],"T-Zellantwort":[144,266],"Antigenstimulation":[146],"ist":[152],"ein":[153,209,362],"Transkriptionsfaktor":[154,277,363],"f\u00fcr":[156,279,287],"Proliferation":[158],"n\u00f6tig":[161,283],"Der":[163],"Verlust":[164],"Proteins":[166],"f\u00fchrte":[167],"gest\u00f6rten":[170],"Zellzyklusprogression":[171],"Antigenstimulation,":[173],"TZellen":[176],"Lage":[180,245],"waren":[181,299],"S-Phase":[184],"einzutreten.":[185],"TCR-Stimulation":[192],"verst\u00e4rkten":[198],"Induktion":[199],"programmierten":[201],"Zelltods":[202],"f\u00fchrte.":[203],"lieferte":[205],"aktivierten":[207],"wichtiges":[210],"\u00dcberlebenssignal.":[211],"Allerdings":[212],"\u00fcbernahm":[213],"unterschiedliche":[222,367],"Rolle,":[223],"da":[224],"vivo":[226],"Stimulationsexperimente":[227],"mit":[228,256],"Ovalbuminpeptiden":[229],"zeigte,":[238,359],"waren,":[246],"auf":[247,392,396],"jeweiligen":[249],"Antigenstimulus":[250],"reagieren.":[252],"Durch":[253],"Infektionsexperimente":[255],"dem":[257,332],"war":[260,284,311],"abh\u00e4ngigen":[265],"w\u00e4hrend":[267],"\u201ewirklichen\u201c":[269],"m\u00f6glich.":[271],"Hier":[272],"zeigte":[273],"sich,":[274],"erfolgreiche":[281],"Virusbeseitigung":[282],"aber":[285],"Aufrechterhaltung":[289],"CD8":[291],"Effektorfunktionen.":[292],"Resistente":[293],"C57Bl/6":[294],"M\u00e4use,":[295],"denen":[296],"fehlt":[298],"Lage,":[304],"Virusinfektion":[306],"kontrollieren.":[308],"Ursache":[309],"daf\u00fcr":[310],"Effektorantwort":[314],"M\u00e4usen":[322],"normal":[323],"verlief,":[324],"h\u00f6chstwahrscheinlich":[326],"vermehrt":[328],"vorkommenden":[329],"Monocyten,":[330],"als":[334,394],"Vermehrungsquelle":[335],"dienten.":[336],"Untersuchungen":[338],"Genexpressionsprofile":[340],"mittels":[341],"DNA-Array":[342],"Real-Time":[344],"PCR":[345],"unstimulierten":[347],"unterschiedlich":[349],"lang":[350],"stimulierten":[351],"wt":[354,421],"defizienten":[357],"TM\u00e4use":[358],"ist,":[364],"Prozesse":[368],"Lymphocyten":[370],"Aktivierung,":[371],"T-Zellproliferation":[372],"Apoptose":[374],"F\u00fcr":[377],"das":[378],"Evi5":[379],"Protein":[380],"Knock":[387],"Out":[388],"Maus":[389],"generiert.":[390],"Sowohl":[391],"DNA-,":[393],"RNA-Ebene":[397],"Rekombination":[400],"Nullallels":[402],"nachgewiesen":[403],"werden.":[404],"Analysen":[406],"h\u00e4matopoetischer":[407],"lymphoider":[409],"Zellen":[410,422],"aus":[411],"Evi5-/-":[412],"M\u00e4usen,":[413],"noch":[415],"Neomycinresistenz":[417],"enthielten,":[418],"zeigten":[419],"gegen\u00fcber":[420],"keinen":[423],"ver\u00e4nderten":[424],"Ph\u00e4notyp":[425],"wurden":[427],"daher":[428],"genauer":[430]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
