{"id":"https://openalex.org/W2289665128","doi":null,"title":"Role of colonic epithelial cells in susceptibility and severity of Citrobacter rodentium infection in mice","display_name":"Role of colonic epithelial cells in susceptibility and severity of Citrobacter rodentium infection in mice","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2289665128","mag":"2289665128"},"language":"en","primary_location":{"id":"pmh:oai:krex.k-state.edu:2097/15326","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2097/15326","pdf_url":"http://hdl.handle.net/2097/15326","source":{"id":"https://openalex.org/S4306402339","display_name":"K-State Research Exchange (Kansas State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I189590672","host_organization_name":"Kansas State University","host_organization_lineage":["https://openalex.org/I189590672"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2097/15326","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057620424","display_name":"Elena V. Gart","orcid":"https://orcid.org/0000-0002-9590-6934","observed_orcids":["https://orcid.org/0000-0002-9590-6934"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"E. V. Gart","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9590-6934","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5057620424"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13849","display_name":"Enterobacteriaceae and Cronobacter Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10486","display_name":"Salmonella and Campylobacter epidemiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/citrobacter-rodentium","display_name":"Citrobacter rodentium","score":0.9940000176429749},{"id":"https://openalex.org/keywords/colonic-epithelial-cells","display_name":"colonic epithelial cells","score":0.9200000166893005},{"id":"https://openalex.org/keywords/mouse-strain-susceptibility","display_name":"mouse strain susceptibility","score":0.5799999833106995},{"id":"https://openalex.org/keywords/acute-diarrhea","display_name":"acute diarrhea","score":0.6589999794960022},{"id":"https://openalex.org/keywords/attaching-and-effacing-lesions","display_name":"attaching and effacing lesions","score":0.8429999947547913},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.8519999980926514},{"id":"https://openalex.org/keywords/epithelial-barrier-function","display_name":"epithelial barrier function","score":0.7639999985694885},{"id":"https://openalex.org/keywords/bacterial-translocation","display_name":"bacterial translocation","score":0.7369999885559082},{"id":"https://openalex.org/keywords/type-iii-secretion-system","display_name":"type III secretion system","score":0.6740000247955322},{"id":"https://openalex.org/keywords/c3h-mice","display_name":"C3H mice","score":0.7620000243186951},{"id":"https://openalex.org/keywords/swiss-webster-mice","display_name":"Swiss Webster mice","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C2910319489","wikidata":"https://www.wikidata.org/wiki/Q16975761","display_name":"Citrobacter rodentium","level":3,"score":0.9958955645561218},{"id":"https://openalex.org/C2775945818","wikidata":"https://www.wikidata.org/wiki/Q134081","display_name":"Citrobacter","level":5,"score":0.5893847346305847},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5014410018920898},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3872193396091461},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3845331072807312},{"id":"https://openalex.org/C2778910516","wikidata":"https://www.wikidata.org/wiki/Q380136","display_name":"Enterobacteriaceae","level":4,"score":0.19933539628982544},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.12291136384010315},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.09289312362670898},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05578389763832092},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:krex.k-state.edu:2097/15326","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2097/15326","pdf_url":"http://hdl.handle.net/2097/15326","source":{"id":"https://openalex.org/S4306402339","display_name":"K-State Research Exchange (Kansas State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I189590672","host_organization_name":"Kansas State University","host_organization_lineage":["https://openalex.org/I189590672"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:2289665128","doi":null,"is_oa":false,"landing_page_url":"https://krex.k-state.edu/dspace/handle/2097/15326","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:krex.k-state.edu:2097/15326","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2097/15326","pdf_url":"http://hdl.handle.net/2097/15326","source":{"id":"https://openalex.org/S4306402339","display_name":"K-State Research Exchange (Kansas State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I189590672","host_organization_name":"Kansas State