{"id":"https://openalex.org/W2289345757","doi":null,"title":"Investigation of promoter histone deacetylation as a mechanism for cyclic adenosine monophospate-stimulated repression of microRNA-375","display_name":"Investigation of promoter histone deacetylation as a mechanism for cyclic adenosine monophospate-stimulated repression of microRNA-375","publication_year":2015,"publication_date":"2015-12-08","ids":{"openalex":"https://openalex.org/W2289345757","mag":"2289345757"},"language":"en","primary_location":{"id":"pmh:oai:dspace.calstate.edu:10211.3/158522","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10211.3/158522","pdf_url":"http://hdl.handle.net/10211.3/158522","source":{"id":"https://openalex.org/S7407064448","display_name":"California State University ScholarWorks (system-wide DSpace)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10211.3/158522","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000694007","display_name":"Alexander R. Stanton","orcid":"https://orcid.org/0000-0003-0139-979X","observed_orcids":["https://orcid.org/0000-0003-0139-979X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Alexander R. Stanton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5000694007"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.5644999742507935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.5644999742507935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.14470000565052032,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.10689999908208847,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-375","display_name":"miR-375","score":0.9679999947547913},{"id":"https://openalex.org/keywords/histone-deacetylation","display_name":"histone deacetylation","score":0.9620000123977661},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.6140000224113464},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.9829999804496765},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.7269999980926514},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.6830000281333923},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.8100000023841858},{"id":"https://openalex.org/keywords/h3k9","display_name":"H3K9","score":0.8399999737739563},{"id":"https://openalex.org/keywords/trichostatin-a","display_name":"trichostatin A","score":0.8600000143051147},{"id":"https://openalex.org/keywords/chromatin-structure","display_name":"chromatin structure","score":0.8289999961853027},{"id":"https://openalex.org/keywords/pdpk1","display_name":"PDPK1","score":0.859000027179718},{"id":"https://openalex.org/keywords/myotrophin","display_name":"myotrophin","score":0.8610000014305115},{"id":"https://openalex.org/keywords/insulin-exocytosis","display_name":"insulin exocytosis","score":0.9229999780654907}],"concepts":[{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.7027336955070496},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.6987342834472656},{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.6650611758232117},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.585286557674408},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5172280073165894},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.4811197817325592},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47043392062187195},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4294314980506897},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3661414384841919},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23659923672676086},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1599411964416504},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.14921829104423523},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07989513874053955},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:dspace.calstate.edu:10211.3/158522","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10211.3/158522","pdf_url":"http://hdl.handle.net/10211.3/158522","source":{"id":"https://openalex.org/S7407064448","display_name":"California State University ScholarWorks (system-wide DSpace)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"pmh:oai:scholarworks.calstate.edu:10211.3/158522","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10211.3/158522","pdf_url":null,"source":{"id":"https://openalex.org/S4306402638","display_name":"CSUN ScholarWorks (California State University, Northridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I157638225","host_organization_name":"California State University, Northridge","host_organization_lineage":["https://openalex.org/I157638225"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},{"id":"mag:2289345757","doi":null,"is_oa":false,"landing_page_url":"http://scholarworks.calstate.edu/handle/10211.3/158522","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dspace.calstate.edu:10211.3/158522","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10211.3/158522","pdf_url":"http://hdl.handle.net/10211.3/158522","source":{"id":"https://openalex.org/S7407064448","display_name":"California State University ScholarWorks (system-wide