{"id":"https://openalex.org/W2290779421","doi":null,"title":"Familial dementia with Lewy bodies (DLB).","display_name":"Familial dementia with Lewy bodies (DLB).","publication_year":1999,"publication_date":"1999-09-01","ids":{"openalex":"https://openalex.org/W2290779421","mag":"2290779421","pmid":"https://pubmed.ncbi.nlm.nih.gov/10505432"},"language":"en","primary_location":{"id":"pmid:10505432","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10505432","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical neuropathology","raw_type":"Case Reports"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"K Ohara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Ohara","raw_affiliation_strings":["Department of Neuropsychiatry, Hyogo College of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuropsychiatry, Hyogo College of Medicine, Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015186946","display_name":"Shigeru Takauchi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Takauchi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002044067","display_name":"Masahiro Kokai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Kokai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034720414","display_name":"Yoshiyuki Morimura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Morimura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034832605","display_name":"Tsuneo Nakajima","orcid":"https://orcid.org/0000-0002-3670-1701","observed_orcids":["https://orcid.org/0000-0002-3670-1701"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Nakajima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5030424289","display_name":"Yukari Morita","orcid":"https://orcid.org/0009-0001-2312-0406","observed_orcids":["https://orcid.org/0009-0001-2312-0406"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Morita","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1447,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.86800099,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"18","issue":"5","first_page":"232","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9276999831199646,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9276999831199646,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.051600001752376556,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dementia-with-lewy-bodies","display_name":"dementia with Lewy bodies","score":0.9629999995231628},{"id":"https://openalex.org/keywords/familial-dementia","display_name":"familial dementia","score":0.8960000276565552},{"id":"https://openalex.org/keywords/first-cousins","display_name":"first cousins","score":0.5839999914169312},{"id":"https://openalex.org/keywords/early-onset-dementia","display_name":"early-onset dementia","score":0.7919999957084656},{"id":"https://openalex.org/keywords/language-disorders","display_name":"language disorders","score":0.6159999966621399},{"id":"https://openalex.org/keywords/paraphasia","display_name":"paraphasia","score":0.9610000252723694},{"id":"https://openalex.org/keywords/psychosis","display_name":"psychosis","score":0.6579999923706055},{"id":"https://openalex.org/keywords/parkinsonism","display_name":"parkinsonism","score":0.9350000023841858},{"id":"https://openalex.org/keywords/compulsions","display_name":"compulsive behavior","score":0.9110000133514404},{"id":"https://openalex.org/keywords/hippocampal-neuronal-loss","display_name":"hippocampal neuronal loss","score":0.8790000081062317},{"id":"https://openalex.org/keywords/neuropathology","display_name":"neuropathology","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C2780130745","wikidata":"https://www.wikidata.org/wiki/Q1650750","display_name":"Neuropathology","level":3,"score":0.8805604577064514},{"id":"https://openalex.org/C2778548049","wikidata":"https://www.wikidata.org/wiki/Q101245788","display_name":"Dementia with Lewy bodies","level":4,"score":0.8664304614067078},{"id":"https://openalex.org/C2776525014","wikidata":"https://www.wikidata.org/wiki/Q1531991","display_name":"Parkinsonism","level":3,"score":0.7365597486495972},{"id":"https://openalex.org/C68026918","wikidata":"https://www.wikidata.org/wiki/Q1970256","display_name":"Senile plaques","level":4,"score":0.5950539112091064},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5874173641204834},{"id":"https://openalex.org/C2779504383","wikidata":"https://www.wikidata.org/wiki/Q41482","display_name":"Autopsy","level":2,"score":0.5825691819190979},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4728929102420807},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45320701599121094},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.4163011312484741},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.38280975818634033},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3785688281059265},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3152826726436615},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.31180840730667114},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2628753185272217}],"mesh":[{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003241","descriptor_name":"Consanguinity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009460","descriptor_name":"Neurologic Examination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010375","descriptor_name":"Pedigree","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020961","descriptor_name":"Lewy Body Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D020961","descriptor_name":"Lewy Body Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:10505432","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10505432","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical neuropathology","raw_type":"Case Reports"},{"id":"mag:2290779421","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10505432","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2049659782","https://openalex.org/W2062055770","https://openalex.org/W2002534269","https://openalex.org/W2072937469","https://openalex.org/W2082558234","https://openalex.org/W1564397321","https://openalex.org/W2010331279","https://openalex.org/W2093490858","https://openalex.org/W2395764184","https://openalex.org/W3009783537"],"abstract_inverted_index":{"We":[0],"report":[1],"a":[2,15,43],"rare":[3],"familial":[4,96,197],"case":[5],"of":[6,22,38,52,76,107,143,152,170,178,193,196],"dementia":[7,106],"with":[8,95,114],"Lewy":[9,78],"bodies":[10],"(DLB).":[11],"The":[12,130],"patient":[13],"was":[14,42,62,181],"man":[16],"who":[17],"died":[18],"at":[19],"the":[20,48,53,58,127,137,149,154,162,166,171,179,190],"age":[21],"51.":[23],"His":[24,81],"parents":[25],"were":[26,33,123],"first":[27],"cousins.":[28],"Among":[29],"three":[30,102,128],"siblings,":[31],"two":[32,139],"diagnosed":[34],"as":[35],"probable":[36],"cases":[37],"DLB,":[39,153],"and":[40,110,116,136],"one":[41],"possible":[44],"case,":[45],"according":[46],"to":[47,64,148,168],"clinical":[49,99],"diagnostic":[50],"criteria":[51],"consortium":[54],"on":[55],"DLB.":[56,198],"Following":[57],"patient's":[59,131],"autopsy,":[60],"he":[61],"found":[63],"have":[65,84],"had":[66],"DLB":[67,97],"without":[68],"neurofibrillary":[69],"tangles":[70],"or":[71],"senile":[72],"plaques":[73],"(pure":[74],"form":[75],"diffuse":[77],"body":[79],"disease).":[80],"other":[82,138],"siblings":[83,103,140],"been":[85],"followed":[86],"for":[87],"more":[88],"than":[89],"ten":[90],"years.":[91],"Although":[92],"these":[93],"patients":[94],"displayed":[98],"variability,":[100],"all":[101],"showed":[104,133,141,157],"progressive":[105,111],"early":[108],"onset":[109],"language":[112],"disorder":[113],"paraphasia":[115],"difficulty":[117],"in":[118,126,146,161,176,189],"finding":[119],"words.":[120],"Psychotic":[121],"features":[122],"also":[124],"seen":[125],"siblings.":[129],"sister":[132],"compulsive":[134],"behavior,":[135],"symptoms":[142],"parkinsonism.":[144],"Neuropathologically,":[145],"addition":[147],"usual":[150],"neuropathology":[151],"autopsy":[155],"findings":[156],"numerous":[158],"small":[159],"spheroids":[160],"stratum":[163],"pyramidale":[164],"from":[165],"subiculum":[167],"CA1":[169],"hippocampus.":[172],"Significant":[173],"neuronal":[174],"loss":[175],"CA2-3":[177],"hippocampus":[180],"detected.":[182],"Axonal":[183],"flow":[184],"disturbance":[185],"may":[186],"be":[187],"involved":[188],"hippocampal":[191],"formations":[192],"this":[194],"incidence":[195]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}