{"id":"https://openalex.org/W2291088030","doi":null,"title":"A stereological approach to measuring striatal cellular changes in transgenic Huntington's disease rats","display_name":"A stereological approach to measuring striatal cellular changes in transgenic Huntington's disease rats","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2291088030","mag":"2291088030"},"language":"en","primary_location":{"id":"pmh:oai:www.duo.uio.no:10852/28786","doi":null,"is_oa":true,"landing_page_url":"http://urn.nb.no/URN:NBN:no-26319","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/masterThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.nb.no/URN:NBN:no-26319","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Saurabh Jain","orcid":"https://orcid.org/0000-0001-7833-0366","observed_orcids":["https://orcid.org/0000-0001-7833-0366"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Saurabh Jain","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7833-0366","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.7432000041007996,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.7432000041007996,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11830","display_name":"Point processes and geometric inequalities","score":0.125900000333786,"subfield":{"id":"https://openalex.org/subfields/2604","display_name":"Applied Mathematics"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.028699999675154686,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":1.0},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.7549999952316284},{"id":"https://openalex.org/keywords/striatal-neurodegeneration","display_name":"striatal degeneration","score":0.8999999761581421},{"id":"https://openalex.org/keywords/transgenic-rats","display_name":"transgenic rats","score":0.6909999847412109},{"id":"https://openalex.org/keywords/stereology","display_name":"stereology","score":0.8109999895095825},{"id":"https://openalex.org/keywords/optical-fractionator","display_name":"optical fractionator","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cell-counting","display_name":"cell counting","score":0.5630000233650208},{"id":"https://openalex.org/keywords/thionin-staining","display_name":"thionin staining","score":0.9589999914169312},{"id":"https://openalex.org/keywords/sampling-parameters","display_name":"sampling parameters","score":0.7179999947547913}],"concepts":[{"id":"https://openalex.org/C2780647506","wikidata":"https://www.wikidata.org/wiki/Q190564","display_name":"Huntington's disease","level":3,"score":0.8725345134735107},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.6134328842163086},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5328104496002197},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5185664296150208},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.47972267866134644},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4521491825580597},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4190395474433899},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.33841657638549805},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25179845094680786},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.24585124850273132},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17106115818023682},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.06437718868255615},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05249530076980591}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.duo.uio.no:10852/28786","doi":null,"is_oa":true,"landing_page_url":"http://urn.nb.no/URN:NBN:no-26319","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"mag:2291088030","doi":null,"is_oa":false,"landing_page_url":"https://www.duo.uio.no/bitstream/handle/10852/28786/Prosjekt-Jain.pdf?sequence=1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:www.duo.uio.no:10852/28786","doi":null,"is_oa":true,"landing_page_url":"http://urn.nb.no/URN:NBN:no-26319","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/masterThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W237141987","https://openalex.org/W1564671169","https://openalex.org/W1982963412","https://openalex.org/W1984325684","https://openalex.org/W1993068285","https://openalex.org/W1993697037","https://openalex.org/W1998241872","https://openalex.org/W2000483565","https://openalex.org/W2005102540","https://openalex.org/W2007640162","https://openalex.org/W2010395737","https://openalex.org/W2010460856","https://openalex.org/W2011930181","https://openalex.org/W2024922324","https://openalex.org/W2029984090","https://openalex.org/W2032471499","https://openalex.org/W2044175751","https://openalex.org/W2047172433","https://openalex.org/W2048809344","https://openalex.org/W2054907051","https://openalex.org/W2062676713","https://openalex.org/W2064679863","https://openalex.org/W2081814623","https://openalex.org/W2082056883","https://openalex.org/W2084849755","https://openalex.org/W2087838692","https://openalex.org/W2106875648","https://openalex.org/W2107196928","https://openalex.org/W2108712999","https://openalex.org/W2111405228","https://openalex.org/W2121642311","https://openalex.org/W2141237727","https://openalex.org/W2149921519","https://openalex.org/W2154070675","https://openalex.org/W2168092251","https://openalex.org/W2272417159"],"related_works":["https://openalex.org/W2007640162","https://openalex.org/W2100658137","https://openalex.org/W7135437553","https://openalex.org/W7135658212","https://openalex.org/W2916550411","https://openalex.org/W2018625683","https://openalex.org/W7097222175","https://openalex.org/W2402981407","https://openalex.org/W7072029547","https://openalex.org/W2026315886"],"abstract_inverted_index":{"Huntington's":[0],"disease":[1,7],"(HD)":[2],"is":[3,50,111,118,130,254],"an":[4,141],"inheritable":[5],"degenerative":[6],"of":[8,46,57,63,101,127,151,190,208,234,240],"the":[9,19,43,58,149,152,171,228,232,249,259],"brain":[10],"characterized":[11],"by":[12],"progressive":[13,88],"neural":[14],"dysfunction":[15],"and":[16,21,28,33,61,92,116,188,192,198,216,237],"degeneration":[17],"in":[18,25,71,78,113,166,170,231,265],"striatum":[20],"cerebral":[22],"cortex,":[23],"resulting":[24],"abnormal":[26],"motor-":[27],"cognitive":[29],"function,":[30],"emotional":[31],"disturbances":[32],"premature":[34],"death.":[35],"While":[36],"considerable":[37],"knowledge":[38],"has":[39,84,155],"been":[40,85,156],"gained":[41],"about":[42],"pathophysiological":[44],"mechanisms":[45],"HD,":[47],"curative":[48],"treatment":[49],"still":[51],"not":[52],"available.":[53],"For":[54],"further":[55],"elucidation":[56],"pathological":[59],"processes":[60],"identification":[62],"potential":[64],"targets":[65],"for":[66,98,146,161],"therapeutic":[67],"interventions,":[68],"\\nexperimental":[69],"investigations":[70,100],"animal":[72],"models":[73],"are":[74],"necessary.":[75],"Transgenic":[76],"rats":[77],"which":[79],"a":[80,95,134,159,195,205,213,238],"truncated":[81],"HD":[82,267],"gene":[83],"inserted,":[86],"develop":[87],"HD-like":[89],"behavioural":[90],"changes,":[91],"thus":[93],"represent":[94],"promising":[96],"model":[97],"experimental":[99],"HD.":[102],"It":[103],"remains":[104],"\\nuncertain":[105],"to":[106,121,139,157,184,193,226,256],"what":[107],"extent":[108],"striatal":[109,163,262],"neurodegeneration":[110],"present":[112,153],"these":[114],"rats,":[115],"it":[117],"therefore":[119],"important":[120],"evaluate":[122],"this":[123],"quantitatively.":[124],"Quantitative":[125],"assessment":[126],"cellular":[128],"populations":[129],"\\ntypically":[131],"obtained":[132],"using":[133],"stereological":[135,143],"method.":[136],"In":[137],"order":[138],"select":[140],"appropriate":[142],"study":[144,154],"designs":[145],"such":[147],"investigations,":[148],"objective":[150,233],"establish":[158],"procedure":[160],"quantifying":[162],"cell":[164],"numbers":[165],"thionin":[167,209],"stained":[168,210],"sections":[169],"rat":[172],"brain.":[173],"A":[174],"non-systematic":[175],"literature":[176],"review,":[177],"combined":[178],"with":[179],"snowball":[180],"sampling,":[181],"was":[182,202,224],"conducted":[183],"retrieve":[185],"original":[186],"articles":[187],"review":[189],"interest":[191],"delineate":[194],"suitable":[196,230,255],"design":[197],"protocol.":[199],"This":[200],"protocol":[201,223,253],"tested":[203],"on":[204],"limited":[206],"material":[207],"\\nsections":[211],"from":[212],"transgenic":[214,266],"HD-rat":[215],"wildtype":[217],"littermate":[218],"control.":[219],"The":[220],"optical":[221],"fractionator":[222],"found":[225],"be":[227],"most":[229],"population":[235],"estimation,":[236],"set":[239],"recommended":[241],"sampling":[242],"parameters":[243],"were":[244],"identified.":[245],"We":[246],"conclude":[247],"that":[248,261],"proposed":[250],"Optical":[251],"Fractionator":[252],"quantitatively":[257],"test":[258],"hypothesis":[260],"neurons":[263],"degenerate":[264],"rats.":[268]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}
