{"id":"https://openalex.org/W2290636701","doi":"https://doi.org/10.15252/embr.201541439","title":"The Tau/A152T mutation, a risk factor for frontotemporal\u2010spectrum disorders, leads to NR2B receptor\u2010mediated excitotoxicity","display_name":"The Tau/A152T mutation, a risk factor for frontotemporal\u2010spectrum disorders, leads to NR2B receptor\u2010mediated excitotoxicity","publication_year":2016,"publication_date":"2016-03-01","ids":{"openalex":"https://openalex.org/W2290636701","doi":"https://doi.org/10.15252/embr.201541439","mag":"2290636701","pmid":"https://pubmed.ncbi.nlm.nih.gov/26931569","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4818782"},"language":"en","primary_location":{"id":"doi:10.15252/embr.201541439","doi":"https://doi.org/10.15252/embr.201541439","is_oa":true,"landing_page_url":"https://doi.org/10.15252/embr.201541439","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/embr.201541439","source":{"id":"https://openalex.org/S57252141","display_name":"EMBO Reports","issn_l":"1469-221X","issn":["1469-221X","1469-3178"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/embr.201541439","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111700126","display_name":"Jochen Martin Decker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jochen Martin Decker","raw_affiliation_strings":["German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany","institution_ids":["https://openalex.org/I2801533059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034349864","display_name":"Lars Kr\u00fcger","orcid":"https://orcid.org/0000-0003-4234-0022","observed_orcids":["https://orcid.org/0000-0003-4234-0022"]},"institutions":[{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lars Kr\u00fcger","raw_affiliation_strings":["German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany","institution_ids":["https://openalex.org/I2801533059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066503488","display_name":"Astrid Sydow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210110850","display_name":"Max Planck Institute for Metabolism Research","ror":"https://ror.org/0199g0r92","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210110850"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Astrid Sydow","raw_affiliation_strings":["German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany Max-Planck-Institute for Metabolism Research (Cologne), Hamburg Outstation, Hamburg, Germany","German Center for Neurodegenerative Diseases (DZNE) Bonn Germany","Max-Planck-Institute for Metabolism Research (Cologne), Hamburg Outstation Hamburg Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany Max-Planck-Institute for Metabolism Research (Cologne), Hamburg Outstation, Hamburg, Germany","institution_ids":["https://openalex.org/I2801533059","https://openalex.org/I4210110850"]},{"raw_affiliation_string":"German Center for Neurodegenerative Diseases (DZNE) Bonn Germany","institution_ids":["https://openalex.org/I2801533059"]},{"raw_affiliation_string":"Max-Planck-Institute for Metabolism Research (Cologne), Hamburg Outstation Hamburg Germany","institution_ids":["https://openalex.org/I4210110850"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083382676","display_name":"Frank J.A. Dennissen","orcid":"https://orcid.org/0000-0001-7446-122X","observed_orcids":["https://orcid.org/0000-0001-7446-122X"]},"institutions":[{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank JA Dennissen","raw_affiliation_strings":["German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany","institution_ids":["https://openalex.org/I2801533059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032440702","display_name":"Zuzana \u0160i\u0161kov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Zuzana Siskova","raw_affiliation_strings":["German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany","institution_ids":["https://openalex.org/I2801533059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047141760","display_name":"Eckhard Mandelkow\ufffd","orcid":"https://orcid.org/0000-0003-4655-4829","observed_orcids":["https://orcid.org/0000-0003-4655-4829"]},"institutions":[{"id":"https://openalex.org/I2800451603","display_name":"Center of Advanced European Studies and Research","ror":"https://ror.org/05350h943","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I2800451603","https://openalex.org/I4387152376"]},{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210110850","display_name":"Max Planck Institute for