{"id":"https://openalex.org/W2290489752","doi":"https://doi.org/10.1042/bj1320791","title":"Control of ornithine decarboxylase activity in stimulated human lymphocytes by putrescine and spermidine","display_name":"Control of ornithine decarboxylase activity in stimulated human lymphocytes by putrescine and spermidine","publication_year":1973,"publication_date":"1973-04-01","ids":{"openalex":"https://openalex.org/W2290489752","doi":"https://doi.org/10.1042/bj1320791","mag":"2290489752","pmid":"https://pubmed.ncbi.nlm.nih.gov/4721611","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1177653"},"language":"en","primary_location":{"id":"doi:10.1042/bj1320791","doi":"https://doi.org/10.1042/bj1320791","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj1320791","pdf_url":"https://portlandpress.com/biochemj/article-pdf/132/4/791/780254/bj1320791.pdf","source":{"id":"https://openalex.org/S4210234214","display_name":"Biochemical Journal","issn_l":"0306-3283","issn":["0306-3283"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://portlandpress.com/biochemj/article-pdf/132/4/791/780254/bj1320791.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110137595","display_name":"John E. Kay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162608824","display_name":"University of Sussex","ror":"https://ror.org/00ayhx656","country_code":"GB","type":"education","lineage":["https://openalex.org/I162608824"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John E. Kay","raw_affiliation_strings":["Biochemistry Group, School of Biological Sciences, University of Sussex, Brighton BN1 9QG, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Group, School of Biological Sciences, University of Sussex, Brighton BN1 9QG, U.K","institution_ids":["https://openalex.org/I162608824"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005934715","display_name":"Valerie J. Lindsay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162608824","display_name":"University of Sussex","ror":"https://ror.org/00ayhx656","country_code":"GB","type":"education","lineage":["https://openalex.org/I162608824"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Valerie J. Lindsay","raw_affiliation_strings":["Biochemistry Group, School of Biological Sciences, University of Sussex, Brighton BN1 9QG, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Group, School of Biological Sciences, University of Sussex, Brighton BN1 9QG, U.K","institution_ids":["https://openalex.org/I162608824"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I162608824"],"apc_list":null,"apc_paid":null,"fwci":2.7232,"has_fulltext":true,"cited_by_count":132,"citation_normalized_percentile":{"value":0.90328145,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"132","issue":"4","first_page":"791","last_page":"796"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ornithine-decarboxylase","display_name":"ornithine decarboxylase","score":1.0},{"id":"https://openalex.org/keywords/putrescine","display_name":"putrescine","score":0.9760000109672546},{"id":"https://openalex.org/keywords/spermidine","display_name":"spermidine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/polyamines","display_name":"polyamines","score":0.7799999713897705},{"id":"https://openalex.org/keywords/human-lymphocytes","display_name":"human lymphocytes","score":0.7919999957084656},{"id":"https://openalex.org/keywords/phytohemagglutinin-stimulation","display_name":"phytohemagglutinin stimulation","score":0.9829999804496765},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.9660000205039978},{"id":"https://openalex.org/keywords/polyamine-biosynthesis","display_name":"polyamine biosynthesis","score":0.7070000171661377},{"id":"https://openalex.org/keywords/protein-synthesis","display_name":"protein synthesis","score":0.6809999942779541},{"id":"https://openalex.org/keywords/rna-synthesis","display_name":"RNA synthesis","score":0.7289999723434448}],"concepts":[{"id":"https://openalex.org/C2777167505","wikidata":"https://www.wikidata.org/wiki/Q410190","display_name":"Putrescine","level":3,"score":0.973586916923523},{"id":"https://openalex.org/C2777497464","wikidata":"https://www.wikidata.org/wiki/Q418834","display_name":"Spermidine","level":3,"score":0.9425894021987915},{"id":"https://openalex.org/C2780050583","wikidata":"https://www.wikidata.org/wiki/Q2702796","display_name":"Phytohaemagglutinin","level":3,"score":0.8050545454025269},{"id":"https://openalex.org/C121289238","wikidata":"https://www.wikidata.org/wiki/Q931579","display_name":"Ornithine