{"id":"https://openalex.org/W2289594376","doi":null,"title":"Application of proteomics and cytomics in human neutrophils functional studies","display_name":"Application of proteomics and cytomics in human neutrophils functional studies","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2289594376","mag":"2289594376"},"language":"en","primary_location":{"id":"pmh:oai:americanae.aecid.es:1798939","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.unb.br/handle/10482/1077","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UnB","raw_type":"info:eu-repo/semantics/masterThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://repositorio.unb.br/handle/10482/1077","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057457409","display_name":"Alexandre Rosa Campos","orcid":"https://orcid.org/0000-0003-3988-7764","observed_orcids":["https://orcid.org/0000-0003-3988-7764"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Alexandre Rosa Campos","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3988-7764","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5057457409"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9380000233650208,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9380000233650208,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.05490000173449516,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.9620000123977661},{"id":"https://openalex.org/keywords/neutrophil-activation","display_name":"neutrophil activation","score":0.8429999947547913},{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"programmed cell death","score":0.9010000228881836},{"id":"https://openalex.org/keywords/proteomics","display_name":"proteomics","score":0.6520000100135803},{"id":"https://openalex.org/keywords/cytomics","display_name":"cytomics","score":0.9509999752044678},{"id":"https://openalex.org/keywords/subcellular-fractionation","display_name":"subcellular fractionation","score":0.7789999842643738},{"id":"https://openalex.org/keywords/digitonin-extraction","display_name":"digitonin extraction","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cytosolic-proteins","display_name":"cytosolic proteins","score":0.9850000143051147},{"id":"https://openalex.org/keywords/flow-cytometry","display_name":"flow cytometry","score":0.6660000085830688},{"id":"https://openalex.org/keywords/systems-biology","display_name":"systems biology","score":0.7429999709129333},{"id":"https://openalex.org/keywords/multi-omics-integration","display_name":"multi-omics integration","score":0.753000020980835}],"concepts":[{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.6380189657211304},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.48867252469062805},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33784884214401245},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15373876690864563},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:americanae.aecid.es:1798939","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.unb.br/handle/10482/1077","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UnB","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"pmh:oai:repositorio.unb.br:10482/1077","doi":null,"is_oa":false,"landing_page_url":"http://repositorio.unb.br/handle/10482/1077","pdf_url":null,"source":{"id":"https://openalex.org/S4377196379","display_name":"RIUnB Institutional Repository (University of Bras\u00edlia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I150729083","host_organization_name":"Universidade de Bras\u00edlia","host_organization_lineage":["https://openalex.org/I150729083"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Disserta\u00e7\u00e3o"},{"id":"mag:2289594376","doi":null,"is_oa":false,"landing_page_url":"https://repositorio.unb.br/bitstream/10482/1077/1/Dissertacao_2007_AlexandreRosa.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:americanae.aecid.es:1798939","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.unb.br/handle/10482/1077","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UnB","raw_type":"info:eu-repo/semantics/masterThesis"},"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":204,"referenced_works":["https://openalex.org/W757598","https://openalex.org/W4267221","https://openalex.org/W59175948","https://openalex.org/W97463538","https://openalex.org/W120020303","https://openalex.org/W126786202","https://openalex.org/W167158724","https://openalex.org/W178700663","https://openalex.org/W248445848","https://openalex.org/W421135038","https://openalex.org/W645866409","https://openalex.org/W1216511763","https://openalex.org/W1499048493","https://openalex.org/W1501628121","https://openalex.org/W1504988702","https