{"id":"https://openalex.org/W2290191763","doi":null,"title":"Rol de las uniones estrechas del epitelio intestinal en la patogenia de la enfermedad de Crohn","display_name":"Rol de las uniones estrechas del epitelio intestinal en la patogenia de la enfermedad de Crohn","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2290191763","mag":"2290191763"},"language":"en","primary_location":{"id":"pmh:oai:ojs.seciu.edu.uy:article/139","doi":null,"is_oa":true,"landing_page_url":"https://revistas.udelar.edu.uy/OJS/index.php/anfamed/article/view/139","pdf_url":"https://revistas.udelar.edu.uy/OJS/index.php/anfamed/article/download/139/127","source":{"id":"https://openalex.org/S2737205574","display_name":"Anales de la Facultad de Medicina","issn_l":"2301-1254","issn":["2301-1254","2393-6231"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","latindex","poland-20","russia-white-list-4","scielo"],"host_organization":"https://openalex.org/P4310318956","host_organization_name":"Universidad de la Rep\u00fablica","host_organization_lineage":["https://openalex.org/P4310318956"],"host_organization_lineage_names":["Universidad de la Rep\u00fablica"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2301-1254","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://revistas.udelar.edu.uy/OJS/index.php/anfamed/article/download/139/127","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011553038","display_name":"Dionisio D\u00edaz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica de Uruguay","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]}],"countries":["UY"],"is_corresponding":false,"raw_author_name":"D\u00edaz, Dionisio","raw_affiliation_strings":[". Estudiante de Medicina , Ciclo de Metodolog\u00eda Cient\u00edfica II , Facultad de Medicina , Universidad de la Rep\u00fablica. Uruguay. La","Facultad de Medicina-Universidad de la Rep\u00fablica"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":". Estudiante de Medicina , Ciclo de Metodolog\u00eda Cient\u00edfica II , Facultad de Medicina , Universidad de la Rep\u00fablica. Uruguay. La","institution_ids":["https://openalex.org/I180910786"]},{"raw_affiliation_string":"Facultad de Medicina-Universidad de la Rep\u00fablica","institution_ids":["https://openalex.org/I180910786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023046446","display_name":"Rodrigo Dorelo","orcid":"https://orcid.org/0000-0001-8516-3973","observed_orcids":["https://orcid.org/0000-0001-8516-3973"]},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica de Uruguay","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]}],"countries":["UY"],"is_corresponding":false,"raw_author_name":"Dorelo, Rodrigo","raw_affiliation_strings":[". Estudiante de Medicina , Ciclo de Metodolog\u00eda Cient\u00edfica II , Facultad de Medicina , Universidad de la Rep\u00fablica. Uruguay. La","Contacto: Silvia Chifflet. Departamento de Bioqu\u00edmica , Facultad de Medicina , Gral Flores 2125 , 11800 Montevideo , Uruguay","Facultad de Medicina-Universidad de la Rep\u00fablica"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":". Estudiante de Medicina , Ciclo de Metodolog\u00eda Cient\u00edfica II , Facultad de Medicina , Universidad de la Rep\u00fablica. Uruguay. La","institution_ids":["https://openalex.org/I180910786"]},{"raw_affiliation_string":"Contacto: Silvia Chifflet. Departamento de Bioqu\u00edmica , Facultad de Medicina , Gral Flores 2125 , 11800 Montevideo , Uruguay","institution_ids":["https://openalex.org/I180910786"]},{"raw_affiliation_string":"Facultad de Medicina-Universidad de la Rep\u00fablica","institution_ids":["https://openalex.org/I180910786"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Fleitas, Diego","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica de Uruguay","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]}],"countries":["UY"],"is_corresponding":false,"raw_author_name":"Fleitas, Diego","raw_affiliation_strings":[". Estudiante de Medicina , Ciclo de Metodolog\u00eda Cient\u00edfica II , Facultad de Medicina , Universidad de la Rep\u00fablica. Uruguay. La","contribuci\u00f3n en la realizaci\u00f3n del trabajo fue equivalente a la de los dem\u00e1s estudiantes","Facultad de Medicina-Universidad de la Rep\u00fablica"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":". Estudiante de Medicina , Ciclo de Metodolog\u00eda Cient\u00edfica II , Facultad de Medicina , Universidad de la Rep\u00fablica. Uruguay. La","institution_ids":["https://openalex.org/I180910786"]},{"raw_affiliation_string":"contribuci\u00f3n