{"id":"https://openalex.org/W22907920","doi":null,"title":"Early mesencephalon/metencephalon patterning and development of the cerebellum.","display_name":"Early mesencephalon/metencephalon patterning and development of the cerebellum.","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W22907920","mag":"22907920","pmid":"https://pubmed.ncbi.nlm.nih.gov/9509514"},"language":"en","primary_location":{"id":"pmid:9509514","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9509514","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Perspectives on developmental neurobiology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042015779","display_name":"Marion Wassef","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I29607241","display_name":"\u00c9cole Normale Sup\u00e9rieure - PSL","ror":"https://ror.org/05a0dhs15","country_code":"FR","type":"other","lineage":["https://openalex.org/I2746051580","https://openalex.org/I29607241"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M Wassef","raw_affiliation_strings":["CNRS URA 1414, Ecole Normale Superieure, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS URA 1414, Ecole Normale Superieure, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I29607241"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041948504","display_name":"Alexandra L. Joyner","orcid":"https://orcid.org/0000-0001-7090-9605","observed_orcids":["https://orcid.org/0000-0001-7090-9605"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A L Joyner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.1752,"has_fulltext":false,"cited_by_count":138,"citation_normalized_percentile":{"value":0.92967693,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"5","issue":"1","first_page":"3","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9434000253677368,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9434000253677368,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.054999999701976776,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12552","display_name":"Fetal and Pediatric Neurological Disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebellar-development","display_name":"cerebellar development","score":0.8569999933242798},{"id":"https://openalex.org/keywords/midbrain","display_name":"midbrain","score":0.9629999995231628},{"id":"https://openalex.org/keywords/metencephalon","display_name":"metencephalon","score":1.0},{"id":"https://openalex.org/keywords/fgf8","display_name":"FGF8","score":0.8809999823570251},{"id":"https://openalex.org/keywords/wnt1","display_name":"Wnt1","score":0.9409999847412109},{"id":"https://openalex.org/keywords/engrailed","display_name":"engrailed","score":0.8820000290870667},{"id":"https://openalex.org/keywords/pax2","display_name":"PAX2","score":0.9309999942779541},{"id":"https://openalex.org/keywords/pax-5","display_name":"Pax-5","score":0.9750000238418579},{"id":"https://openalex.org/keywords/homeobox-genes","display_name":"homeobox genes","score":0.7760000228881836},{"id":"https://openalex.org/keywords/brain-regionalization","display_name":"brain regionalization","score":0.6579999923706055},{"id":"https://openalex.org/keywords/chick-embryo","display_name":"chick embryo","score":0.828000009059906},{"id":"https://openalex.org/keywords/mouse-mutants","display_name":"mouse mutants","score":0.9520000219345093},{"id":"https://openalex.org/keywords/fate-mapping","display_name":"fate mapping","score":0.5180000066757202},{"id":"https://openalex.org/keywords/cell-transplantation","display_name":"cell transplantation","score":0.6050000190734863}],"concepts":[{"id":"https://openalex.org/C121587040","wikidata":"https://www.wikidata.org/wiki/Q898769","display_name":"Homeobox","level":4,"score":0.8743876218795776},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7581285238265991},{"id":"https://openalex.org/C64632358","wikidata":"https://www.wikidata.org/wiki/Q95351881","display_name":"engrailed","level":5,"score":0.6639407277107239},{"id":"https://openalex.org/C2779652256","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellum","level":2,"score":0.6024789214134216},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.5935181379318237},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5812680125236511},{"id":"https://openalex.org/C552161191","wikidata":"https://www.wikidata.org/wiki/Q185080","display_name":"Midbrain","level":3,"score":0.5463796257972717},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5237534046173096},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.4628531038761139},{"id":"https://openalex.org/C183074962","wikidata":"https://www.wikidata.org/wiki/Q213713","display_name":"Developmental biology","level":2,"score":0.4419451355934143},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4056876301765442},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.38302069902420044},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3596588373184204},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.18621918559074402}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005314","descriptor_name":"Embryonic and Fetal Development","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005865","descriptor_name":"Gestational Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008636","descriptor_name":"Mesencephalon","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D008636","descriptor_name":"Mesencephalon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011149","descriptor_name":"Pons","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D011149","descriptor_name":"Pons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019521","descriptor_name":"Body