{"id":"https://openalex.org/W2291007196","doi":"https://doi.org/10.7314/apjcp.2016.17.2.497","title":"The Value of Preoperative CA 125 Levels in Prediction of Myometrial Invasion in Patients with Early-stage Endometrioid-type Endometrial Cancer","display_name":"The Value of Preoperative CA 125 Levels in Prediction of Myometrial Invasion in Patients with Early-stage Endometrioid-type Endometrial Cancer","publication_year":2016,"publication_date":"2016-03-07","ids":{"openalex":"https://openalex.org/W2291007196","doi":"https://doi.org/10.7314/apjcp.2016.17.2.497","mag":"2291007196","pmid":"https://pubmed.ncbi.nlm.nih.gov/26925634"},"language":"en","primary_location":{"id":"doi:10.7314/apjcp.2016.17.2.497","doi":"https://doi.org/10.7314/apjcp.2016.17.2.497","is_oa":true,"landing_page_url":"https://doi.org/10.7314/apjcp.2016.17.2.497","pdf_url":"http://koreascience.or.kr:80/article/JAKO201610659891851.pdf","source":{"id":"https://openalex.org/S121579133","display_name":"Asian Pacific Journal of Cancer Prevention","issn_l":"1513-7368","issn":["1513-7368","2476-762X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319060","host_organization_name":"West Asia Organization for Cancer Prevention","host_organization_lineage":["https://openalex.org/P4310319060"],"host_organization_lineage_names":["West Asia Organization for Cancer Prevention"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific Journal of Cancer Prevention","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2291007196"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://koreascience.or.kr:80/article/JAKO201610659891851.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001384665","display_name":"Zeynep Atguden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1303077703","display_name":"Ministry of Health","ror":"https://ror.org/00pkvys92","country_code":"TR","type":"government","lineage":["https://openalex.org/I1303077703"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Zeynep Atguden","raw_affiliation_strings":["Gynecology and Obstetrics Department, Akropol Medical Hospital, Ankara, Turkey E-mail : serenateris@hotmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gynecology and Obstetrics Department, Akropol Medical Hospital, Ankara, Turkey E-mail : serenateris@hotmail.com","institution_ids":["https://openalex.org/I1303077703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001615164","display_name":"A\u015fk\u0131n Yildiz","orcid":"https://orcid.org/0000-0003-2364-6069","observed_orcids":["https://orcid.org/0000-0003-2364-6069"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Askin Yildiz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073746077","display_name":"Hayri Aks\u00fct","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hayri Aksut","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009912988","display_name":"Serenat Eri\u015f Yal\u00e7\u0131n","orcid":"https://orcid.org/0000-0002-6465-325X","observed_orcids":["https://orcid.org/0000-0002-6465-325X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Serenat Eris Yalcin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102886293","display_name":"Yakup Yal\u00e7\u0131n","orcid":"https://orcid.org/0000-0002-8826-6481","observed_orcids":["https://orcid.org/0000-0002-8826-6481"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yakup Yalcin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027896321","display_name":"Dilek Uysal","orcid":"https://orcid.org/0000-0002-8591-3065","observed_orcids":["https://orcid.org/0000-0002-8591-3065","https://orcid.org/0000-0002-9590-0524"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dilek Uysal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5076259137","display_name":"Hakan Yetimalar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hakan Yetimalar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":200,"currency":"USD","value_usd":200},"apc_paid":{"value":200,"currency":"USD","value_usd":200},"fwci":1.0573,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.75896307,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"17","issue":"2","first_page":"497","last_page":"501"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11589","display_name":"Gynecological conditions