{"id":"https://openalex.org/W2290765521","doi":"https://doi.org/10.1200/jco.2006.24.18_suppl.17550","title":"A randomized phase I trial of melphalan + bortezomib as conditioning for autologous transplant for myeloma","display_name":"A randomized phase I trial of melphalan + bortezomib as conditioning for autologous transplant for myeloma","publication_year":2006,"publication_date":"2006-06-20","ids":{"openalex":"https://openalex.org/W2290765521","doi":"https://doi.org/10.1200/jco.2006.24.18_suppl.17550","mag":"2290765521"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2006.24.18_suppl.17550","doi":"https://doi.org/10.1200/jco.2006.24.18_suppl.17550","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2006.24.18_suppl.17550","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077897003","display_name":"Jonathan L. Kaufman","orcid":"https://orcid.org/0000-0002-5687-6429","observed_orcids":["https://orcid.org/0000-0002-5687-6429"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. L. Kaufman","raw_affiliation_strings":["Emory University, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011386306","display_name":"Edmund K. Waller","orcid":"https://orcid.org/0000-0003-0816-6729","observed_orcids":["https://orcid.org/0000-0003-0816-6729"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. K. Waller","raw_affiliation_strings":["Emory University, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110592632","display_name":"C. Torre","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Torre","raw_affiliation_strings":["Emory University, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039848860","display_name":"Stephanie McMillan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. McMillan","raw_affiliation_strings":["Emory University, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052203408","display_name":"Amelia A. Langston","orcid":"https://orcid.org/0000-0003-0649-1915","observed_orcids":["https://orcid.org/0000-0003-0649-1915"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Langston","raw_affiliation_strings":["Emory University, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082892912","display_name":"Christopher R. Flowers","orcid":"https://orcid.org/0000-0002-9524-3990","observed_orcids":["https://orcid.org/0000-0002-9524-3990"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Flowers","raw_affiliation_strings":["Emory University, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083914569","display_name":"Mary Jo Lechowicz","orcid":"https://orcid.org/0000-0003-1997-1950","observed_orcids":["https://orcid.org/0000-0003-1997-1950"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Lechowicz","raw_affiliation_strings":["Emory University, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030308961","display_name":"Mourad Tighiouart","orcid":"https://orcid.org/0000-0001-8021-5690","observed_orcids":["https://orcid.org/0000-0001-8021-5690"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Tighiouart","raw_affiliation_strings":["Emory University, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023276777","display_name":"Sagar Lonial","orcid":"https://orcid.org/0000-0002-8322-9323","observed_orcids":["https://orcid.org/0000-0002-8322-9323"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Lonial","raw_affiliation_strings":["Emory University, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I150468666"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"18_suppl","first_page":"17550","last_page":"17550"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9670000076293945},{"id":"https://openalex.org/keywords/melphalan","display_name":"melphalan","score":0.8370000123977661},{"id":"https://openalex.org/keywords/bortezomib","display_name":"bortezomib","score":1.0},{"id":"https://openalex.org/keywords/conditioning-regimen","display_name":"conditioning regimen","score":0.6809999942779541},{"id":"https://openalex.org/keywords/autologous-stem-cell-transplantation","display_name":"autologous stem cell transplantation","score":0.9269999861717224},{"id":"https://openalex.org/keywords/high-dose-chemotherapy","display_name":"high-dose chemotherapy","score":0.8740000128746033},{"id":"https://openalex.org/keywords/proteasome-inhibitors","display_name":"proteasome inhibitors","score":0.8989999890327454},{"id":"https://openalex.org/keywords/mcl-1","display_name":"Mcl-1","score":0.8669999837875366},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8629999756813049},{"id":"https://openalex.org/keywords/dna-repair-enzymes","display_name":"DNA repair enzymes","score":0.8109999895095825},{"id":"https://openalex.org/keywords/drug-sequence","display_name":"drug sequence","score":0.48399999737739563},{"id":"https://openalex.org/keywords/toxicity","display_name":"toxicity","score":0.6299999952316284},{"id":"https://openalex.org/keywords/engraftment","display_name":"engraftment","score":0.7839999794960022},{"id":"https://openalex.org/keywords/optimal-dosing","display_name":"optimal dosing","score":0.4880000054836273},{"id":"https://openalex.org/keywords/plasma-cells","display_name":"plasma