{"id":"https://openalex.org/W2289756568","doi":null,"title":"THE EFFECTS OF TRICLOSAN, 2,4-D, AND THEIR BY-PRODUCTS ON THE ADRENOCORTICAL CELLS OF RAINBOW TROUT","display_name":"THE EFFECTS OF TRICLOSAN, 2,4-D, AND THEIR BY-PRODUCTS ON THE ADRENOCORTICAL CELLS OF RAINBOW TROUT","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2289756568","mag":"2289756568"},"language":"en","primary_location":{"id":"pmh:oai:www.uleth.ca:10133/3154","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10133/3154","pdf_url":"http://hdl.handle.net/10133/3154","source":{"id":"https://openalex.org/S4306401508","display_name":"Open ULeth Scholarship (OPUS) (University of Lethbridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I107949126","host_organization_name":"University of Lethbridge","host_organization_lineage":["https://openalex.org/I107949126"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10133/3154","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080903439","display_name":"Andrea B. Dann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Andrea B. Dann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5080903439"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.02199999988079071,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11505","display_name":"Reproductive biology and impacts on aquatic species","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triclosan","display_name":"triclosan","score":0.9990000128746033},{"id":"https://openalex.org/keywords/2-4-d","display_name":"2,4-D","score":0.9670000076293945},{"id":"https://openalex.org/keywords/dichlorophenoxyacetic-acid","display_name":"dichlorophenoxyacetic acid","score":0.9020000100135803},{"id":"https://openalex.org/keywords/methyl-triclosan","display_name":"methyl-triclosan","score":0.9760000109672546},{"id":"https://openalex.org/keywords/dichlorophenols","display_name":"dichlorophenols","score":0.9959999918937683},{"id":"https://openalex.org/keywords/endocrine-disruptors","display_name":"endocrine disruptors","score":0.8519999980926514},{"id":"https://openalex.org/keywords/adrenocortical-cells","display_name":"adrenocortical cells","score":0.9480000138282776},{"id":"https://openalex.org/keywords/rainbow-trout","display_name":"rainbow trout","score":0.9950000047683716},{"id":"https://openalex.org/keywords/degradation-products","display_name":"degradation products","score":0.6140000224113464},{"id":"https://openalex.org/keywords/primary-culture","display_name":"primary cell culture","score":0.4410000145435333}],"concepts":[{"id":"https://openalex.org/C2994167347","wikidata":"https://www.wikidata.org/wiki/Q187986","display_name":"Rainbow trout","level":3,"score":0.9364394545555115},{"id":"https://openalex.org/C2781289450","wikidata":"https://www.wikidata.org/wiki/Q408646","display_name":"Triclosan","level":2,"score":0.8071927428245544},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.44416919350624084},{"id":"https://openalex.org/C2776558979","wikidata":"https://www.wikidata.org/wiki/Q1052","display_name":"Rainbow","level":2,"score":0.421072393655777},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3899271488189697},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.38458752632141113},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3139301836490631},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25883153080940247},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.2515067458152771},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09483873844146729},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09182000160217285},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.uleth.ca:10133/3154","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10133/3154","pdf_url":"http://hdl.handle.net/10133/3154","source":{"id":"https://openalex.org/S4306401508","display_name":"Open ULeth Scholarship (OPUS) (University of Lethbridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I107949126","host_organization_name":"University of