{"id":"https://openalex.org/W2289603825","doi":"https://doi.org/10.1186/s13059-016-0882-7","title":"Characterization of chromatin accessibility with a transposome hypersensitive sites sequencing (THS-seq) assay","display_name":"Characterization of chromatin accessibility with a transposome hypersensitive sites sequencing (THS-seq) assay","publication_year":2016,"publication_date":"2016-02-04","ids":{"openalex":"https://openalex.org/W2289603825","doi":"https://doi.org/10.1186/s13059-016-0882-7","mag":"2289603825","pmid":"https://pubmed.ncbi.nlm.nih.gov/26846207","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4743176"},"language":"en","primary_location":{"id":"doi:10.1186/s13059-016-0882-7","doi":"https://doi.org/10.1186/s13059-016-0882-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13059-016-0882-7","pdf_url":"https://genomebiology.biomedcentral.com/counter/pdf/10.1186/s13059-016-0882-7","source":{"id":"https://openalex.org/S81160022","display_name":"Genome biology","issn_l":"1465-6906","issn":["1465-6906","1465-6914","1474-7596","1474-760X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://genomebiology.biomedcentral.com/counter/pdf/10.1186/s13059-016-0882-7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057223773","display_name":"Brandon Chin Sos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandon Chin Sos","raw_affiliation_strings":["Biomedical Sciences Graduate Program, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, USA","Department of Bioengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Sciences Graduate Program, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Bioengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012672452","display_name":"Ho-Lim Fung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ho-Lim Fung","raw_affiliation_strings":["Department of Bioengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015430784","display_name":"Derek Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Derek Rui Gao","raw_affiliation_strings":["Department of Bioengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074854892","display_name":"Trina Osothprarop","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I178645029","display_name":"Illumina (United States)","ror":"https://ror.org/05k34t975","country_code":"US","type":"company","lineage":["https://openalex.org/I178645029"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trina Faye Osothprarop","raw_affiliation_strings":["Illumina Inc, 5200 Illumina Way, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Illumina Inc, 5200 Illumina Way, San Diego, CA, USA","institution_ids":["https://openalex.org/I178645029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078683510","display_name":"Amirali Kia","orcid":"https://orcid.org/0000-0002-5509-808X","observed_orcids":["https://orcid.org/0000-0002-5509-808X"]},"institutions":[{"id":"https://openalex.org/I178645029","display_name":"Illumina (United States)","ror":"https://ror.org/05k34t975","country_code":"US","type":"company","lineage":["https://openalex.org/I178645029"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amirali Kia","raw_affiliation_strings":["Illumina Inc, 5200 Illumina Way, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Illumina Inc, 5200 Illumina Way, San Diego, CA, USA","institution_ids":["https://openalex.org/I178645029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110116170","display_name":"Molly Min He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I178645029","display_name":"Illumina (United States)","ror":"https://ror.org/05k34t975","country_code":"US","type":"company","lineage":["https://openalex.org/I178645029"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Molly Min He","raw_affiliation_strings":["Illumina Inc, 5200 Illumina Way, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Illumina Inc, 5200 Illumina Way, San Diego, CA, USA","institution_ids":["https://openalex.org/I178645029"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100342359","display_name":"Kun Zhang","orcid":"https://orcid.org/0000-0002-7596-5224","observed_orcids":["https://orcid.org/0000-0002-7596-5224"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kun Zhang","raw_affiliation_strings":["Biomedical Sciences Graduate Program, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, USA. kzhang@bioeng.ucsd.edu","Department of Bioengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, USA. kzhang@bioeng.ucsd.edu","Biomedical Sciences Graduate Program, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Sciences Graduate