and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ca125","display_name":"CA125","score":0.9919999837875366},{"id":"https://openalex.org/keywords/endometrioid-endometrial-carcinoma","display_name":"endometrioid endometrial cancer","score":0.8769999742507935},{"id":"https://openalex.org/keywords/early-stage-endometrial-cancer","display_name":"early-stage endometrial cancer","score":0.9010000228881836},{"id":"https://openalex.org/keywords/myometrial-invasion","display_name":"myometrial invasion","score":0.9700000286102295},{"id":"https://openalex.org/keywords/preoperative-serum-biomarkers","display_name":"preoperative serum biomarkers","score":0.6990000009536743},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6970000267028809},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C2777088508","wikidata":"https://www.wikidata.org/wiki/Q944777","display_name":"Endometrial cancer","level":3,"score":0.7264240980148315},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7184262275695801},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.6937047839164734},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.46996447443962097},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.447022020816803},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.4085088074207306},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3712169826030731},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08194217085838318},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009215","descriptor_name":"Myometrium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009215","descriptor_name":"Myometrium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009215","descriptor_name":"Myometrium","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011300","descriptor_name":"Preoperative Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D016889","descriptor_name":"Endometrial Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016889","descriptor_name":"Endometrial Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016889","descriptor_name":"Endometrial Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D018269","descriptor_name":"Carcinoma, Endometrioid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018269","descriptor_name":"Carcinoma, Endometrioid","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018269","descriptor_name":"Carcinoma, Endometrioid","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D018394","descriptor_name":"CA-125 Antigen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D060787","descriptor_name":"Neoplasm Grading","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.7314/apjcp.2016.17.2.497","doi":"https://doi.org/10.7314/apjcp.2016.17.2.497","is_oa":true,"landing_page_url":"https://doi.org/10.7314/apjcp.2016.17.2.497","pdf_url":"http://koreascience.or.kr:80/article/JAKO201610659891851.pdf","source":{"id":"https://openalex.org/S121579133","display_name":"Asian Pacific Journal of Cancer Prevention","issn_l":"1513-7368","issn":["1513-7368","2476-762X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319060","host_organization_name":"West Asia Organization for Cancer Prevention","host_organization_lineage":["https://openalex.org/P4310319060"],"host_organization_lineage_names":["West Asia Organization for Cancer Prevention"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific Journal of Cancer Prevention","raw_type":"journal-article"},{"id":"pmid:26925634","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26925634","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific journal of cancer prevention : APJCP","raw_type":"Journal Article"},{"id":"pmh:761a2ffd-f77f-4d48-9189-d93c0e366819","doi":null,"is_oa":false,"landing_page_url":"https://avesis.uludag.edu.tr/publication/details/761a2ffd-f77f-4d48-9189-d93c0e366819/oai","pdf_url":null,"source":{"id":"https://openalex.org/S7407055210","display_name":"Bursa Uludag University - AVESIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.60692/c597b-njm84","doi":"https://doi.org/10.60692/c597b-njm84","is_oa":true,"landing_page_url":"https://doi.org/10.60692/c597b-njm84","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/t4d8v-rz908","doi":"https://doi.org/10.60692/t4d8v-rz908","is_oa":true,"landing_page_url":"https://doi.org/10.60692/t4d8v-rz908","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.7314/apjcp.2016.17.2.497","doi":"https://doi.org/10.7314/apjcp.2016.17.2.497","is_oa":true,"landing_page_url":"https://doi.org/10.7314/apjcp.2016.17.2.497","pdf_url":"http://koreascience.or.kr:80/article/JAKO201610659891851.pdf","source":{"id":"https://openalex.org/S121579133","display_name":"Asian