{"id":"https://openalex.org/W2290984097","doi":"https://doi.org/10.3892/mmr.2016.4948","title":"Role of neuroinflammation in neurodegenerative diseases (Review)","display_name":"Role of neuroinflammation in neurodegenerative diseases (Review)","publication_year":2016,"publication_date":"2016-02-29","ids":{"openalex":"https://openalex.org/W2290984097","doi":"https://doi.org/10.3892/mmr.2016.4948","mag":"2290984097","pmid":"https://pubmed.ncbi.nlm.nih.gov/26935478","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4805095"},"language":"en","primary_location":{"id":"doi:10.3892/mmr.2016.4948","doi":"https://doi.org/10.3892/mmr.2016.4948","is_oa":true,"landing_page_url":"https://doi.org/10.3892/mmr.2016.4948","pdf_url":"http://www.spandidos-publications.com/10.3892/mmr.2016.4948/download","source":{"id":"https://openalex.org/S95395365","display_name":"Molecular Medicine Reports","issn_l":"1791-2997","issn":["1791-2997","1791-3004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine Reports","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2290984097"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.spandidos-publications.com/10.3892/mmr.2016.4948/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100367133","display_name":"Weiwei Chen","orcid":"https://orcid.org/0000-0002-8423-1177","observed_orcids":["https://orcid.org/0000-0002-8423-1177"]},"institutions":[{"id":"https://openalex.org/I4210132906","display_name":"Xuzhou Central Hospital","ror":"https://ror.org/048q23a93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132906"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"WEI-WEI CHEN","raw_affiliation_strings":["Department of Neurology, Xuzhou Central Hospital, Xuzhou, Jiangsu 221009, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Xuzhou Central Hospital, Xuzhou, Jiangsu 221009, P.R. China","institution_ids":["https://openalex.org/I4210132906"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100461903","display_name":"Xia Zhang","orcid":"https://orcid.org/0000-0002-0360-4091","observed_orcids":["https://orcid.org/0000-0002-0360-4091"]},"institutions":[{"id":"https://openalex.org/I4210132906","display_name":"Xuzhou Central Hospital","ror":"https://ror.org/048q23a93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132906"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"XIA ZHANG","raw_affiliation_strings":["Department of Neurology, Xuzhou Central Hospital, Xuzhou, Jiangsu 221009, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Xuzhou Central Hospital, Xuzhou, Jiangsu 221009, P.R. China","institution_ids":["https://openalex.org/I4210132906"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008482365","display_name":"Wenjuan Huang","orcid":"https://orcid.org/0000-0002-8056-373X","observed_orcids":["https://orcid.org/0000-0002-8056-373X"]},"institutions":[{"id":"https://openalex.org/I4210132906","display_name":"Xuzhou Central Hospital","ror":"https://ror.org/048q23a93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132906"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"WEN-JUAN HUANG","raw_affiliation_strings":["Department of Neurology, Xuzhou Central Hospital, Xuzhou, Jiangsu 221009, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Xuzhou Central Hospital, Xuzhou, Jiangsu 221009, P.R. China","institution_ids":["https://openalex.org/I4210132906"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5008482365"],"corresponding_institution_ids":["https://openalex.org/I4210132906"],"apc_list":null,"apc_paid":null,"fwci":5.8631,"has_fulltext":true,"cited_by_count":965,"citation_normalized_percentile":{"value":0.98220065,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"13","issue":"4","first_page":"3391","last_page":"3396"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":1.0},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.8650000095367432},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9269999861717224},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8870000243186951},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9760000109672546},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":1.0},{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":1.0},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9319999814033508},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