Lethbridge","host_organization_lineage":["https://openalex.org/I107949126"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2289756568","doi":null,"is_oa":false,"landing_page_url":"https://www.uleth.ca/dspace/bitstream/handle/10133/3154/dann,%20andrea.pdf?sequence=1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:www.uleth.ca:10133/3154","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10133/3154","pdf_url":"http://hdl.handle.net/10133/3154","source":{"id":"https://openalex.org/S4306401508","display_name":"Open ULeth Scholarship (OPUS) (University of Lethbridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I107949126","host_organization_name":"University of Lethbridge","host_organization_lineage":["https://openalex.org/I107949126"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310768","display_name":"University of Lethbridge","ror":"https://ror.org/044j76961"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2289756568.pdf","grobid_xml":"https://content.openalex.org/works/W2289756568.grobid-xml"},"referenced_works_count":209,"referenced_works":["https://openalex.org/W1032319","https://openalex.org/W160335679","https://openalex.org/W162009948","https://openalex.org/W171399093","https://openalex.org/W193227718","https://openalex.org/W1548202795","https://openalex.org/W1669810599","https://openalex.org/W1738907399","https://openalex.org/W1926839001","https://openalex.org/W1937163697","https://openalex.org/W1958622927","https://openalex.org/W1963841973","https://openalex.org/W1963942552","https://openalex.org/W1964004502","https://openalex.org/W1964030921","https://openalex.org/W1965664704","https://openalex.org/W1967015579","https://openalex.org/W1969452596","https://openalex.org/W1969803280","https://openalex.org/W1976836723","https://openalex.org/W1978010430","https://openalex.org/W1979543372","https://openalex.org/W1982002615","https://openalex.org/W1982633116","https://openalex.org/W1984974848","https://openalex.org/W1985117877","https://openalex.org/W1985759320","https://openalex.org/W1986020857","https://openalex.org/W1988197327","https://openalex.org/W1988686484","https://openalex.org/W1989613035","https://openalex.org/W1989779310","https://openalex.org/W1992158459","https://openalex.org/W1993251141","https://openalex.org/W1993477523","https://openalex.org/W1993633251","https://openalex.org/W1995177974","https://openalex.org/W1996464902","https://openalex.org/W1996983728","https://openalex.org/W2003808881","https://openalex.org/W2004624433","https://openalex.org/W2006863266","https://openalex.org/W2008029340","https://openalex.org/W2009553684","https://openalex.org/W2009553946","https://openalex.org/W2009584158","https://openalex.org/W2009638175","https://openalex.org/W2010336132","https://openalex.org/W2011461285","https://openalex.org/W2011506271","https://openalex.org/W2011679013","https://openalex.org/W2012144992","https://openalex.org/W2012529237","https://openalex.org/W2012673559","https://openalex.org/W2013095403","https://openalex.org/W2015734637","https://openalex.org/W2015825607","https://openalex.org/W2017283207","https://openalex.org/W2017541876","https://openalex.org/W2020876088","https://openalex.org/W2022912234","https://openalex.org/W2023592880","https://openalex.org/W2023860405","https://openalex.org/W2024598483","https://openalex.org/W2025803518","https://openalex.org/W2025823859","https://openalex.org/W2025891905","https://openalex.org/W2026200312","https://openalex.org/W2027806294","https://openalex.org/W2028644455","https://openalex.org/W2032757094","https://openalex.org/W2033296044","https://openalex.org/W2033500126","https://openalex.org/W2034144685","https://openalex.org/W2034726356","https://openalex.org/W2035291337","https://openalex.org/W2035909576","https://openalex.org/W2036417566","https://openalex.org/W2037766564","https://openalex.org/W2038078724","https://openalex.org/W2042298854","https://openalex.org/W2042305578","https://openalex.org/W2043277302","https://openalex.org/W2044076843","https://openalex.org/W2044165644","https://openalex.org/W2044444633","https://openalex.org/W2044812713","https://openalex.org/W2046600118","https://openalex.org