University","host_organization_lineage":["https://openalex.org/I189590672"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2289665128.pdf","grobid_xml":"https://content.openalex.org/works/W2289665128.grobid-xml"},"referenced_works_count":145,"referenced_works":["https://openalex.org/W179907124","https://openalex.org/W1218972376","https://openalex.org/W1498038195","https://openalex.org/W1536411339","https://openalex.org/W1559486758","https://openalex.org/W1573547148","https://openalex.org/W1611178069","https://openalex.org/W1876321204","https://openalex.org/W1897118574","https://openalex.org/W1897432826","https://openalex.org/W1913631541","https://openalex.org/W1933987408","https://openalex.org/W1945391093","https://openalex.org/W1959271098","https://openalex.org/W1964591951","https://openalex.org/W1966302535","https://openalex.org/W1968105406","https://openalex.org/W1973152745","https://openalex.org/W1976021701","https://openalex.org/W1976624239","https://openalex.org/W1982509114","https://openalex.org/W1983987058","https://openalex.org/W1985396638","https://openalex.org/W1987985249","https://openalex.org/W1990845730","https://openalex.org/W1992622869","https://openalex.org/W1997981215","https://openalex.org/W1998203126","https://openalex.org/W1999379197","https://openalex.org/W2001312445","https://openalex.org/W2004633453","https://openalex.org/W2005848280","https://openalex.org/W2005879027","https://openalex.org/W2012010459","https://openalex.org/W2012401588","https://openalex.org/W2014818191","https://openalex.org/W2016045507","https://openalex.org/W2016826598","https://openalex.org/W2016850513","https://openalex.org/W2017430900","https://openalex.org/W2018650498","https://openalex.org/W2020986381","https://openalex.org/W2022711399","https://openalex.org/W2025028919","https://openalex.org/W2026858016","https://openalex.org/W2027995647","https://openalex.org/W2028437274","https://openalex.org/W2029062603","https://openalex.org/W2030364983","https://openalex.org/W2031244173","https://openalex.org/W2032925493","https://openalex.org/W2034280103","https://openalex.org/W2036609896","https://openalex.org/W2036684468","https://openalex.org/W2037166067","https://openalex.org/W2037565352","https://openalex.org/W2040921311","https://openalex.org/W2042116386","https://openalex.org/W2042297039","https://openalex.org/W2047136706","https://openalex.org/W2047685947","https://openalex.org/W2048512273","https://openalex.org/W2049715526","https://openalex.org/W2050126106","https://openalex.org/W2051137629","https://openalex.org/W2057610674","https://openalex.org/W2061321571","https://openalex.org/W2065231269","https://openalex.org/W2067303627","https://openalex.org/W2067786063","https://openalex.org/W2070443323","https://openalex.org/W2070632858","https://openalex.org/W2070850862","https://openalex.org/W2074981124","https://openalex.org/W2077089570","https://openalex.org/W2084954530","https://openalex.org/W2086934900","https://openalex.org/W2091422963","https://openalex.org/W2091657419","https://openalex.org/W2097818551","https://openalex.org/W2098924153","https://openalex.org/W2100403561","https://openalex.org/W2101051206","https://openalex.org/W2101988700","https://openalex.org/W2102267843","https://openalex.org/W2104328367","https://openalex.org/W2104714420","https://openalex.org/W2105244198","https://openalex.org/W2105330702","https://openalex.org/W2105510531","https://openalex.org/W2106579717","https://openalex.org/W2107066107","https://openalex.org/W2110693699","https://openalex.org/W2112794401","https://openalex.org/W2113102948","https://openalex.org/W2113737673","https://openalex.org/W2116021107","https://openalex.org/W2116160740","https://openalex.org/W2117856246","https://openalex.org/W2119842624","https://openalex.org/W2119874529","https://openalex.org/W2124446505","https://openalex.org/W2124705707","https://openalex.org/W2125590017","https://openalex.org/W2126905872","https://openalex.org/W2127255479","https://openalex.org/W2127449370","https://openalex.org/W2129124575","https://openalex.org/W2131159435","https://openalex.org/W2135126732","https://openalex.org/W2135428422","https://openalex.org/W2135528327","https://openalex.org/W2137803034","https://openalex.org/W2137949241","https://openalex.org/W2140150379","https://openalex.org/W2140577004","https://openalex.org/W2141217361","https://openalex.org/W2141853317","https://openalex.org/W2142717583","https://openalex.org/W2143063214","https://openalex.org/W2144603992","https://openalex.org/W2145109926","https://openalex.org/W2145121851","https://openalex.org/W2145446900","https://openalex.org/W2150267721","https://openalex.org/W2152668112","https://openalex.org/W2156358568","https://openalex.org/W2157556054","https://openalex.org/W2158010031","https://openalex.org/W2158817608","https://openalex.org/W2159590405","https://openalex.org/W2159980792","https://openalex.org/W