{"id":"https://openalex.org/W2290762340","doi":"https://doi.org/10.1155/2016/2969740","title":"A Comparison of Measures of Endothelial Function in Patients with Peripheral Arterial Disease and Age and Gender Matched Controls","display_name":"A Comparison of Measures of Endothelial Function in Patients with Peripheral Arterial Disease and Age and Gender Matched Controls","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2290762340","doi":"https://doi.org/10.1155/2016/2969740","mag":"2290762340","pmid":"https://pubmed.ncbi.nlm.nih.gov/26942010","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4752993"},"language":"en","primary_location":{"id":"doi:10.1155/2016/2969740","doi":"https://doi.org/10.1155/2016/2969740","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2016/2969740","pdf_url":"https://downloads.hindawi.com/journals/ijvm/2016/2969740.pdf","source":{"id":"https://openalex.org/S44177516","display_name":"International Journal of Vascular Medicine","issn_l":"2090-2824","issn":["2090-2824","2090-2832"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Vascular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://downloads.hindawi.com/journals/ijvm/2016/2969740.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013195435","display_name":"Richard B. Allan","orcid":"https://orcid.org/0000-0002-0344-4008","observed_orcids":["https://orcid.org/0000-0002-0344-4008"]},"institutions":[{"id":"https://openalex.org/I169541294","display_name":"Flinders University","ror":"https://ror.org/01kpzv902","country_code":"AU","type":"education","lineage":["https://openalex.org/I169541294"]},{"id":"https://openalex.org/I2802931750","display_name":"Flinders Medical Centre","ror":"https://ror.org/020aczd56","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2802931750"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Richard B. Allan","raw_affiliation_strings":["Department of Vascular and Endovascular Surgery, Flinders Medical Centre, Bedford Park, SA 5042, Australia","Department of Vascular and Endovascular Surgery, Flinders University, Bedford Park, SA 5042, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vascular and Endovascular Surgery, Flinders Medical Centre, Bedford Park, SA 5042, Australia","institution_ids":["https://openalex.org/I2802931750"]},{"raw_affiliation_string":"Department of Vascular and Endovascular Surgery, Flinders University, Bedford Park, SA 5042, Australia","institution_ids":["https://openalex.org/I169541294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029301392","display_name":"Simon V. Vun","orcid":"https://orcid.org/0000-0002-6159-2340","observed_orcids":["https://orcid.org/0000-0002-6159-2340"]},"institutions":[{"id":"https://openalex.org/I169541294","display_name":"Flinders University","ror":"https://ror.org/01kpzv902","country_code":"AU","type":"education","lineage":["https://openalex.org/I169541294"]},{"id":"https://openalex.org/I2802931750","display_name":"Flinders Medical Centre","ror":"https://ror.org/020aczd56","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2802931750"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Simon V. Vun","raw_affiliation_strings":["Department of Vascular and Endovascular Surgery, Flinders Medical Centre, Bedford Park, SA 5042, Australia","Department of Vascular and Endovascular Surgery, Flinders University, Bedford Park, SA 5042, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vascular and Endovascular Surgery, Flinders Medical Centre, Bedford Park, SA 5042, Australia","institution_ids":["https://openalex.org/I2802931750"]},{"raw_affiliation_string":"Department of Vascular and Endovascular Surgery, Flinders University, Bedford Park, SA 5042, Australia","institution_ids":["https://openalex.org/I169541294"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112071651","display_name":"J. Ian Spark","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169541294","display_name":"Flinders University","ror":"https://ror.org/01kpzv902","country_code":"AU","type":"education","lineage":["https://openalex.org/I169541294"]},{"id":"https://openalex.org/I2802931750","display_name":"Flinders Medical Centre","ror":"https://ror.org/020aczd56","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2802931750"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"J. Ian Spark","raw_affiliation_strings":["Department of Vascular and Endovascular Surgery, Flinders Medical Centre, Bedford Park, SA 5042, Australia","Department of Vascular and Endovascular Surgery, Flinders University, Bedford Park, SA 5042, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vascular and