://openalex.org/W1505101625","https://openalex.org/W1505149221","https://openalex.org/W1505835018","https://openalex.org/W1524249696","https://openalex.org/W1565380190","https://openalex.org/W1575308338","https://openalex.org/W1586099293","https://openalex.org/W1597610606","https://openalex.org/W1597678601","https://openalex.org/W1617969468","https://openalex.org/W1633020330","https://openalex.org/W1751395305","https://openalex.org/W1769382158","https://openalex.org/W1775146462","https://openalex.org/W1877636182","https://openalex.org/W1897193595","https://openalex.org/W1928988650","https://openalex.org/W1958568600","https://openalex.org/W1963558983","https://openalex.org/W1964443249","https://openalex.org/W1964791336","https://openalex.org/W1965191744","https://openalex.org/W1965700082","https://openalex.org/W1965765359","https://openalex.org/W1966571906","https://openalex.org/W1969633895","https://openalex.org/W1969901996","https://openalex.org/W1969966502","https://openalex.org/W1970266617","https://openalex.org/W1970308705","https://openalex.org/W1970440081","https://openalex.org/W1971028875","https://openalex.org/W1971050831","https://openalex.org/W1974830441","https://openalex.org/W1976645829","https://openalex.org/W1977184198","https://openalex.org/W1979492674","https://openalex.org/W1979542564","https://openalex.org/W1982930121","https://openalex.org/W1984888820","https://openalex.org/W1984987668","https://openalex.org/W1985771129","https://openalex.org/W1985822851","https://openalex.org/W1986582680","https://openalex.org/W1987445292","https://openalex.org/W1989512428","https://openalex.org/W1990034508","https://openalex.org/W1992299948","https://openalex.org/W1992881340","https://openalex.org/W1992930552","https://openalex.org/W1994193027","https://openalex.org/W1994965038","https://openalex.org/W1995536857","https://openalex.org/W1996254162","https://openalex.org/W2000781818","https://openalex.org/W2003607269","https://openalex.org/W2005640894","https://openalex.org/W2005930045","https://openalex.org/W2008220701","https://openalex.org/W2008588972","https://openalex.org/W2008969370","https://openalex.org/W2010772726","https://openalex.org/W2011485759","https://openalex.org/W2012025231","https://openalex.org/W2014150942","https://openalex.org/W2014578458","https://openalex.org/W2014833685","https://openalex.org/W2017450535","https://openalex.org/W2017973513","https://openalex.org/W2020018374","https://openalex.org/W2021732259","https://openalex.org/W2023096047","https://openalex.org/W2023127291","https://openalex.org/W2027949951","https://openalex.org/W2029987169","https://openalex.org/W2030208822","https://openalex.org/W2030272562","https://openalex.org/W2030705576","https://openalex.org/W2031729422","https://openalex.org/W2031884770","https://openalex.org/W2034738351","https://openalex.org/W2035700643","https://openalex.org/W2039708570","https://openalex.org/W2040282922","https://openalex.org/W2041195097","https://openalex.org/W2044936649","https://openalex.org/W2045340003","https://openalex.org/W2045362817","https://openalex.org/W2046432663","https://openalex.org/W2047406342","https://openalex.org/W2048333869","https://openalex.org/W2049877297","https://openalex.org/W2051514868","https://openalex.org/W2053340213","https://openalex.org/W2054466780","https://openalex.org/W2054854596","https://openalex.org/W2055063265","https://openalex.org/W2055858936","https://openalex.org/W2058135122","https://openalex.org/W2059149560","https://openalex.org/W2059999532","https://openalex.org/W2060372462","https://openalex.org/W2060762539","https://openalex.org/W2061092989","https://openalex.org/W2061567983","https://openalex.org/W2063731065","https://openalex.org/W2066071024","https://openalex.org/W2067485115","https://openalex.org/W2068356217","https://openalex.org/W2069093132","https://openalex.org/W2069288734","https://openalex.org/W2069375519","https://openalex.org/W2070548987","https://openalex.org/W2072796605","https://openalex.org/W2075241233","https://openalex.org/W2076515797","https://openalex.org/W2076575307","https://openalex.org/W2079096224","https://openalex.org/W2079168625","https://openalex.org/W2079608251","https://openalex.org/W2080063528","https://openalex.org/W2082516237","https://openalex.org/W2083020576","https://openalex.org/W2083441358","https://openalex.org/W2084814184","https://openalex.org/W2086042125","https://openalex.org/W2091387465","https://openalex.org/W2092450124","https://openalex.org/W2093048036","https://openalex.org/W2093852073","https://openalex.org/W2094709229","https://openalex.org/W2097399083","https://openalex.org/W2097871689","https://openalex