{"id":"https://openalex.org/W2290421689","doi":"https://doi.org/10.1016/s0022-3565(24)38158-3","title":"Muscarinic M3 Receptor Inactivation Reveals a Pertussis Toxin-Sensitive Contractile Response in the Guinea Pig Colon: Evidence for M2/M3 Receptor Interactions","display_name":"Muscarinic M3 Receptor Inactivation Reveals a Pertussis Toxin-Sensitive Contractile Response in the Guinea Pig Colon: Evidence for M2/M3 Receptor Interactions","publication_year":1999,"publication_date":"1999-04-01","ids":{"openalex":"https://openalex.org/W2290421689","doi":"https://doi.org/10.1016/s0022-3565(24)38158-3","mag":"2290421689","pmid":"https://pubmed.ncbi.nlm.nih.gov/10087039"},"language":"en","primary_location":{"id":"doi:10.1016/s0022-3565(24)38158-3","doi":"https://doi.org/10.1016/s0022-3565(24)38158-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-3565(24)38158-3","pdf_url":null,"source":{"id":"https://openalex.org/S102125482","display_name":"Journal of Pharmacology and Experimental Therapeutics","issn_l":"0022-3565","issn":["0022-3565","1521-0103"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pharmacology and Experimental Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028310362","display_name":"Gregory William Sawyer","orcid":"https://orcid.org/0000-0003-4612-3754","observed_orcids":["https://orcid.org/0000-0003-4612-3754"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory W. Sawyer","raw_affiliation_strings":["Department of Pharmacology, College of Medicine, University of California, Irvine, Irvine, California","Department of Pharmacology, College of Medicine, University of California, Irvine, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, College of Medicine, University of California, Irvine, Irvine, California","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Pharmacology, College of Medicine, University of California, Irvine, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024466186","display_name":"Frederick J. Ehlert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Frederick J. Ehlert","raw_affiliation_strings":["Department of Pharmacology, College of Medicine, University of California, Irvine, Irvine, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, College of Medicine, University of California, Irvine, Irvine, California","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5024466186"],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":1.2634,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.78766322,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"289","issue":"1","first_page":"464","last_page":"476"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/muscarinic-m3-receptor","display_name":"M3 muscarinic receptor","score":0.9139999747276306},{"id":"https://openalex.org/keywords/m2-muscarinic-receptor","display_name":"M2 muscarinic receptor","score":0.9829999804496765},{"id":"https://openalex.org/keywords/receptor-heterogeneity","display_name":"receptor heterogeneity","score":0.4620000123977661},{"id":"https://openalex.org/keywords/pertussis-toxin-sensitivity","display_name":"pertussis toxin sensitivity","score":0.7900000214576721},{"id":"https://openalex.org/keywords/colonic-smooth-muscle-contraction","display_name":"colonic smooth muscle contraction","score":0.7070000171661377},{"id":"https://openalex.org/keywords/oxotremorine-m","display_name":"oxotremorine-M","score":0.9829999804496765},{"id":"https://openalex.org/keywords/af-dx-116","display_name":"AF-DX 116","score":0.9480000138282776},{"id":"https://openalex.org/keywords/guinea-pig-colon","display_name":"guinea pig colon","score":0.9580000042915344}],"concepts":[{"id":"https://openalex.org/C49773422","wikidata":"https://www.wikidata.org/wiki/Q4859345","display_name":"Pertussis toxin","level":4,"score":0.9296376705169678},{"id":"https://openalex.org/C2778824757","wikidata":"https://www.wikidata.org/wiki/Q676896","display_name":"Oxotremorine","level":4,"score":0.7884335517883301},{"id":"https://openalex.org/C33789571","wikidata":"https://www.wikidata.org/wiki/Q410959","display_name":"Muscarinic acetylcholine receptor","level":3,"score":0.7352467775344849},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6065881252288818},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.5579591393470764},{"id":"https://openalex.org/C2777383412","wikidata":"https://www.wikidata.org/wiki/Q4770891","display_name":"Antagonism","level":3,"score":0.5028047561645508},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4518754184246063},{"id":"https://openalex.org/C47488739","wikidata":"https://www.wikidata.org/wiki/Q17861931","display_name":"Muscarinic acetylcholine receptor M2","level":4,"score":0.4350099265575409},{"id":"https://openalex.org/C2778815084","wikidata":"https://www.wikidata.org/wiki/Q79803","display_name":"Guinea pig","level":2,"score":0.4244147837162018},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39021551609039307},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38577523827552795},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3852662444114685},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37786930799484253},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.3595011830329895},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14690560102462769},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13401231169700623}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004158","descriptor_name":"Diphenylacetic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010095","descriptor_name":"Oxotremorine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D010095","descriptor_name":"Oxotremorine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010566","descriptor_name":"Virulence Factors, Bordetella","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010716","descriptor_name":"Phosphatidylinositols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010890","descriptor_name":"Pirenzepine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D010890","descriptor_name":"Pirenzepine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011976","descriptor_name":"Receptors, Muscarinic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011976","descriptor_name":"Receptors, Muscarinic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018721","descriptor_name":"Muscarinic Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018727","descriptor_name":"Muscarinic Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D037342","descriptor_name":"Pertussis Toxin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D043585","descriptor_name":"Receptor, Muscarinic M2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043587","descriptor_name":"Receptor, Muscarinic M3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0022-3565(24)38158-3","doi":"https://doi.org/10.1016/s0022-3565(24)38158-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-3565(24)38158-3","pdf_url":null,"source":{"id":"https://openalex.org/S102125482","display_name":"Journal of Pharmacology and Experimental Therapeutics","issn_l":"0022-3565","issn":["0022-3565","1521-0103"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pharmacology and Experimental Therapeutics","raw_type":"journal-article"},{"id":"pmid:10087039","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10087039","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of pharmacology and experimental therapeutics","raw_type":"Journal Article"},{"id":"mag:2290421689","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10087039","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.428600013256073,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3810672640","display_name":null,"funder_award_id":"NS-30882","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5413945727","display_name":"AUTONOMIC MUSCARINIC RECEPTOR SIGNALING MECHANISMS","funder_award_id":"5r01ns030882-08","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W150678807","https://openalex.org/W266767676","https://openalex.org/W597852105","https://openalex.org/W657142851","https://openalex.org/W1565125984","https://openalex.org/W1828467682","https://openalex.org/W1889236699","https://openalex.org/W1911466926","https://openalex.org/W1927660002","https://openalex.org/W1935326419","https://openalex.org/W1966547779","https://openalex.org/W1995645167","https://openalex.org/W2019662916","https://openalex.org/W2022013923","https://openalex.org/W2045272094","https://openalex.org/W2059855350","https://openalex.org/W2066482395","https://openalex.org/W2071554154","https://openalex.org/W2077716740","https://openalex.org/W2161754666","https://openalex.org/W2223661252","https://openalex.org/W2273862655","https://openalex.org/W2300711531","https://openalex.org/W2331540743","https://openalex.org/W2333501001","https://openalex.org/W2335952218","https://openalex.org/W2396063396","https://openalex.org/W2396506071","https://openalex.org/W2407014164","https://openalex.org/W6609907547","https://openalex.org/W6702694878"],"related_works":["https://openalex.org/W2045272094","https://openalex.org/W2273862655","https://openalex.org/W7097499749","https://openalex.org/W2026965429","https://openalex.org/W1925112771","https://openalex.org/W2103841880","https://openalex.org/W2125966086","https://openalex.org/W2088061842","https://openalex.org/W2122897115","https://openalex.org/W2058412082"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
