{"id":"https://openalex.org/W2290746239","doi":"https://doi.org/10.1161/circ.126.suppl_21.a19231","title":"Abstract 19231: Chemotactic Properties of Perivascular Adipose Tissue in Angiotensin Ii Dependent Hypertension","display_name":"Abstract 19231: Chemotactic Properties of Perivascular Adipose Tissue in Angiotensin Ii Dependent Hypertension","publication_year":2012,"publication_date":"2012-11-20","ids":{"openalex":"https://openalex.org/W2290746239","doi":"https://doi.org/10.1161/circ.126.suppl_21.a19231","mag":"2290746239"},"language":"en","primary_location":{"id":"doi:10.1161/circ.126.suppl_21.a19231","doi":"https://doi.org/10.1161/circ.126.suppl_21.a19231","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.126.suppl_21.a19231","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074974116","display_name":"Ryszard Nosalski","orcid":"https://orcid.org/0000-0003-4661-8773","observed_orcids":["https://orcid.org/0000-0003-4661-8773"]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Ryszard Nosalski","raw_affiliation_strings":["Dept of Internal and Agricultural Medicine, Jagiellonian Univ Sch of Medicine, Cracow, Poland","Ryszard Nosalski"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Internal and Agricultural Medicine, Jagiellonian Univ Sch of Medicine, Cracow, Poland","institution_ids":["https://openalex.org/I126596746"]},{"raw_affiliation_string":"Ryszard Nosalski","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000650554","display_name":"Tomasz P Mikolajczyk","orcid":"https://orcid.org/0000-0002-7990-2896","observed_orcids":["https://orcid.org/0000-0002-7990-2896"]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Tomasz Mikolajczyk","raw_affiliation_strings":["Dept of Internal and Agricultural Medicine, Jagiellonian Univ Sch of Medicine, Cracow, Poland","Tomasz Mikolajczyk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Internal and Agricultural Medicine, Jagiellonian Univ Sch of Medicine, Cracow, Poland","institution_ids":["https://openalex.org/I126596746"]},{"raw_affiliation_string":"Tomasz Mikolajczyk","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063556944","display_name":"Ryszard Korbut","orcid":"https://orcid.org/0000-0002-3442-6435","observed_orcids":["https://orcid.org/0000-0002-3442-6435"]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Ryszard Korbut","raw_affiliation_strings":["Dept of Pharmacology, Jagiellonian Univ Sch of Medicine, Cracow, Poland","Ryszard Korbut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Pharmacology, Jagiellonian Univ Sch of Medicine, Cracow, Poland","institution_ids":["https://openalex.org/I126596746"]},{"raw_affiliation_string":"Ryszard Korbut","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011627807","display_name":"David Glenn Harrison","orcid":"https://orcid.org/0000-0001-9363-6451","observed_orcids":["https://orcid.org/0000-0001-9363-6451"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Harrison","raw_affiliation_strings":["Div of Clinical Pharmacology, Vanderbilt Univ, Nashville, TN","David Harrison"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Div of Clinical Pharmacology, Vanderbilt Univ, Nashville, TN","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"David Harrison","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040329167","display_name":"Tomasz Jan Guzik","orcid":"https://orcid.org/0000-0002-5039-7849","observed_orcids":["https://orcid.org/0000-0002-5039-7849","https://orcid.org/0000-0003-2012-1187"]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Tomasz Guzik","raw_affiliation_strings":["Dept of Internal and Agricultural Medicine, Jagiellonian Univ Sch of Medicine, Cracow, Poland","Tomasz Guzik"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Internal and Agricultural Medicine, Jagiellonian Univ Sch of Medicine, Cracow, Poland","institution_ids":["https://openalex.org/I126596746"]},{"raw_affiliation_string":"Tomasz Guzik","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"126","issue":"suppl_21","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12979","display_name":"Cardiovascular Disease and Adiposity","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12979","display_name":"Cardiovascular Disease and Adiposity","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/perivascular-adipose-tissue","display_name":"perivascular adipose tissue","score":0.9150000214576721},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.8650000095367432},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.8859999775886536},{"id":"https://openalex.org/keywords/t-cell-chemotaxis","display_name":"T cell chemotaxis","score":0.8360000252723694},{"id":"https://openalex.org/keywords/ccl5","display_name":"RANTES","score":0.9959999918937683},{"id":"https://openalex.org/keywords/ccr5","display_name":"CCR5","score":0.7329999804496765},{"id":"https://openalex.org/keywords/chemokine-receptors","display_name":"chemokine receptors","score":0.8169999718666077},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.6000000238418579},{"id":"https://openalex.org/keywords/adipose-tissue-inflammation","display_name":"adipose tissue inflammation","score":0.6190000176429749},{"id":"https://openalex.org/keywords/subcutaneous-adipose-tissue","display_name":"subcutaneous