Metabolism Research","ror":"https://ror.org/0199g0r92","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210110850"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Eckhard Mandelkow","raw_affiliation_strings":["German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany Max-Planck-Institute for Metabolism Research (Cologne), Hamburg Outstation, Hamburg, Germany Caesar Research Center, Bonn, Germany eva.mandelkow@dzne.de","German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany Max-Planck-Institute for Metabolism Research (Cologne), Hamburg Outstation, Hamburg, Germany Caesar Research Center, Bonn, Germany","Caesar Research Center Bonn Germany","German Center for Neurodegenerative Diseases (DZNE) Bonn Germany","Max-Planck-Institute for Metabolism Research (Cologne), Hamburg Outstation Hamburg Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany Max-Planck-Institute for Metabolism Research (Cologne), Hamburg Outstation, Hamburg, Germany Caesar Research Center, Bonn, Germany eva.mandelkow@dzne.de","institution_ids":["https://openalex.org/I2801533059","https://openalex.org/I4210110850"]},{"raw_affiliation_string":"German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany Max-Planck-Institute for Metabolism Research (Cologne), Hamburg Outstation, Hamburg, Germany Caesar Research Center, Bonn, Germany","institution_ids":["https://openalex.org/I2801533059","https://openalex.org/I4210110850"]},{"raw_affiliation_string":"Caesar Research Center Bonn Germany","institution_ids":["https://openalex.org/I2800451603"]},{"raw_affiliation_string":"German Center for Neurodegenerative Diseases (DZNE) Bonn Germany","institution_ids":["https://openalex.org/I2801533059"]},{"raw_affiliation_string":"Max-Planck-Institute for Metabolism Research (Cologne), Hamburg Outstation Hamburg Germany","institution_ids":["https://openalex.org/I4210110850"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003261774","display_name":"Eva\u2010Maria Mandelkow","orcid":"https://orcid.org/0000-0002-7715-4038","observed_orcids":["https://orcid.org/0000-0002-7715-4038"]},"institutions":[{"id":"https://openalex.org/I2800451603","display_name":"Center of Advanced European Studies and Research","ror":"https://ror.org/05350h943","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I2800451603","https://openalex.org/I4387152376"]},{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210110850","display_name":"Max Planck Institute for Metabolism Research","ror":"https://ror.org/0199g0r92","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210110850"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Eva\u2010Maria Mandelkow","raw_affiliation_strings":["German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany Max-Planck-Institute for Metabolism Research (Cologne), Hamburg Outstation, Hamburg, Germany Caesar Research Center, Bonn, Germany eva.mandelkow@dzne.de","German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany Max-Planck-Institute for Metabolism Research (Cologne), Hamburg Outstation, Hamburg, Germany Caesar Research Center, Bonn, Germany","Caesar Research Center Bonn Germany","German Center for Neurodegenerative Diseases (DZNE) Bonn Germany","Max-Planck-Institute for Metabolism Research (Cologne), Hamburg Outstation Hamburg Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany Max-Planck-Institute for Metabolism Research (Cologne), Hamburg Outstation, Hamburg, Germany Caesar Research Center, Bonn, Germany eva.mandelkow@dzne.de","institution_ids":["https://openalex.org/I2801533059","https://openalex.org/I4210110850"]},{"raw_affiliation_string":"German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany Max-Planck-Institute for Metabolism Research (Cologne), Hamburg Outstation, Hamburg, Germany Caesar Research Center, Bonn, Germany","institution_ids":["https://openalex.org/I2801533059","https://openalex.org/I4210110850"]},{"raw_affiliation_string":"Caesar Research Center Bonn Germany","institution_ids":["https://openalex.org/I2800451603"]},{"raw_affiliation_string":"German Center for Neurodegenerative Diseases (DZNE) Bonn Germany","institution_ids":["https://openalex.org/I2801533059"]},{"raw_affiliation_string":"Max-Planck-Institute for Metabolism Research (Cologne), Hamburg Outstation Hamburg