Pacific Journal of Cancer Prevention","issn_l":"1513-7368","issn":["1513-7368","2476-762X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319060","host_organization_name":"West Asia Organization for Cancer Prevention","host_organization_lineage":["https://openalex.org/P4310319060"],"host_organization_lineage_names":["West Asia Organization for Cancer Prevention"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific Journal of Cancer Prevention","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2291007196.pdf","grobid_xml":"https://content.openalex.org/works/W2291007196.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W99787990","https://openalex.org/W191615067","https://openalex.org/W1963592300","https://openalex.org/W1970778300","https://openalex.org/W1990722281","https://openalex.org/W1995212493","https://openalex.org/W2010397777","https://openalex.org/W2031608979","https://openalex.org/W2035853119","https://openalex.org/W2037688420","https://openalex.org/W2058589542","https://openalex.org/W2093234526","https://openalex.org/W2100196054","https://openalex.org/W2103172167","https://openalex.org/W2124593467","https://openalex.org/W2136076925","https://openalex.org/W2166111068","https://openalex.org/W2166167773","https://openalex.org/W2171632856","https://openalex.org/W2400227466"],"related_works":["https://openalex.org/W3199281537","https://openalex.org/W1204709711","https://openalex.org/W2063046532","https://openalex.org/W191615067","https://openalex.org/W3161349243","https://openalex.org/W2376104164","https://openalex.org/W4390884411","https://openalex.org/W2128201398","https://openalex.org/W2744468027","https://openalex.org/W2166111068"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"evaluate":[2,86],"the":[3,55,87,121,139,145,157],"relationship":[4,88,119,146],"between":[5,31,89,120,147],"pre-operative":[6,48,90],"CA-125":[7,50,59,91,100,128,153,206,236],"levels":[8,51,92],"and":[9,23,34,46,65,76,83,93,110,127,150,156,166,180,222],"myometrial":[10,69,94,108,116,125,161],"invasion":[11,70,126,162],"in":[12,54,104,112,214,239],"patients":[13,25,40,105,215,240],"with":[14,28,41,106,216,241],"early-stage":[15],"endometrioid-type":[16,219],"endometrial":[17,29,244],"cancer.":[18,245],"MATERIALS":[19],"AND":[20],"METHODS:":[21],"Two-hundred":[22],"sixty":[24],"were":[26,52,71,81,169],"diagnosed":[27],"cancer":[30],"January":[32],"2007":[33],"December":[35],"2012.":[36],"Of":[37],"these,":[38],"136":[39],"stage":[42,218],"1":[43],"endometrioid":[44],"histologic-type":[45],"documented":[47],"serum":[49,99,205],"included":[53],"study.":[56],"Age,":[57],"preoperative":[58,204],"level,":[60],"histologic":[61],"grade,":[62,64],"surgical":[63],"presence":[66,122,158],"of":[67,123,159,187],"deep":[68,107,115,124,160],"recorded.":[72],"Additionally,":[73],"16,":[74,148],"20,":[75,132],"35":[77,133,151,183],"IU/ml":[78,152,189],"cutoff":[79],"values":[80,130,155,168,207,238],"used":[82,209],"compared":[84,195],"to":[85,196,233],"invasion.":[95,117],"RESULTS:":[96],"The":[97,118,185],"average":[98],"level":[101],"was":[102,135,141,163,192],"35.4\u00b136.7":[103],"invasion,":[109],"21.5\u00b135.8":[111],"cases":[113],"without":[114],"cut-off":[129,154,190,237],"(16,":[131],"IU/ml)":[134],"statistically":[136],"significant,":[137],"although":[138],"correlation":[140],"weak":[142],"(p<0.05).":[143],"When":[144],"20":[149,178],"studied,":[164],"specifity":[165],"sensitivity":[167,186],"identified":[170],"as:":[171],"0.60-0.68":[172],"for":[173,177,182],"16":[174,188],"IU/ml;":[175,179],"0.73-0.48":[176],"0.89-0.33":[181],"IU/ml.":[184],"value":[191],"higher":[193],"when":[194],"other":[197],"values.":[198],"CONCLUSIONS:":[199],"This":[200],"study":[201],"demonstrates":[202],"that":[203],"maybe":[208],"as":[210,223],"a":[211,224],"predictive":[212],"test":[213],"early":[217],"endometrium":[220],"cancer,":[221],"prognostic":[225],"factor":[226],"alone.":[227],"Further":[228],"studies":[229],"should":[230],"be":[231],"conducted":[232],"identify":[234],"different":[235],"low":[242],"risk":[243]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}