{"id":"https://openalex.org/W2291201138","doi":"https://doi.org/10.1152/ajpendo.1998.274.2.e365","title":"Gluconeogenesis measured with [U-13C]glucose and mass isotopomer analysis of apoB-100 amino acids in pigs","display_name":"Gluconeogenesis measured with [U-13C]glucose and mass isotopomer analysis of apoB-100 amino acids in pigs","publication_year":1998,"publication_date":"1998-02-01","ids":{"openalex":"https://openalex.org/W2291201138","doi":"https://doi.org/10.1152/ajpendo.1998.274.2.e365","mag":"2291201138","pmid":"https://pubmed.ncbi.nlm.nih.gov/9486170"},"language":"en","primary_location":{"id":"doi:10.1152/ajpendo.1998.274.2.e365","doi":"https://doi.org/10.1152/ajpendo.1998.274.2.e365","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpendo.1998.274.2.e365","pdf_url":null,"source":{"id":"https://openalex.org/S196637695","display_name":"American Journal of Physiology-Endocrinology and Metabolism","issn_l":"0193-1849","issn":["0193-1849","1522-1555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Endocrinology and Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056693356","display_name":"Linda Wykes","orcid":"https://orcid.org/0000-0002-5738-3853","observed_orcids":["https://orcid.org/0000-0002-5738-3853"]},"institutions":[{"id":"https://openalex.org/I1336096307","display_name":"United States Department of Agriculture","ror":"https://ror.org/01na82s61","country_code":"US","type":"government","lineage":["https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210141908","display_name":"Children's Nutrition Research Center at Baylor College of Medicine","ror":"https://ror.org/03s936v76","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210141908","https://openalex.org/I4210145274"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda J. Wykes","raw_affiliation_strings":["United States Department of Agriculture/Agriculture Research Service Children\u2019s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"United States Department of Agriculture/Agriculture Research Service Children\u2019s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030","institution_ids":["https://openalex.org/I1336096307","https://openalex.org/I181547552","https://openalex.org/I4210141908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108647086","display_name":"Farook Jahoor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336096307","display_name":"United States Department of Agriculture","ror":"https://ror.org/01na82s61","country_code":"US","type":"government","lineage":["https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210141908","display_name":"Children's Nutrition Research Center at Baylor College of Medicine","ror":"https://ror.org/03s936v76","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210141908","https://openalex.org/I4210145274"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Farook Jahoor","raw_affiliation_strings":["United States Department of Agriculture/Agriculture Research Service Children\u2019s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"United States Department of Agriculture/Agriculture Research Service Children\u2019s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030","institution_ids":["https://openalex.org/I1336096307","https://openalex.org/I181547552","https://openalex.org/I4210141908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111758793","display_name":"Peter J. Reeds","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336096307","display_name":"United States Department of Agriculture","ror":"https://ror.org/01na82s61","country_code":"US","type":"government","lineage":["https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210141908","display_name":"Children's Nutrition Research Center at Baylor College of Medicine","ror":"https://ror.org/03s936v76","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210141908","https://openalex.org/I4210145274"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter J. Reeds","raw_affiliation_strings":["United States Department of Agriculture/Agriculture Research Service Children\u2019s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"United States Department of Agriculture/Agriculture Research Service