{"id":"https://openalex.org/W2290162269","doi":"https://doi.org/10.1093/ofid/ofv133.353","title":"Use of Investigational Antiviral Drug Pocapavir to Treat Enteroviral Sepsis in Twin Neonates","display_name":"Use of Investigational Antiviral Drug Pocapavir to Treat Enteroviral Sepsis in Twin Neonates","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2290162269","doi":"https://doi.org/10.1093/ofid/ofv133.353","mag":"2290162269"},"language":"en","primary_location":{"id":"doi:10.1093/ofid/ofv133.353","doi":"https://doi.org/10.1093/ofid/ofv133.353","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofv133.353","pdf_url":null,"source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/ofid/ofv133.353","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020559792","display_name":"Jessica R. Cataldi","orcid":"https://orcid.org/0000-0002-4480-0304","observed_orcids":["https://orcid.org/0000-0002-4480-0304"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jessica Cataldi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012035679","display_name":"Eric E. Rhoden","orcid":"https://orcid.org/0000-0001-8642-9948","observed_orcids":["https://orcid.org/0000-0001-8642-9948"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric Rhoden","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022426711","display_name":"Steven M. Oberste","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steve Oberste","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046334601","display_name":"Jeffrey R. Hincks","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey Hincks","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106132458","display_name":"Marc S. Collett","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marc Collett","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030486422","display_name":"Clyde J. Wright","orcid":"https://orcid.org/0000-0002-8449-5631","observed_orcids":["https://orcid.org/0000-0002-8449-5631"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Clyde Wright","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5034976745","display_name":"Edwin J. Asturias","orcid":"https://orcid.org/0000-0002-1275-0787","observed_orcids":["https://orcid.org/0000-0002-1275-0787"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Edwin Asturias","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4053,"currency":"USD","value_usd":4053},"apc_paid":{"value":4053,"currency":"USD","value_usd":4053},"fwci":0.2445,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.67701204,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"2","issue":"suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11961","display_name":"Neonatal and Maternal Infections","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13847","display_name":"Literature Analysis and Criticism","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coxsackievirus-b3","display_name":"coxsackievirus B3","score":0.902999997138977},{"id":"https://openalex.org/keywords/neonatal-infection","display_name":"neonatal infection","score":0.7689999938011169},{"id":"https://openalex.org/keywords/monochorionic-diamniotic-twins","display_name":"monochorionic diamniotic twins","score":0.8100000023841858},{"id":"https://openalex.org/keywords/capsid-inhibitor","display_name":"capsid inhibitor","score":0.6740000247955322},{"id":"https://openalex.org/keywords/nosocomial-infections","display_name":"nosocomial infections","score":0.7409999966621399},{"id":"https://openalex.org/keywords/preterm-infants","display_name":"preterm infants","score":0.6110000014305115},{"id":"https://openalex.org/keywords/plasma-drug-concentration","display_name":"plasma drug concentration","score":0.5529999732971191},{"id":"https://openalex.org/keywords/antiviral-susceptibility","display_name":"antiviral susceptibility","score":0.6940000057220459},{"id":"https://openalex.org/keywords/intracranial-hemorrhage","display_name":"intracranial hemorrhage","score":0.8840000033378601},{"id":"https://openalex.org/keywords/liver-failure","display_name":"liver failure","score":0.7870000004768372},{"id":"https://openalex.org/keywords/intravenous-immunoglobulin","display_name":"intravenous immunoglobulin","score":0.7170000076293945}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9319695234298706},{"id":"https://openalex.org/C2910824759","wikidata":"https://www.wikidata.org/wiki/Q6060674","display_name":"Investigational Drugs","level":3,"score":0.539030134677887},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5316370725631714},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4360823333263397},{"id":"https://openalex.org/C2779756493","wikidata":"https://www.wikidata.org/wiki/Q846227","display_name":"Antiviral