Patterning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9509514","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9509514","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Perspectives on developmental neurobiology","raw_type":"Journal Article"},{"id":"mag:22907920","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9509514","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W2124503498","https://openalex.org/W2024939177","https://openalex.org/W2134235045","https://openalex.org/W2029719206","https://openalex.org/W1994496955","https://openalex.org/W1969212973","https://openalex.org/W2158314083","https://openalex.org/W2949605486","https://openalex.org/W1977982687","https://openalex.org/W1996901909","https://openalex.org/W2103308780","https://openalex.org/W2038361003","https://openalex.org/W2025253673","https://openalex.org/W4233232184","https://openalex.org/W2158302966","https://openalex.org/W2085171372","https://openalex.org/W2077043341","https://openalex.org/W2055816317","https://openalex.org/W1986945099","https://openalex.org/W2060966245","https://openalex.org/W1973158918","https://openalex.org/W1974892519","https://openalex.org/W2074255757","https://openalex.org/W1999941230","https://openalex.org/W2069660013","https://openalex.org/W2050693310","https://openalex.org/W2089618088","https://openalex.org/W2036125344","https://openalex.org/W2007862933","https://openalex.org/W2320329035","https://openalex.org/W2064016764","https://openalex.org/W2055863954","https://openalex.org/W2141024922","https://openalex.org/W1967623338","https://openalex.org/W2087218100","https://openalex.org/W2057717321","https://openalex.org/W2117570650","https://openalex.org/W2167134011","https://openalex.org/W2166770858","https://openalex.org/W4236349369","https://openalex.org/W2171144208","https://openalex.org/W2071348194","https://openalex.org/W1992181634","https://openalex.org/W2030514235","https://openalex.org/W1983937104","https://openalex.org/W2086071590","https://openalex.org/W2158283585","https://openalex.org/W2014624745","https://openalex.org/W2032970576","https://openalex.org/W2114003573","https://openalex.org/W2096350486","https://openalex.org/W2160356927","https://openalex.org/W2323567758","https://openalex.org/W1970873909","https://openalex.org/W2007770992","https://openalex.org/W2136265564","https://openalex.org/W4237215357","https://openalex.org/W2055502338","https://openalex.org/W4238097708","https://openalex.org/W2121143800","https://openalex.org/W2000215968","https://openalex.org/W1970381087"],"related_works":["https://openalex.org/W2002571774","https://openalex.org/W1853890854","https://openalex.org/W1982433848","https://openalex.org/W2079078954","https://openalex.org/W2562087449","https://openalex.org/W2079165221","https://openalex.org/W7140244238","https://openalex.org/W2050969004","https://openalex.org/W1528642580","https://openalex.org/W2135991245"],"abstract_inverted_index":{"Experimental":[0],"studies":[1,27,48,97,136,201],"in":[2,20,28,41,49,90,137,189,193],"chick":[3,29,50],"and":[4,44,74,102,111,143,175,181,215],"analysis":[5],"of":[6,60,66,106,118,121,150,155,195,205,212],"mouse":[7,138],"mutants":[8],"have":[9,30,51,139,184],"provided":[10],"a":[11,58,86,119,210],"framework":[12],"for":[13,147],"studying":[14],"the":[15,22,36,42,53,67,79,91,100,107,115,122,125,132,156,162,171,176,190,206,221],"early":[16,34],"developmental":[17],"processes":[18],"involved":[19,89],"specifying":[21,75],"cerebellar":[23,207],"anlage.":[24],"Fate":[25],"mapping":[26],"shown":[31,140],"that":[32,63,99,141,183,203,218],"at":[33,131],"stages":[35],"cerebellum":[37],"derives":[38],"from":[39],"cells":[40,151],"mesencephalon":[43],"metencephalon":[45],"(mes-met).":[46],"Transplantation":[47],"implicated":[52,84],"mes-met":[54,133,196],"junction":[55],"(isthmus)":[56],"as":[57,85],"source":[59],"secreted":[61,163],"factors":[62],"organize":[64],"development":[65,149],"entire":[68],"mes-met,":[69,191],"perhaps":[70],"by":[71],"stimulating":[72],"proliferation":[73],"positional":[76],"values":[77],"across":[78],"region.":[80],"Fgf-8":[81],"has":[82],"been":[83],"major":[87],"factor":[88,164],"isthmus":[92],"organizing":[93],"activity.":[94],"Gene":[95],"expression":[96,104,127,173,187],"indicate":[98],"anterior":[101,169],"posterior":[103],"domains":[105,188],"homeobox":[108],"genes":[109],"Otx-2":[110,142],"Gbx-2,":[112],"respectively,":[113],"are":[114,145],"earliest":[116],"indication":[117],"division":[120],"brain.":[123],"Furthermore,":[124],"Otx-2/Gbx-2":[126,172],"border":[128,174],"later":[129],"resides":[130],"junction.":[134],"Genetic":[135],"Gbx-2":[144],"required":[146],"normal":[148],"on":[152],"both":[153],"sides":[154],"border.":[157],"In":[158],"addition,":[159],"mutations":[160],"affecting":[161],"Wnt-1,":[165],"which":[166],"is":[167],"expressed":[168],"to":[170],"homeodomain":[177],"transcription":[178],"factors,":[179],"Engrailed-1,2":[180],"Pax-2,5":[182],"broad":[185],"overlapping":[186],"result":[192],"deletions":[194],"structures.":[197],"Taken":[198],"together,":[199],"these":[200],"suggest":[202],"specification":[204],"territory":[208],"requires":[209],"hierarchy":[211],"complex":[213],"cellular":[214],"genetic":[216],"interactions":[217],"gradually":[219],"subdivide":[220],"brain":[222],"into":[223],"smaller":[224],"regions.":[225]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