Children\u2019s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030","institution_ids":["https://openalex.org/I1336096307","https://openalex.org/I181547552","https://openalex.org/I4210141908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5815,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.59038479,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"274","issue":"2","first_page":"E365","last_page":"E376"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.40869998931884766,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.40869998931884766,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.14560000598430634,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12915","display_name":"Biochemical Acid Research Studies","score":0.06880000233650208,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gluconeogenesis","display_name":"gluconeogenesis","score":0.9729999899864197},{"id":"https://openalex.org/keywords/u-13c-glucose","display_name":"[U-13C]glucose","score":0.8600000143051147},{"id":"https://openalex.org/keywords/apolipoprotein-b-100","display_name":"apolipoprotein B-100","score":0.9369999766349792},{"id":"https://openalex.org/keywords/pyruvate-carboxylase","display_name":"pyruvate carboxylase","score":0.9940000176429749},{"id":"https://openalex.org/keywords/pyruvate-dehydrogenase","display_name":"pyruvate dehydrogenase","score":0.9900000095367432},{"id":"https://openalex.org/keywords/very-low-density-lipoprotein","display_name":"VLDL","score":0.8140000104904175},{"id":"https://openalex.org/keywords/plasma-amino-acids","display_name":"plasma amino acids","score":0.5559999942779541},{"id":"https://openalex.org/keywords/aspartate","display_name":"aspartic acid","score":0.4699999988079071},{"id":"https://openalex.org/keywords/glutamate","display_name":"glutamate","score":0.8080000281333923},{"id":"https://openalex.org/keywords/alanine","display_name":"alanine","score":0.9900000095367432}],"concepts":[{"id":"https://openalex.org/C140137476","wikidata":"https://www.wikidata.org/wiki/Q21114968","display_name":"Pyruvate carboxylase","level":3,"score":0.808749794960022},{"id":"https://openalex.org/C127124265","wikidata":"https://www.wikidata.org/wiki/Q2100870","display_name":"Isotopomers","level":3,"score":0.7648667097091675},{"id":"https://openalex.org/C20904676","wikidata":"https://www.wikidata.org/wiki/Q191835","display_name":"Gluconeogenesis","level":3,"score":0.7635821104049683},{"id":"https://openalex.org/C111133373","wikidata":"https://www.wikidata.org/wiki/Q21132608","display_name":"Citrate synthase","level":3,"score":0.7029780745506287},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.6447298526763916},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5487488508224487},{"id":"https://openalex.org/C2779856020","wikidata":"https://www.wikidata.org/wiki/Q218642","display_name":"Alanine","level":3,"score":0.5049498677253723},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4766938388347626},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.3525160551071167},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35166671872138977},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34139466285705566},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.2841220796108246},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2598201334476471},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.20204588770866394},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.07850337028503418},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06739133596420288},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000409","descriptor_name":"Alanine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001055","descriptor_name":"Apolipoproteins B","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D001055","descriptor_name":"Apolipoproteins B","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001224","descriptor_name":"Aspartic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002247","descriptor_name":"Carbon Isotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005943","descriptor_name":"Gluconeogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D007201","descriptor_name":"Indicator Dilution Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007553","descriptor_name":"Isotope Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010071","descriptor_name":"Oxaloacetates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011768","descriptor_name":"Pyruvate Dehydrogenase Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053299","descriptor_name":"Apolipoprotein B-100","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1152/ajpendo.1998.274.2.e365","doi":"https://doi.org/10.1152/ajpendo.1998.274.2.e365","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpendo.1998.274.2.e365","pdf_url":null,"source":{"id":"https://openalex.org/S196637695","display_name":"American Journal of Physiology-Endocrinology and Metabolism","issn_l":"0193-1849","issn":["0193-1849","1522-1555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Endocrinology and Metabolism","raw_type":"journal-article"},{"id":"pmid:9486170","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9486170","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"},{"id":"mag:2182372343","doi":null,"is_oa":false,"landing_page_url":"https://ajpendo.physiology.org/content/ajpendo/274/2/e365.