.org/W2100936098","https://openalex.org/W2101401045","https://openalex.org/W2107414760","https://openalex.org/W2108322397","https://openalex.org/W2108664926","https://openalex.org/W2109277456","https://openalex.org/W2113755819","https://openalex.org/W2113946990","https://openalex.org/W2114819441","https://openalex.org/W2115707658","https://openalex.org/W2119062616","https://openalex.org/W2119573636","https://openalex.org/W2121974555","https://openalex.org/W2123119225","https://openalex.org/W2124407952","https://openalex.org/W2127856785","https://openalex.org/W2128635872","https://openalex.org/W2128988773","https://openalex.org/W2129059285","https://openalex.org/W2130312879","https://openalex.org/W2130410032","https://openalex.org/W2132416882","https://openalex.org/W2137471507","https://openalex.org/W2140626436","https://openalex.org/W2141204359","https://openalex.org/W2142032598","https://openalex.org/W2142168833","https://openalex.org/W2143586010","https://openalex.org/W2143886761","https://openalex.org/W2146495023","https://openalex.org/W2148957569","https://openalex.org/W2154912073","https://openalex.org/W2155178750","https://openalex.org/W2157952919","https://openalex.org/W2158825156","https://openalex.org/W2159286440","https://openalex.org/W2160773533","https://openalex.org/W2161574105","https://openalex.org/W2163605714","https://openalex.org/W2166861900","https://openalex.org/W2166998713","https://openalex.org/W2167119716","https://openalex.org/W2168909179","https://openalex.org/W2172116519","https://openalex.org/W2245811633","https://openalex.org/W2283638681","https://openalex.org/W2330176280","https://openalex.org/W2345239183","https://openalex.org/W2409706327","https://openalex.org/W2414674520","https://openalex.org/W2414983659","https://openalex.org/W2497081091","https://openalex.org/W2616844296","https://openalex.org/W2886310122","https://openalex.org/W4242509007","https://openalex.org/W4313376921"],"related_works":["https://openalex.org/W7119311387","https://openalex.org/W7097731212","https://openalex.org/W7026613818","https://openalex.org/W6979849860","https://openalex.org/W2128950935","https://openalex.org/W2302004581","https://openalex.org/W2421462135","https://openalex.org/W7095282049","https://openalex.org/W4239631814","https://openalex.org/W2402826741"],"abstract_inverted_index":{"Biomedical":[0],"research":[1],"commonly":[2],"starts":[3],"by":[4],"raising":[5],"a":[6,10,27,37,80,90,139],"hypothesis":[7],"to":[8,21,69,96,99,106,147,169,179],"solve":[9,26],"problem.":[11],"In":[12,103],"this":[13,104,125],"context,":[14,105],"scientists":[15],"select":[16],"the":[17,23,31,46,60,71,86,109,120,128,151],"most":[18],"appropriate":[19],"method(s)":[20],"answer":[22],"question":[24],"and":[25,56,115,122,181],"common":[28],"dilemma.":[29],"Over":[30],"past":[32],"decade,":[33],"we":[34,62],"have":[35],"witnessed":[36],"revolution":[38],"of":[39,74,89,130,157,161],"new":[40],"technologies":[41,50],"in":[42,119,144],"molecular":[43,152],"biology":[44,82,132],"\u2013":[45],"Omics":[47],"Science.":[48],"Highscale":[49],"such":[51,134],"as":[52,135],"metabolomics,":[53],"cytomics,":[54],"genomics":[55],"proteomics":[57,142],"are":[58],"changing":[59],"way":[61],"study":[63,126],"complex":[64],"biological":[65],"systems.":[66],"Current":[67],"approaches":[68,133],"understanding":[70],"functional":[72],"diversity":[73],"an":[75,97,145],"organism":[76],"preferentially":[77],"strive":[78],"for":[79],"systems":[81],"approach":[83],"whereby":[84],"first":[85],"phenotypic":[87,155],"classification":[88],"specific":[91],"cytome":[92],"is":[93],"achieved":[94],"prior":[95],"attempt":[98,146],"perform":[100],"proteomic":[101],"analysis.":[102],"better":[107],"understand":[108],"features":[110],"that":[111],"involve":[112],"neutrophil":[113],"activation":[114],"programmed":[116],"cell":[117,131],"death":[118],"pathological":[121],"healthy":[123],"states,":[124],"proposes":[127],"integration":[129],"flow":[136],"cytometry":[137],"with":[138,154],"very":[140],"robust":[141],"platform":[143],"integrate":[148],"data":[149,156],"at":[150],"level":[153],"neutrophils.":[158],"The":[159],"application":[160],"subcellular":[162],"fractionation":[163],"method":[164],"using":[165],"digitonin":[166],"detergent":[167],"extraction":[168],"enrich":[170],"cytosolic":[171],"proteins":[172],"from":[173],"neutrophils":[174],"was":[175],"found":[176],"reproducible,":[177],"simple":[178],"perform,":[180],"inexpensive.":[182],"________________________________________________________________________________________":[183],"ABSTRACT":[184]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2016-06-24T00:00:00"}