drug","level":3,"score":0.42155927419662476},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.4186152219772339},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4156324863433838},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.33619630336761475},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32197049260139465},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2834000587463379},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.17247053980827332}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/ofid/ofv133.353","doi":"https://doi.org/10.1093/ofid/ofv133.353","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofv133.353","pdf_url":null,"source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/ofid/ofv133.353","doi":"https://doi.org/10.1093/ofid/ofv133.353","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofv133.353","pdf_url":null,"source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1981282970","https://openalex.org/W2951112664","https://openalex.org/W4413841844","https://openalex.org/W4414166469","https://openalex.org/W4408799116","https://openalex.org/W2010537391","https://openalex.org/W2052899857","https://openalex.org/W2264983484","https://openalex.org/W7168032137","https://openalex.org/W4400539927"],"abstract_inverted_index":{"Background.":[0],"Enteroviral":[1],"sepsis":[2],"can":[3],"cause":[4],"severe":[5,263,321],"morbidity":[6],"and":[7,40,54,68,75,83,97,108,117,126,128,132,151,176,195,259,266,279,340,358,368],"mortality":[8],"among":[9],"neonates.":[10],"There":[11],"is":[12,18,307],"no":[13,290],"effective":[14,230],"treatment.":[15],"Pocapavir":[16,306],"(V-073)":[17],"an":[19],"investigational":[20,164],"enterovirus":[21],"(EV)":[22],"capsid":[23],"inhibitor":[24],"being":[25],"developed":[26,65,104,123],"for":[27,168,234,311],"poliovirus":[28],"indications.":[29],"In":[30],"vitro":[31],"studies":[32],"show":[33],"activity":[34],"against":[35],"other":[36,331],"EVs":[37],"including":[38],"coxsackieviruses":[39],"echoviruses.":[41],"Monochorionic":[42],"diamoniotic":[43],"twins":[44,156],"born":[45],"at":[46,242],"27":[47],"weeks":[48],"gestation":[49],"acquired":[50],"nosocomial":[51],"EV":[52,88,137,158,292,313,344],"infection":[53],"were":[55,157,201,209,246,303],"treated":[56],"with":[57,320,333,347],"pocapavir.":[58],"At":[59],"2":[60,96,135],"months":[61],"old,":[62],"Twin":[63,85,102,113,121,249,273,287],"B":[64,114,250],"respiratory":[66,77],"distress":[67],"apnea,":[69],"followed":[70],"quickly":[71],"by":[72,160,211],"liver,":[73],"cardiac":[74],"hypoxemic":[76],"failure,":[78],"metabolic":[79],"acidosis,":[80],"profound":[81],"anemia":[82,125],"thrombocytopenia.":[84],"B's":[86],"serum":[87,136,199,226,297],"PCR":[89,138],"was":[90,100,139,171,188],"positive":[91,159],"day":[92,111,185],"of":[93,186,236,268],"illness":[94],"(DOIB)":[95],"IVIG":[98],"treatment":[99,170,310,328],"given.":[101],"A":[103,122,146,274,288],"abdominal":[105],"distension,":[106],"fever,":[107],"apnea":[109],"1":[110],"after":[112,325],"became":[115],"ill":[116],"also":[118],"received":[119,251,275],"IVIG.":[120],"moderate":[124],"thrombocytopenia,":[127],"mildly":[129],"elevated":[130],"AST/ALT,":[131],"on":[133,270,293],"DOIA":[134,277],"positive.":[140],"Cerebral":[141],"spinal":[142],"fluid":[143],"from":[144,154,173,179,220,224,296],"twin":[145,332],"as":[147,149],"well":[148,339],"throat":[150],"rectal":[152],"swabs":[153],"both":[155,221],"PCR.":[161],"Methods.":[162],"Emergency":[163],"new":[165],"drug":[166,240],"approval":[167],"pocapavir":[169,187,196,235,252,276],"obtained":[172,178],"the":[174,180,330],"FDA":[175],"consent":[177],"parents.":[181],"5":[182,284],"mg/kg":[183],"per":[184],"given":[189],"via":[190],"nasogastric":[191],"tube.":[192],"Virus":[193,223],"culture":[194,295],"susceptibility":[197],"in":[198,203,343],"samples":[200,227],"measured":[202],"HeLa":[204],"cells.":[205],"Drug":[206],"plasma":[207],"levels":[208,241],"determined":[210],"LC-MS/MS.":[212],"Results.":[213],"CDC":[214],"molecular":[215],"typing":[216],"identified":[217],"coxsackievirus":[218],"B3":[219],"twins.":[222],"pre-dose":[225],"had":[228,289,341],"median":[229],"concentration":[231],"(EC50)":[232],"values":[233],"39-60":[237],"ng/mL.":[238,248],"Plasma":[239],"6-8":[243],"hours":[244],"postdose":[245],"132-312":[247],"DOIB":[253,271],"4-7,":[254],"but":[255],"progressive":[256],"liver":[257],"failure":[258],"coagulopathy":[260],"led":[261],"to":[262],"intracranial":[264],"bleeding":[265],"withdrawal":[267],"support":[269],"7.":[272],"3-16":[278],"recovered":[280],"without":[281],"sequelae.":[282],"After":[283],"days":[285,327],"dosing,":[286],"detectable":[291],"cell":[294],"sample.":[298],"No":[299],"drug-related":[300],"adverse":[301],"events":[302],"noted.":[304],"Conclusion.":[305],"a":[308],"potential":[309],"neonatal":[312],"sepsis.":[314],"For":[315],"these":[316],"preterm":[317],"twins,":[318],"one":[319],"fulminant":[322],"disease":[323,336],"died":[324],"4":[326],"while":[329],"less":[334],"advanced":[335],"tolerated":[337],"therapy":[338],"reduction":[342],"titers":[345],"coincident":[346],"clinical":[348],"improvement.":[349],"Disclosures.":[350],"J.":[351],"Hincks,":[352],"ViroDefense,":[353],"Inc:":[354,364],"Board":[355,365],"Member,":[356,366],"Employee":[357,367],"Shareholder,":[359,369],"Salary;":[360],"M.":[361],"Collett,":[362],"ViroDefense":[363],"Salary":[370]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2016-06-24T00:00:00"}