2160352413","https://openalex.org/W2163543661","https://openalex.org/W2163807503","https://openalex.org/W2163830368","https://openalex.org/W2166338423","https://openalex.org/W2166710590","https://openalex.org/W2169361032","https://openalex.org/W2170372540","https://openalex.org/W2171561168","https://openalex.org/W2278577252","https://openalex.org/W2321995885","https://openalex.org/W2776663677","https://openalex.org/W7098852363"],"related_works":["https://openalex.org/W2386007323","https://openalex.org/W2783111791","https://openalex.org/W1535822734","https://openalex.org/W2622379095","https://openalex.org/W2097818551","https://openalex.org/W2076472576","https://openalex.org/W1974958670","https://openalex.org/W1971740873","https://openalex.org/W6959397047","https://openalex.org/W4408856633"],"abstract_inverted_index":{"Acute":[0],"diarrhea":[1,355],"induced":[2,282],"by":[3,47],"Escherichia":[4],"coli":[5,30,50,55,142],"is":[6,23],"an":[7,119],"important":[8],"illness":[9],"in":[10,13,19,32,39,121,183,188,204,222,238,239,268,289,306,315,322,349,365],"humans,":[11],"especially":[12],"children":[14],"under":[15],"age":[16],"of":[17,58,92,106,128,140,151,173,191,194,224,231,257,271,309,334,340,352,359,367,374,378,381],"two":[18,86],"developing":[20,366],"countries.Citrobacter":[21],"rodentium":[22,135,175,211,226,242,273,281],"used":[24],"as":[25,124,126,177,179,185,187,217,265],"murine":[26,40,324],"model":[27,219,270],"for":[28,209,220,370],"E.":[29,49,54,141],"infection":[31,77],"humans":[33],"because":[34],"it":[35],"causes":[36],"ultrastructural":[37],"changes":[38,180,305],"colonic":[41,152,228,246,302,310],"epithelium":[42,311],"comparable":[43],"to":[44,76,99,112,118,146,244],"lesions":[45,254,303],"produced":[46],"enteropathogenic":[48],"(EPEC)":[51],"and":[52,70,78,84,130,143,168,233,251,255,274,286,304,331,356,372],"enterohemorrhagic":[53],"(EHEC).Adult":[56],"mice":[57,72,93,195,235,292,297],"many":[59],"strains":[60,91,193],"develop":[61],"self-limiting":[62],"epithelial":[63,153,229,247],"hyperplasia":[64],"when":[65],"infected,":[66],"whereas":[67,293],"adult":[68],"C3H":[69,291,316],"FVB":[71],"are":[73,144,196],"highly":[74],"susceptible":[75,90,232],"demonstrate":[79],"mortality":[80,288],"rates":[81],"between":[82],"60":[83],"100%":[85,287],"weeks":[87],"after":[88],"infection.These":[89],"also":[94,215],"have":[95,162],"higher":[96],"bacterial":[97],"translocation":[98],"mesenteric":[100],"lymph":[101],"nodes.In":[102],"mice,":[103],"the":[104,157,189,323,329,332,335,350,357],"cause":[105],"death":[107],"could":[108],"be":[109,363],"hypovolemia":[110],"due":[111,117],"dehydration":[113],"that":[114,181,279,326],"may":[115],"occur":[116,182],"increase":[120],"paracellular":[122],"permeability":[123],"well":[125,178,186],"dysregulation":[127],"apical":[129],"basolateral":[131],"ion":[132],"transporting":[133],"proteins.C.":[134],"virulence":[136],"factors":[137,347],"resemble":[138],"those":[139],"believed":[145],"primarily":[147],"alter":[148],"tight":[149],"junctions":[150],"cells.Effectors":[154],"delivered":[155],"via":[156],"type":[158],"III":[159],"secretory":[160],"system":[161],"been":[163],"associated":[164],"with":[165],"actin":[166],"condensation":[167],"pedestal":[169],"formation.The":[170],"exact":[171],"mechanisms":[172],"C.":[174,210,225,272,280,341,353],"infection,":[176,212,336,360],"vitro":[184,205,269],"intestine":[190],"various":[192],"not":[197],"completely":[198],"understood.This":[199],"study":[200,318,344],"introduced":[201],"a":[202,218,266],"new":[203],"Ptk6":[206,245],"cell":[207,263],"line":[208,264],"which":[213,260,361],"can":[214,362],"serve":[216],"EPEC":[221,275],"humans.Effect":[223],"on":[227],"cells":[230],"resistant":[234],"was":[236],"determined":[237,319],"vivo":[240],"study.C.":[241],"attached":[243],"cells,":[248],"inducing":[249],"attaching":[250],"effacing":[252],"(A/E)":[253],"loss":[256],"monolayer":[258],"integrity,":[259],"charachterizes":[261],"this":[262],"relevant":[267],"infections.Murine":[276],"studies":[277],"revealed":[278],"more":[283,313],"severe":[284],"disease":[285],"juvenile":[290],"Swiss":[294],"Webster":[295],"(SW)":[296],"expressed":[298],"only":[299],"moderate":[300],"morbidity.The":[301],"barrier":[307],"function":[308],"were":[312],"prominent":[314],"mice.This":[317],"potential":[320],"targets":[321],"colon":[325],"play":[327],"role":[328],"establishment":[330],"outcome":[333,358],"indicating":[337],"multifactorial":[338],"nature":[339],"rodentium-induced":[342],"diarrhea.This":[343],"identified":[345],"host":[346],"involved":[348],"initiation":[351],"rodentium-associated":[354],"useful":[364],"novel":[368],"strategies":[369],"preventing":[371],"treatment":[373],"infectious":[375],"colitis.v":[376],"Table":[377],"Contents":[379],"List":[380],"Figures":[382],"......":[383]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}