DSpace)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2289345757.pdf","grobid_xml":"https://content.openalex.org/works/W2289345757.grobid-xml"},"referenced_works_count":72,"referenced_works":["https://openalex.org/W1237155366","https://openalex.org/W1526229661","https://openalex.org/W1572009433","https://openalex.org/W1598254642","https://openalex.org/W1963952972","https://openalex.org/W1975437957","https://openalex.org/W1976177239","https://openalex.org/W1977481910","https://openalex.org/W1978976893","https://openalex.org/W1986931072","https://openalex.org/W2002698073","https://openalex.org/W2003943923","https://openalex.org/W2006164944","https://openalex.org/W2013872193","https://openalex.org/W2014064723","https://openalex.org/W2015001567","https://openalex.org/W2016167871","https://openalex.org/W2019252344","https://openalex.org/W2024725357","https://openalex.org/W2033362878","https://openalex.org/W2041803958","https://openalex.org/W2045748545","https://openalex.org/W2054109341","https://openalex.org/W2061574308","https://openalex.org/W2063708051","https://openalex.org/W2069296649","https://openalex.org/W2071596792","https://openalex.org/W2071981322","https://openalex.org/W2073803015","https://openalex.org/W2074511950","https://openalex.org/W2074633223","https://openalex.org/W2075907707","https://openalex.org/W2078028724","https://openalex.org/W2080356693","https://openalex.org/W2082213106","https://openalex.org/W2084951237","https://openalex.org/W2095959590","https://openalex.org/W2096266214","https://openalex.org/W2096304780","https://openalex.org/W2099517697","https://openalex.org/W2100285856","https://openalex.org/W2105100736","https://openalex.org/W2106929712","https://openalex.org/W2109136664","https://openalex.org/W2109365834","https://openalex.org/W2113150125","https://openalex.org/W2113544353","https://openalex.org/W2114041992","https://openalex.org/W2120211068","https://openalex.org/W2120805065","https://openalex.org/W2128167237","https://openalex.org/W2128882718","https://openalex.org/W2130979840","https://openalex.org/W2131957545","https://openalex.org/W2135613885","https://openalex.org/W2137137048","https://openalex.org/W2139122866","https://openalex.org/W2139776902","https://openalex.org/W2139966272","https://openalex.org/W2144472092","https://openalex.org/W2144792857","https://openalex.org/W2146358743","https://openalex.org/W2146716725","https://openalex.org/W2146877877","https://openalex.org/W2151428158","https://openalex.org/W2156629568","https://openalex.org/W2159205789","https://openalex.org/W2161068194","https://openalex.org/W2163784004","https://openalex.org/W2165804743","https://openalex.org/W2168230240","https://openalex.org/W2172157991"],"related_works":["https://openalex.org/W7023988759","https://openalex.org/W4226187734","https://openalex.org/W3021506718","https://openalex.org/W3023793897","https://openalex.org/W2026166033","https://openalex.org/W3028766808","https://openalex.org/W7011544113","https://openalex.org/W3041832574","https://openalex.org/W2151428158","https://openalex.org/W2197036734"],"abstract_inverted_index":{"Type":[0],"2":[1,173],"Diabetes":[2],"(T2D)":[3],"is":[4,22,144,177,245],"a":[5,9,178,233],"disease":[6,47],"which":[7,110,130,165,197],"affects":[8],"large":[10],"percentage":[11],"of":[12,19,43,61,79,89,107,136,192,225,240,253,264,288],"the":[13,17,41,52,55,62,87,90,108,116,132,147,193,222,226,250,265,272,286],"United":[14],"States":[15],"and":[16,33,54,105,120,125,134,172],"risk":[18],"developing":[20],"T2D":[21,29,68],"increasing":[23],"according":[24],"to":[25,71,249],"recent":[26],"CDC":[27],"estimates.":[28],"can":[30],"be":[31,282],"fatal,":[32],"although":[34],"patients":[35,53,84],"are":[36,48,97,113,138,198,267],"living":[37],"longer":[38],"with":[39,206],"it,":[40],"costs":[42],"caring":[44],"for":[45,181,285],"this":[46,184,243],"burdensome":[49],"on":[50],"both":[51],"health":[56],"care":[57],"system.":[58],"Better":[59],"understanding":[60],"aberrations":[63],"in":[64,82,115,221,242],"cell":[65],"signaling":[66],"during":[67,183,269],"could":[69],"lead":[70],"insights":[72],"that":[73,100,278],"may":[74,280],"restore":[75],"proper":[76],"signaling.":[77],"Investigations":[78],"genetic":[80],"dysregulation":[81],"these":[83],"has":[85,188],"implicated":[86],"overexpression":[88],"small":[91],"regulatory":[92],"RNA":[93],"microRNA(miR)-375.":[94],"These":[95],"miRNA":[96],"post-transcriptional":[98],"regulators":[99],"function":[101],"through":[102,157,174],"translational":[103],"silencing,":[104],"two":[106,190],"genes":[109],"miR-375":[111,137,194,227],"silences":[112],"involved":[114],"pancreatic":[117],"??-cell":[118],"viability":[119],"insulin":[121],"exocytosis":[122],"(phosphoinositide-dependent":[123],"kinase-1":[124],"myotrophin":[126],"respectively).":[127],"The":[128,238],"factors":[129],"govern":[131],"activation":[133],"repression":[135,182,287],"not":[139,217],"well":[140],"known,":[141],"but":[142],"it":[143,275,279],"downregulated":[145],"by":[146,210,232,256],"cyclic":[148],"adenosine":[149],"monophosphate":[150],"(cAMP)/":[151],"protein":[152],"kinase":[153],"A":[154],"(PKA)":[155],"pathway":[156],"an":[158],"unknown":[159],"mechanism.":[160],"Since":[161],"cAMP":[162,211,270],"activates":[163,167],"PKA,":[164],"then":[166],"histone":[168,201],"deacetylase":[169],"(HDAC)":[170],"1":[171],"phosphorylation,":[175],"deacetylation":[176,215],"possible":[179],"mechanism":[180],"pathway.":[185],"This":[186],"study":[187],"identified":[189],"regions":[191,263],"upstream":[195,228],"promoter":[196,229,266],"deacetylated":[199,268],"at":[200],"H3":[202],"lysine":[203],"9/14":[204],"corresponding":[205],"decreased":[207],"transcriptional":[208],"initiation":[209],"induction.":[212],"Observed":[213],"cAMP-induced":[214],"does":[216],"cause":[218],"overall":[219],"changes":[220,274],"chromatin":[223],"structure":[224],"as":[230],"analyzed":[231],"micrococcal":[234],"nuclease":[235],"protection":[236],"assay.":[237],"necessity":[239],"HDAC":[241,254,257],"process":[244],"still":[246],"unclear":[247],"due":[248],"broad":[251],"effects":[252],"inhibition":[255],"inhibitor":[258],"trichostatin":[259],"A.":[260],"While":[261],"some":[262],"signaling,":[271],"moderate":[273],"confers":[276],"suggest":[277],"only":[281],"partially":[283],"responsible":[284],"miR-375.":[289]},"counts_by_year":[],"updated_date":"2026-09-09T07:26:56.047234","created_date":"2016-06-24T00:00:00"}