adipose tissue","score":0.7120000123977661},{"id":"https://openalex.org/keywords/cd4-cd8-t-cells","display_name":"CD4+CD8+ T cells","score":0.753000020980835},{"id":"https://openalex.org/keywords/ccr3","display_name":"CCR3","score":0.4339999854564667},{"id":"https://openalex.org/keywords/ccr1","display_name":"CCR1","score":0.9509999752044678},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.75},{"id":"https://openalex.org/keywords/mip-1","display_name":"MIP-1","score":0.9660000205039978}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9184508323669434},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.7823917865753174},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.5892952084541321},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.4797010123729706},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3940069377422333},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.36690670251846313},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34742337465286255},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32290828227996826},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.17907854914665222},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.11273020505905151}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.126.suppl_21.a19231","doi":"https://doi.org/10.1161/circ.126.suppl_21.a19231","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1161/circ.126.suppl_21.a19231","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2280670060","https://openalex.org/W2337180881","https://openalex.org/W2332019830","https://openalex.org/W96484220","https://openalex.org/W3152888125","https://openalex.org/W204205961","https://openalex.org/W3175608312","https://openalex.org/W201655236","https://openalex.org/W2040709359","https://openalex.org/W2019552241"],"abstract_inverted_index":{"Introduction.":[0],"Recent":[1],"studies":[2],"show":[3],"that":[4],"immune":[5],"system":[6],"is":[7],"involved":[8],"in":[9,20,56,80,95,99,129,148,227,238,262,292],"hypertension":[10],"(HT).":[11],"Angiotensin":[12],"II":[13,205,270],"(AngII)":[14],"causes":[15],"accumulation":[16],"of":[17,28,45,68,87,104,110,126,175,209,250,258,265],"T":[18,39,51,69,96,127,150,176,196,212,230,242,259,272],"cells":[19,40,52,70,128,151,177,213,231,243,260],"perivascular":[21],"adipose":[22],"tissue":[23],"(pvAT)":[24],"but":[25,198,277],"precise":[26],"mechanisms":[27],"their":[29],"infiltration":[30],"remain":[31],"unclear.":[32],"Hypothesis.":[33],"RANTES":[34,77,105,193,215,283,287],"and":[35,53,63,116,295],"it\u2019s":[36],"receptors":[37,47,132,288],"recruit":[38],"towards":[41,71,155,214,252],"pvAT.":[42],"Methods.":[43],"Expression":[44,109],"chemokine":[46,54],"on":[48,297],"peripheral":[49],"blood":[50,210],"ligands":[55,113],"pvAT":[57,100,130,156,171,228,276],"was":[58,78,90,118,186,225,264],"studied":[59,79],"by":[60,216,246,280],"flow":[61],"cytometry":[62],"quantitative":[64],"RT-PCR":[65],"respectively.":[66],"Chemotaxis":[67],"pvAT,":[72],"vAT":[73,181,263,279],"(epidydymal":[74],"AT)":[75],"or":[76],"Boyden":[81],"chambers.":[82],"Results.":[83],"14":[84],"day":[85],"infusion":[86,206],"AngII":[88,121,159,233],"(490mg/d/kg)":[89],"associated":[91],"with":[92,101],"significant":[93],"increase":[94,103],"cell":[97,273],"content":[98,125],"concomitant":[102],"mRNA":[106],"expression":[107],"(p<0.001).":[108],"other":[111],"CCR5":[112,141,296],"MCP-1,":[114],"MIP-1\u03b1":[115],"MIP-1\u03b2":[117],"significantly":[119,122],"decreased.":[120],"increased":[123,153,207],"total":[124],"expressing":[131],"for":[133],"RANTES:":[134],"CCR1":[135,294],"(27.9\u00b14.6%":[136],"vs.15.7\u00b11%),":[137],"CCR3":[138],"(17.1\u00b11.4%":[139],"vs.10.5\u00b11.4%),":[140],"(23.6\u00b10.9%":[142],"vs.17\u00b10.9%),":[143],"while":[144],"having":[145],"no":[146],"effect":[147],"vAT.":[149],"showed":[152],"chemotaxis":[154,208,223],"obtained":[157],"from":[158,202,232],"infused":[160],"mice":[161,235],"when":[162],"compared":[163],"to":[164,180],"sham":[165],"animals":[166],"(4.4\u00b10.7":[167],"vs.0.17\u00b10.17;":[168],"p<0.01).":[169,240],"Moreover":[170,192],"attracted":[172],"higher":[173],"amount":[174],"as":[178],"compare":[179],"(4.4\u00b10.7%":[182],"vs.0.8\u00b10.1%;":[183],"p<0.05);":[184],"there":[185],"minimal":[187,266],"migration":[188,251,256,274],"toward":[189],"subcutaneous":[190],"fat.":[191],"(10ng/ml)":[194],"recruited":[195],"cells,":[197,201],"not":[199,278],"B":[200],"blood.":[203],"Ang":[204,269],"derived":[211],"2-fold":[217],"(p<0.01).":[218],"However":[219],"the":[220,247],"most":[221],"prominent":[222],"potential":[224],"observed":[226],"isolated":[229],"treated":[234],"(2.4\u00b10.3%":[236],"vs.0.8\u00b10.2%":[237],"sham,":[239],"CD4-CD8-":[241],"were":[244],"characterized":[245],"highest":[248],"rate":[249],"RANTES.":[253],"In":[254],"contrast,":[255],"capability":[257],"resident":[261],"rate.":[267],"Conclusions.":[268],"enhances":[271],"into":[275],"increasing":[281],"local":[282],"expression.":[284],"All":[285],"known":[286],"are":[289],"involved.":[290],"And":[291],"particular":[293],"CD3+CD4-CD8-":[298],"cells.":[299]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}