.9729999899864197},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.9559999704360962},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.4779999852180481}],"concepts":[{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.9426227807998657},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.9240232706069946},{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.717204749584198},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6696161031723022},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5696284770965576},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5514400005340576},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.5029229521751404},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.42097383737564087},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41522789001464844},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3426591753959656},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3368512988090515},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21414411067962646},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13957667350769043}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D008659","descriptor_name":"Metabolic Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3892/mmr.2016.4948","doi":"https://doi.org/10.3892/mmr.2016.4948","is_oa":true,"landing_page_url":"https://doi.org/10.3892/mmr.2016.4948","pdf_url":"http://www.spandidos-publications.com/10.3892/mmr.2016.4948/download","source":{"id":"https://openalex.org/S95395365","display_name":"Molecular Medicine Reports","issn_l":"1791-2997","issn":["1791-2997","1791-3004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine Reports","raw_type":"journal-article"},{"id":"pmid:26935478","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26935478","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular medicine reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4805095","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4805095/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Med Rep","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3892/mmr.2016.4948","doi":"https://doi.org/10.3892/mmr.2016.4948","is_oa":true,"landing_page_url":"https://doi.org/10.3892/mmr.2016.4948","pdf_url":"http://www.spandidos-publications.com/10.3892/mmr.2016.4948/download","source":{"id":"https://openalex.org/S95395365","display_name":"Molecular Medicine Reports","issn_l":"1791-2997","issn":["1791-2997","1791-3004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Medicine Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2290984097.pdf","grobid_xml":"https://content.openalex.org/works/W2290984097.grobid-xml"},"referenced_works_count":89,"referenced_works":["https://openalex.org/W55423442","https://openalex.org/W170549786","https://openalex.org/W599635317","https://openalex.org/W1540436551","https://openalex.org/W1965942744","https://openalex.org/W1969425174","https://openalex.org/W1971200109","https://openalex.org/W1974918593","https://openalex.org/W1976738954","https://openalex.org/W1977887358","https://openalex.org/W1978493172","https://openalex.org/W1981764021","https://openalex.org/W1986031990","https://openalex.org/W1987007950","https://openalex.org/W1994784385","https://openalex.org/W1995089933","https://openalex.org/W1996024251","https://openalex.org/W1998136513","https://openalex.org/W1998922807","https://openalex.org/W2002537642","https://openalex.org/W2003129702","https://openalex.org/W2009695591","https://openalex.org/W2009765999","https://openalex.org/W2016384657","https://openalex.org/W2019724009","https://openalex.org/W2021822341","https://openalex.org/W2026545194","https://openalex.org/W2028090656","https://openalex.org/W2038197998","https://openalex.org/W2039414363","https://openalex.org/W2040705134","https://openalex.org/W2040921716","https://openalex.org/W2045864910","https://openalex.org/W2046346645","https://openalex.org/W2047183155","https://openalex.org/W2050320551","https://openalex.org/W2058742494","https://openalex.org/W2058886900","https://openalex.org/W2060852391","https://openalex.org/W2068915304","https://openalex.org/W2072622521","https://openalex.org/W2073449985","https://openalex.org/W2074661552","https://openalex.org/W2076545903","https://openalex.org/W2082184929","https://openalex.org/W2082429191","https://openalex.org/W2088940658","https://openalex.org/W2091600573","https://openalex.org/W2092273900","https://openalex.org/W2094511836","https://openalex.org/W2101328621","https://openalex.org/W2101628038","https://openalex.org/W2105043890","https://openalex.org/W2106117608","https://openalex.org/W2107550410","https://openalex.org/W2112880160","https://openalex.org/W2116041320","https://openalex.org/W2118826874","https://openalex.org/W2121506107","https://openalex.org/W2125278063","https://openalex.org/W2127521961","https://openalex.org/W2132324173","https://openalex.org/W2136567014","https://openalex.org/W2136787853","https://openalex.org/W2138192231","https://openalex.org/W2140075426","https://openalex.org/W2140380746","https://openalex.org/W2142454365","https://openalex.org/W2145938600","https://openalex.org/W2147075251","https://openalex.org/W2147416316","https://openalex.org/W2151283331","https://openalex.org/W2151293405","https://openalex.org/W2158512964","https://openalex.org/W2158695265","https://openalex.org/W2160239222","https://openalex.org/W2163526164","https://openalex.org/W2163751922","https://openalex.org/W2165092386","https://openalex.org/W2166839330","https://openalex.org/W2167326264","https://openalex.org/W2169860974","https://openalex.org/W2280708766","https://openalex.org/W2318634426","https://openalex.org/W2620406790","https://openalex.org/W2996009626","https://openalex.org/W4239347934","https://openalex.org/W4247759744","https://openalex.org/W6649432361"],"related_works":["https://openalex.org/W2788252641","https://openalex.org/W2055857680","https://openalex.org/W4383894096","https://openalex.org/W4399627724","https://openalex.org/W7214062987","https://openalex.org/W2046970066","https://openalex.org/W7219500796","https://openalex.org/W4408314322","https://openalex.org/W4394757778","https://openalex.org/W7135454271"],"abstract_inverted_index":{"Neurodegeneration":[0,22],"is":[1,23],"a":[2,89],"phenomenon":[3],"that":[4,52,109],"occurs":[5],"in":[6,30,37,99,114,133,136,162],"the":[7,12,15,38,73,100,110,125,134,143,155,159],"central":[8],"nervous":[9],"system":[10],"through":[11],"hallmarks":[13],"associating":[14],"loss":[16],"of":[17,61,91,102,112,128,145],"neuronal":[18],"structure":[19],"and":[20,28,48,56,104,147],"function.":[21],"observed":[24,36],"after":[25],"viral":[26],"insult":[27],"mostly":[29],"various":[31],"so-called":[32],"'neurodegenerative":[33],"diseases',":[34],"generally":[35],"elderly,":[39],"such":[40],"as":[41,76],"Alzheimer's":[42],"disease,":[43],"multiple":[44,81],"sclerosis,":[45],"Parkinson's":[46],"disease":[47],"amyotrophic":[49],"lateral":[50],"sclerosis":[51],"negatively":[53],"affect":[54],"mental":[55,148],"physical":[57],"functioning.":[58],"Causative":[59],"agents":[60],"neurodegeneration":[62,115],"have":[63,71],"yet":[64],"to":[65,142],"be":[66,117],"identified.":[67],"However,":[68],"recent":[69],"data":[70,107],"identified":[72],"inflammatory":[74,138,160],"process":[75,161],"being":[77],"closely":[78],"linked":[79,141],"with":[80,87],"neurodegenerative":[82,92,163],"pathways,":[83],"which":[84,123],"are":[85,97,124,140],"associated":[86],"depression,":[88],"consequence":[90],"disease.":[93],"Accordingly,":[94],"pro\u2011inflammatory":[95,121],"cytokines":[96],"important":[98],"pathophysiology":[101],"depression":[103],"dementia.":[105],"These":[106],"suggest":[108],"role":[111,156],"neuroinflammation":[113],"must":[116],"fully":[118],"elucidated,":[119],"since":[120],"agents,":[122],"causative":[126],"effects":[127],"neuroinflammation,":[129],"occur":[130],"widely,":[131],"particularly":[132],"elderly":[135],"whom":[137],"mechanisms":[139],"pathogenesis":[144],"functional":[146],"impairments.":[149],"In":[150],"this":[151],"review,":[152],"we":[153],"investigated":[154],"played":[157],"by":[158],"diseases.":[164]},"counts_by_year":[{"year":2026,"cited_by_count":47},{"year":2025,"cited_by_count":71},{"year":2024,"cited_by_count":128},{"year":2023,"cited_by_count":121},{"year":2022,"cited_by_count":143},{"year":2021,"cited_by_count":111},{"year":2020,"cited_by_count":131},{"year":2019,"cited_by_count":100},{"year":2018,"cited_by_count":60},{"year":2017,"cited_by_count":45},{"year":2016,"cited_by_count":8}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}