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1483934588","https://openalex.org/W1490420782","https://openalex.org/W1542238138","https://openalex.org/W1542309964","https://openalex.org/W1557317496","https://openalex.org/W1602530349","https://openalex.org/W1845404045","https://openalex.org/W1963562093","https://openalex.org/W1968453958","https://openalex.org/W1982977571","https://openalex.org/W2017776273","https://openalex.org/W2021210726","https://openalex.org/W2033529979","https://openalex.org/W2040750115","https://openalex.org/W2070546700","https://openalex.org/W2071979246","https://openalex.org/W2076234020","https://openalex.org/W2079151410","https://openalex.org/W2084247271","https://openalex.org/W2102697998","https://openalex.org/W2104313218","https://openalex.org/W2150855617","https://openalex.org/W2158563866","https://openalex.org/W2168113735","https://openalex.org/W2199432246","https://openalex.org/W2257196569","https://openalex.org/W2273544461","https://openalex.org/W2296007365","https://openalex.org/W2344966715","https://openalex.org/W2397591196","https://openalex.org/W2399996154","https://openalex.org/W2412814412"],"related_works":["https://openalex.org/W1602530349","https://openalex.org/W2182372343","https://openalex.org/W2079151410","https://openalex.org/W2105062330","https://openalex.org/W1761209412","https://openalex.org/W2078662881","https://openalex.org/W1542238138","https://openalex.org/W1542309964","https://openalex.org/W2029027376","https://openalex.org/W2262102700"],"abstract_inverted_index":{"Infant":[0],"pigs":[1],"(8.5":[2],"kg)":[3],"were":[4,46,57,86],"fasted":[5],"for":[6,11],"16":[7],"h":[8,13],"and":[9,28,30,34,44,53,77,94,102,109,119,133,155,165,168,179],"infused":[10],"6":[12],"with":[14,88],"[U-13C]glucose.":[15],"The":[16,48,84,98],"fractional":[17,67],"abundances":[18],"of":[19,24,31,50,64,69,80,125,129,143,146,172,184,193,201],"all":[20],"13C":[21],"mass":[22],"isotopomers":[23],"plasma":[25],"glucose,":[26],"lactate,":[27],"pyruvate":[29,70,82,147,180],"plasma,":[32],"hepatic,":[33],"very":[35],"low":[36],"density":[37],"lipoprotein":[38],"apolipoprotein":[39],"B-100":[40],"(apoB-100)":[41],"alanine,":[42],"glutamate,":[43],"aspartate":[45,194],"measured.":[47],"ratios":[49],"[13C3]aspartate.":[51],"[13C3]glutamate,":[52],"[13C3]alanine":[54],"in":[55,195,205],"apoB-100":[56,196],"used":[58],"to":[59,72,149],"estimate":[60,200],"the":[61,66,73,78,126,144,150,173,185,191,202,211],"positional":[62,127],"equilibrium":[63,128],"[13C3]oxaloacetate,":[65],"contribution":[68,145],"carboxylase":[71,148],"hepatic":[74,81,186,206],"oxaloacetate":[75,151,207],"flux,":[76],"activity":[79],"dehydrogenase.":[83],"values":[85],"compared":[87],"those":[89],"based":[90],"on":[91],"glucose":[92,174],"labeling":[93,192],"previously":[95],"published":[96],"equations.":[97],"two":[99],"methods":[100],"[Katz":[101],"Lee":[103,134,166],"method":[104],"(J.":[105],"Katz,":[106],"P.A.":[107],"Wals.,":[108],"W.-N.":[110],"P.":[111],"Lee.":[112],"J.":[113],"Biol.":[114],"Chem.":[115],"264:":[116],"12994-13001,":[117],"1989)":[118],"apoB":[120,137],"method]":[121],"gave":[122],"similar":[123],"estimates":[124,142],"[13C3]oxaloacetate":[130],"(0.59,":[131],"Katz":[132,154],"method;":[135],"0.61,":[136],"method)":[138,167,171],"but":[139,208],"slightly":[140],"different":[141],"flux":[152],"(0.36,":[153],"Lee;":[156],"0.31":[157],"apoB).":[158],"Gluconeogenesis":[159],"apparently":[160],"contributed":[161,182],"between":[162],"71":[163],"(Katz":[164],"80%":[169],"(apoB":[170],"entry":[175],"rate":[176],"(25":[177],"mumol.kg-1.min-1),":[178],"dehydrogenase":[181],"20%":[183],"acetyl-CoA.":[187],"We":[188],"conclude":[189],"that":[190],"provides":[197],"a":[198],"good":[199],"isotopomer":[203],"distribution":[204],"may":[209],"underestimate":[210],"absolute":[212],"isotopic":[213],"enrichment":[214],"by":[215],"50%.":[216]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}