{"id":"https://openalex.org/W2290686998","doi":null,"title":"8-Mop/uva Inhibits Maturation Of Extracorporeal Photochemotherapy (ecp) Generated Dendritic Cells","display_name":"8-Mop/uva Inhibits Maturation Of Extracorporeal Photochemotherapy (ecp) Generated Dendritic Cells","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2290686998","mag":"2290686998"},"language":"en","primary_location":{"id":"mag:2290686998","doi":null,"is_oa":false,"landing_page_url":"https://elischolar.library.yale.edu/cgi/viewcontent.cgi?article=1613&context=ymtdl","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108492461","display_name":"Abigail H. Baird","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Abigail Hart Baird","raw_affiliation_strings":["Yale University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5108492461"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11811","display_name":"Cutaneous lymphoproliferative disorders research","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracorporeal-photopheresis","display_name":"extracorporeal photopheresis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/8-methoxypsoralen","display_name":"8-methoxypsoralen","score":0.9850000143051147},{"id":"https://openalex.org/keywords/uva-irradiation","display_name":"UVA irradiation","score":0.8420000076293945},{"id":"https://openalex.org/keywords/dendritic-cell-maturation","display_name":"dendritic cell maturation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cutaneous-t-cell-lymphoma","display_name":"cutaneous T-cell lymphoma","score":0.8730000257492065},{"id":"https://openalex.org/keywords/graft-versus-host-disease","display_name":"graft-versus-host disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8029999732971191},{"id":"https://openalex.org/keywords/costimulatory-molecules","display_name":"costimulatory molecules","score":0.8399999737739563},{"id":"https://openalex.org/keywords/hla-dr","display_name":"HLA-DR","score":0.7929999828338623},{"id":"https://openalex.org/keywords/cd83","display_name":"CD83","score":0.9620000123977661},{"id":"https://openalex.org/keywords/cd4-t-cell-stimulation","display_name":"CD4+ T cell stimulation","score":0.7639999985694885},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C2778297628","wikidata":"https://www.wikidata.org/wiki/Q5009843","display_name":"CD80","level":5,"score":0.8166483640670776},{"id":"https://openalex.org/C2781101188","wikidata":"https://www.wikidata.org/wiki/Q5009846","display_name":"CD86","level":4,"score":0.7883248329162598},{"id":"https://openalex.org/C2781468836","wikidata":"https://www.wikidata.org/wiki/Q774032","display_name":"Photopheresis","level":3,"score":0.5933934450149536},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.5805360078811646},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5784146785736084},{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.5673536062240601},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5614367127418518},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.4994325637817383},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4290725886821747},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3746412396430969},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.36860454082489014},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3612084984779358},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3489856719970703},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34417927265167236},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3417927622795105},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.2962856888771057},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.20623350143432617},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2290686998","doi":null,"is_oa":false,"landing_page_url":"https://elischolar.library.yale.edu/cgi/viewcontent.cgi?article=1613&context=ymtdl","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W47217405","https://openalex.org/W87144048","https://openalex.org/W1661347229","https://openalex.org/W1675113161","https://openalex.org/W1819577662","https://openalex.org/W1846859874","https://openalex.org/W1891894356","https://openalex.org/W1968950760","https://openalex.org/W1971077650","https://openalex.org/W1972251272","https://openalex.org/W1982992199","https://openalex.org/W1987237595","https://openalex.org/W1991011546","https://openalex.org/W1992178721","https://openalex.org/W1994873440","https://openalex.org/W1995801549","https://openalex.org/W1996385095","https://openalex.org/W1996677978","https://openalex.org/W1996869817","https://openalex.org/W1997124356","https://openalex.org/W2005159588","https://openalex.org/W2010912814","https://openalex.org/W2011096466","https://openalex.org/W2014008695","https://openalex.org/W