{"id":"https://openalex.org/W2290921674","doi":null,"title":"Mechanisms by which the IKK-related Kinases Affect Energy Expenditure.","display_name":"Mechanisms by which the IKK-related Kinases Affect Energy Expenditure.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2290921674","mag":"2290921674"},"language":"en","primary_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/107243","doi":null,"is_oa":true,"landing_page_url":"http://deepblue.lib.umich.edu/bitstream/2027.42/107243/1/jonmow_1.pdf","pdf_url":"https://hdl.handle.net/2027.42/107243","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/2027.42/107243","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019976583","display_name":"Jonathan C. Mowers","orcid":"https://orcid.org/0000-0002-9077-1225","observed_orcids":["https://orcid.org/0000-0002-9077-1225"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jonathan Mowers","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9077-1225","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5019976583"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.7875999808311462,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.7875999808311462,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.19930000603199005,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ikkepsilon","display_name":"IKK\u03b5","score":0.9700000286102295},{"id":"https://openalex.org/keywords/tbk1","display_name":"TBK1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/energy-expenditure","display_name":"energy expenditure","score":0.8080000281333923},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7919999957084656},{"id":"https://openalex.org/keywords/adipose-tissue-inflammation","display_name":"adipose tissue inflammation","score":0.8939999938011169},{"id":"https://openalex.org/keywords/amlexanox","display_name":"amlexanox","score":0.7929999828338623},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.7519999742507935},{"id":"https://openalex.org/keywords/beta-adrenergic-signaling","display_name":"beta-adrenergic signaling","score":0.9549999833106995},{"id":"https://openalex.org/keywords/pde3b","display_name":"PDE3B","score":0.7860000133514404},{"id":"https://openalex.org/keywords/lipolysis","display_name":"lipolysis","score":0.9110000133514404},{"id":"https://openalex.org/keywords/ucp1","display_name":"UCP1","score":0.8209999799728394},{"id":"https://openalex.org/keywords/3t3-l1-adipocytes","display_name":"3T3-L1 adipocytes","score":0.8420000076293945},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.8320000171661377},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.7580000162124634},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8790000081062317},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.656000018119812},{"id":"https://openalex.org/keywords/14-3-3beta","display_name":"14-3-3\u03b2","score":0.8130000233650208},{"id":"https://openalex.org/keywords/hormone-sensitive-lipase","display_name":"hormone-sensitive lipase","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C2776035688","wikidata":"https://www.wikidata.org/wiki/Q1606558","display_name":"Affect (linguistics)","level":2,"score":0.6764341592788696},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4818645417690277},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3229076564311981},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.27909550070762634},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1820051372051239},{"id":"https://openalex.org/C46312422","wikidata":"https://www.wikidata.org/wiki/Q11024","display_name":"Communication","level":1,"score":0.11342653632164001}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/107243","doi":null,"is_oa":true,"landing_page_url":"http://deepblue.lib.umich.edu/bitstream/2027.42/107243/1/jonmow_1.pdf","pdf_url":"https://hdl.handle.net/2027.42/107243","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2290921674","doi":null,"is_oa":false,"landing_page_url":"https://deepblue.lib.umich.edu/handle/2027.42/107243","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/107243","doi":null,"is_oa":true,"landing_page_url":"http://deepblue.lib.umich.edu/bitstream/2027.42/107243/1/jonmow_1.pdf","pdf_url":"https://hdl.handle.net/2027.42/107243","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/7","display_name":"Affordable and clean energy","score":0.4699999988079071}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2290921674.pdf","grobid_xml":"https://content.openalex.org/works/W2290921674.