cells","score":0.44999998807907104},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.7059999704360962},{"id":"https://openalex.org/keywords/thalidomide","display_name":"thalidomide","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C2778684742","wikidata":"https://www.wikidata.org/wiki/Q2298283","display_name":"Melphalan","level":3,"score":0.926986575126648},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.89402836561203},{"id":"https://openalex.org/C2777478702","wikidata":"https://www.wikidata.org/wiki/Q419319","display_name":"Bortezomib","level":3,"score":0.7640130519866943},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.7214270830154419},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6266566514968872},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5044823884963989},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4746994376182556},{"id":"https://openalex.org/C2779609412","wikidata":"https://www.wikidata.org/wiki/Q203174","display_name":"Thalidomide","level":3,"score":0.451435387134552},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.43417590856552124},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.394938200712204},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3592684268951416},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3385361135005951}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2006.24.18_suppl.17550","doi":"https://doi.org/10.1200/jco.2006.24.18_suppl.17550","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2006.24.18_suppl.17550","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7900000214576721,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2368327561","https://openalex.org/W1989604393","https://openalex.org/W2377458274","https://openalex.org/W2409439928","https://openalex.org/W1976805847","https://openalex.org/W2104965094","https://openalex.org/W2063424779","https://openalex.org/W2141779216","https://openalex.org/W3028919400","https://openalex.org/W2092753516"],"abstract_inverted_index":{"17550":[0],"High":[1],"dose":[2,93,357],"chemotherapy":[3,18,37],"and":[4,81,94,147,159,186,196,223,254,311,326,330,347,358],"autologous":[5],"transplant":[6,118],"(HDT)":[7],"clearly":[8],"benefits":[9],"most":[10],"patients":[11,138,210,233],"with":[12,36,122,216,333],"myeloma,":[13],"but":[14],"the":[15,53,90,123,133,219,226,231,267,275,281,285,297,337],"addition":[16,124],"of":[17,96,125,129,135,336,345,360],"or":[19,110],"TBI":[20],"to":[21,39,67,88,101,194,214,274],"melphalan":[22,188],"(M)":[23],"does":[24],"not":[25,200],"improve":[26],"outcomes.":[27],"Bortezomib":[28],"(B)":[29],"is":[30,65,320,353],"a":[31,74,258,292],"proteasome":[32],"inhibitor":[33],"which":[34,57],"synergizes":[35],"due":[38],"its":[40],"effects":[41],"on":[42,142,266,313],"DNA":[43,308],"repair":[44,309],"enzymes.":[45],"Recent":[46],"data":[47,332],"has":[48,174],"shown":[49],"that":[50,60],"B":[51,61,80,104,111,220,227,236,286,346],"upregulates":[52],"anti-apoptotic":[54],"protein":[55,165],"MCL-1,":[56],"would":[58],"suggest":[59],"followed":[62,69],"by":[63,70],"M":[64,68,288,348],"inferior":[66],"B.":[71],"We":[72],"designed":[73],"randomized":[75,100,213],"phase":[76],"I":[77],"trial":[78],"combining":[79],"Melphalan":[82],"200":[83,109,207],"mg/m2":[84],"(Mel200)":[85],"in":[86,189,218,225,246,251,255,262,284,296],"order":[87],"determine":[89],"toxicity,":[91],"optimal":[92,356],"sequence":[95,359],"administration.":[97],"Patients":[98],"were":[99,120,155,162,199],"receive":[102],"either":[103],"24":[105,112],"hours":[106,113],"before":[107,237,325],"Mel":[108,115],"after":[114,287,327],"200.":[116],"Standard":[117],"criteria":[119],"used":[121],"requiring":[126],"measurable":[127],"numbers":[128],"plasma":[130],"cells":[131,161,316],"at":[132],"time":[134],"transplant.":[136],"Enrolled":[137],"underwent":[139],"BM":[140],"aspirate":[141],"day":[143,148,239,268,276,298],"-4":[144],"(before":[145,150],"B)":[146],"0":[149,240,269,299],"PBSC":[151],"infusion).":[152],"Bone":[153],"marrows":[154],"tested":[156],"for":[157,164,307,322,351],"apoptosis,":[158],"myeloma":[160,248,263,301],"sorted":[163,314],"analysis.":[166],"Age":[167],"range":[168],"was":[169,291],"48\u201374":[170],"years.":[171],"Prior":[172],"therapy":[173],"included":[175],"Velcade":[176],"(n":[177,183],"=":[178,184],"2,":[179],"both":[180],"responsive)":[181],"thalidomide":[182],"2)":[185],"prior":[187],"2":[190],"(1":[191],"HDT).":[192],"Time":[193],"WBC":[195],"Plt":[197],"engraftment":[198],"different":[201],"from":[202],"historical":[203],"cohorts":[204],"receiving":[205],"MEL":[206],"alone.":[208],"Four":[209],"have":[211],"been":[212],"date":[215],"3":[217,232],"\u201cbefore\u201c":[221],"arm,":[222,289],"1":[224],"\u201cafter\u201d":[228],"arm.":[229],"Of":[230],"who":[234],"received":[235],"M,":[238],"bone":[241],"marrow":[242,247,270,300],"revealed":[243],"minimal":[244],"changes":[245],"cell":[249,264,302],"apoptosis":[250,265],"two":[252],"patients,":[253],"one":[256],"patient":[257,282],">20":[259],"fold":[260,294],"increase":[261,295],"sample":[271],"when":[272],"compared":[273],"-":[277],"4":[278],"marrow.":[279],"In":[280],"enrolled":[283],"there":[290],"10":[293],"apoptosis.":[303],"Western":[304],"blot":[305],"analysis":[306],"enzymes":[310],"MCL-1":[312],"tumor":[315],"are":[317],"planned,":[318],"as":[319,349],"ELISA":[321],"secreted":[323],"cytokines":[324],"therapy.":[328],"Toxicity":[329],"response":[331],"an":[334],"update":[335],"molecular":[338],"correlates":[339],"will":[340],"be":[341],"presented.":[342],"The":[343,355],"combination":[344],"conditioning":[350],"HDT":[352],"feasible.":[354],"administration":[361],"remains":[362],"unknown.":[363],"Accrual":[364],"continues.":[365],"[Table:":[366],"see":[367],"text]":[368]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}