{"id":"https://openalex.org/W2290173634","doi":null,"title":"The Interplay Between PGC-1 and Autophagy During Metabolic Alterations in Skeletal Muscle","display_name":"The Interplay Between PGC-1 and Autophagy During Metabolic Alterations in Skeletal Muscle","publication_year":2015,"publication_date":"2015-01-28","ids":{"openalex":"https://openalex.org/W2290173634","mag":"2290173634"},"language":"en","primary_location":{"id":"pmh:oai:yorkspace.library.yorku.ca:10315/30012","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10315/30012","pdf_url":"http://hdl.handle.net/10315/30012","source":{"id":"https://openalex.org/S4306400473","display_name":"YorkSpace (York University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I192455969","host_organization_name":"York University","host_organization_lineage":["https://openalex.org/I192455969"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Electronic Thesis or Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10315/30012","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073818953","display_name":"Anna Vainshtein","orcid":"https://orcid.org/0000-0003-0368-5044","observed_orcids":["https://orcid.org/0000-0003-0368-5044"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Anna Vainshtein","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0368-5044","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5073818953"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.8476999998092651,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.8476999998092651,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.1371999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pgc-1alpha","display_name":"PGC-1\u03b1","score":0.9940000176429749},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9890000224113464},{"id":"https://openalex.org/keywords/mitophagy","display_name":"mitophagy","score":0.9929999709129333},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.9739999771118164},{"id":"https://openalex.org/keywords/denervation","display_name":"denervation","score":0.6079999804496765},{"id":"https://openalex.org/keywords/muscle-atrophy","display_name":"muscle atrophy","score":0.8140000104904175},{"id":"https://openalex.org/keywords/mitochondrial-turnover","display_name":"mitochondrial turnover","score":0.6980000138282776},{"id":"https://openalex.org/keywords/exhaustive-exercise","display_name":"exhaustive exercise","score":0.7149999737739563},{"id":"https://openalex.org/keywords/mitochondrial-biogenesis","display_name":"mitochondrial biogenesis","score":0.7229999899864197},{"id":"https://openalex.org/keywords/lysosomal-degradation","display_name":"lysosomal degradation","score":0.5899999737739563},{"id":"https://openalex.org/keywords/transcriptional-coactivator","display_name":"transcriptional coactivator","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.9250907897949219},{"id":"https://openalex.org/C2779324830","wikidata":"https://www.wikidata.org/wiki/Q1806192","display_name":"Mitophagy","level":4,"score":0.8486731052398682},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.7519229650497437},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6434570550918579},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.605607271194458},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5401574373245239},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4733990430831909},{"id":"https://openalex.org/C2776263037","wikidata":"https://www.wikidata.org/wiki/Q1557686","display_name":"Muscle atrophy","level":3,"score":0.4465145170688629},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.43919599056243896},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42504602670669556},{"id":"https://openalex.org/C2780216420","wikidata":"https://www.wikidata.org/wiki/Q83330","display_name":"Lysosome","level":3,"score":0.41614145040512085},{"id":"https://openalex.org/C2776805190","wikidata":"https://www.wikidata.org/wiki/Q1187030","display_name":"Denervation","level":2,"score":0.41539159417152405},{"id":"https://openalex.org/C2777229759","wikidata":"https://www.wikidata.org/wiki/Q6881848","display_name":"Mitochondrial biogenesis","level":3,"score":0.41462385654449463},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21863272786140442},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09621596336364746},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.07115727663040161},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:yorkspace.library.yorku.ca:10315/30012","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10315/30012","pdf_url":"http://hdl.handle.net/10315/30012","source":{"id":"https://openalex.org/S4306400473","display_name":"YorkSpace (York University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I192455969","host_organization_name":"York