en la realizaci\u00f3n del trabajo fue equivalente a la de los dem\u00e1s estudiantes","institution_ids":[]},{"raw_affiliation_string":"Facultad de Medicina-Universidad de la Rep\u00fablica","institution_ids":["https://openalex.org/I180910786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001112988","display_name":"Silvia Chifflet","orcid":"https://orcid.org/0000-0003-4935-8591","observed_orcids":["https://orcid.org/0000-0003-4935-8591"]},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica de Uruguay","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]}],"countries":["UY"],"is_corresponding":false,"raw_author_name":"Chifflet, Silvia","raw_affiliation_strings":[". Docente supervisor . Departamento de Bioqu\u00edmica de la Facultad de Medicina , Universidad de la Rep\u00fablica , Montevideo , Uruguay","Facultad de Medicina-Universidad de la Rep\u00fablica"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":". Docente supervisor . Departamento de Bioqu\u00edmica de la Facultad de Medicina , Universidad de la Rep\u00fablica , Montevideo , Uruguay","institution_ids":["https://openalex.org/I180910786"]},{"raw_affiliation_string":"Facultad de Medicina-Universidad de la Rep\u00fablica","institution_ids":["https://openalex.org/I180910786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I180910786"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.16115722,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.01850000023841858,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.9810000061988831},{"id":"https://openalex.org/keywords/intestinal-epithelium","display_name":"intestinal epithelium","score":0.8920000195503235},{"id":"https://openalex.org/keywords/epithelial-barrier-dysfunction","display_name":"epithelial barrier dysfunction","score":0.8840000033378601},{"id":"https://openalex.org/keywords/paracellular-barrier","display_name":"paracellular barrier","score":0.7239999771118164},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7829999923706055},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.7799999713897705},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.796999990940094}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.5841532349586487},{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.4327068328857422},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2159796953201294},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.19371142983436584},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.06361287832260132},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.02980363368988037}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:ojs.seciu.edu.uy:article/139","doi":null,"is_oa":true,"landing_page_url":"https://revistas.udelar.edu.uy/OJS/index.php/anfamed/article/view/139","pdf_url":"https://revistas.udelar.edu.uy/OJS/index.php/anfamed/article/download/139/127","source":{"id":"https://openalex.org/S2737205574","display_name":"Anales de la Facultad de Medicina","issn_l":"2301-1254","issn":["2301-1254","2393-6231"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","latindex","poland-20","russia-white-list-4","scielo"],"host_organization":"https://openalex.org/P4310318956","host_organization_name":"Universidad de la Rep\u00fablica","host_organization_lineage":["https://openalex.org/P4310318956"],"host_organization_lineage_names":["Universidad de la Rep\u00fablica"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2301-1254","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:colibri.udelar.edu.uy:20.500.12008/30690","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.12008/30690","pdf_url":"https://www.colibri.udelar.edu.uy/jspui/bitstream/20.500.12008/30690/1/Rol%20de%20las%20uniones%20estrechas%20del%20epitelio%20intestinal%20en%20la%20patogenia%20de%20la%20enfermedad%20de%20Crohn.pdf","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:Universidad de la Rep\u00fablica","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:16518581b71f4157acbcda763c11d242","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/16518581b71f4157acbcda763c11d242","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Anales de la Facultad de Medicina, Vol 2, Iss 0, Pp 48-58 (2015)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:9d52e4fbc2a143998dd53a5724eefffa","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9d52e4fbc2a143998dd53a5724eefffa","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Anales de la Facultad de Medicina, Vol 2 (2015)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:ojs.seciu.edu.uy:article/139","doi":null,"is_oa":true,"landing_page_url":"https://revistas.udelar.edu.uy/OJS/index.php/anfamed/article/view/139","pdf_url":"https://revistas.udelar.edu.uy/OJS/index.php/anfamed/article/download/139/127","source":{"id":"https://openalex.org/S2737205574","display_name":"Anales de la Facultad de Medicina","issn_l":"2301-1254","issn":["2301-1254","2393-6231"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","latindex","poland-20","russia-white-list-4","scielo"],"host_organization":"https://openalex.org/P4310318956","host_organization_name":"Universidad de la Rep\u00fablica","host_organization_lineage":["https://openalex.org/P4310318956"],"host_organization_lineage_names":["Universidad de la Rep\u00fablica"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2301-1254","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2290191763.pdf","grobid_xml":"https://content.openalex.org/works/W2290191763.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1554042779","https://openalex.org/W1980725116","https://openalex.org/W1981910576","https://openalex.org/W1988528086","https://openalex.org/W1991810959","https://openalex.org/W1997848360","https://openalex.org/W2001365037","https://openalex.org/W2032367064","https://openalex.org/W2044560609","https://openalex.org/W2053952699","https://openalex.org/W2055222262","https://openalex.org/W2091720415","https://openalex.org/W2093875409","https://openalex.org/W2100941645","https://openalex.org/W2111570058","https://openalex.org/W2118762743","https://openalex.org/W2120914031","https://openalex.org/W2137946551","https://openalex.org/W2138611522","https://openalex.org/W2150267721","https://openalex.org/W2150933705","https://openalex.org/W2151201474","https://openalex.org/W2160899610","https://openalex.org/W2166710590","https://openalex.org/W2168220121","https://openalex.org/W2170505336","https://openalex.org/W2321453230"],"related_works":["https://openalex.org/W7062091611","https://openalex.org/W75411042","https://openalex.org/W2593281894","https://openalex.org/W2166710590","https://openalex.org/W2152213080","https://openalex.org/W2357404801","https://openalex.org/W2330707041","https://openalex.org/W4410546774","https://openalex.org/W2078609476","https://openalex.org/W4252584383"],"abstract_inverted_index":{"Crohn\u2019s":[0,92,94,150,178],"disease":[1,6,95,151,179],"is":[2,74,152],"an":[3,16,108],"inflammatory":[4],"bowel":[5],"that":[7,20,77],"affects":[8],"the":[9,48,68,71,78,81,89,101,105,117,122,130,140,143,146,159,165,172,187,195],"intestinal":[10],"wall.":[11],"This":[12],"wall":[13],"consists":[14],"of":[15,31,70,80,91,100,104,111,116,129,145,156,161,167,174,189,197],"epithelial":[17,54,82],"cell":[18],"layer":[19],"forms":[21],"a":[22,39,44,62,85,98],"continuous":[23,45],"polarized":[24],"monolayer,":[25],"closely":[26],"connected":[27],"by":[28],"various":[29],"types":[30],"cellular":[32],"junctions.":[33],"Among":[34],"these,":[35],"tight":[36,106,131,147,162,168,190],"junctions":[37,132,148,163,169,191],"play":[38],"relevant":[40],"role.":[41],"They":[42],"form":[43],"structure":[46],"delimiting":[47],"apical":[49],"and":[50,55,114,127,136,149,164],"basolateral":[51],"domains":[52],"in":[53,59,88,158,171],"endothelial":[56],"cells,":[57],"creating":[58],"this":[60],"way":[61],"selective":[63],"paracellular":[64],"barrier,":[65],"fundamental":[66],"for":[67,194],"homeostasis":[69],"organism.":[72],"There":[73],"increasing":[75],"evidence":[76,138],"dysfunction":[79,144],"barrier":[83,102],"plays":[84],"central":[86],"role":[87,155],"physiopathology":[90],"disease.":[93],"patients":[96],"exhibit":[97],"loss":[99],"function":[103,128],"junctions,":[107],"increased":[109],"production":[110],"pro-inflammatory":[112],"cytokines":[113],"dysregulation":[115],"immune":[118],"system.In":[119],"his":[120],"review":[121],"molecular":[123],"composition,":[124],"structure,":[125],"interactions":[126],"are":[133,180,200],"briefly":[134],"described,":[135],"recent":[137,184],"on":[139],"relationship":[141],"between":[142],"commented.":[153],"The":[154],"microbiota":[157],"regulation":[160],"participation":[166],"deregulation":[170],"development":[173,196],"cancer":[175],"associated":[176],"to":[177],"also":[181],"detailed.":[182],"Finally,":[183],"findings":[185],"about":[186],"employment":[188],"as":[192],"targets":[193],"new":[198],"drugs":[199],"described.":[201]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