Program, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, USA. kzhang@bioeng.ucsd.edu","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Bioengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, USA. kzhang@bioeng.ucsd.edu","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Biomedical Sciences Graduate Program, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100342359"],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":{"value":5490,"currency":"USD","value_usd":5490},"apc_paid":{"value":5490,"currency":"USD","value_usd":5490},"fwci":4.1566,"has_fulltext":true,"cited_by_count":54,"citation_normalized_percentile":{"value":0.9448645,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"17","issue":"1","first_page":"20","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chromatin-accessibility","display_name":"chromatin accessibility","score":1.0},{"id":"https://openalex.org/keywords/tn5-transposase","display_name":"Tn5 transposase","score":0.8349999785423279},{"id":"https://openalex.org/keywords/dnase-i-hypersensitive-sites","display_name":"DNase I hypersensitive sites","score":0.718999981880188},{"id":"https://openalex.org/keywords/in-vitro-transcription","display_name":"in vitro transcription","score":0.5619999766349792},{"id":"https://openalex.org/keywords/distal-enhancers","display_name":"distal enhancers","score":0.8889999985694885},{"id":"https://openalex.org/keywords/protein-dna-interactions","display_name":"protein-DNA interactions","score":0.8389999866485596}],"concepts":[{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.9273632764816284},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8065066933631897},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.605043351650238},{"id":"https://openalex.org/C67258246","wikidata":"https://www.wikidata.org/wiki/Q5065897","display_name":"ChIA-PET","level":5,"score":0.58021080493927},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5559781789779663},{"id":"https://openalex.org/C58237431","wikidata":"https://www.wikidata.org/wiki/Q5958570","display_name":"Hypersensitive site","level":5,"score":0.547241747379303},{"id":"https://openalex.org/C172510086","wikidata":"https://www.wikidata.org/wiki/Q410629","display_name":"Transposase","level":5,"score":0.5286527276039124},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.5283975005149841},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5189385414123535},{"id":"https://openalex.org/C2779377703","wikidata":"https://www.wikidata.org/wiki/Q14901483","display_name":"Deoxyribonuclease I","level":4,"score":0.5181373357772827},{"id":"https://openalex.org/C176619506","wikidata":"https://www.wikidata.org/wiki/Q5065899","display_name":"ChIP-sequencing","level":5,"score":0.49732235074043274},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.48888319730758667},{"id":"https://openalex.org/C93946551","wikidata":"https://www.wikidata.org/wiki/Q5113914","display_name":"Chromosome conformation capture","level":5,"score":0.48084530234336853},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4263265132904053},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3517484962940216},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3393286466598511},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30615943670272827},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.2960902452468872},{"id":"https://openalex.org/C4918238","wikidata":"https://www.wikidata.org/wiki/Q121438","display_name":"Transposable element","level":4,"score":0.21030375361442566},{"id":"https://openalex.org/C167227067","wikidata":"https://www.wikidata.org/wiki/Q5113739","display_name":"Chromatin remodeling","level":4,"score":0.20956063270568848},{"id":"https://openalex.org/C3017666073","wikidata":"https://www.wikidata.org/wiki/Q1764062","display_name":"Base sequence","level":3,"score":0.14809593558311462}],"mesh":[{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003850","descriptor_name":"Deoxyribonuclease I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004251","descriptor_name":"DNA Transposable Elements","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019895","descriptor_name":"Transposases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s13059-016-0882-7","doi":"https://doi.org/10.1186/s13059-016-0882-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13059-016-0882-7","pdf_url":"https://genomebiology.biomedcentral.com/counter/pdf/10.1186/s13059-016-0882-7","source":{"id":"https://openalex.org/S81160022","display_name":"Genome biology","issn_l":"1465-6906","issn":["1465-6906","1465-6914","1474-7596","1474-760X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4743176","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4743176","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Biol","raw_type":"Text"},{"id":"pmid:26846207","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26846207","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome biology","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt0g9401xq","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/0g9401xq","pdf_url":"https://escholarship.org/content/qt0g9401xq/qt0g9401xq.