{"id":"https://openalex.org/W2289556302","doi":null,"title":"Pain pathways and mechanisms of neuropathic pain V\u00edas y mecanismos de dolor neurop\u00e1tico","display_name":"Pain pathways and mechanisms of neuropathic pain V\u00edas y mecanismos de dolor neurop\u00e1tico","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2289556302","mag":"2289556302"},"language":"es","primary_location":{"id":"pmh:oai:doaj.org/article:b9805de1584745cf99395e353b6fec4c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/b9805de1584745cf99395e353b6fec4c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Neurol\u00f3gica Colombiana, Vol 23, Iss 3 (2007)","raw_type":"article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090241942","display_name":"Oscar A. de Le\u00f3n-Casasola","orcid":"https://orcid.org/0000-0002-0837-9196","observed_orcids":["https://orcid.org/0000-0002-0837-9196"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Oscar A. de Leon\u2010Casasola","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0837-9196","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5090241942"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.29883179,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.9929999709129333},{"id":"https://openalex.org/keywords/pain-pathways","display_name":"pain pathways","score":0.8420000076293945},{"id":"https://openalex.org/keywords/nociceptors","display_name":"nociceptors","score":0.8859999775886536},{"id":"https://openalex.org/keywords/nociception","display_name":"nociception","score":0.5830000042915344},{"id":"https://openalex.org/keywords/pain-transduction","display_name":"pain transduction","score":0.7519999742507935},{"id":"https://openalex.org/keywords/pain-transmission","display_name":"pain transmission","score":0.7630000114440918},{"id":"https://openalex.org/keywords/a-delta-fibers","display_name":"A-delta fibers","score":0.8920000195503235},{"id":"https://openalex.org/keywords/c-fibers","display_name":"C-fibers","score":0.9990000128746033},{"id":"https://openalex.org/keywords/polymodal-nociceptors","display_name":"polymodal nociceptors","score":0.906000018119812},{"id":"https://openalex.org/keywords/descending-pain-modulation","display_name":"descending pain modulation","score":0.968999981880188},{"id":"https://openalex.org/keywords/opioid-receptors","display_name":"opioid receptors","score":0.781000018119812},{"id":"https://openalex.org/keywords/endorphins","display_name":"endorphins","score":0.8989999890327454},{"id":"https://openalex.org/keywords/morphine","display_name":"morphine","score":0.8050000071525574},{"id":"https://openalex.org/keywords/spinal-cord-dorsal-horn","display_name":"dorsal horn","score":0.8230000138282776}],"concepts":[{"id":"https://openalex.org/C172659308","wikidata":"https://www.wikidata.org/wiki/Q412542","display_name":"Nociceptor","level":4,"score":0.8693629503250122},{"id":"https://openalex.org/C104211972","wikidata":"https://www.wikidata.org/wiki/Q7067309","display_name":"Noxious stimulus","level":4,"score":0.8133431673049927},{"id":"https://openalex.org/C71331990","wikidata":"https://www.wikidata.org/wiki/Q5275422","display_name":"Diffuse noxious inhibitory control","level":5,"score":0.7362473011016846},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7204107046127319},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.6303789615631104},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.452247679233551},{"id":"https://openalex.org/C2777107010","wikidata":"https://www.wikidata.org/wiki/Q2798704","display_name":"Neuropathic pain","level":2,"score":0.4346635341644287},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.41809144616127014},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.381883442401886},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34661537408828735},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3089909553527832},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.26772645115852356},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0968160629272461}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:doaj.org/article:b9805de1584745cf99395e353b6fec4c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/b9805de1584745cf99395e353b6fec4c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Neurol\u00f3gica Colombiana, Vol 23, Iss 3 (2007)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:c08ae2e642494caab9a3583e32719cd1","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/c08ae2e642494caab9a3583e32719cd1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Neurol\u00f3gica Colombiana, Vol 23, Iss 3 (2007)","raw_type":"article"},{"id":"mag:2289556302","doi":null,"is_oa":false,"landing_page_url":"http://www.acnweb.org/acta/2007_23_3_107.