University","host_organization_lineage":["https://openalex.org/I192455969"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Electronic Thesis or Dissertation"},{"id":"mag:2290173634","doi":null,"is_oa":false,"landing_page_url":"https://yorkspace.library.yorku.ca/xmlui/handle/10315/30012","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:yorkspace.library.yorku.ca:10315/30012","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10315/30012","pdf_url":"http://hdl.handle.net/10315/30012","source":{"id":"https://openalex.org/S4306400473","display_name":"YorkSpace (York University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I192455969","host_organization_name":"York University","host_organization_lineage":["https://openalex.org/I192455969"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Electronic Thesis or Dissertation"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2290173634.pdf","grobid_xml":"https://content.openalex.org/works/W2290173634.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W2097019206"],"related_works":["https://openalex.org/W2112956181","https://openalex.org/W2057731584","https://openalex.org/W1160967900","https://openalex.org/W2281774672","https://openalex.org/W2212789884","https://openalex.org/W2051175021","https://openalex.org/W2766773814","https://openalex.org/W4389023327","https://openalex.org/W2806349849","https://openalex.org/W1524273338"],"abstract_inverted_index":{"PGC-1\u03b1":[0,28,77,111,131,155,161,216,247,292,307],"is":[1,29,44,65,71,217,235,293,315],"a":[2,8,45,186,312],"transcriptional":[3],"co-activator":[4,18],"well":[5,159,284],"established":[6],"as":[7,158,160,271,283,285],"potent":[9],"regulator":[10],"of":[11,35,54,85,102,120,130,135,146,197,208,222,246,255,264,276],"oxidative":[12],"metabolism":[13],"in":[14,82,91,114,117,132,143,174,180,185,224,248,261,295,299,311],"skeletal":[15,86,115,225,300],"muscle.":[16],"This":[17],"mediates":[19],"metabolic":[20,68,230,319],"adaptation":[21],"to":[22,106,182,317],"exercise":[23],"by":[24,273],"orchestrating":[25],"mitochondrial":[26,249,267,277,297],"biogenesis.":[27],"also":[30],"integral":[31],"for":[32,51,73,210,219,238],"the":[33,52,61,83,100,108,118,128,133,144,190,220,244,262],"maintenance":[34],"muscle":[36,87,116,121,141,226,301],"mass":[37],"and":[38,57,70,112,137,169,179,200,279],"function":[39],"during":[40,67,139],"atrophic":[41],"conditions.":[42],"\\nAutophagy":[43],"highly":[46],"conserved":[47],"proteolytic":[48],"pathway":[49],"responsible":[50],"degradation":[53],"dysfunctional":[55],"organelles":[56],"protein":[58],"aggregates":[59],"through":[60,302],"lysosomal":[62,201],"machinery.":[63],"Autophagy":[64],"upregulated":[66],"distress":[69],"essential":[72],"cell":[74],"survival.":[75],"While":[76],"has":[78,93],"been":[79,95],"extensively":[80],"studied":[81],"context":[84],"adaptations,":[88],"its":[89],"role":[90,129,245],"autophagy":[92,113,136,168,199,223],"not":[94,236],"dissected.":[96],"To":[97,148],"this":[98,103,150,239],"end,":[99],"purpose":[101],"dissertation":[104],"was":[105,269],"examine":[107],"interplay":[109],"between":[110],"spectrum":[119],"contractile":[122],"states.":[123],"\\n":[124],"We":[125,165,258],"first":[126],"assessed":[127],"regulation":[134],"mitophagy":[138,170],"chronic":[140],"disuse":[142],"form":[145],"denervation.":[147],"do":[149],"we":[151,193,213,242],"denervated":[152],"wildtype":[153],"(WT),":[154],"knockout":[156],"(KO)":[157],"overexpressing":[162],"(Tg)":[163],"animals.":[164],"found":[166,259],"that":[167,215,233,260,291,314],"flux":[171],"were":[172],"compromised":[173],"KO":[175],"animals":[176,192],"both":[177],"basally,":[178],"response":[181],"denervation,":[183],"resulting":[184],"myopathic":[187],"phenotype.":[188],"In":[189],"Tg":[191],"uncovered":[194],"enhanced":[195],"levels":[196],"certain":[198],"markers,":[202],"but":[203,232],"surprisingly":[204],"noticed":[205],"reduced":[206,274],"targeting":[207],"mitochondria":[209],"degradation.":[211],"Overall":[212],"concluded":[214],"important":[218],"fine-tuning":[221],"based":[227],"on":[228],"cellular":[229,318],"state,":[231],"it":[234],"required":[237],"process.":[240],"\\nNext":[241],"evaluated":[243],"turnover":[250,268],"following":[251],"an":[252],"acute":[253],"bout":[254],"exhaustive":[256],"exercise.":[257],"absence":[263],"PGC-1\u03b1,":[265],"exercise-induced":[266],"compromised,":[270],"evident":[272],"expression":[275],"genes":[278],"diminished":[280],"autophagy/mitophagy":[281,310],"induction,":[282],"flux.":[286],"\\nCollectively,":[287],"our":[288],"data":[289],"demonstrate":[290],"instrumental":[294],"maintaining":[296],"health":[298],"enhancing":[303],"organelle":[304],"turnover.":[305],"Moreover,":[306],"can":[308],"fine-tune":[309],"manner":[313],"specific":[316],"state.":[320]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
