{"id":"https://openalex.org/W2291153466","doi":"https://doi.org/10.1080/23723556.2015.1075094","title":"Selenoprotein P in colitis-associated carcinoma","display_name":"Selenoprotein P in colitis-associated carcinoma","publication_year":2015,"publication_date":"2015-07-30","ids":{"openalex":"https://openalex.org/W2291153466","doi":"https://doi.org/10.1080/23723556.2015.1075094","mag":"2291153466","pmid":"https://pubmed.ncbi.nlm.nih.gov/27314080","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4909462"},"language":"en","primary_location":{"id":"doi:10.1080/23723556.2015.1075094","doi":"https://doi.org/10.1080/23723556.2015.1075094","is_oa":true,"landing_page_url":"https://doi.org/10.1080/23723556.2015.1075094","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/23723556.2015.1075094?needAccess=true&role=button","source":{"id":"https://openalex.org/S2764839827","display_name":"Molecular & Cellular Oncology","issn_l":"2372-3548","issn":["2372-3548","2372-3556"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular & Cellular Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/23723556.2015.1075094?needAccess=true&role=button","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006975909","display_name":"Sarah P. Short","orcid":"https://orcid.org/0000-0001-9606-7370","observed_orcids":["https://orcid.org/0000-0001-9606-7370"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah P. Short","raw_affiliation_strings":["Department of Cancer Biology, Vanderbilt University, Nashville, TN, USA","Department of Medicine, Division of Gastroenterology, Vanderbilt University, Nashville, TN, USA","Vanderbilt Ingram Cancer Center, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Vanderbilt University, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Medicine, Division of Gastroenterology, Vanderbilt University, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt Ingram Cancer Center, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058014182","display_name":"Caitlyn Whitten-Barrett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caitlyn Whitten-Barrett","raw_affiliation_strings":["Department of Cancer Biology, Vanderbilt University, Nashville, TN, USA","Department of Medicine, Division of Gastroenterology, Vanderbilt University, Nashville, TN, USA","Vanderbilt Ingram Cancer Center, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Vanderbilt University, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Medicine, Division of Gastroenterology, Vanderbilt University, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt Ingram Cancer Center, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076258077","display_name":"Christopher S. Williams","orcid":"https://orcid.org/0000-0002-1541-579X","observed_orcids":["https://orcid.org/0000-0002-1541-579X"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4210101790","display_name":"VA Tennessee Valley Healthcare System","ror":"https://ror.org/01c9rqr26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210101790","https://openalex.org/I4210112672"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher S. Williams","raw_affiliation_strings":["Department of Cancer Biology, Vanderbilt University, Nashville, TN, USA","Department of Medicine, Division of Gastroenterology, Vanderbilt University, Nashville, TN, USA","Vanderbilt Ingram Cancer Center, Nashville, TN, USA","Veterans Affairs Tennessee Valley Health Care System, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Vanderbilt University, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Medicine, Division of Gastroenterology, Vanderbilt University, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt Ingram Cancer Center, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299"]},{"raw_affiliation_string":"Veterans Affairs Tennessee Valley Health Care System, Nashville, TN, USA","institution_ids":["https://openalex.org/I4210101790"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5076258077"],"corresponding_institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4210101790","https://openalex.org/I4390039299"],"apc_list":{"value":1250,"currency":"GBP","value_usd":1590},"apc_paid":null,"fwci":0.2969,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.65575911,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"3","issue":"3","first_page":"e1075094","last_page":"e1075094"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11107","display_name":"Selenium in Biological Systems","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11107","display_name":"Selenium in Biological Systems","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11931","display_name":"Organoselenium and organotellurium chemistry","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/selenoprotein-p","display_name":"selenoprotein P","score":0.996999979019165},{"id":"https://openalex.org/keywords/colitis-associated-cancer","display_name":"colitis-associated colorectal cancer","score":0.8220000267028809},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.9900000095367432},{"id":"https://openalex.org/keywords/selenium-deficiency","display_name":"selenium deficiency","score":0.7689999938011169},{"id":"https://openalex.org/keywords/haploinsufficiency","display_name":"haploinsufficiency","score":0.9430000185966492},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.7860000133514404},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7649999856948853},{"id":"https://openalex.org/keywords/intestinal-epithelium","display_name":"intestinal epithelium","score":0.6380000114440918},{"id":"https://openalex.org/keywords/colon-cancer-risk","display_name":"colon cancer risk","score":0.6520000100135803}],"concepts":[{"id":"https://openalex.org/C2909795905","wikidata":"https://www.wikidata.org/wiki/Q7447908","display_name":"Selenoprotein