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":2,"referenced_works":["https://openalex.org/W2066362290","https://openalex.org/W3151231921"],"related_works":["https://openalex.org/W2338521849","https://openalex.org/W7221840426","https://openalex.org/W4220853838","https://openalex.org/W4211236075","https://openalex.org/W3044494073","https://openalex.org/W2171959049","https://openalex.org/W1970620781","https://openalex.org/W104278114","https://openalex.org/W4388242353","https://openalex.org/W2601965892"],"abstract_inverted_index":{"Several":[0],"neural":[1],"steps":[2],"are":[3,49,84,108,115,149,236],"involved":[4],"in":[5,54,66,90,120,176,180,241,279],"the":[6,15,43,55,59,70,75,80,91,121,162,172,177,188,193,197,206,209,218,238,242,247,256,263,267,274,280,288,292,297],"processing":[7,163],"of":[8,17,63,93,123,136,161,164,196,208,266,277,291,299],"noxious":[9,24,47,64,131,165,184,189],"signals":[10,53],"that":[11,118,167,205,303],"can":[12],"lead":[13],"to":[14,22,38,51,74,79,96,102,126,182,200,211,261,309],"experience":[16],"pain.":[18],"Nociceptors":[19],"readily":[20],"respond":[21,37,101],"different":[23],"modalities":[25,137],"such":[26,306],"as":[27,307],"thermal,":[28,140],"mechanical":[29,105],"or":[30],"chemical":[31,142],"stimuli,":[32],"but":[33],"nociceptors":[34,56],"do":[35],"not":[36],"non-noxious":[39],"stimuli.":[40],"Transduction,":[41],"is":[42,72,154,214,296],"process":[44,62,170],"by":[45],"which":[46,67,88,174],"stimuli":[48,143,166],"converted":[50],"electrical":[52],"and":[57,77,107,129,141,147,157,186,232,244,283],"transmission,":[58],"second":[60],"stage":[61],"signals,":[65],"information":[68,132],"from":[69,133],"periphery":[71],"relayed":[73],"thalamus":[76],"then":[78],"cortex.":[81],"A-delta":[82],"fibers":[83,87,100,117],"thinly":[85],"myelinated":[86],"conduct":[89,119],"range":[92,122],"2":[94,127],"m/s":[95,125,128],"20":[97],"m/s.":[98],"These":[99],"high":[103,111],"intensity":[104],"stimulation":[106],"therefore":[109],"termed":[110,150],"threshold":[112],"mechanoreceptors,":[113],"C-fibers":[114,278],"non-myelinated":[116],"0.5":[124],"transmit":[130],"a":[134,155,183],"variety":[135],"including":[138],"mechanical,":[139],"for":[144],"this":[145],"reason,":[146],"they":[148,235],"polymodal":[151],"nociceptors.":[152],"Modulation":[153],"third":[156],"critically":[158],"important":[159],"aspect":[160],"occurs.":[168],"This":[169],"represents":[171],"changes":[173],"occur":[175],"nervous":[178],"system":[179],"response":[181],"stimulus":[185],"allows":[187,304],"signal":[190,210],"received":[191],"at":[192,273,287],"dorsal":[194],"horn":[195],"spinal":[198,281],"cord":[199],"be":[201],"selectively":[202],"inhibited,":[203],"so":[204],"transmission":[207,259,265],"higher":[212],"centers":[213],"modified.":[215],"Endorphins":[216],"activate":[217],"descending":[219,248],"modulatory":[220],"systems":[221,249,302],"through":[222],"specific":[223],"receptors":[224,240,254,272,286],"called":[225],"\u201copioid":[226],"receptors\u201d.":[227],"When":[228],"physicians":[229],"gives":[230],"morphine,":[231],"others":[233],"opiates,":[234],"activating":[237,252,270,284],"opioid":[239,253,271,285],"midbrain":[243],"\u201cturning":[245],"on\u201d":[246],"(through":[250],"disinhibition),":[251],"on":[255],"second-order":[257],"pain":[258,268,313],"cells":[260],"prevent":[262],"ascending":[264],"signal,":[269],"central":[275],"terminals":[276,290],"cord,":[282],"peripheral":[289],"nociceptive":[293],"C-fibers.":[294],"It":[295],"activation":[298],"these":[300],"four":[301],"opiates":[305],"morphine":[308],"produce":[310],"clinically":[311],"useful":[312],"relief.":[314]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