Germany","institution_ids":["https://openalex.org/I4210110850"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5003261774"],"corresponding_institution_ids":["https://openalex.org/I2800451603","https://openalex.org/I2801533059","https://openalex.org/I4210110850"],"apc_list":{"value":7990,"currency":"USD","value_usd":7990},"apc_paid":null,"fwci":5.155,"has_fulltext":true,"cited_by_count":130,"citation_normalized_percentile":{"value":0.96768656,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"17","issue":"4","first_page":"552","last_page":"569"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/frontotemporal-dementia","display_name":"frontotemporal dementia","score":0.8519999980926514},{"id":"https://openalex.org/keywords/nmda-receptor-nr2b","display_name":"NMDA receptor NR2B","score":0.8360000252723694},{"id":"https://openalex.org/keywords/extrasynaptic-nmda-receptors","display_name":"extrasynaptic NMDA receptors","score":0.9079999923706055},{"id":"https://openalex.org/keywords/excitotoxicity","display_name":"excitotoxicity","score":0.9890000224113464},{"id":"https://openalex.org/keywords/glutamate-excitotoxicity","display_name":"glutamate excitotoxicity","score":0.7250000238418579},{"id":"https://openalex.org/keywords/mossy-fiber-pathway","display_name":"mossy fiber pathway","score":0.8479999899864197},{"id":"https://openalex.org/keywords/hippocampal-ca3-neurons","display_name":"CA3 neurons","score":0.8349999785423279},{"id":"https://openalex.org/keywords/tau-hyperphosphorylation","display_name":"tau hyperphosphorylation","score":0.7129999995231628},{"id":"https://openalex.org/keywords/tau-aggregation","display_name":"tau aggregation","score":0.6769999861717224},{"id":"https://openalex.org/keywords/epileptiform-activity","display_name":"epileptiform activity","score":0.8140000104904175},{"id":"https://openalex.org/keywords/ceftriaxone","display_name":"ceftriaxone","score":0.843999981880188},{"id":"https://openalex.org/keywords/transgenic-mouse-model","display_name":"transgenic mouse model","score":0.6940000057220459},{"id":"https://openalex.org/keywords/progressive-supranuclear-palsy","display_name":"progressive supranuclear palsy","score":0.7120000123977661},{"id":"https://openalex.org/keywords/corticobasal-degeneration","display_name":"corticobasal degeneration","score":0.9860000014305115}],"concepts":[{"id":"https://openalex.org/C2781012912","wikidata":"https://www.wikidata.org/wiki/Q901117","display_name":"Excitotoxicity","level":4,"score":0.8366793394088745},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5728704929351807},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.475055456161499},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.4105485677719116},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4068196415901184},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.39826932549476624},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33995386958122253},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29718446731567383},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23409122228622437},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2256641685962677},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1884365677833557},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.1880384087562561}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009924","descriptor_name":"Organ Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056654","descriptor_name":"CA3 Region, Hippocampal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056654","descriptor_name":"CA3 Region, Hippocampal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D057180","descriptor_name":"Frontotemporal Dementia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.15252/embr.201541439","doi":"https://doi.org/10.15252/embr.201541439","is_oa":true,"landing_page_url":"https://doi.org/10.15252/embr.201541439","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/embr.201541439","source":{"id":"https://openalex.org/S57252141","display_name":"EMBO Reports","issn_l":"1469-221X","issn":["1469-221X","1469-3178"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4818782","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4818782","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO Rep","raw_type":"Text"},{"id":"pmid:26931569","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26931569","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO reports","raw_type":"Journal Article"},{"id":"pmh:oai:pub.dzne.de:138485","doi":null,"is_oa":false,"landing_page_url":"https://pub.dzne.de/record/138485","pdf_url":null,"source":{"id":"https://openalex.org/S7407051172","display_name":"DZNE Pub","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801533059","host_organization_name":"German