Endovascular Surgery, Flinders Medical Centre, Bedford Park, SA 5042, Australia","institution_ids":["https://openalex.org/I2802931750"]},{"raw_affiliation_string":"Department of Vascular and Endovascular Surgery, Flinders University, Bedford Park, SA 5042, Australia","institution_ids":["https://openalex.org/I169541294"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5112071651"],"corresponding_institution_ids":["https://openalex.org/I169541294","https://openalex.org/I2802931750"],"apc_list":{"value":1000,"currency":"USD","value_usd":1000},"apc_paid":{"value":1000,"currency":"USD","value_usd":1000},"fwci":1.7069,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.84675878,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"2016","issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10926","display_name":"Peripheral Artery Disease Management","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peripheral-arterial-disease","display_name":"peripheral arterial disease","score":0.7770000100135803},{"id":"https://openalex.org/keywords/endothelial-function","display_name":"endothelial function","score":0.9750000238418579},{"id":"https://openalex.org/keywords/flow-mediated-dilation","display_name":"flow-mediated dilation","score":0.9139999747276306},{"id":"https://openalex.org/keywords/reactive-hyperemia-index","display_name":"reactive hyperemia index","score":0.9779999852180481},{"id":"https://openalex.org/keywords/serum-nitric-oxide","display_name":"serum nitric oxide","score":0.8889999985694885},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.9710000157356262},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.7509999871253967}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8724154233932495},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.7192302942276001},{"id":"https://openalex.org/C3018348675","wikidata":"https://www.wikidata.org/wiki/Q4797557","display_name":"Arterial disease","level":3,"score":0.692557692527771},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5366142988204956},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.42155206203460693},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4204106628894806},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.32746562361717224},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.19521325826644897},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":8,"locations":[{"id":"doi:10.1155/2016/2969740","doi":"https://doi.org/10.1155/2016/2969740","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2016/2969740","pdf_url":"https://downloads.hindawi.com/journals/ijvm/2016/2969740.pdf","source":{"id":"https://openalex.org/S44177516","display_name":"International Journal of Vascular Medicine","issn_l":"2090-2824","issn":["2090-2824","2090-2832"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Vascular Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3748997","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4752993","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:26942010","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26942010","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of vascular medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4752993","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4752993/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Vasc Med","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:10fe8bea3aed4bbba906771a73df388d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/10fe8bea3aed4bbba906771a73df388d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Vascular Medicine, Vol 2016 (2016)","raw_type":"article"},{"id":"pmh:oai:dspace.flinders.edu.au:2328/36442","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2328/36442","pdf_url":null,"source":{"id":"https://openalex.org/S4306401120","display_name":"Flinders Academic Commons (Flinders University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169541294","host_organization_name":"Flinders University","host_organization_lineage":["https://openalex.org/I169541294"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:dspace.flinders.edu.au:2328/38051","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2328/38051","pdf_url":null,"source":{"id":"https://openalex.org/S4306401120","display_name":"Flinders Academic Commons (Flinders University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169541294","host_organization_name":"Flinders University","host_organization_lineage":["https://openalex.org/I169541294"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:fac.flinders.edu.au:2328/36442","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.1155/2016/2969740","pdf_url":null,"source":{"id":"https://openalex.org/S4306401120","display_name":"Flinders