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2110528304","https://openalex.org/W2074868578","https://openalex.org/W4240802377","https://openalex.org/W2033863085","https://openalex.org/W2996637893","https://openalex.org/W2786396437","https://openalex.org/W3029035455","https://openalex.org/W2304692886","https://openalex.org/W2019013457","https://openalex.org/W1992704001"],"abstract_inverted_index":{"Numerous":[0],"studies":[1,287],"have":[2],"implicated":[3],"an":[4],"inflammatory":[5,221],"link":[6],"between":[7],"obesity":[8],"and":[9,29,60,72,86,116,134,155,159,186,216,229,231,243,266,273,283,295,301,311],"type":[10],"2":[11],"diabetes.":[12],"We":[13],"applied":[14],"a":[15,107,120],"multidisciplinary":[16],"approach":[17],"spanning":[18],"from":[19],"in":[20,25,38,74,96,104,113,142,162,168,174,200,212,250,280,313],"vivo":[21],"animal":[22],"physiology":[23],"to":[24,31,52,176,202,270,272],"vitro":[26],"cell":[27],"culture":[28],"biochemistry":[30],"address":[32],"the":[33,65,89,135,150,237,260,307],"role":[34],"of":[35,43,64,79,84,166,181,184,188,208,233,239,247,297,309],"obesity-related":[36],"inflammation":[37],"adipose":[39,75,143],"tissue.":[40,76,144],"The":[41,111,179,245],"inhibitor":[42,93],"\u03baB":[44],"kinase":[45,61,92],"\u03b2":[46],"(IKK\u03b2)":[47],"has":[48],"previously":[49],"been":[50],"linked":[51],"insulin":[53],"resistance.":[54],"High-fat":[55],"diet":[56,123],"dramatically":[57],"increased":[58,127],"protein":[59,91,140],"activity":[62],"levels":[63,141,183,249],"two":[66],"noncanonical":[67],"IKK":[68],"family":[69],"members,":[70],"IKK\u03b5":[71,80,85,114,154,167,209,215,254,265,300,310],"TBK1,":[73,87],"Genetic":[77],"ablation":[78],"or":[81,204,210,255],"pharmacologic":[82],"inhibition":[83],"using":[88],"selective":[90],"amlexanox,":[94],"resulted":[95],"many":[97],"metabolic":[98],"improvements,":[99],"including":[100],"reduced":[101,290],"weight":[102],"gain":[103],"mice":[105,118],"on":[106,119],"high":[108,121],"fat":[109,122],"diet.":[110],"improvements":[112],"knockout":[115],"amlexanox-treated":[117],"were":[124,197,268],"correlated":[125],"with":[126,146],"energy":[128],"expenditure,":[129],"core":[130],"body":[131],"temperature,":[132],"adipogenesis,":[133],"proton":[136],"uncoupling":[137],"protein,":[138],"UCP1":[139,172],"Studies":[145],"3T3-L1":[147,163,169,213,251],"adipocytes":[148,170,252],"elucidated":[149],"mechanism":[151],"by":[152,206,220,259,299],"which":[153],"TBK1":[156,211,217,256,267,302,312],"regulate":[157],"cAMP":[158,248,291],"\u03b2-adrenergic":[160,177,240],"signaling":[161],"adipocytes.":[164,214,314],"Expression":[165],"decreased":[171],"expression":[173],"response":[175,201],"stimulation.":[178],"rate":[180],"lipolysis,":[182],"cAMP,":[185,242],"phosphorylation":[187,294],"PKA":[189],"substrates":[190],"such":[191,223],"as":[192,224],"hormone":[193],"sensitive":[194],"lipase":[195],"(HSL)":[196],"also":[198],"diminished":[199],"isoproterenol":[203],"forskolin":[205],"overexpression":[207],"are":[218],"induced":[219],"stimuli,":[222],"tumor":[225],"necrosis":[226],"\u03b1":[227],"(TNF\u03b1)":[228],"Poly(I:C),":[230],"blockade":[232],"these":[234],"kinases":[235],"reversed":[236,258],"diminution":[238],"signaling,":[241],"lipolysis.":[244],"reduction":[246],"expressing":[253],"was":[257],"phosphodiesterase":[261],"3B":[262],"inhibitor,":[263],"zardaverine.":[264],"found":[269],"bind":[271],"phosphorylate":[274],"PDE3B":[275,298],"at":[276],"serine":[277],"318,":[278],"resulting":[279],"its":[281],"activation":[282,296],"14-3-3\u03b2":[284],"binding.":[285],"These":[286],"suggest":[288],"that":[289],"production":[292],"through":[293],"is":[303],"responsible":[304],"for":[305],"mediating":[306],"effects":[308]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}