/W2049368003","https://openalex.org/W2049865914","https://openalex.org/W2050105320","https://openalex.org/W2050958029","https://openalex.org/W2051109387","https://openalex.org/W2051663204","https://openalex.org/W2051873660","https://openalex.org/W2053067859","https://openalex.org/W2053643737","https://openalex.org/W2054590302","https://openalex.org/W2054820556","https://openalex.org/W2056468041","https://openalex.org/W2057051544","https://openalex.org/W2058306453","https://openalex.org/W2058706892","https://openalex.org/W2060192370","https://openalex.org/W2060309278","https://openalex.org/W2062199032","https://openalex.org/W2062365197","https://openalex.org/W2062447063","https://openalex.org/W2062921804","https://openalex.org/W2064712871","https://openalex.org/W2065427800","https://openalex.org/W2065445500","https://openalex.org/W2065695329","https://openalex.org/W2067140886","https://openalex.org/W2068888241","https://openalex.org/W2069513152","https://openalex.org/W2069662842","https://openalex.org/W2070217301","https://openalex.org/W2070975150","https://openalex.org/W2072765031","https://openalex.org/W2073244152","https://openalex.org/W2073527456","https://openalex.org/W2074657519","https://openalex.org/W2074735643","https://openalex.org/W2075440994","https://openalex.org/W2076397330","https://openalex.org/W2076494603","https://openalex.org/W2076904650","https://openalex.org/W2076912174","https://openalex.org/W2077318232","https://openalex.org/W2077481700","https://openalex.org/W2077902342","https://openalex.org/W2078034047","https://openalex.org/W2078799392","https://openalex.org/W2079648635","https://openalex.org/W2079813845","https://openalex.org/W2080432829","https://openalex.org/W2080735446","https://openalex.org/W2080998720","https://openalex.org/W2081399377","https://openalex.org/W2081889687","https://openalex.org/W2083513354","https://openalex.org/W2084396772","https://openalex.org/W2085215470","https://openalex.org/W2085503745","https://openalex.org/W2085924198","https://openalex.org/W2086257736","https://openalex.org/W2089187855","https://openalex.org/W2090582095","https://openalex.org/W2091818086","https://openalex.org/W2098078529","https://openalex.org/W2098971483","https://openalex.org/W2099170248","https://openalex.org/W2104445964","https://openalex.org/W2104839725","https://openalex.org/W2106317719","https://openalex.org/W2106595852","https://openalex.org/W2110199291","https://openalex.org/W2117179435","https://openalex.org/W2118270418","https://openalex.org/W2118818259","https://openalex.org/W2119622056","https://openalex.org/W2119646277","https://openalex.org/W2120674443","https://openalex.org/W2120796546","https://openalex.org/W2122251639","https://openalex.org/W2122409052","https://openalex.org/W2122830910","https://openalex.org/W2122979248","https://openalex.org/W2125145074","https://openalex.org/W2125734610","https://openalex.org/W2127879973","https://openalex.org/W2128676243","https://openalex.org/W2128685723","https://openalex.org/W2132095490","https://openalex.org/W2132157796","https://openalex.org/W2133314499","https://openalex.org/W2133820152","https://openalex.org/W2138697156","https://openalex.org/W2139608359","https://openalex.org/W2140087383","https://openalex.org/W2141919009","https://openalex.org/W2142443542","https://openalex.org/W2144009167","https://openalex.org/W2145560174","https://openalex.org/W2147322409","https://openalex.org/W2147452643","https://openalex.org/W2147924926","https://openalex.org/W2147976950","https://openalex.org/W2150357382","https://openalex.org/W2152208038","https://openalex.org/W2154310483","https://openalex.org/W2154435839","https://openalex.org/W2154786792","https://openalex.org/W2156743194","https://openalex.org/W2160818462","https://openalex.org/W2161384518","https://openalex.org/W2161772205","https://openalex.org/W2163412789","https://openalex.org/W2164141618","https://openalex.org/W2165248513","https://openalex.org/W2165730944","https://openalex.org/W2171854519","https://openalex.org/W2183044194","https://openalex.org/W2272559722","https://openalex.org/W2395921726","https://openalex.org/W2524573204","https://openalex.org/W2916730911","https://openalex.org/W4256036191"],"related_works":["https://openalex.org/W2012673559","https://openalex.org/W2062199032","https://openalex.org/W7127070479","https://openalex.org/W2083073730","https://openalex.org/W2125924792","https://openalex.org/W2746924912","https://openalex.org/W1983739189","https://openalex.org/W3033691346","https://openalex.org/W1972075558","https://openalex.org/W4292227337"],"abstract_inverted_index":{"The":[0],"ubiquitous":[1],"presence":[2],"of":[3,28,33,52,113,126,177,237,239],"anthropogenic":[4],"chemicals":[5,30,174,185],"and":[6,22,46,107,143,149,159,214,243,265],"their":[7,144,200,223],"transformation":[8,145],"products":[9],"in":[10,74,87,94,199],"surface":[11],"water":[12],"represents":[13],"a":[14,23,91,132,138,162],"toxicological":[15],"concern":[16],"from":[17],"both":[18],"an":[19],"ecological":[20],"standpoint":[21],"human":[24],"perspective":[25],"as":[26],"many":[27,95],"these":[29,173,240],"are":[31,175],"capable":[32,176],"altering":[34],"hormonal":[35],"function.Endocrine":[36],"disrupting":[37,124],"compounds":[38],"can":[39],"be":[40,219],"traced":[41],"back":[42],"to":[43,76,120,218,233,252,273,276],"numerous":[44],"sources":[45],"may":[47,249],"fall":[48],"under":[49],"the":[50,66,77,122,205,235,244,262,268],"class":[51],"pesticide,":[53,139],"industrial":[54],"chemical,":[55],"pharmaceutical,":[56],"personal":[57,133],"care":[58,134],"product,":[59,135],"and/or":[60],"heavy":[61],"metals.The":[62],"adrenal":[63],"gland":[64],"is":[65,169,231],"most":[67],"common":[68],"target":[69],"for":[70,164,256],"endocrine":[71,123,165],"disruptors,":[72],"although":[73,167],"comparison":[75],"sex":[78],"steroids,":[79],"this":[80,181],"system":[81],"has":[82,153],"received":[83],"much":[84],"less":[85],"attention":[86],"published":[88],"research.Corticosteroids":[89],"play":[90],"pivotal":[92],"role":[93],"physiological":[96],"processes,":[97],"including":[98],"immunity,":[99],"cognitive":[100],"function,":[101],"growth,":[102],"metabolism,":[103],"reproduction,":[104],"mineral":[105],"balance,":[106],"blood":[108],"pressure.A":[109],"primary":[110],"cell":[111],"culture":[112],"rainbow":[114],"trout":[115],"adrenocortical":[116],"cells":[117],"was":[118,208],"used":[119],"investigate":[121],"activity":[125],"two":[127],"commonly":[128],"detected":[129],"water-borne":[130],"toxicants,":[131],"triclosan":[136],"(TCS),":[137],"dichlorophenoxyacetic":[140],"acid":[141],"(2,4-D),":[142],"products,":[146],"methyl-triclosan":[147],"(M-TCS)":[148],"dichlorophenol":[150],"(DCP).Previously,":[151],"it":[152,168],"been":[154],"shown":[155],"that":[156,203,247],"TCS,":[157,212],"2,4-D,":[158,209],"DCP":[160],"exhibit":[161],"potential":[163],"disruption,":[166],"currently":[170],"unknown":[171],"if":[172],"affecting":[178],"corticosteroid":[179,191,241],"balance.In":[180],"study,":[182],"all":[183,257],"four":[184],"showed":[186],"significant":[187],"inhibitory":[188],"effects":[189],"on":[190],"synthesis,":[192],"even":[193],"though":[194],"there":[195],"were":[196],"considerable":[197],"differences":[198],"activity.The":[201],"chemical":[202],"exhibited":[204],"highest":[206],"toxicity":[207],"followed":[210],"by":[211],"DCP,":[213],"M-TCS.Both":[215],"parent-compounds":[216],"proved":[217],"more":[220],"toxic":[221],"than":[222],"degradation":[224],"products.More":[225],"research":[226],"with":[227,267],"suitable":[228],"test":[229],"systems":[230],"needed":[232],"determine":[234],"mechanism(s)":[236],"action":[238],"disruptors":[242],"health":[245],"risk":[246],"they":[248],"present..":[250],"like":[251,272],"acknowledge":[253],"Roger":[254],"Royer":[255],"his":[258],"hard":[259],"work":[260],"maintaining":[261],"aquatic":[263],"facility":[264],"assisting":[266],"animal":[269],"husbandry.I":[270],"would":[271],"express":[274],"appreciation":[275],"my":[277],"academic":[278],"supervisory":[279],"committee":[280],"members,":[281],"Dr.":[282]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}