decarboxylase","level":3,"score":0.7471243739128113},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5776193737983704},{"id":"https://openalex.org/C2776109719","wikidata":"https://www.wikidata.org/wiki/Q424597","display_name":"Spermine","level":3,"score":0.5446211695671082},{"id":"https://openalex.org/C2776796294","wikidata":"https://www.wikidata.org/wiki/Q410198","display_name":"Ornithine","level":4,"score":0.5173991918563843},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.47222068905830383},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4649708569049835},{"id":"https://openalex.org/C2780115381","wikidata":"https://www.wikidata.org/wiki/Q421959","display_name":"Polyamine","level":2,"score":0.44905638694763184},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3305875062942505},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1444263756275177},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.13265514373779297},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.08443644642829895}],"mesh":[{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D002247","descriptor_name":"Carbon Isotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002262","descriptor_name":"Carboxy-Lyases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003513","descriptor_name":"Cycloheximide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009952","descriptor_name":"Ornithine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010649","descriptor_name":"Phenylalanine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011700","descriptor_name":"Putrescine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012436","descriptor_name":"S-Adenosylmethionine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013095","descriptor_name":"Spermidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013936","descriptor_name":"Thymidine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014316","descriptor_name":"Tritium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014529","descriptor_name":"Uridine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D037102","descriptor_name":"Lectins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1042/bj1320791","doi":"https://doi.org/10.1042/bj1320791","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj1320791","pdf_url":"https://portlandpress.com/biochemj/article-pdf/132/4/791/780254/bj1320791.pdf","source":{"id":"https://openalex.org/S4210234214","display_name":"Biochemical Journal","issn_l":"0306-3283","issn":["0306-3283"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1177653","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1177653","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},{"id":"pmid:4721611","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4721611","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1042/bj1320791","doi":"https://doi.org/10.1042/bj1320791","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj1320791","pdf_url":"https://portlandpress.com/biochemj/article-pdf/132/4/791/780254/bj1320791.pdf","source":{"id":"https://openalex.org/S4210234214","display_name":"Biochemical Journal","issn_l":"0306-3283","issn":["0306-3283"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2290489752.pdf","grobid_xml":"https://content.openalex.org/works/W2290489752.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W170491672","https://openalex.org/W594429199","https://openalex.org/W1526850712","https://openalex.org/W1902923832","https://openalex.org/W1984286096","https://openalex.org/W1998446096","https://openalex.org/W2043440587","https://openalex.org/W2053654911","https://openalex.org/W2081293999","https://openalex.org/W2107832402","https://openalex.org/W2115713071","https://openalex.org/W2343612689","https://openalex.org/W6611372971"],"related_works":["https://openalex.org/W2067615069","https://openalex.org/W2050902768","https://openalex.org/W2049973170","https://openalex.org/W2010390575","https://openalex.org/W1968714063","https://openalex.org/W2037089642","https://openalex.org/W1560497510","https://openalex.org/W1496546960","https://openalex.org/W2009882932","https://openalex.org/W2072012569"],"abstract_inverted_index":{"Ornithine":[0],"decarboxylase":[1],"activity":[2],"in":[3],"extracts":[4],"of":[5,16,19,35,50,61],"phytohaemagglutinin-stimulated":[6],"human":[7],"lymphocytes":[8],"is":[9,29,45,63,73],"rapidly":[10],"and":[11],"extensively":[12],"inhibited":[13],"by":[14,38,70],"additions":[15],"micromolar":[17],"concentrations":[18],"putrescine":[20,62],"or":[21,41],"spermidine":[22,40,69],"to":[23,32],"the":[24,36,48,71],"culture":[25],"medium.":[26],"This":[27],"inhibition":[28,34],"not":[30,55],"due":[31],"feedback":[33],"enzyme":[37],"putrescine,":[39],"their":[42],"metabolites.":[43],"Inhibition":[44],"dependent":[46],"on":[47],"continuation":[49],"protein":[51],"synthesis,":[52],"but":[53],"does":[54],"require":[56],"RNA":[57],"synthesis.":[58],"The":[59],"effect":[60],"abolished":[64],"when":[65],"its":[66],"conversion":[67],"into":[68],"cells":[72],"prevented.":[74]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}