2019072400","https://openalex.org/W2021925054","https://openalex.org/W2025019393","https://openalex.org/W2025482003","https://openalex.org/W2027041559","https://openalex.org/W2039436354","https://openalex.org/W2044874678","https://openalex.org/W2052555146","https://openalex.org/W2053980323","https://openalex.org/W2055297450","https://openalex.org/W2055860284","https://openalex.org/W2057537431","https://openalex.org/W2059098968","https://openalex.org/W2062463337","https://openalex.org/W2063451038","https://openalex.org/W2076232389","https://openalex.org/W2087581939","https://openalex.org/W2088553840","https://openalex.org/W2090559129","https://openalex.org/W2091493364","https://openalex.org/W2093332059","https://openalex.org/W2097758026","https://openalex.org/W2101878159","https://openalex.org/W2102474483","https://openalex.org/W2104032434","https://openalex.org/W2104043654","https://openalex.org/W2112407455","https://openalex.org/W2122445377","https://openalex.org/W2124802225","https://openalex.org/W2128961069","https://openalex.org/W2130835454","https://openalex.org/W2132254923","https://openalex.org/W2144377698","https://openalex.org/W2144694610","https://openalex.org/W2153008625","https://openalex.org/W2158770157","https://openalex.org/W2161000130","https://openalex.org/W2165859652","https://openalex.org/W2166670863","https://openalex.org/W2181915620","https://openalex.org/W2247563856","https://openalex.org/W2337557724","https://openalex.org/W2394835687","https://openalex.org/W2396226214","https://openalex.org/W2413199457","https://openalex.org/W2992138612"],"related_works":["https://openalex.org/W1535196380","https://openalex.org/W2339591044","https://openalex.org/W3004596412","https://openalex.org/W2966067861","https://openalex.org/W2090348620","https://openalex.org/W2803489808","https://openalex.org/W2226961567","https://openalex.org/W2163148162","https://openalex.org/W2043483672","https://openalex.org/W2593827781"],"abstract_inverted_index":{"Extracorporeal":[0],"photochemotherapy":[1],"(ECP),":[2],"a":[3,7,94,155,217,225],"cellular":[4],"therapy":[5],"involving":[6],"light":[8],"activated":[9,88],"drug,":[10],"is":[11,45],"FDA":[12],"approved":[13],"for":[14,24,166],"the":[15,119,228,234],"treatment":[16,44,175,235],"of":[17,26,79,118,140,161,178,231,236],"Cutaneous":[18],"T-cell":[19],"lymphoma":[20],"(CTCL)":[21],"and":[22,30,52,69,82,122,138,147,184,192,196,215,238],"used":[23],"reversal":[25],"Graft-versus-Host":[27],"Disease":[28],"(GHVD)":[29],"solid":[31,239],"organ":[32,240],"transplant":[33,241],"rejection.":[34,242],"The":[35],"mechanism":[36],"by":[37,49,143],"which":[38],"ECP":[39,55,98,120,211,232],"functions":[40],"as":[41],"an":[42,114],"immunomodulating":[43],"unknown,":[46],"although":[47],"work":[48],"our":[50],"lab":[51],"others":[53],"suggests":[54],"generates":[56],"functional":[57,148],"Dendritic":[58],"cells":[59,109,142,162],"(DC)":[60],"that":[61,86],"may":[62,223],"be":[63,75],"involved":[64,76],"in":[65,77,97,113,115,159,201,227,233],"tolerization.":[66],"Both":[67],"radiation":[68],"chemotherapy":[70,89],"have":[71],"been":[72],"shown":[73],"to":[74,190,198],"generation":[78],"tolerizing":[80,95,218,221],"DC,":[81,195],"so":[83],"we":[84,153],"hypothesized":[85],"UVA":[87,131],"8-Methoxypsoralen":[90],"(8MOP)":[91],"exposure":[92,209],"induces":[93,216],"phenotype":[96,137],"generated":[99,141],"DC.":[100],"In":[101,150],"this":[102],"study,":[103],"normal":[104],"donor":[105],"peripheral":[106],"blood":[107],"mononuclear":[108],"(PBMC)":[110],"were":[111],"treated":[112,127],"vitro":[116],"model":[117],"apparatus,":[121],"collected":[123],"(no8MOP/UVA":[124],"sample)":[125],"or":[126],"with":[128],"8MOP":[129],"(100ng/ml),":[130],"(2J/cm)":[132],"(8MOP/UVA":[133],"sample).":[134],"We":[135],"measured":[136],"functionality":[139],"two-color":[144],"flow":[145],"cytometry":[146],"assays.":[149],"all":[151],"populations,":[152],"noted":[154],"statistically":[156],"significant":[157],"increase":[158],"percentage":[160],"staining":[163],"double":[164],"positive":[165,193],"DC":[167,180,213,222],"markers":[168,181],"(HLA-DR+/CD83+)":[169],"18":[170],"hours":[171],"post":[172],"treatment.":[173],"8MOP/UVA":[174,208],"reduced":[176],"expression":[177],"mature":[179],"(membrane":[182],"HLA-DR/CD83)":[183],"costimulatory":[185],"molecules":[186],"(CD80/CD86)":[187],"when":[188],"compared":[189],"no8MOP/UVA":[191],"control":[194],"failed":[197],"stimulate":[199],"CD4+Tcells":[200],"antigen":[202],"presenting":[203],"assay.":[204],"These":[205,220],"data":[206],"suggest":[207],"during":[210],"inhibits":[212],"maturation":[214],"phenotype.":[219],"play":[224],"role":[226],"immunosuppressive":[229],"effects":[230],"GVHD":[237]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}