P","level":5,"score":0.8551568984985352},{"id":"https://openalex.org/C2776841403","wikidata":"https://www.wikidata.org/wiki/Q2745644","display_name":"Selenoprotein","level":5,"score":0.8214089870452881},{"id":"https://openalex.org/C68838962","wikidata":"https://www.wikidata.org/wiki/Q852654","display_name":"Haploinsufficiency","level":4,"score":0.7213340997695923},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.7208394408226013},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.7134185433387756},{"id":"https://openalex.org/C553756173","wikidata":"https://www.wikidata.org/wiki/Q876","display_name":"Selenium","level":2,"score":0.6074591875076294},{"id":"https://openalex.org/C2779135701","wikidata":"https://www.wikidata.org/wiki/Q1322302","display_name":"Selenium deficiency","level":5,"score":0.5640302300453186},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5607535243034363},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5527193546295166},{"id":"https://openalex.org/C14522933","wikidata":"https://www.wikidata.org/wiki/Q531507","display_name":"Micronutrient","level":2,"score":0.4718760550022125},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4666329324245453},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45893049240112305},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43640294671058655},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.41744565963745117},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4143252968788147},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.411247581243515},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40771910548210144},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.38574904203414917},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.3312665820121765},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3031264841556549},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.19393885135650635},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12112146615982056},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09602117538452148},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.07422670722007751},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.06961852312088013},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1080/23723556.2015.1075094","doi":"https://doi.org/10.1080/23723556.2015.1075094","is_oa":true,"landing_page_url":"https://doi.org/10.1080/23723556.2015.1075094","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/23723556.2015.1075094?needAccess=true&role=button","source":{"id":"https://openalex.org/S2764839827","display_name":"Molecular & Cellular Oncology","issn_l":"2372-3548","issn":["2372-3548","2372-3556"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular & Cellular Oncology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3924198","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4909462","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4909462","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4909462","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Oncol","raw_type":"Text"},{"id":"pmid:27314080","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27314080","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular & cellular oncology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1080/23723556.2015.1075094","doi":"https://doi.org/10.1080/23723556.2015.1075094","is_oa":true,"landing_page_url":"https://doi.org/10.1080/23723556.2015.1075094","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/23723556.2015.1075094?needAccess=true&role=button","source":{"id":"https://openalex.org/S2764839827","display_name":"Molecular & Cellular Oncology","issn_l":"2372-3548","issn":["2372-3548","2372-3556"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular & Cellular Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G264925784","display_name":"Tissue-specific contribution of Selenoprotein P in colitis and oxidative damage","funder_award_id":"F32DK108492","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3680560677","display_name":"Selenium in gastrointestinal inflammatory diseases","funder_award_id":"R01DK099204","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4794827","display_name":null,"funder_award_id":"290326","funder_id":"https://openalex.org/F4320312926","funder_display_name":"Crohn's and Colitis Foundation"}],"funders":[{"id":"https://openalex.org/F4320306301","display_name":"Crohn's and Colitis Foundation of America","ror":"https://ror.org/05f2xbq60"},{"id":"https://openalex.org/F4320312926","display_name":"Crohn's and Colitis Foundation","ror":"https://ror.org/05f2xbq60"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2291153466.pdf","grobid_xml":"https://content.openalex.org/works/W2291153466.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W1546056545","https://openalex.org/W1848100020","https://openalex.org/W1966609569","https://openalex.org/W2007445491","https://openalex.org/W2081640160","https://openalex.org/W2096166220","https://openalex.org/W2099286609","https://openalex.org/W2110762028","https://openalex.org/W2116488711","https://openalex.org/W2163169815"],"related_works":["https://openalex.org/W1546056545","https://openalex.org/W2517871167","https://openalex.org/W3114626274","https://openalex.org/W2898902671","https://openalex.org/W4249611875","https://openalex.org/W4241704401","https://openalex.org/W2803939863","https://openalex.org/W3105685683","https://openalex.org/W2007445491","https://openalex.org/W4382893980"],"abstract_inverted_index":{"Patients":[0],"with":[1],"inflammatory":[2],"bowel":[3],"disease":[4],"are":[5],"often":[6],"deficient":[7],"in":[8,47],"micronutrients":[9],"such":[10],"as":[11],"selenium":[12,25],"and":[13,43],"have":[14],"an":[15],"increased":[16],"risk":[17],"of":[18],"colon":[19],"cancer.":[20,33],"We":[21],"tested":[22],"whether":[23],"the":[24,48],"transport":[26],"protein,":[27],"selenoprotein":[28],"P,":[29],"could":[30],"modify":[31],"colitis-associated":[32],"Our":[34],"results":[35],"indicate":[36],"that":[37],"global":[38],"SEPP1":[39],"haploinsufficiency":[40],"augments":[41],"tumorigenesis":[42],"mediates":[44],"oxidative":[45],"damage":[46],"intestine.":[49]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}