Center for Neurodegenerative Diseases","host_organization_lineage":["https://openalex.org/I2801533059"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"EMBO reports 17(4), 552-569 (2016). doi:10.15252/embr.201541439","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.mpg.de:item_2259847","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11858/00-001M-0000-002A-0BFE-9","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"EMBO Reports","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.15252/embr.201541439","doi":"https://doi.org/10.15252/embr.201541439","is_oa":true,"landing_page_url":"https://doi.org/10.15252/embr.201541439","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/embr.201541439","source":{"id":"https://openalex.org/S57252141","display_name":"EMBO Reports","issn_l":"1469-221X","issn":["1469-221X","1469-3178"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322434","display_name":"Max-Planck-Gesellschaft","ror":"https://ror.org/01hhn8329"},{"id":"https://openalex.org/F4320323170","display_name":"Deutsches Zentrum f\u00fcr Neurodegenerative Erkrankungen","ror":"https://ror.org/043j0f473"},{"id":"https://openalex.org/F4320334040","display_name":"Tau Consortium","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2290636701.pdf","grobid_xml":"https://content.openalex.org/works/W2290636701.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W192077740","https://openalex.org/W1530155692","https://openalex.org/W1577577364","https://openalex.org/W1597597862","https://openalex.org/W1965859168","https://openalex.org/W1966556202","https://openalex.org/W1966599992","https://openalex.org/W1967993742","https://openalex.org/W1968553823","https://openalex.org/W1968937229","https://openalex.org/W1970686195","https://openalex.org/W1970910654","https://openalex.org/W1978457897","https://openalex.org/W1980311878","https://openalex.org/W1981890392","https://openalex.org/W1982864908","https://openalex.org/W1984854704","https://openalex.org/W1988036480","https://openalex.org/W1994030229","https://openalex.org/W2001261203","https://openalex.org/W2003102216","https://openalex.org/W2003171800","https://openalex.org/W2005609503","https://openalex.org/W2012405577","https://openalex.org/W2022532556","https://openalex.org/W2022959246","https://openalex.org/W2024380057","https://openalex.org/W2030377743","https://openalex.org/W2030575711","https://openalex.org/W2030674642","https://openalex.org/W2032653084","https://openalex.org/W2033198098","https://openalex.org/W2033283296","https://openalex.org/W2041142924","https://openalex.org/W2041956586","https://openalex.org/W2052742260","https://openalex.org/W2058829280","https://openalex.org/W2059127030","https://openalex.org/W2061538653","https://openalex.org/W2062605351","https://openalex.org/W2068046501","https://openalex.org/W2076333797","https://openalex.org/W2078167209","https://openalex.org/W2079054696","https://openalex.org/W2080612159","https://openalex.org/W2083204774","https://openalex.org/W2085877811","https://openalex.org/W2087140031","https://openalex.org/W2095151099","https://openalex.org/W2096557110","https://openalex.org/W2096610613","https://openalex.org/W2097717784","https://openalex.org/W2103740237","https://openalex.org/W2108044151","https://openalex.org/W2114444638","https://openalex.org/W2116635659","https://openalex.org/W2118516203","https://openalex.org/W2120675188","https://openalex.org/W2125985978","https://openalex.org/W2132265466","https://openalex.org/W2132844263","https://openalex.org/W2133603940","https://openalex.org/W2134906491","https://openalex.org/W2141260882","https://openalex.org/W2146521940","https://openalex.org/W2148908036","https://openalex.org/W2149497936","https://openalex.org/W2149548143","https://openalex.org/W2150110395","https://openalex.org/W2152468922","https://openalex.org/W2159643400","https://openalex.org/W2167937350","https://openalex.org/W2170906442","https://openalex.org/W2292902805","https://openalex.org/W4210979710"],"related_works":["https://openalex.org/W6889903045","https://openalex.org/W2614703394","https://openalex.org/W2806833258","https://openalex.org/W4402759222","https://openalex.org/W2292902805","https://openalex.org/W2005895876","https://openalex.org/W4405742281","https://openalex.org/W2029964084","https://openalex.org/W2161452575","https://openalex.org/W2342908538"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":21},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}