Academic Commons (Flinders University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169541294","host_organization_name":"Flinders University","host_organization_lineage":["https://openalex.org/I169541294"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1155/2016/2969740","doi":"https://doi.org/10.1155/2016/2969740","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2016/2969740","pdf_url":"https://downloads.hindawi.com/journals/ijvm/2016/2969740.pdf","source":{"id":"https://openalex.org/S44177516","display_name":"International Journal of Vascular Medicine","issn_l":"2090-2824","issn":["2090-2824","2090-2832"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Vascular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2290762340.pdf","grobid_xml":"https://content.openalex.org/works/W2290762340.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1555489744","https://openalex.org/W1983475919","https://openalex.org/W1992856469","https://openalex.org/W2000851646","https://openalex.org/W2002017644","https://openalex.org/W2007469578","https://openalex.org/W2008202040","https://openalex.org/W2013762947","https://openalex.org/W2022177619","https://openalex.org/W2026631125","https://openalex.org/W2038273086","https://openalex.org/W2061005453","https://openalex.org/W2073179272","https://openalex.org/W2082275003","https://openalex.org/W2087031555","https://openalex.org/W2092704432","https://openalex.org/W2116999983","https://openalex.org/W2126202424","https://openalex.org/W2130020370","https://openalex.org/W2133942398","https://openalex.org/W2134987998","https://openalex.org/W2157114667","https://openalex.org/W2162520541","https://openalex.org/W2162794447","https://openalex.org/W2164232203","https://openalex.org/W2166977140","https://openalex.org/W2197812094","https://openalex.org/W2565726191"],"related_works":["https://openalex.org/W2121440066","https://openalex.org/W1983475919","https://openalex.org/W2131332052","https://openalex.org/W46869161","https://openalex.org/W2555552068","https://openalex.org/W2137422068","https://openalex.org/W2087119994","https://openalex.org/W2140291024","https://openalex.org/W2109646195","https://openalex.org/W1985326793"],"abstract_inverted_index":{"This":[0,209],"study":[1],"compared":[2],"flow-mediated":[3],"dilatation":[4],"(FMD),":[5],"peripheral":[6,22],"artery":[7,23],"tonometry":[8],"(PAT),":[9],"and":[10,45,80,90,93,101,122,165,173],"serum":[11,81],"nitric":[12],"oxide":[13],"(NO)":[14],"measures":[15],"of":[16,50,221],"endothelial":[17,207,223],"function":[18,67],"in":[19,105,125,162,181,188],"patients":[20,31,92,106,164,182,190,198],"with":[21,42,107,183],"disease":[24],"(PAD)":[25],"against":[26],"age/gender":[27,47],"matched":[28,48],"controls.":[29],"25":[30,51],"(mean":[32,54],"age:":[33,55],"72.4":[34,56],"years,":[35,57],"M":[36,58],":":[37,40,59,62],"F":[38,60],"18":[39,61],"7)":[41,63],"established":[43,204],"PAD":[44,89,108,112,126,189,197],"an":[46],"group":[49],"healthy":[52],"controls":[53],"were":[64,98,103,138,160,191],"studied.":[65],"Endothelial":[66],"was":[68],"measured":[69],"using":[70,78],"the":[71,96,143,196,203,219],"%":[72],"FMD,":[73],"reactive":[74],"hyperemia":[75],"index":[76],"(RHI)":[77],"PAT":[79,174],"NO":[82,136],"(\u03bcmol).":[83],"Difference":[84],"for":[85,111,206,218],"each":[86],"method":[87,217],"between":[88,95,142],"control":[91,116,130,150],"correlation":[94],"methods":[97],"investigated.":[99],"FMD":[100,110,172,186,212],"RHI":[102,124,200],"lower":[104,178],"(median":[109],"=":[113,117,120,127,131,134,147,152,156],"2.16%":[114],"versus":[115,129],"3.77%,":[118],"p":[119,133,155],"0.034":[121],"median":[123,146,151],"1.64":[128],"1.92,":[132],"0.005).":[135],"levels":[137],"not":[139],"significantly":[140],"different":[141],"groups":[144],"(PAD":[145],"7.70":[148],"\u03bcmol,":[149,154],"13.05":[153],"0.662).":[157],"These":[158],"results":[159,187],"obtained":[161],"elderly":[163],"cannot":[166],"be":[167],"extrapolated":[168],"to":[169],"younger":[170],"individuals.":[171],"both":[175],"demonstrated":[176],"a":[177,214],"hyperaemic":[179],"response":[180],"PAD;":[184],"however,":[185],"unequivocally":[192],"reduced":[193],"whereas":[194],"half":[195],"had":[199],"values":[201],"above":[202],"threshold":[205],"dysfunction.":[208],"suggests":[210],"that":[211],"is":[213],"more":[215],"appropriate":[216],"measurement":[220],"NO-mediated":[222],"function.":[224]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