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genome Biology, vol 17, iss 1","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt0g9401xq","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/0g9401xq","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genome biology, vol 17, iss 1","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13059-016-0882-7","doi":"https://doi.org/10.1186/s13059-016-0882-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13059-016-0882-7","pdf_url":"https://genomebiology.biomedcentral.com/counter/pdf/10.1186/s13059-016-0882-7","source":{"id":"https://openalex.org/S81160022","display_name":"Genome biology","issn_l":"1465-6906","issn":["1465-6906","1465-6914","1474-7596","1474-760X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5600485393","display_name":"Regulation and Function of Polarity and Asymmetric Cell Division in Immunity","funder_award_id":"R01AI095277","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8393704952","display_name":"Genome-methylome Interactions","funder_award_id":"R01GM097253","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2289603825.pdf","grobid_xml":"https://content.openalex.org/works/W2289603825.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W18848980","https://openalex.org/W1492083415","https://openalex.org/W1602702667","https://openalex.org/W1964963969","https://openalex.org/W1979594866","https://openalex.org/W1980829286","https://openalex.org/W1996065618","https://openalex.org/W1998000745","https://openalex.org/W2008051478","https://openalex.org/W2020541351","https://openalex.org/W2026863186","https://openalex.org/W2038240598","https://openalex.org/W2039728576","https://openalex.org/W2049684926","https://openalex.org/W2065324308","https://openalex.org/W2068518785","https://openalex.org/W2071010503","https://openalex.org/W2092988184","https://openalex.org/W2101411738","https://openalex.org/W2104939059","https://openalex.org/W2110503722","https://openalex.org/W2112741367","https://openalex.org/W2117757143","https://openalex.org/W2122818453","https://openalex.org/W2125079242","https://openalex.org/W2133247083","https://openalex.org/W2136144150","https://openalex.org/W2139115185","https://openalex.org/W2139838862","https://openalex.org/W2146734921","https://openalex.org/W2149118429","https://openalex.org/W2164643779","https://openalex.org/W4297943700","https://openalex.org/W4298026142"],"related_works":["https://openalex.org/W2954028412","https://openalex.org/W1531821806","https://openalex.org/W6921359119","https://openalex.org/W4400737811","https://openalex.org/W2969158314","https://openalex.org/W4385495058","https://openalex.org/W3016866540","https://openalex.org/W3103634088","https://openalex.org/W4297997544","https://openalex.org/W3190092036"],"abstract_inverted_index":{"Chromatin":[0],"accessibility":[1,85],"captures":[2],"in":[3,42,68],"vivo":[4],"protein-chromosome":[5],"binding":[6],"status,":[7],"and":[8,19,84],"is":[9],"considered":[10],"an":[11,73],"informative":[12],"proxy":[13],"for":[14,30,54],"protein-DNA":[15],"interactions.":[16],"DNase":[17],"I":[18],"Tn5":[20,35,75],"transposase":[21],"assays":[22],"require":[23],"thousands":[24],"to":[25,37],"millions":[26],"of":[27,39,58,63,86],"fresh":[28],"cells":[29,40],"comprehensive":[31],"chromatin":[32,44,59],"mapping.":[33],"Applying":[34],"tagmentation":[36],"hundreds":[38],"results":[41],"sparse":[43],"maps.":[45],"We":[46],"present":[47],"a":[48],"transposome":[49],"hypersensitive":[50],"sites":[51],"sequencing":[52],"assay":[53],"highly":[55],"sensitive":[56],"characterization":[57],"accessibility.":[60],"Linear":[61],"amplification":[62],"accessible":[64],"DNA":[65],"ends":[66],"with":[67,72,93],"vitro":[69],"transcription,":[70],"coupled":[71],"engineered":[74],"super-mutant,":[76],"demonstrates":[77],"improved":[78],"sensitivity":[79],"on":[80],"limited":[81],"input":[82],"materials,":[83],"small":[87],"regions":[88],"near":[89],"distal":[90],"enhancers,":[91],"compared":[92],"ATAC-seq.":[94]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}